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Protein

Lipopolysaccharide 1,6-galactosyltransferase

Gene

rfaB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Adds a galactose goup to a glucose group of LPS.

Pathwayi: LPS core biosynthesis

This protein is involved in the pathway LPS core biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway LPS core biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

  • lipopolysaccharide-1,6-galactosyltransferase activity Source: EcoCyc

GO - Biological processi

  • lipopolysaccharide core region biosynthetic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciEcoCyc:EG11351-MONOMER.
ECOL316407:JW3603-MONOMER.
MetaCyc:EG11351-MONOMER.
UniPathwayiUPA00958.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipopolysaccharide 1,6-galactosyltransferase (EC:2.4.1.-)
Alternative name(s):
UDP-D-galactose--(Glucosyl)lipopolysaccharide-alpha-1,3-D-galactosyltransferase
Gene namesi
Name:rfaB
Synonyms:waaB
Ordered Locus Names:b3628, JW3603
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11351. rfaB.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Lipopolysaccharide 1,6-galactosyltransferasePRO_0000080303Add
BLAST

Proteomic databases

PaxDbiP27127.

Interactioni

Protein-protein interaction databases

BioGridi4263407. 258 interactions.
DIPiDIP-10663N.
IntActiP27127. 1 interaction.
STRINGi511145.b3628.

Structurei

3D structure databases

ProteinModelPortaliP27127.
SMRiP27127. Positions 138-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107XU6. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000288854.
InParanoidiP27127.
KOiK02840.
PhylomeDBiP27127.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27127-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIAFIGEAV SGFGGMETVI RDVITTFRQQ HIQSEMFFFC RNDKMDKGWL
60 70 80 90 100
EGIKYSCSFS NIRLGFLRRA KHIHALSKWL QEYQPDIVIC IDVISCLFAA
110 120 130 140 150
KARKKSGIDM PVFSWPHFSL DHKKHAEYIT CADYHLAISS GIKQQMINRG
160 170 180 190 200
VAESTINVIF NPVETKDSVI PAPEEGETAT FIYVGRMKFE GQKRVKDLLD
210 220 230 240 250
GLSQAKGNWK LHVLGDGSDF EKCQAYGREL NIDDRIVWYG WQQYPWELVQ
260 270 280 290 300
QDIEKVSALL LTSSFEGFPM TLLEALSWGI PCISADCVSG PADIIQPDVN
310 320 330 340 350
GHLYQPGDIA GFVTLLNKYI AGEIHIEHEK IPASIDEFYQ SKYYDRLHKV

IISAISRRK
Length:359
Mass (Da):40,826
Last modified:November 24, 2009 - v2
Checksum:i191088896F4A45F4
GO

Sequence cautioni

The sequence AAA24085 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAB18605 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE77664 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80599 Genomic DNA. Translation: AAA24085.1. Different initiation.
U00039 Genomic DNA. Translation: AAB18605.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76652.2.
AP009048 Genomic DNA. Translation: BAE77664.1. Different initiation.
PIRiB42982.
RefSeqiNP_418085.2. NC_000913.3.
WP_000683964.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76652; AAC76652; b3628.
BAE77664; BAE77664; BAE77664.
GeneIDi948144.
KEGGiecj:JW3603.
eco:b3628.
PATRICi32122743. VBIEscCol129921_3748.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80599 Genomic DNA. Translation: AAA24085.1. Different initiation.
U00039 Genomic DNA. Translation: AAB18605.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76652.2.
AP009048 Genomic DNA. Translation: BAE77664.1. Different initiation.
PIRiB42982.
RefSeqiNP_418085.2. NC_000913.3.
WP_000683964.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP27127.
SMRiP27127. Positions 138-311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263407. 258 interactions.
DIPiDIP-10663N.
IntActiP27127. 1 interaction.
STRINGi511145.b3628.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Proteomic databases

PaxDbiP27127.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76652; AAC76652; b3628.
BAE77664; BAE77664; BAE77664.
GeneIDi948144.
KEGGiecj:JW3603.
eco:b3628.
PATRICi32122743. VBIEscCol129921_3748.

Organism-specific databases

EchoBASEiEB1326.
EcoGeneiEG11351. rfaB.

Phylogenomic databases

eggNOGiENOG4107XU6. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000288854.
InParanoidiP27127.
KOiK02840.
PhylomeDBiP27127.

Enzyme and pathway databases

UniPathwayiUPA00958.
BioCyciEcoCyc:EG11351-MONOMER.
ECOL316407:JW3603-MONOMER.
MetaCyc:EG11351-MONOMER.

Miscellaneous databases

PROiP27127.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRFAB_ECOLI
AccessioniPrimary (citable) accession number: P27127
Secondary accession number(s): Q2M7U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: November 24, 2009
Last modified: September 7, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.