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P27209

- RDRP_TNVD

UniProt

P27209 - RDRP_TNVD

Protein

RNA-directed RNA polymerase

Gene

ORF1

Organism
Tobacco necrosis virus (strain D) (TNV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 3 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    RNA-dependent RNA polymerase that plays an essential role in the virus replication.Curated

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA binding Source: InterPro
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase (EC:2.7.7.48)
    Alternative name(s):
    Protein p82
    Cleaved into the following chain:
    Gene namesi
    ORF Names:ORF1
    OrganismiTobacco necrosis virus (strain D) (TNV)
    Taxonomic identifieri12056 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeBetanecrovirus
    Virus hostiChenopodium amaranticolor [TaxID: 66262]
    Chenopodium quinoa (Quinoa) [TaxID: 63459]
    Cucumis sativus (Cucumber) [TaxID: 3659]
    Nicotiana clevelandii (Wild tobacco) [TaxID: 81866]
    Nicotiana tabacum (Common tobacco) [TaxID: 4097]
    Phaseolus vulgaris (Kidney bean) (French bean) [TaxID: 3885]
    Tulipa gesneriana (Garden tulip) [TaxID: 13306]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 725725RNA-directed RNA polymerasePRO_0000040219Add
    BLAST
    Chaini1 – 202202Protein p23PRO_0000040220Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP27209.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini424 – 544121RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    IPR013707. Tombusvirus_p33.
    [Graphical view]
    PfamiPF00998. RdRP_3. 1 hit.
    PF08500. Tombus_P33. 1 hit.
    [Graphical view]
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P27209-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESLPIVLLS LISKAVVLIC SLLTLIIQNS TAVTWGLACV WLAYVSFRFL    50
    FQVKITVHPA ARETFESMVR KFQAESMFSE EATPCIVSVG DKDADLTPDP 100
    QREDIKIVKS SRRVSYAVRV AHVAKAQVGL LANSRANELV YSRLCREEMV 150
    KHGVRPSHIA HMVPLAVAAC FIPLDSDFLA ASIRQGEGMR ERRALLGPSW 200
    EKXGGLLVTS GFTTPTWRGD PRGMLVTKGP PLAKPRKLYR FTGMGTHIRY 250
    GVHDHSLGNV RRGLVERLYM VEVKGELQPT PKPTPGAFNQ MSRFSDRLSI 300
    HLPKTTRLTP REFLGFYTGR KLERYQKAVE SLEMHPVREK DAWLSTFVKA 350
    EKLNITAKPD PAPRVIQPRD PRYNVEVGRF LRHSEEMLFK AINKTFGGRT 400
    IFKGLSSDQA GEEFKTLWDS FKDPVGIGMD ASRFDQHISK DALEFEHKMW 450
    LSMFPKSERA ELARLLSWQI NNRGLARCPD GEIRYRVEGC RMSGDMNTSS 500
    GNCYIMCATV HNWCDNIKHI KHFRLANNGD DCMLVVERSD EKKVRNGLIE 550
    YYATLGFTMK VEPTVDVLER LEFCQTRPVL VDGKYRMVRN LHQSMSKDLH 600
    SLHDLDSSAA RNAWVTAVGT GGRCMNDGVP VLKEFFKQFP DYNLEVKKGS 650
    DMAQKLRDDW KYKFNRTAAF QDLIPTQESR YSFWLAFGLL PDEQIALENG 700
    FSPLKMEIVN EQIQEETSLL QFSGA 725
    Length:725
    Mass (Da):82,357
    Last modified:October 5, 2010 - v3
    Checksum:i5A57467158A30634
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00942 Genomic RNA. Translation: BAA00785.1.
    D00942 Genomic RNA. Translation: BAA00786.1.
    PIRiJU0368. RRWQTD.

    Keywords - Coding sequence diversityi

    RNA suppression of termination

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00942 Genomic RNA. Translation: BAA00785.1 .
    D00942 Genomic RNA. Translation: BAA00786.1 .
    PIRi JU0368. RRWQTD.

    3D structure databases

    ProteinModelPortali P27209.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    IPR013707. Tombusvirus_p33.
    [Graphical view ]
    Pfami PF00998. RdRP_3. 1 hit.
    PF08500. Tombus_P33. 1 hit.
    [Graphical view ]
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete nucleotide sequence of tobacco necrosis virus strain D."
      Coutts R.H.A., Rigden J.E., Slabas A.R., Lomonossoff G.P., Wise P.J.
      J. Gen. Virol. 72:1521-1529(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. Coutts R.H.A.
      Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.

    Entry informationi

    Entry nameiRDRP_TNVD
    AccessioniPrimary (citable) accession number: P27209
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 63 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Readthrough of the terminator UAG occurs at position 203.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3