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P27172

- DPOL_MUHVS

UniProt

P27172 - DPOL_MUHVS

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Protein
DNA polymerase catalytic subunit
Gene
UL54
Organism
Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. DNA-directed DNA polymerase activity Source: UniProtKB-KW
  3. nucleotide binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase catalytic subunit (EC:2.7.7.7)
Gene namesi
Name:UL54
OrganismiMurid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus)
Taxonomic identifieri10367 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeMuromegalovirus
Virus hostiMus musculus (Mouse) [TaxID: 10090]
ProteomesiUP000008774: Genome

Subcellular locationi

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10971097DNA polymerase catalytic subunit
PRO_0000046508Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP27172.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.90.1600.10. 2 hits.
InterProiIPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 1 hit.
[Graphical view]
PRINTSiPR00106. DNAPOLB.
SMARTiSM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 2 hits.
PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27172-1 [UniParc]FASTAAdd to Basket

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MDTCVETFFN PYLRRKPRRD WRRCEDNNKN FLQVVPRGVL YDGATGLIKV     50
QSGMEPRMFY AEKEYVLNPD KPWPTLRTRG WCRGPYSDDV RFHTYDQVVN 100
LVLADSDEQI SPRWNSHVVP AGNVIRMFGA TDEGVSVCVN VFGQKAYFYC 150
ERMQSEDLKN TVYDIADKVP EPCSPFSVSI SPVTKSSFYG YGLGHIPNLY 200
RLSFNNWNMC RKIGKRMLEE GRKVYELGVD PLARFLIDRK IPSFGWCLAR 250
RYSVRAAGYV SRAQLEIDCD VADILPIEEQ SNWPFYRCLS FDIECMSGTG 300
AFPAAENVDD IIIQISCVCF GVGEMVHHAY DVHADLSTPA VPENHLFTIG 350
PCAPIPDVKI YTFPSEYEML RGFFIFLSWY SPEFITGYNI NGFDIKYILT 400
RAEKLYKMDV GQFTKLRRGG RMFVFSPEKG KAGFGTSNTV KVFWSGTVVL 450
DMYPVCTAKA SSPNYKLDTM AEIYLKKKKD DLSYKEIPVQ FSAGDEGRAP 500
GGKYCLQDAV LVRELFEMLA FHFEAAAIAR LARIPLRKVI FDGQQIRIYT 550
CLLEECSGRD MILPNMPSLG HGAAAAIEEA AAGGEGDETS EGENSNNSRT 600
VGYQGATVLE PECGFHHVPV CVFDFASLYP SIIMSNNLCY STLLVEGSPE 650
VPEKDVLRVE IGDQCHRFVR ENVHRSLLAE LLVRWLTQRK LVREAMKQCT 700
NEMQRMIMDK QQLALKVTCN AFYGFTGVAA GMLPCLPIAA SITKIGRDML 750
LATAGHIEDR CNRPDFLRTV LGLPPEAIDP EALRVKIIYG DTDSVFAAFY 800
GIDKEALLKA VGALAANVTN ALFKEPVRLE FEKMFVSLMM ICKKRYIGKV 850
HGSQNLSMKG VDLVRRTACG FVKAVVSDVL HMVFNDETVS EGTMKLSRMT 900
FDDLKKNGIP CEFGPVVSRL CRARDDLHLK KVPVPELTLS SVLSQELSCY 950
KQKNLPHLAV IRRLAARKEE LPAVGDRVEY VLTLPDGCKK NVPNYEIAED 1000
PRHVVEAKLS INAEKYYEQV VKAVTNTLMP VFPRDMPKRE KFFSLVVPQR 1050
IYIPDQFLHL CGNVNELARG GDDSDGGDSE KENMDTERSS SHEAMET 1097
Length:1,097
Mass (Da):123,574
Last modified:August 1, 1992 - v1
Checksum:i07310048ACC350BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73549 Genomic DNA. Translation: AAA45940.1.
U68299 Genomic DNA. No translation available.
PIRiB40780. DJBEMC.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73549 Genomic DNA. Translation: AAA45940.1 .
U68299 Genomic DNA. No translation available.
PIRi B40780. DJBEMC.

3D structure databases

ProteinModelPortali P27172.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
3.90.1600.10. 2 hits.
InterProi IPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view ]
Pfami PF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 1 hit.
[Graphical view ]
PRINTSi PR00106. DNAPOLB.
SMARTi SM00486. POLBc. 1 hit.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 2 hits.
PROSITEi PS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Transcription analysis and sequence of the putative murine cytomegalovirus DNA polymerase gene."
    Elliott R., Clark C., Jaquish D., Spector D.H.
    Virology 185:169-186(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Analysis of the complete DNA sequence of murine cytomegalovirus."
    Rawlinson W.D., Farrell H.E., Barrell B.G.
    J. Virol. 70:8833-8849(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDPOL_MUHVS
AccessioniPrimary (citable) accession number: P27172
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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