P27172 (DPOL_MUHVS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA polymerase
EC=2.7.7.7

Gene names

Name:

UL54

Organism

Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus) [Reference proteome]

Taxonomic identifier

10367 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Betaherpesvirinae › Muromegalovirus › Murid herpesvirus 1

Virus host

Mus musculus (Mouse) [TaxID: 10090]

Protein attributes

Sequence length	1097 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Subcellular location	Host nucleus.
Sequence similarities	Belongs to the DNA polymerase type-B family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Host nucleus
Ligand	DNA-binding
Molecular function	DNA-directed DNA polymerase Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1097	1097	DNA polymerase		PRO_0000046508

Sequences

	Sequence		Length	Mass (Da)
	P27172 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 07310048ACC350BD	FASTA	1,097	123,574
	10 20 30 40 50 60 MDTCVETFFN PYLRRKPRRD WRRCEDNNKN FLQVVPRGVL YDGATGLIKV QSGMEPRMFY 70 80 90 100 110 120 AEKEYVLNPD KPWPTLRTRG WCRGPYSDDV RFHTYDQVVN LVLADSDEQI SPRWNSHVVP 130 140 150 160 170 180 AGNVIRMFGA TDEGVSVCVN VFGQKAYFYC ERMQSEDLKN TVYDIADKVP EPCSPFSVSI 190 200 210 220 230 240 SPVTKSSFYG YGLGHIPNLY RLSFNNWNMC RKIGKRMLEE GRKVYELGVD PLARFLIDRK 250 260 270 280 290 300 IPSFGWCLAR RYSVRAAGYV SRAQLEIDCD VADILPIEEQ SNWPFYRCLS FDIECMSGTG 310 320 330 340 350 360 AFPAAENVDD IIIQISCVCF GVGEMVHHAY DVHADLSTPA VPENHLFTIG PCAPIPDVKI 370 380 390 400 410 420 YTFPSEYEML RGFFIFLSWY SPEFITGYNI NGFDIKYILT RAEKLYKMDV GQFTKLRRGG 430 440 450 460 470 480 RMFVFSPEKG KAGFGTSNTV KVFWSGTVVL DMYPVCTAKA SSPNYKLDTM AEIYLKKKKD 490 500 510 520 530 540 DLSYKEIPVQ FSAGDEGRAP GGKYCLQDAV LVRELFEMLA FHFEAAAIAR LARIPLRKVI 550 560 570 580 590 600 FDGQQIRIYT CLLEECSGRD MILPNMPSLG HGAAAAIEEA AAGGEGDETS EGENSNNSRT 610 620 630 640 650 660 VGYQGATVLE PECGFHHVPV CVFDFASLYP SIIMSNNLCY STLLVEGSPE VPEKDVLRVE 670 680 690 700 710 720 IGDQCHRFVR ENVHRSLLAE LLVRWLTQRK LVREAMKQCT NEMQRMIMDK QQLALKVTCN 730 740 750 760 770 780 AFYGFTGVAA GMLPCLPIAA SITKIGRDML LATAGHIEDR CNRPDFLRTV LGLPPEAIDP 790 800 810 820 830 840 EALRVKIIYG DTDSVFAAFY GIDKEALLKA VGALAANVTN ALFKEPVRLE FEKMFVSLMM 850 860 870 880 890 900 ICKKRYIGKV HGSQNLSMKG VDLVRRTACG FVKAVVSDVL HMVFNDETVS EGTMKLSRMT 910 920 930 940 950 960 FDDLKKNGIP CEFGPVVSRL CRARDDLHLK KVPVPELTLS SVLSQELSCY KQKNLPHLAV 970 980 990 1000 1010 1020 IRRLAARKEE LPAVGDRVEY VLTLPDGCKK NVPNYEIAED PRHVVEAKLS INAEKYYEQV 1030 1040 1050 1060 1070 1080 VKAVTNTLMP VFPRDMPKRE KFFSLVVPQR IYIPDQFLHL CGNVNELARG GDDSDGGDSE 1090 KENMDTERSS SHEAMET

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Transcription analysis and sequence of the putative murine cytomegalovirus DNA polymerase gene." Elliott R., Clark C., Jaquish D., Spector D.H. Virology 185:169-186(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Analysis of the complete DNA sequence of murine cytomegalovirus." Rawlinson W.D., Farrell H.E., Barrell B.G. J. Virol. 70:8833-8849(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M73549 Genomic DNA. Translation: AAA45940.1. U68299 Genomic DNA. No translation available.
PIR	DJBEMC. B40780.
3D structure databases
ProteinModelPortal	P27172.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.90.1600.10. 2 hits.
InterPro	IPR006172. DNA-dir_DNA_pol_B. IPR017964. DNA-dir_DNA_pol_B_CS. IPR006133. DNA-dir_DNA_pol_B_exonuc. IPR006134. DNA-dir_DNA_pol_B_multi_dom. IPR023211. DNA_pol_palm_dom. IPR012337. RNaseH-like_dom. [Graphical view]
Pfam	PF00136. DNA_pol_B. 1 hit. PF03104. DNA_pol_B_exo1. 1 hit. [Graphical view]
PRINTS	PR00106. DNAPOLB.
SMART	SM00486. POLBc. 1 hit. [Graphical view]
SUPFAM	SSF53098. RNaseH_fold. 1 hit.
PROSITE	PS00116. DNA_POLYMERASE_B. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DPOL_MUHVS

Accession

Primary (citable) accession number: P27172

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program