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P27172 (DPOL_MUHVS) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA polymerase catalytic subunit

EC=2.7.7.7
Gene names
Name:UL54
OrganismMurid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus) [Reference proteome]
Taxonomic identifier10367 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeMuromegalovirus
Virus hostMus musculus (Mouse) [TaxID: 10090]

Protein attributes

Sequence length1097 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Subcellular location

Host nucleus.

Sequence similarities

Belongs to the DNA polymerase type-B family.

Ontologies

Keywords
   Biological processDNA replication
   Cellular componentHost nucleus
   LigandDNA-binding
   Molecular functionDNA-directed DNA polymerase
Nucleotidyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componenthost cell nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

DNA-directed DNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10971097DNA polymerase catalytic subunit
PRO_0000046508

Sequences

Sequence LengthMass (Da)Tools
P27172 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 07310048ACC350BD

FASTA1,097123,574
        10         20         30         40         50         60 
MDTCVETFFN PYLRRKPRRD WRRCEDNNKN FLQVVPRGVL YDGATGLIKV QSGMEPRMFY 

        70         80         90        100        110        120 
AEKEYVLNPD KPWPTLRTRG WCRGPYSDDV RFHTYDQVVN LVLADSDEQI SPRWNSHVVP 

       130        140        150        160        170        180 
AGNVIRMFGA TDEGVSVCVN VFGQKAYFYC ERMQSEDLKN TVYDIADKVP EPCSPFSVSI 

       190        200        210        220        230        240 
SPVTKSSFYG YGLGHIPNLY RLSFNNWNMC RKIGKRMLEE GRKVYELGVD PLARFLIDRK 

       250        260        270        280        290        300 
IPSFGWCLAR RYSVRAAGYV SRAQLEIDCD VADILPIEEQ SNWPFYRCLS FDIECMSGTG 

       310        320        330        340        350        360 
AFPAAENVDD IIIQISCVCF GVGEMVHHAY DVHADLSTPA VPENHLFTIG PCAPIPDVKI 

       370        380        390        400        410        420 
YTFPSEYEML RGFFIFLSWY SPEFITGYNI NGFDIKYILT RAEKLYKMDV GQFTKLRRGG 

       430        440        450        460        470        480 
RMFVFSPEKG KAGFGTSNTV KVFWSGTVVL DMYPVCTAKA SSPNYKLDTM AEIYLKKKKD 

       490        500        510        520        530        540 
DLSYKEIPVQ FSAGDEGRAP GGKYCLQDAV LVRELFEMLA FHFEAAAIAR LARIPLRKVI 

       550        560        570        580        590        600 
FDGQQIRIYT CLLEECSGRD MILPNMPSLG HGAAAAIEEA AAGGEGDETS EGENSNNSRT 

       610        620        630        640        650        660 
VGYQGATVLE PECGFHHVPV CVFDFASLYP SIIMSNNLCY STLLVEGSPE VPEKDVLRVE 

       670        680        690        700        710        720 
IGDQCHRFVR ENVHRSLLAE LLVRWLTQRK LVREAMKQCT NEMQRMIMDK QQLALKVTCN 

       730        740        750        760        770        780 
AFYGFTGVAA GMLPCLPIAA SITKIGRDML LATAGHIEDR CNRPDFLRTV LGLPPEAIDP 

       790        800        810        820        830        840 
EALRVKIIYG DTDSVFAAFY GIDKEALLKA VGALAANVTN ALFKEPVRLE FEKMFVSLMM 

       850        860        870        880        890        900 
ICKKRYIGKV HGSQNLSMKG VDLVRRTACG FVKAVVSDVL HMVFNDETVS EGTMKLSRMT 

       910        920        930        940        950        960 
FDDLKKNGIP CEFGPVVSRL CRARDDLHLK KVPVPELTLS SVLSQELSCY KQKNLPHLAV 

       970        980        990       1000       1010       1020 
IRRLAARKEE LPAVGDRVEY VLTLPDGCKK NVPNYEIAED PRHVVEAKLS INAEKYYEQV 

      1030       1040       1050       1060       1070       1080 
VKAVTNTLMP VFPRDMPKRE KFFSLVVPQR IYIPDQFLHL CGNVNELARG GDDSDGGDSE 

      1090 
KENMDTERSS SHEAMET 

« Hide

References

« Hide 'large scale' references
[1]"Transcription analysis and sequence of the putative murine cytomegalovirus DNA polymerase gene."
Elliott R., Clark C., Jaquish D., Spector D.H.
Virology 185:169-186(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Analysis of the complete DNA sequence of murine cytomegalovirus."
Rawlinson W.D., Farrell H.E., Barrell B.G.
J. Virol. 70:8833-8849(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M73549 Genomic DNA. Translation: AAA45940.1.
U68299 Genomic DNA. No translation available.
PIRDJBEMC. B40780.

3D structure databases

ProteinModelPortalP27172.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.420.10. 1 hit.
3.90.1600.10. 2 hits.
InterProIPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamPF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 1 hit.
[Graphical view]
PRINTSPR00106. DNAPOLB.
SMARTSM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMSSF53098. SSF53098. 2 hits.
PROSITEPS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDPOL_MUHVS
AccessionPrimary (citable) accession number: P27172
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families