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P27176

- L_PUUMG

UniProt

P27176 - L_PUUMG

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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Puumala virus (strain Bank vole/Russia/CG1820/1984)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. cap snatching Source: UniProtKB-KW
  2. transcription, DNA-templated Source: InterPro
  3. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Cap snatching, Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene namesi
Name:L
OrganismiPuumala virus (strain Bank vole/Russia/CG1820/1984)
Taxonomic identifieri1337063 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
ProteomesiUP000008481: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21562156RNA-directed RNA polymerase LPRO_0000222022Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini956 – 1142187RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the hantavirus RNA polymerase family.Curated
Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR026382. CapSnatchArena.
IPR016268. RNA-dir_pol_hantavirus.
IPR024378. RNA-dir_pol_N_hantavirus.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamiPF04196. Bunya_RdRp. 1 hit.
PF12426. DUF3674. 1 hit.
[Graphical view]
PIRSFiPIRSF000825. L_HantaV. 1 hit.
TIGRFAMsiTIGR04202. capSnatchArena. 1 hit.
PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27176-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MEKYREIHER VKEAVPGETS AVECLDLLDR LYAVRHDVVD QMIKHDWSDN
60 70 80 90 100
KDKEQPIGLV LLMAGVPNDV IQSMEKRIIP GSPSGQILRS FFKMTPDNYK
110 120 130 140 150
ITGNLIEFIE VTVTADVARG VREKILKYQG GLEFIEQLLQ IEAQKGNCQS
160 170 180 190 200
GFRIKFDVVA IRTDGSNIST QWPSRRNEGV VQAMRLIQAD INFVREHLIK
210 220 230 240 250
NDERGALEAM FNLKFHVTGP KVRTFDIPNY RPQQLCQPVL ENLVEYCKNW
260 270 280 290 300
LGTDHAFAFK EVTGQRVFNV FRDEEELHAS KYGHSRKPRN FLLCQISLQV
310 320 330 340 350
PYLPSTIASD QYDTRLACSE ILKNYPETPL QLLARDMAYK YITLDNEDII
360 370 380 390 400
NYYNPRVYFK PTQNIKEPGT FKLNLSNMDP KSKALIDVIS KDSKKGVFGE
410 420 430 440 450
LIDSIDVASQ VQQNECAKTI EKILSDLEVN LGDSTAGLDQ PKRTTGVDDI
460 470 480 490 500
LRKFYDNELV KYLISVIRKT TARHLGHLLR DITESLIAHA GLKRSKYWSA
510 520 530 540 550
HGYAYGSVLL CILPSKSLEV AGSFIRFFTV FKEGLGLIDA DNLDSKVEID
560 570 580 590 600
GVTWCFSKII SLDLNRLLAL NIAFEKSLLA TATWFQYYTE DQGHFPLQHA
610 620 630 640 650
LRSVFAFHFL LATSQKMKLC AIFDNLRYLI PAVTSTYSGF EPLIRKFFER
660 670 680 690 700
PFKSALEVYL YNIIKTLLVS LAQNNKIRFY SRVRLLGLTV DQSSIGASGV
710 720 730 740 750
YPSLMSRVVY KHYRSLISEA TTCFFLFEKG LHGNLTEEAK IHLETVEWAR
760 770 780 790 800
KFREKERKLG SYIMEEGYHI QDVLNNQVVV EQQLFCQEVV ELAAQELNTY
810 820 830 840 850
LHAKSQVMAS NIMNKHWDKP YFSQTRNISL KGMSGALQED GHLAASVTLI
860 870 880 890 900
EAIRFLNHSQ NNPTVLELYE QTKKQKAQAR IVRKYQRTEA DRGFFITTLP
910 920 930 940 950
TRVRLEIIED YYDAIARVVP EEYISYGGET KILNIQQALE KALRWASGES
960 970 980 990 1000
EIQSSIGHSI KLKRKLMYVS ADATKWSPGD NSAKFRRFTQ SLYDGLRDDK
1010 1020 1030 1040 1050
LKNCVVDALR NIYETDFFIS RKLHRYIDNM GELSDEVLDF LSFFPNKVSA
1060 1070 1080 1090 1100
SIKGNWLQGN LNKCSSLFGA AVSLLFKRVW AKLYPELECF FEFAHHSDDA
1110 1120 1130 1140 1150
LFIYGYLEPV DDGTEWFQYV TQQIQAGNFH WHAVNQEMWK SMFNLHEHIL
1160 1170 1180 1190 1200
LMGSIKISPK KTTVSPTNAE FLSTFFEGCA VSIPFIKILL GSLSDLPGLG
1210 1220 1230 1240 1250
YFDDLAAAQS RCVKALDMGA CPQLAQLGIV LCTSKVERLY GTAPGMVNNP
1260 1270 1280 1290 1300
TAYLKVDRSL IPIPLGGDGS MSIMELATAG IGMADKNILK NAFITYKHAK
1310 1320 1330 1340 1350
KDNDRYVLGL FKFLMSLSDD IFQHDRLGEF SFVGKVQWKV FTPKSEFEFY
1360 1370 1380 1390 1400
DQYSRKYLEL WSEQHPVYDY IIPRGRDNLL VYLVRKLNDP SIVTAMTMQS
1410 1420 1430 1440 1450
PLQLRFRMQA KQHMKVCKLD GEWVTFREVL AAADAFASEY RPTLQDMELF
1460 1470 1480 1490 1500
QTLVNCTFSK EYAWRDFLNE VQCDVLTTRQ IHRPKVARTF TVKEKDQTIQ
1510 1520 1530 1540 1550
NPITAVIGYK YASKVDEISD VLDSAIHPDS LSTDLQLMRE GVYRELGLDI
1560 1570 1580 1590 1600
SQPNVLKKVA PLLYKSGKSR IVIVQGNVEG TAESICSYWL KTMSLVKTIK
1610 1620 1630 1640 1650
VKPKKEVLKA VSLYGKKEKA GDLTHLAAMR LCIEVWRWCK ANEQDSVSWL
1660 1670 1680 1690 1700
KYLMFENKTL EQWIDSFCSR GVLPVDPEIQ CLGLLVYDLK GQKGLLQIQA
1710 1720 1730 1740 1750
NRRAYSGKQY DAYCVQTYNE ETKLYEGDLR VTFNFGIDCA RLEIFWDKRE
1760 1770 1780 1790 1800
YILETSITQR NVLKILMEEV TKELLRCGMR FKTEQVNSSR SVVLFKTESG
1810 1820 1830 1840 1850
FEWGKPNVPC IVYRNCTLRT GLRVRQPTNK AFSITIQANG FRAMAQLDEE
1860 1870 1880 1890 1900
NPRFLLAHAY HNLKDVRYQA LQAVGNVWFK MTQHKLFINP IISAGLLENF
1910 1920 1930 1940 1950
MKGLPAAIPP AAYSLIMNKA KISVDLFMFN ELLALINPQN VLNLDGIEET
1960 1970 1980 1990 2000
SEGYTTVSTI SSTQWSEEVS LTMDDSDDDG DASQLDYTID LDDIDFETID
2010 2020 2030 2040 2050
LKEDIEHFLQ DESAYTGDLL IQTEETEIRK LRGMIKILEP VKLIKSWVSK
2060 2070 2080 2090 2100
GLSIDKIYNP VNIILMTRYM SKHYNFHAKQ LSLMDPYDLT EFESIVKGWG
2110 2120 2130 2140 2150
ECVKDRFIEL DQEAQRKVTE ERVLPEDVLP DSLFSFRHAD ILLKRLFPRD

SASSFY
Length:2,156
Mass (Da):247,050
Last modified:August 1, 1992 - v1
Checksum:i1D3C0A34C0DF99A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63194 Genomic RNA. No translation available.
PIRiA40319. RRVUNE.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63194 Genomic RNA. No translation available.
PIRi A40319. RRVUNE.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR026382. CapSnatchArena.
IPR016268. RNA-dir_pol_hantavirus.
IPR024378. RNA-dir_pol_N_hantavirus.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view ]
Pfami PF04196. Bunya_RdRp. 1 hit.
PF12426. DUF3674. 1 hit.
[Graphical view ]
PIRSFi PIRSF000825. L_HantaV. 1 hit.
TIGRFAMsi TIGR04202. capSnatchArena. 1 hit.
PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary structure of the large (L) RNA segment of nephropathia epidemica virus strain Hallnas B1 coding for the viral RNA polymerase."
    Stohwasser R., Raab K., Darai G., Bautz E.K.F.
    Virology 183:386-391(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiL_PUUMG
AccessioniPrimary (citable) accession number: P27176
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 1, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Caution

The sequence was wrongly described as Hallnas B1 strain.1 Publication

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3