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Protein

DNA polymerase catalytic subunit

Gene

UL54

Organism
Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA replication, Viral DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase catalytic subunit (EC:2.7.7.7)
Gene namesi
Name:UL54
OrganismiMurid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus)
Taxonomic identifieri10367 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeMuromegalovirus
Virus hostiMus musculus (Mouse) [TaxID: 10090]
Proteomesi
  • UP000008774 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000465081 – 1097DNA polymerase catalytic subunitAdd BLAST1097

Proteomic databases

PRIDEiP27172

Structurei

3D structure databases

ProteinModelPortaliP27172
SMRiP27172
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.Curated

Phylogenomic databases

OrthoDBiVOG0900001M

Family and domain databases

Gene3Di3.30.420.10, 1 hit
3.90.1600.10, 3 hits
InterProiView protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR017964 DNA-dir_DNA_pol_B_CS
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR023211 DNA_pol_palm_dom_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 1 hit
PRINTSiPR00106 DNAPOLB
SMARTiView protein in SMART
SM00486 POLBc, 1 hit
SUPFAMiSSF53098 SSF53098, 2 hits
PROSITEiView protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

Sequencei

Sequence statusi: Complete.

P27172-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTCVETFFN PYLRRKPRRD WRRCEDNNKN FLQVVPRGVL YDGATGLIKV
60 70 80 90 100
QSGMEPRMFY AEKEYVLNPD KPWPTLRTRG WCRGPYSDDV RFHTYDQVVN
110 120 130 140 150
LVLADSDEQI SPRWNSHVVP AGNVIRMFGA TDEGVSVCVN VFGQKAYFYC
160 170 180 190 200
ERMQSEDLKN TVYDIADKVP EPCSPFSVSI SPVTKSSFYG YGLGHIPNLY
210 220 230 240 250
RLSFNNWNMC RKIGKRMLEE GRKVYELGVD PLARFLIDRK IPSFGWCLAR
260 270 280 290 300
RYSVRAAGYV SRAQLEIDCD VADILPIEEQ SNWPFYRCLS FDIECMSGTG
310 320 330 340 350
AFPAAENVDD IIIQISCVCF GVGEMVHHAY DVHADLSTPA VPENHLFTIG
360 370 380 390 400
PCAPIPDVKI YTFPSEYEML RGFFIFLSWY SPEFITGYNI NGFDIKYILT
410 420 430 440 450
RAEKLYKMDV GQFTKLRRGG RMFVFSPEKG KAGFGTSNTV KVFWSGTVVL
460 470 480 490 500
DMYPVCTAKA SSPNYKLDTM AEIYLKKKKD DLSYKEIPVQ FSAGDEGRAP
510 520 530 540 550
GGKYCLQDAV LVRELFEMLA FHFEAAAIAR LARIPLRKVI FDGQQIRIYT
560 570 580 590 600
CLLEECSGRD MILPNMPSLG HGAAAAIEEA AAGGEGDETS EGENSNNSRT
610 620 630 640 650
VGYQGATVLE PECGFHHVPV CVFDFASLYP SIIMSNNLCY STLLVEGSPE
660 670 680 690 700
VPEKDVLRVE IGDQCHRFVR ENVHRSLLAE LLVRWLTQRK LVREAMKQCT
710 720 730 740 750
NEMQRMIMDK QQLALKVTCN AFYGFTGVAA GMLPCLPIAA SITKIGRDML
760 770 780 790 800
LATAGHIEDR CNRPDFLRTV LGLPPEAIDP EALRVKIIYG DTDSVFAAFY
810 820 830 840 850
GIDKEALLKA VGALAANVTN ALFKEPVRLE FEKMFVSLMM ICKKRYIGKV
860 870 880 890 900
HGSQNLSMKG VDLVRRTACG FVKAVVSDVL HMVFNDETVS EGTMKLSRMT
910 920 930 940 950
FDDLKKNGIP CEFGPVVSRL CRARDDLHLK KVPVPELTLS SVLSQELSCY
960 970 980 990 1000
KQKNLPHLAV IRRLAARKEE LPAVGDRVEY VLTLPDGCKK NVPNYEIAED
1010 1020 1030 1040 1050
PRHVVEAKLS INAEKYYEQV VKAVTNTLMP VFPRDMPKRE KFFSLVVPQR
1060 1070 1080 1090
IYIPDQFLHL CGNVNELARG GDDSDGGDSE KENMDTERSS SHEAMET
Length:1,097
Mass (Da):123,574
Last modified:August 1, 1992 - v1
Checksum:i07310048ACC350BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73549 Genomic DNA Translation: AAA45940.1
U68299 Genomic DNA No translation available.
PIRiB40780 DJBEMC

Similar proteinsi

Entry informationi

Entry nameiDPOL_MUHVS
AccessioniPrimary (citable) accession number: P27172
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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