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P27176

- L_PUUMG

UniProt

P27176 - L_PUUMG

Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Puumala virus (strain Bank vole/Russia/CG1820/1984)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. cap snatching Source: UniProtKB-KW
    2. transcription, DNA-templated Source: InterPro
    3. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Cap snatching, Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase L (EC:2.7.7.48)
    Short name:
    Protein L
    Alternative name(s):
    Large structural protein
    Replicase
    Transcriptase
    Gene namesi
    Name:L
    OrganismiPuumala virus (strain Bank vole/Russia/CG1820/1984)
    Taxonomic identifieri1337063 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
    ProteomesiUP000008481: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 21562156RNA-directed RNA polymerase LPRO_0000222022Add
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini956 – 1142187RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the hantavirus RNA polymerase family.Curated
    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR026382. CapSnatchArena.
    IPR016268. RNA-dir_pol_hantavirus.
    IPR024378. RNA-dir_pol_N_hantavirus.
    IPR007099. RNA-dir_pol_NSvirus.
    IPR007322. RNA_pol_bunyavir.
    [Graphical view]
    PfamiPF04196. Bunya_RdRp. 1 hit.
    PF12426. DUF3674. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000825. L_HantaV. 1 hit.
    TIGRFAMsiTIGR04202. capSnatchArena. 1 hit.
    PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P27176-1 [UniParc]FASTAAdd to Basket

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    MEKYREIHER VKEAVPGETS AVECLDLLDR LYAVRHDVVD QMIKHDWSDN     50
    KDKEQPIGLV LLMAGVPNDV IQSMEKRIIP GSPSGQILRS FFKMTPDNYK 100
    ITGNLIEFIE VTVTADVARG VREKILKYQG GLEFIEQLLQ IEAQKGNCQS 150
    GFRIKFDVVA IRTDGSNIST QWPSRRNEGV VQAMRLIQAD INFVREHLIK 200
    NDERGALEAM FNLKFHVTGP KVRTFDIPNY RPQQLCQPVL ENLVEYCKNW 250
    LGTDHAFAFK EVTGQRVFNV FRDEEELHAS KYGHSRKPRN FLLCQISLQV 300
    PYLPSTIASD QYDTRLACSE ILKNYPETPL QLLARDMAYK YITLDNEDII 350
    NYYNPRVYFK PTQNIKEPGT FKLNLSNMDP KSKALIDVIS KDSKKGVFGE 400
    LIDSIDVASQ VQQNECAKTI EKILSDLEVN LGDSTAGLDQ PKRTTGVDDI 450
    LRKFYDNELV KYLISVIRKT TARHLGHLLR DITESLIAHA GLKRSKYWSA 500
    HGYAYGSVLL CILPSKSLEV AGSFIRFFTV FKEGLGLIDA DNLDSKVEID 550
    GVTWCFSKII SLDLNRLLAL NIAFEKSLLA TATWFQYYTE DQGHFPLQHA 600
    LRSVFAFHFL LATSQKMKLC AIFDNLRYLI PAVTSTYSGF EPLIRKFFER 650
    PFKSALEVYL YNIIKTLLVS LAQNNKIRFY SRVRLLGLTV DQSSIGASGV 700
    YPSLMSRVVY KHYRSLISEA TTCFFLFEKG LHGNLTEEAK IHLETVEWAR 750
    KFREKERKLG SYIMEEGYHI QDVLNNQVVV EQQLFCQEVV ELAAQELNTY 800
    LHAKSQVMAS NIMNKHWDKP YFSQTRNISL KGMSGALQED GHLAASVTLI 850
    EAIRFLNHSQ NNPTVLELYE QTKKQKAQAR IVRKYQRTEA DRGFFITTLP 900
    TRVRLEIIED YYDAIARVVP EEYISYGGET KILNIQQALE KALRWASGES 950
    EIQSSIGHSI KLKRKLMYVS ADATKWSPGD NSAKFRRFTQ SLYDGLRDDK 1000
    LKNCVVDALR NIYETDFFIS RKLHRYIDNM GELSDEVLDF LSFFPNKVSA 1050
    SIKGNWLQGN LNKCSSLFGA AVSLLFKRVW AKLYPELECF FEFAHHSDDA 1100
    LFIYGYLEPV DDGTEWFQYV TQQIQAGNFH WHAVNQEMWK SMFNLHEHIL 1150
    LMGSIKISPK KTTVSPTNAE FLSTFFEGCA VSIPFIKILL GSLSDLPGLG 1200
    YFDDLAAAQS RCVKALDMGA CPQLAQLGIV LCTSKVERLY GTAPGMVNNP 1250
    TAYLKVDRSL IPIPLGGDGS MSIMELATAG IGMADKNILK NAFITYKHAK 1300
    KDNDRYVLGL FKFLMSLSDD IFQHDRLGEF SFVGKVQWKV FTPKSEFEFY 1350
    DQYSRKYLEL WSEQHPVYDY IIPRGRDNLL VYLVRKLNDP SIVTAMTMQS 1400
    PLQLRFRMQA KQHMKVCKLD GEWVTFREVL AAADAFASEY RPTLQDMELF 1450
    QTLVNCTFSK EYAWRDFLNE VQCDVLTTRQ IHRPKVARTF TVKEKDQTIQ 1500
    NPITAVIGYK YASKVDEISD VLDSAIHPDS LSTDLQLMRE GVYRELGLDI 1550
    SQPNVLKKVA PLLYKSGKSR IVIVQGNVEG TAESICSYWL KTMSLVKTIK 1600
    VKPKKEVLKA VSLYGKKEKA GDLTHLAAMR LCIEVWRWCK ANEQDSVSWL 1650
    KYLMFENKTL EQWIDSFCSR GVLPVDPEIQ CLGLLVYDLK GQKGLLQIQA 1700
    NRRAYSGKQY DAYCVQTYNE ETKLYEGDLR VTFNFGIDCA RLEIFWDKRE 1750
    YILETSITQR NVLKILMEEV TKELLRCGMR FKTEQVNSSR SVVLFKTESG 1800
    FEWGKPNVPC IVYRNCTLRT GLRVRQPTNK AFSITIQANG FRAMAQLDEE 1850
    NPRFLLAHAY HNLKDVRYQA LQAVGNVWFK MTQHKLFINP IISAGLLENF 1900
    MKGLPAAIPP AAYSLIMNKA KISVDLFMFN ELLALINPQN VLNLDGIEET 1950
    SEGYTTVSTI SSTQWSEEVS LTMDDSDDDG DASQLDYTID LDDIDFETID 2000
    LKEDIEHFLQ DESAYTGDLL IQTEETEIRK LRGMIKILEP VKLIKSWVSK 2050
    GLSIDKIYNP VNIILMTRYM SKHYNFHAKQ LSLMDPYDLT EFESIVKGWG 2100
    ECVKDRFIEL DQEAQRKVTE ERVLPEDVLP DSLFSFRHAD ILLKRLFPRD 2150
    SASSFY 2156
    Length:2,156
    Mass (Da):247,050
    Last modified:August 1, 1992 - v1
    Checksum:i1D3C0A34C0DF99A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63194 Genomic RNA. No translation available.
    PIRiA40319. RRVUNE.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63194 Genomic RNA. No translation available.
    PIRi A40319. RRVUNE.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR026382. CapSnatchArena.
    IPR016268. RNA-dir_pol_hantavirus.
    IPR024378. RNA-dir_pol_N_hantavirus.
    IPR007099. RNA-dir_pol_NSvirus.
    IPR007322. RNA_pol_bunyavir.
    [Graphical view ]
    Pfami PF04196. Bunya_RdRp. 1 hit.
    PF12426. DUF3674. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000825. L_HantaV. 1 hit.
    TIGRFAMsi TIGR04202. capSnatchArena. 1 hit.
    PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of the large (L) RNA segment of nephropathia epidemica virus strain Hallnas B1 coding for the viral RNA polymerase."
      Stohwasser R., Raab K., Darai G., Bautz E.K.F.
      Virology 183:386-391(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiL_PUUMG
    AccessioniPrimary (citable) accession number: P27176
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Caution

    The sequence was wrongly described as Hallnas B1 strain.1 Publication

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3