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P27176

- L_PUUMG

UniProt

P27176 - L_PUUMG

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Protein
RNA-directed RNA polymerase L
Gene
L
Organism
Puumala virus (strain Bank vole/Russia/CG1820/1984)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  2. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. cap snatching Source: UniProtKB-KW
  2. transcription, DNA-templated Source: InterPro
  3. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Cap snatching, Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene namesi
Name:L
OrganismiPuumala virus (strain Bank vole/Russia/CG1820/1984)
Taxonomic identifieri1337063 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
ProteomesiUP000008481: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21562156RNA-directed RNA polymerase L
PRO_0000222022Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini956 – 1142187RdRp catalytic
Add
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR026382. CapSnatchArena.
IPR016268. RNA-dir_pol_hantavirus.
IPR024378. RNA-dir_pol_N_hantavirus.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamiPF04196. Bunya_RdRp. 1 hit.
PF12426. DUF3674. 1 hit.
[Graphical view]
PIRSFiPIRSF000825. L_HantaV. 1 hit.
TIGRFAMsiTIGR04202. capSnatchArena. 1 hit.
PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27176-1 [UniParc]FASTAAdd to Basket

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MEKYREIHER VKEAVPGETS AVECLDLLDR LYAVRHDVVD QMIKHDWSDN     50
KDKEQPIGLV LLMAGVPNDV IQSMEKRIIP GSPSGQILRS FFKMTPDNYK 100
ITGNLIEFIE VTVTADVARG VREKILKYQG GLEFIEQLLQ IEAQKGNCQS 150
GFRIKFDVVA IRTDGSNIST QWPSRRNEGV VQAMRLIQAD INFVREHLIK 200
NDERGALEAM FNLKFHVTGP KVRTFDIPNY RPQQLCQPVL ENLVEYCKNW 250
LGTDHAFAFK EVTGQRVFNV FRDEEELHAS KYGHSRKPRN FLLCQISLQV 300
PYLPSTIASD QYDTRLACSE ILKNYPETPL QLLARDMAYK YITLDNEDII 350
NYYNPRVYFK PTQNIKEPGT FKLNLSNMDP KSKALIDVIS KDSKKGVFGE 400
LIDSIDVASQ VQQNECAKTI EKILSDLEVN LGDSTAGLDQ PKRTTGVDDI 450
LRKFYDNELV KYLISVIRKT TARHLGHLLR DITESLIAHA GLKRSKYWSA 500
HGYAYGSVLL CILPSKSLEV AGSFIRFFTV FKEGLGLIDA DNLDSKVEID 550
GVTWCFSKII SLDLNRLLAL NIAFEKSLLA TATWFQYYTE DQGHFPLQHA 600
LRSVFAFHFL LATSQKMKLC AIFDNLRYLI PAVTSTYSGF EPLIRKFFER 650
PFKSALEVYL YNIIKTLLVS LAQNNKIRFY SRVRLLGLTV DQSSIGASGV 700
YPSLMSRVVY KHYRSLISEA TTCFFLFEKG LHGNLTEEAK IHLETVEWAR 750
KFREKERKLG SYIMEEGYHI QDVLNNQVVV EQQLFCQEVV ELAAQELNTY 800
LHAKSQVMAS NIMNKHWDKP YFSQTRNISL KGMSGALQED GHLAASVTLI 850
EAIRFLNHSQ NNPTVLELYE QTKKQKAQAR IVRKYQRTEA DRGFFITTLP 900
TRVRLEIIED YYDAIARVVP EEYISYGGET KILNIQQALE KALRWASGES 950
EIQSSIGHSI KLKRKLMYVS ADATKWSPGD NSAKFRRFTQ SLYDGLRDDK 1000
LKNCVVDALR NIYETDFFIS RKLHRYIDNM GELSDEVLDF LSFFPNKVSA 1050
SIKGNWLQGN LNKCSSLFGA AVSLLFKRVW AKLYPELECF FEFAHHSDDA 1100
LFIYGYLEPV DDGTEWFQYV TQQIQAGNFH WHAVNQEMWK SMFNLHEHIL 1150
LMGSIKISPK KTTVSPTNAE FLSTFFEGCA VSIPFIKILL GSLSDLPGLG 1200
YFDDLAAAQS RCVKALDMGA CPQLAQLGIV LCTSKVERLY GTAPGMVNNP 1250
TAYLKVDRSL IPIPLGGDGS MSIMELATAG IGMADKNILK NAFITYKHAK 1300
KDNDRYVLGL FKFLMSLSDD IFQHDRLGEF SFVGKVQWKV FTPKSEFEFY 1350
DQYSRKYLEL WSEQHPVYDY IIPRGRDNLL VYLVRKLNDP SIVTAMTMQS 1400
PLQLRFRMQA KQHMKVCKLD GEWVTFREVL AAADAFASEY RPTLQDMELF 1450
QTLVNCTFSK EYAWRDFLNE VQCDVLTTRQ IHRPKVARTF TVKEKDQTIQ 1500
NPITAVIGYK YASKVDEISD VLDSAIHPDS LSTDLQLMRE GVYRELGLDI 1550
SQPNVLKKVA PLLYKSGKSR IVIVQGNVEG TAESICSYWL KTMSLVKTIK 1600
VKPKKEVLKA VSLYGKKEKA GDLTHLAAMR LCIEVWRWCK ANEQDSVSWL 1650
KYLMFENKTL EQWIDSFCSR GVLPVDPEIQ CLGLLVYDLK GQKGLLQIQA 1700
NRRAYSGKQY DAYCVQTYNE ETKLYEGDLR VTFNFGIDCA RLEIFWDKRE 1750
YILETSITQR NVLKILMEEV TKELLRCGMR FKTEQVNSSR SVVLFKTESG 1800
FEWGKPNVPC IVYRNCTLRT GLRVRQPTNK AFSITIQANG FRAMAQLDEE 1850
NPRFLLAHAY HNLKDVRYQA LQAVGNVWFK MTQHKLFINP IISAGLLENF 1900
MKGLPAAIPP AAYSLIMNKA KISVDLFMFN ELLALINPQN VLNLDGIEET 1950
SEGYTTVSTI SSTQWSEEVS LTMDDSDDDG DASQLDYTID LDDIDFETID 2000
LKEDIEHFLQ DESAYTGDLL IQTEETEIRK LRGMIKILEP VKLIKSWVSK 2050
GLSIDKIYNP VNIILMTRYM SKHYNFHAKQ LSLMDPYDLT EFESIVKGWG 2100
ECVKDRFIEL DQEAQRKVTE ERVLPEDVLP DSLFSFRHAD ILLKRLFPRD 2150
SASSFY 2156
Length:2,156
Mass (Da):247,050
Last modified:August 1, 1992 - v1
Checksum:i1D3C0A34C0DF99A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63194 Genomic RNA. No translation available.
PIRiA40319. RRVUNE.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63194 Genomic RNA. No translation available.
PIRi A40319. RRVUNE.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR026382. CapSnatchArena.
IPR016268. RNA-dir_pol_hantavirus.
IPR024378. RNA-dir_pol_N_hantavirus.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view ]
Pfami PF04196. Bunya_RdRp. 1 hit.
PF12426. DUF3674. 1 hit.
[Graphical view ]
PIRSFi PIRSF000825. L_HantaV. 1 hit.
TIGRFAMsi TIGR04202. capSnatchArena. 1 hit.
PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary structure of the large (L) RNA segment of nephropathia epidemica virus strain Hallnas B1 coding for the viral RNA polymerase."
    Stohwasser R., Raab K., Darai G., Bautz E.K.F.
    Virology 183:386-391(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiL_PUUMG
AccessioniPrimary (citable) accession number: P27176
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Caution

The sequence was wrongly described (1 Publication) as Hallnas B1 strain.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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