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P27168

- COX2_DAUCA

UniProt

P27168 - COX2_DAUCA

Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Daucus carota (Wild carrot)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi188 – 1881Copper ACurated
    Metal bindingi223 – 2231Copper ACurated
    Metal bindingi227 – 2271Copper ACurated
    Metal bindingi231 – 2311Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:COX2
    Synonyms:COXII
    Encoded oniMitochondrion
    OrganismiDaucus carota (Wild carrot)
    Taxonomic identifieri4039 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsApialesApiaceaeApioideaeScandiceaeDaucinaeDaucus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261Cytochrome c oxidase subunit 2PRO_0000183567Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP27168.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini56 – 8732Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini109 – 261153Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei88 – 10821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P27168-1 [UniParc]FASTAAdd to Basket

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    MSFTGIFHFF TNSPCDAAEP WQLGSQDAAT PMMQGIIDLH HDIFFFLILI    50
    LVFVSRILVR ALWHFHSKKN PIPQRIVHGT TIEILRTIFP SIIPMFIAIP 100
    SFALLYSMDE VVVDPAMTIK AIGHQWYRTY EYSDYNSSDE QSLTFDSYTI 150
    PEDDPELGQS RLLEVDNRVV VPAKTHLRII VTSADVPHSW AVPSSGVKCD 200
    AVPGRLNQIS ISVQREGVYY GQCSEICGTN HAFTPIVVEA VSRKDYGSRV 250
    SNQLIPQTGE A 261
    Length:261
    Mass (Da):29,301
    Last modified:August 1, 1992 - v1
    Checksum:i190436545ACE5B7C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63625 Genomic DNA. Translation: CAA45171.1.
    M19054 Genomic DNA. Translation: AAA70199.1.
    PIRiS20464. OBPZ2M.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63625 Genomic DNA. Translation: CAA45171.1 .
    M19054 Genomic DNA. Translation: AAA70199.1 .
    PIRi S20464. OBPZ2M.

    3D structure databases

    ProteinModelPortali P27168.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The coxII gene in carrot mitochondria contains two introns."
      Lippok B., Brennicke A., Wissinger B.
      Mol. Gen. Genet. 232:322-327(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. Sativum.
    2. "Cytochrome oxidase subunit II gene from carrot contains an intron."
      Turano F.J., de Bonte L.R., Wilson K.G., Matthews B.F.
      Plant Physiol. 84:1074-1079(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-113.

    Entry informationi

    Entry nameiCOX2_DAUCA
    AccessioniPrimary (citable) accession number: P27168
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3