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Protein

DNA polymerase catalytic subunit

Gene

UL54

Organism
Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. DNA-directed DNA polymerase activity Source: UniProtKB-KW
  3. nucleotide binding Source: InterPro

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase catalytic subunit (EC:2.7.7.7)
Gene namesi
Name:UL54
OrganismiMurid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus)
Taxonomic identifieri10367 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeMuromegalovirus
Virus hostiMus musculus (Mouse) [TaxID: 10090]
ProteomesiUP000008774: Genome

Subcellular locationi

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10971097DNA polymerase catalytic subunitPRO_0000046508Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP27172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.Curated

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.90.1600.10. 2 hits.
InterProiIPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 1 hit.
[Graphical view]
PRINTSiPR00106. DNAPOLB.
SMARTiSM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 2 hits.
PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27172-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTCVETFFN PYLRRKPRRD WRRCEDNNKN FLQVVPRGVL YDGATGLIKV
60 70 80 90 100
QSGMEPRMFY AEKEYVLNPD KPWPTLRTRG WCRGPYSDDV RFHTYDQVVN
110 120 130 140 150
LVLADSDEQI SPRWNSHVVP AGNVIRMFGA TDEGVSVCVN VFGQKAYFYC
160 170 180 190 200
ERMQSEDLKN TVYDIADKVP EPCSPFSVSI SPVTKSSFYG YGLGHIPNLY
210 220 230 240 250
RLSFNNWNMC RKIGKRMLEE GRKVYELGVD PLARFLIDRK IPSFGWCLAR
260 270 280 290 300
RYSVRAAGYV SRAQLEIDCD VADILPIEEQ SNWPFYRCLS FDIECMSGTG
310 320 330 340 350
AFPAAENVDD IIIQISCVCF GVGEMVHHAY DVHADLSTPA VPENHLFTIG
360 370 380 390 400
PCAPIPDVKI YTFPSEYEML RGFFIFLSWY SPEFITGYNI NGFDIKYILT
410 420 430 440 450
RAEKLYKMDV GQFTKLRRGG RMFVFSPEKG KAGFGTSNTV KVFWSGTVVL
460 470 480 490 500
DMYPVCTAKA SSPNYKLDTM AEIYLKKKKD DLSYKEIPVQ FSAGDEGRAP
510 520 530 540 550
GGKYCLQDAV LVRELFEMLA FHFEAAAIAR LARIPLRKVI FDGQQIRIYT
560 570 580 590 600
CLLEECSGRD MILPNMPSLG HGAAAAIEEA AAGGEGDETS EGENSNNSRT
610 620 630 640 650
VGYQGATVLE PECGFHHVPV CVFDFASLYP SIIMSNNLCY STLLVEGSPE
660 670 680 690 700
VPEKDVLRVE IGDQCHRFVR ENVHRSLLAE LLVRWLTQRK LVREAMKQCT
710 720 730 740 750
NEMQRMIMDK QQLALKVTCN AFYGFTGVAA GMLPCLPIAA SITKIGRDML
760 770 780 790 800
LATAGHIEDR CNRPDFLRTV LGLPPEAIDP EALRVKIIYG DTDSVFAAFY
810 820 830 840 850
GIDKEALLKA VGALAANVTN ALFKEPVRLE FEKMFVSLMM ICKKRYIGKV
860 870 880 890 900
HGSQNLSMKG VDLVRRTACG FVKAVVSDVL HMVFNDETVS EGTMKLSRMT
910 920 930 940 950
FDDLKKNGIP CEFGPVVSRL CRARDDLHLK KVPVPELTLS SVLSQELSCY
960 970 980 990 1000
KQKNLPHLAV IRRLAARKEE LPAVGDRVEY VLTLPDGCKK NVPNYEIAED
1010 1020 1030 1040 1050
PRHVVEAKLS INAEKYYEQV VKAVTNTLMP VFPRDMPKRE KFFSLVVPQR
1060 1070 1080 1090
IYIPDQFLHL CGNVNELARG GDDSDGGDSE KENMDTERSS SHEAMET
Length:1,097
Mass (Da):123,574
Last modified:August 1, 1992 - v1
Checksum:i07310048ACC350BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73549 Genomic DNA. Translation: AAA45940.1.
U68299 Genomic DNA. No translation available.
PIRiB40780. DJBEMC.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73549 Genomic DNA. Translation: AAA45940.1.
U68299 Genomic DNA. No translation available.
PIRiB40780. DJBEMC.

3D structure databases

ProteinModelPortaliP27172.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.90.1600.10. 2 hits.
InterProiIPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 1 hit.
[Graphical view]
PRINTSiPR00106. DNAPOLB.
SMARTiSM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 2 hits.
PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Transcription analysis and sequence of the putative murine cytomegalovirus DNA polymerase gene."
    Elliott R., Clark C., Jaquish D., Spector D.H.
    Virology 185:169-186(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Analysis of the complete DNA sequence of murine cytomegalovirus."
    Rawlinson W.D., Farrell H.E., Barrell B.G.
    J. Virol. 70:8833-8849(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDPOL_MUHVS
AccessioniPrimary (citable) accession number: P27172
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: January 7, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.