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P27176 (L_PUUMG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
RNA-directed RNA polymerase L

Short name=Protein L
EC=2.7.7.48
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene names
Name:L
OrganismPuumala virus (strain Bank vole/Russia/CG1820/1984) [Complete proteome]
Taxonomic identifier1337063 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeHantavirus

Protein attributes

Sequence length2156 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Sequence similarities

Belongs to the hantavirus RNA polymerase family.

Contains 1 RdRp catalytic domain.

Caution

The sequence was wrongly described (Ref.1) as Hallnas B1 strain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 21562156RNA-directed RNA polymerase L
PRO_0000222022

Regions

Domain956 – 1142187RdRp catalytic

Sequences

Sequence LengthMass (Da)Tools
P27176 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 1D3C0A34C0DF99A6

FASTA2,156247,050
        10         20         30         40         50         60 
MEKYREIHER VKEAVPGETS AVECLDLLDR LYAVRHDVVD QMIKHDWSDN KDKEQPIGLV 

        70         80         90        100        110        120 
LLMAGVPNDV IQSMEKRIIP GSPSGQILRS FFKMTPDNYK ITGNLIEFIE VTVTADVARG 

       130        140        150        160        170        180 
VREKILKYQG GLEFIEQLLQ IEAQKGNCQS GFRIKFDVVA IRTDGSNIST QWPSRRNEGV 

       190        200        210        220        230        240 
VQAMRLIQAD INFVREHLIK NDERGALEAM FNLKFHVTGP KVRTFDIPNY RPQQLCQPVL 

       250        260        270        280        290        300 
ENLVEYCKNW LGTDHAFAFK EVTGQRVFNV FRDEEELHAS KYGHSRKPRN FLLCQISLQV 

       310        320        330        340        350        360 
PYLPSTIASD QYDTRLACSE ILKNYPETPL QLLARDMAYK YITLDNEDII NYYNPRVYFK 

       370        380        390        400        410        420 
PTQNIKEPGT FKLNLSNMDP KSKALIDVIS KDSKKGVFGE LIDSIDVASQ VQQNECAKTI 

       430        440        450        460        470        480 
EKILSDLEVN LGDSTAGLDQ PKRTTGVDDI LRKFYDNELV KYLISVIRKT TARHLGHLLR 

       490        500        510        520        530        540 
DITESLIAHA GLKRSKYWSA HGYAYGSVLL CILPSKSLEV AGSFIRFFTV FKEGLGLIDA 

       550        560        570        580        590        600 
DNLDSKVEID GVTWCFSKII SLDLNRLLAL NIAFEKSLLA TATWFQYYTE DQGHFPLQHA 

       610        620        630        640        650        660 
LRSVFAFHFL LATSQKMKLC AIFDNLRYLI PAVTSTYSGF EPLIRKFFER PFKSALEVYL 

       670        680        690        700        710        720 
YNIIKTLLVS LAQNNKIRFY SRVRLLGLTV DQSSIGASGV YPSLMSRVVY KHYRSLISEA 

       730        740        750        760        770        780 
TTCFFLFEKG LHGNLTEEAK IHLETVEWAR KFREKERKLG SYIMEEGYHI QDVLNNQVVV 

       790        800        810        820        830        840 
EQQLFCQEVV ELAAQELNTY LHAKSQVMAS NIMNKHWDKP YFSQTRNISL KGMSGALQED 

       850        860        870        880        890        900 
GHLAASVTLI EAIRFLNHSQ NNPTVLELYE QTKKQKAQAR IVRKYQRTEA DRGFFITTLP 

       910        920        930        940        950        960 
TRVRLEIIED YYDAIARVVP EEYISYGGET KILNIQQALE KALRWASGES EIQSSIGHSI 

       970        980        990       1000       1010       1020 
KLKRKLMYVS ADATKWSPGD NSAKFRRFTQ SLYDGLRDDK LKNCVVDALR NIYETDFFIS 

      1030       1040       1050       1060       1070       1080 
RKLHRYIDNM GELSDEVLDF LSFFPNKVSA SIKGNWLQGN LNKCSSLFGA AVSLLFKRVW 

      1090       1100       1110       1120       1130       1140 
AKLYPELECF FEFAHHSDDA LFIYGYLEPV DDGTEWFQYV TQQIQAGNFH WHAVNQEMWK 

      1150       1160       1170       1180       1190       1200 
SMFNLHEHIL LMGSIKISPK KTTVSPTNAE FLSTFFEGCA VSIPFIKILL GSLSDLPGLG 

      1210       1220       1230       1240       1250       1260 
YFDDLAAAQS RCVKALDMGA CPQLAQLGIV LCTSKVERLY GTAPGMVNNP TAYLKVDRSL 

      1270       1280       1290       1300       1310       1320 
IPIPLGGDGS MSIMELATAG IGMADKNILK NAFITYKHAK KDNDRYVLGL FKFLMSLSDD 

      1330       1340       1350       1360       1370       1380 
IFQHDRLGEF SFVGKVQWKV FTPKSEFEFY DQYSRKYLEL WSEQHPVYDY IIPRGRDNLL 

      1390       1400       1410       1420       1430       1440 
VYLVRKLNDP SIVTAMTMQS PLQLRFRMQA KQHMKVCKLD GEWVTFREVL AAADAFASEY 

      1450       1460       1470       1480       1490       1500 
RPTLQDMELF QTLVNCTFSK EYAWRDFLNE VQCDVLTTRQ IHRPKVARTF TVKEKDQTIQ 

      1510       1520       1530       1540       1550       1560 
NPITAVIGYK YASKVDEISD VLDSAIHPDS LSTDLQLMRE GVYRELGLDI SQPNVLKKVA 

      1570       1580       1590       1600       1610       1620 
PLLYKSGKSR IVIVQGNVEG TAESICSYWL KTMSLVKTIK VKPKKEVLKA VSLYGKKEKA 

      1630       1640       1650       1660       1670       1680 
GDLTHLAAMR LCIEVWRWCK ANEQDSVSWL KYLMFENKTL EQWIDSFCSR GVLPVDPEIQ 

      1690       1700       1710       1720       1730       1740 
CLGLLVYDLK GQKGLLQIQA NRRAYSGKQY DAYCVQTYNE ETKLYEGDLR VTFNFGIDCA 

      1750       1760       1770       1780       1790       1800 
RLEIFWDKRE YILETSITQR NVLKILMEEV TKELLRCGMR FKTEQVNSSR SVVLFKTESG 

      1810       1820       1830       1840       1850       1860 
FEWGKPNVPC IVYRNCTLRT GLRVRQPTNK AFSITIQANG FRAMAQLDEE NPRFLLAHAY 

      1870       1880       1890       1900       1910       1920 
HNLKDVRYQA LQAVGNVWFK MTQHKLFINP IISAGLLENF MKGLPAAIPP AAYSLIMNKA 

      1930       1940       1950       1960       1970       1980 
KISVDLFMFN ELLALINPQN VLNLDGIEET SEGYTTVSTI SSTQWSEEVS LTMDDSDDDG 

      1990       2000       2010       2020       2030       2040 
DASQLDYTID LDDIDFETID LKEDIEHFLQ DESAYTGDLL IQTEETEIRK LRGMIKILEP 

      2050       2060       2070       2080       2090       2100 
VKLIKSWVSK GLSIDKIYNP VNIILMTRYM SKHYNFHAKQ LSLMDPYDLT EFESIVKGWG 

      2110       2120       2130       2140       2150 
ECVKDRFIEL DQEAQRKVTE ERVLPEDVLP DSLFSFRHAD ILLKRLFPRD SASSFY 

« Hide

References

[1]"Primary structure of the large (L) RNA segment of nephropathia epidemica virus strain Hallnas B1 coding for the viral RNA polymerase."
Stohwasser R., Raab K., Darai G., Bautz E.K.F.
Virology 183:386-391(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M63194 Genomic RNA. No translation available.
PIRRRVUNE. A40319.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR026382. CapSnatchArena.
IPR016268. RNA-dir_pol_hantavirus.
IPR024378. RNA-dir_pol_N_hantavirus.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamPF04196. Bunya_RdRp. 1 hit.
PF12426. DUF3674. 1 hit.
[Graphical view]
PIRSFPIRSF000825. L_HantaV. 1 hit.
TIGRFAMsTIGR04202. capSnatchArena. 1 hit.
PROSITEPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameL_PUUMG
AccessionPrimary (citable) accession number: P27176
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families