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P27172

- DPOL_MUHVS

UniProt

P27172 - DPOL_MUHVS

Protein

DNA polymerase catalytic subunit

Gene

UL54

Organism
Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. DNA-directed DNA polymerase activity Source: UniProtKB-KW
    3. nucleotide binding Source: InterPro

    Keywords - Molecular functioni

    DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymerase catalytic subunit (EC:2.7.7.7)
    Gene namesi
    Name:UL54
    OrganismiMurid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus)
    Taxonomic identifieri10367 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeMuromegalovirus
    Virus hostiMus musculus (Mouse) [TaxID: 10090]
    ProteomesiUP000008774: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. host cell nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10971097DNA polymerase catalytic subunitPRO_0000046508Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP27172.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DNA polymerase type-B family.Curated

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    3.90.1600.10. 2 hits.
    InterProiIPR006172. DNA-dir_DNA_pol_B.
    IPR017964. DNA-dir_DNA_pol_B_CS.
    IPR006133. DNA-dir_DNA_pol_B_exonuc.
    IPR006134. DNA-dir_DNA_pol_B_multi_dom.
    IPR023211. DNA_pol_palm_dom.
    IPR012337. RNaseH-like_dom.
    [Graphical view]
    PfamiPF00136. DNA_pol_B. 1 hit.
    PF03104. DNA_pol_B_exo1. 1 hit.
    [Graphical view]
    PRINTSiPR00106. DNAPOLB.
    SMARTiSM00486. POLBc. 1 hit.
    [Graphical view]
    SUPFAMiSSF53098. SSF53098. 2 hits.
    PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P27172-1 [UniParc]FASTAAdd to Basket

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    MDTCVETFFN PYLRRKPRRD WRRCEDNNKN FLQVVPRGVL YDGATGLIKV     50
    QSGMEPRMFY AEKEYVLNPD KPWPTLRTRG WCRGPYSDDV RFHTYDQVVN 100
    LVLADSDEQI SPRWNSHVVP AGNVIRMFGA TDEGVSVCVN VFGQKAYFYC 150
    ERMQSEDLKN TVYDIADKVP EPCSPFSVSI SPVTKSSFYG YGLGHIPNLY 200
    RLSFNNWNMC RKIGKRMLEE GRKVYELGVD PLARFLIDRK IPSFGWCLAR 250
    RYSVRAAGYV SRAQLEIDCD VADILPIEEQ SNWPFYRCLS FDIECMSGTG 300
    AFPAAENVDD IIIQISCVCF GVGEMVHHAY DVHADLSTPA VPENHLFTIG 350
    PCAPIPDVKI YTFPSEYEML RGFFIFLSWY SPEFITGYNI NGFDIKYILT 400
    RAEKLYKMDV GQFTKLRRGG RMFVFSPEKG KAGFGTSNTV KVFWSGTVVL 450
    DMYPVCTAKA SSPNYKLDTM AEIYLKKKKD DLSYKEIPVQ FSAGDEGRAP 500
    GGKYCLQDAV LVRELFEMLA FHFEAAAIAR LARIPLRKVI FDGQQIRIYT 550
    CLLEECSGRD MILPNMPSLG HGAAAAIEEA AAGGEGDETS EGENSNNSRT 600
    VGYQGATVLE PECGFHHVPV CVFDFASLYP SIIMSNNLCY STLLVEGSPE 650
    VPEKDVLRVE IGDQCHRFVR ENVHRSLLAE LLVRWLTQRK LVREAMKQCT 700
    NEMQRMIMDK QQLALKVTCN AFYGFTGVAA GMLPCLPIAA SITKIGRDML 750
    LATAGHIEDR CNRPDFLRTV LGLPPEAIDP EALRVKIIYG DTDSVFAAFY 800
    GIDKEALLKA VGALAANVTN ALFKEPVRLE FEKMFVSLMM ICKKRYIGKV 850
    HGSQNLSMKG VDLVRRTACG FVKAVVSDVL HMVFNDETVS EGTMKLSRMT 900
    FDDLKKNGIP CEFGPVVSRL CRARDDLHLK KVPVPELTLS SVLSQELSCY 950
    KQKNLPHLAV IRRLAARKEE LPAVGDRVEY VLTLPDGCKK NVPNYEIAED 1000
    PRHVVEAKLS INAEKYYEQV VKAVTNTLMP VFPRDMPKRE KFFSLVVPQR 1050
    IYIPDQFLHL CGNVNELARG GDDSDGGDSE KENMDTERSS SHEAMET 1097
    Length:1,097
    Mass (Da):123,574
    Last modified:August 1, 1992 - v1
    Checksum:i07310048ACC350BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73549 Genomic DNA. Translation: AAA45940.1.
    U68299 Genomic DNA. No translation available.
    PIRiB40780. DJBEMC.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73549 Genomic DNA. Translation: AAA45940.1 .
    U68299 Genomic DNA. No translation available.
    PIRi B40780. DJBEMC.

    3D structure databases

    ProteinModelPortali P27172.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    3.90.1600.10. 2 hits.
    InterProi IPR006172. DNA-dir_DNA_pol_B.
    IPR017964. DNA-dir_DNA_pol_B_CS.
    IPR006133. DNA-dir_DNA_pol_B_exonuc.
    IPR006134. DNA-dir_DNA_pol_B_multi_dom.
    IPR023211. DNA_pol_palm_dom.
    IPR012337. RNaseH-like_dom.
    [Graphical view ]
    Pfami PF00136. DNA_pol_B. 1 hit.
    PF03104. DNA_pol_B_exo1. 1 hit.
    [Graphical view ]
    PRINTSi PR00106. DNAPOLB.
    SMARTi SM00486. POLBc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53098. SSF53098. 2 hits.
    PROSITEi PS00116. DNA_POLYMERASE_B. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Transcription analysis and sequence of the putative murine cytomegalovirus DNA polymerase gene."
      Elliott R., Clark C., Jaquish D., Spector D.H.
      Virology 185:169-186(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Analysis of the complete DNA sequence of murine cytomegalovirus."
      Rawlinson W.D., Farrell H.E., Barrell B.G.
      J. Virol. 70:8833-8849(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDPOL_MUHVS
    AccessioniPrimary (citable) accession number: P27172
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3