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Protein

Annexin A11

Gene

ANXA11

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to calcyclin in a calcium-dependent manner. Required for midbody formation and completion of the terminal phase of cytokinesis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A11
Alternative name(s):
Annexin XI
Annexin-11
Calcyclin-associated annexin-50
Short name:
CAP-50
Gene namesi
Name:ANXA11
Synonyms:ANX11
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm By similarity
  • Melanosome By similarity
  • Nucleus envelope By similarity
  • Nucleusnucleoplasm By similarity
  • Cytoplasmcytoskeletonspindle By similarity

  • Note: Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus. Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000675091 – 503Annexin A11Add BLAST503

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei246N6-acetyllysineBy similarity1
Modified residuei253N6-acetyllysineBy similarity1
Modified residuei477N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP27214.
PeptideAtlasiP27214.
PRIDEiP27214.

Expressioni

Tissue specificityi

Expressed in a wide variety of tissues.

Interactioni

Subunit structurei

Interacts with PDCD6 in a calcium-dependent manner (By similarity). Interacts with KIF23 during cytokinesis (By similarity). Isoform 1 but not isoform 2 interacts with S100A6.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027893.

Structurei

3D structure databases

ProteinModelPortaliP27214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati207 – 267Annexin 1Add BLAST61
Repeati279 – 339Annexin 2Add BLAST61
Repeati363 – 423Annexin 3Add BLAST61
Repeati438 – 498Annexin 4Add BLAST61

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP27214.
KOiK17095.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR008157. AnnexinXI.
[Graphical view]
PANTHERiPTHR10502:SF29. PTHR10502:SF29. 3 hits.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01810. ANNEXINXI.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P27214-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYPGYPPPA GGYPPGAPGG GAWGGAGYPP PTMPPIGLDN VANYAGQFNQ
60 70 80 90 100
DYLSGVAANM SGTFGGANVP NLYPGAPGGG YPPVPPGGFG QPPPAQQPVP
110 120 130 140 150
SYGMYPPPGG NPTSGMPSYP PYPGAPVPGQ PMLPPGQQPP GVYPGQPPMT
160 170 180 190 200
YPGQSPVPPP GQQPVPSYPG YSGSGTVTPA VSPAQFGNRG TITDASGFDP
210 220 230 240 250
LRDAEVLRKA MKGFGTDEQA IIDCLGSRSN KQRQQILLSF KTAYGKDLIK
260 270 280 290 300
DLKSELSGNF EKTILALMKT PVLFDAYEIK EAIKGAGTDE ACLIEILASR
310 320 330 340 350
SNEHIRELNR VYKTEFKKTL EEAIRSDTSG HFQRLLISLS QGNRDESTNV
360 370 380 390 400
DMTLVQRDVQ ELYAAGENRL GTDESKFNAI LCSRSRAHLV AVFNEYQRMT
410 420 430 440 450
GRDIEKSICR EMSGDLEQGM LAVVKCLKNT PAFFAERLNK AMRGAGTKDR
460 470 480 490 500
TLIRIMVSRS EIDLLDIRAE YKRLYGKSLY HDITGDTSGD YRKILLKICG

GND
Length:503
Mass (Da):54,018
Last modified:August 1, 1992 - v1
Checksum:i3AF6503CCA6D05A1
GO
Isoform 2 (identifier: P27214-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-56: GGAWGGAGYP...QFNQDYLSGV → VPELESHAGG...LAAVLLVRAT

Show »
Length:505
Mass (Da):54,216
Checksum:i7A811EEC5A3F6FBD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113T → P in AAI19827 (Ref. 3) Curated1
Sequence conflicti326S → G AA sequence (PubMed:1618851).Curated1
Sequence conflicti334R → Q AA sequence (PubMed:1618851).Curated1
Sequence conflicti455I → D AA sequence (PubMed:1618851).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00028920 – 56GGAWG…YLSGV → VPELESHAGGPQGLFAAMDR AVSDGPAMMLAAVLLVRAT in isoform 2. CuratedAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M82802 mRNA. Translation: AAA30379.1.
Z11742 mRNA. Translation: CAA77801.1.
BC119826 mRNA. Translation: AAI19827.1.
PIRiA42113. LUBO11.
S23447.
RefSeqiNP_776927.1. NM_174502.2. [P27214-2]
UniGeneiBt.5150.

Genome annotation databases

GeneIDi282142.
KEGGibta:282142.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M82802 mRNA. Translation: AAA30379.1.
Z11742 mRNA. Translation: CAA77801.1.
BC119826 mRNA. Translation: AAI19827.1.
PIRiA42113. LUBO11.
S23447.
RefSeqiNP_776927.1. NM_174502.2. [P27214-2]
UniGeneiBt.5150.

3D structure databases

ProteinModelPortaliP27214.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027893.

Proteomic databases

PaxDbiP27214.
PeptideAtlasiP27214.
PRIDEiP27214.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282142.
KEGGibta:282142.

Organism-specific databases

CTDi311.

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP27214.
KOiK17095.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR008157. AnnexinXI.
[Graphical view]
PANTHERiPTHR10502:SF29. PTHR10502:SF29. 3 hits.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01810. ANNEXINXI.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANX11_BOVIN
AccessioniPrimary (citable) accession number: P27214
Secondary accession number(s): P27215, Q0VD55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 5, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

The subcellular location study was carried out using a rat fibroblast cell line.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.