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P27168 (COX2_DAUCA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Synonyms:COXII
Encoded onMitochondrion
OrganismDaucus carota (Carrot)
Taxonomic identifier4039 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsApialesApiaceaeApioideaeScandiceaeDaucinaeDaucus

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Cytochrome c oxidase subunit 2
PRO_0000183567

Regions

Topological domain1 – 3434Mitochondrial intermembrane Potential
Transmembrane35 – 5521Helical; Potential
Topological domain56 – 8732Mitochondrial matrix Potential
Transmembrane88 – 10821Helical; Potential
Topological domain109 – 261153Mitochondrial intermembrane Potential

Sites

Metal binding1881Copper A Probable
Metal binding2231Copper A Probable
Metal binding2271Copper A Probable
Metal binding2311Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P27168 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 190436545ACE5B7C

FASTA26129,301
        10         20         30         40         50         60 
MSFTGIFHFF TNSPCDAAEP WQLGSQDAAT PMMQGIIDLH HDIFFFLILI LVFVSRILVR 

        70         80         90        100        110        120 
ALWHFHSKKN PIPQRIVHGT TIEILRTIFP SIIPMFIAIP SFALLYSMDE VVVDPAMTIK 

       130        140        150        160        170        180 
AIGHQWYRTY EYSDYNSSDE QSLTFDSYTI PEDDPELGQS RLLEVDNRVV VPAKTHLRII 

       190        200        210        220        230        240 
VTSADVPHSW AVPSSGVKCD AVPGRLNQIS ISVQREGVYY GQCSEICGTN HAFTPIVVEA 

       250        260 
VSRKDYGSRV SNQLIPQTGE A 

« Hide

References

[1]"The coxII gene in carrot mitochondria contains two introns."
Lippok B., Brennicke A., Wissinger B.
Mol. Gen. Genet. 232:322-327(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. Sativum.
[2]"Cytochrome oxidase subunit II gene from carrot contains an intron."
Turano F.J., de Bonte L.R., Wilson K.G., Matthews B.F.
Plant Physiol. 84:1074-1079(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-113.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X63625 Genomic DNA. Translation: CAA45171.1.
M19054 Genomic DNA. Translation: AAA70199.1.
PIROBPZ2M. S20464.

3D structure databases

ProteinModelPortalP27168.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_DAUCA
AccessionPrimary (citable) accession number: P27168
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families