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P27209 (RDRP_TNVD) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA-directed RNA polymerase

EC=2.7.7.48
Alternative name(s):
Protein p82

Cleaved into the following chain:

  1. Protein p23
Gene names
ORF Names:ORF1
OrganismTobacco necrosis virus (strain D) (TNV)
Taxonomic identifier12056 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeBetanecrovirus
Virus hostChenopodium amaranticolor [TaxID: 66262]
Chenopodium quinoa (Quinoa) [TaxID: 63459]
Cucumis sativus (Cucumber) [TaxID: 3659]
Nicotiana clevelandii (Wild tobacco) [TaxID: 81866]
Nicotiana tabacum (Common tobacco) [TaxID: 4097]
Phaseolus vulgaris (Kidney bean) (French bean) [TaxID: 3885]
Tulipa gesneriana (Garden tulip) [TaxID: 13306]

Protein attributes

Sequence length725 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

RNA-dependent RNA polymerase that plays an essential role in the virus replication Probable.

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Miscellaneous

Readthrough of the terminator UAG occurs at position 203.

Sequence similarities

Belongs to the tombusviridae RNA polymerase family.

Contains 1 RdRp catalytic domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 725725RNA-directed RNA polymerase
PRO_0000040219
Chain1 – 202202Protein p23
PRO_0000040220

Regions

Domain424 – 544121RdRp catalytic

Sequences

Sequence LengthMass (Da)Tools
P27209 [UniParc].

Last modified October 5, 2010. Version 3.
Checksum: 5A57467158A30634

FASTA72582,357
        10         20         30         40         50         60 
MESLPIVLLS LISKAVVLIC SLLTLIIQNS TAVTWGLACV WLAYVSFRFL FQVKITVHPA 

        70         80         90        100        110        120 
ARETFESMVR KFQAESMFSE EATPCIVSVG DKDADLTPDP QREDIKIVKS SRRVSYAVRV 

       130        140        150        160        170        180 
AHVAKAQVGL LANSRANELV YSRLCREEMV KHGVRPSHIA HMVPLAVAAC FIPLDSDFLA 

       190        200        210        220        230        240 
ASIRQGEGMR ERRALLGPSW EKXGGLLVTS GFTTPTWRGD PRGMLVTKGP PLAKPRKLYR 

       250        260        270        280        290        300 
FTGMGTHIRY GVHDHSLGNV RRGLVERLYM VEVKGELQPT PKPTPGAFNQ MSRFSDRLSI 

       310        320        330        340        350        360 
HLPKTTRLTP REFLGFYTGR KLERYQKAVE SLEMHPVREK DAWLSTFVKA EKLNITAKPD 

       370        380        390        400        410        420 
PAPRVIQPRD PRYNVEVGRF LRHSEEMLFK AINKTFGGRT IFKGLSSDQA GEEFKTLWDS 

       430        440        450        460        470        480 
FKDPVGIGMD ASRFDQHISK DALEFEHKMW LSMFPKSERA ELARLLSWQI NNRGLARCPD 

       490        500        510        520        530        540 
GEIRYRVEGC RMSGDMNTSS GNCYIMCATV HNWCDNIKHI KHFRLANNGD DCMLVVERSD 

       550        560        570        580        590        600 
EKKVRNGLIE YYATLGFTMK VEPTVDVLER LEFCQTRPVL VDGKYRMVRN LHQSMSKDLH 

       610        620        630        640        650        660 
SLHDLDSSAA RNAWVTAVGT GGRCMNDGVP VLKEFFKQFP DYNLEVKKGS DMAQKLRDDW 

       670        680        690        700        710        720 
KYKFNRTAAF QDLIPTQESR YSFWLAFGLL PDEQIALENG FSPLKMEIVN EQIQEETSLL 


QFSGA 

« Hide

References

[1]"The complete nucleotide sequence of tobacco necrosis virus strain D."
Coutts R.H.A., Rigden J.E., Slabas A.R., Lomonossoff G.P., Wise P.J.
J. Gen. Virol. 72:1521-1529(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]Coutts R.H.A.
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D00942 Genomic RNA. Translation: BAA00785.1.
D00942 Genomic RNA. Translation: BAA00786.1.
PIRRRWQTD. JU0368.

3D structure databases

ProteinModelPortalP27209.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
IPR013707. Tombusvirus_p33.
[Graphical view]
PfamPF00998. RdRP_3. 1 hit.
PF08500. Tombus_P33. 1 hit.
[Graphical view]
PROSITEPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRDRP_TNVD
AccessionPrimary (citable) accession number: P27209
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 62 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families