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Protein

L-rhamnose-proton symporter

Gene

rhaT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-mannose and L-xylose, but at reduced rates.

GO - Molecular functioni

  • rhamnose transmembrane transporter activity Source: UniProtKB-HAMAP
  • symporter activity Source: EcoCyc

GO - Biological processi

  • rhamnose transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Symport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:RHAT-MONOMER.
ECOL316407:JW3878-MONOMER.
MetaCyc:RHAT-MONOMER.

Protein family/group databases

TCDBi2.A.7.6.1. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
L-rhamnose-proton symporter
Alternative name(s):
L-rhamnose-H(+) transport protein
Gene namesi
Name:rhaT
Ordered Locus Names:b3907, JW3878
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11313. rhaT.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 5PeriplasmicCurated5
Transmembranei6 – 26HelicalCuratedAdd BLAST21
Topological domaini27 – 36CytoplasmicCurated10
Transmembranei37 – 57HelicalCuratedAdd BLAST21
Topological domaini58 – 61PeriplasmicCurated4
Transmembranei62 – 82HelicalCuratedAdd BLAST21
Topological domaini83 – 96CytoplasmicCuratedAdd BLAST14
Transmembranei97 – 117HelicalCuratedAdd BLAST21
Topological domaini118 – 130PeriplasmicCuratedAdd BLAST13
Transmembranei131 – 152HelicalCuratedAdd BLAST22
Topological domaini153 – 174CytoplasmicCuratedAdd BLAST22
Transmembranei175 – 195HelicalCuratedAdd BLAST21
Topological domaini196 – 208PeriplasmicCuratedAdd BLAST13
Transmembranei209 – 229HelicalCuratedAdd BLAST21
Topological domaini230 – 254CytoplasmicCuratedAdd BLAST25
Transmembranei255 – 275HelicalCuratedAdd BLAST21
Topological domaini276 – 289PeriplasmicCuratedAdd BLAST14
Transmembranei290 – 310HelicalCuratedAdd BLAST21
Topological domaini311 – 321CytoplasmicCuratedAdd BLAST11
Transmembranei322 – 342HelicalCuratedAdd BLAST21
Topological domaini343 – 344PeriplasmicCurated2

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002082721 – 344L-rhamnose-proton symporterAdd BLAST344

Proteomic databases

PaxDbiP27125.
PRIDEiP27125.

Expressioni

Inductioni

Induced by L-rhamnose via the RhaR-RhaS regulatory cascade. Also induced by L-mannose or L-xylose.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4263535. 4 interactors.
STRINGi511145.b3907.

Structurei

3D structure databases

ProteinModelPortaliP27125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107YRA. Bacteria.
COG0697. LUCA.
HOGENOMiHOG000274531.
InParanoidiP27125.
KOiK02856.
OMAiQFFFYGM.
PhylomeDBiP27125.

Family and domain databases

HAMAPiMF_01532. RhaT. 1 hit.
InterProiIPR004673. L-rhamnose-proton_sym_RhaT.
[Graphical view]
PfamiPF06379. RhaT. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00776. RhaT. 1 hit.

Sequencei

Sequence statusi: Complete.

P27125-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNAITMGIF WHLIGAASAA CFYAPFKKVK KWSWETMWSV GGIVSWIILP
60 70 80 90 100
WAISALLLPN FWAYYSSFSL STRLPVFLFG AMWGIGNINY GLTMRYLGMS
110 120 130 140 150
MGIGIAIGIT LIVGTLMTPI INGNFDVLIS TEGGRMTLLG VLVALIGVGI
160 170 180 190 200
VTRAGQLKER KMGIKAEEFN LKKGLVLAVM CGIFSAGMSF AMNAAKPMHE
210 220 230 240 250
AAAALGVDPL YVALPSYVVI MGGGAIINLG FCFIRLAKVK DLSLKADFSL
260 270 280 290 300
AKSLIIHNVL LSTLGGLMWY LQFFFYAWGH ARIPAQYDYI SWMLHMSFYV
310 320 330 340
LCGGIVGLVL KEWNNAGRRP VTVLSLGCVV IIVAANIVGI GMAN
Length:344
Mass (Da):37,320
Last modified:August 1, 1992 - v1
Checksum:iF73C3CC9CBEA3C28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85158 Genomic DNA. Translation: AAA24529.1.
X60699 Genomic DNA. Translation: CAA43109.1.
L19201 Genomic DNA. Translation: AAB03040.1.
U00096 Genomic DNA. Translation: AAC76889.1.
AP009048 Genomic DNA. Translation: BAE77402.1.
PIRiB42436.
RefSeqiNP_418343.1. NC_000913.3.
WP_000063526.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76889; AAC76889; b3907.
BAE77402; BAE77402; BAE77402.
GeneIDi948398.
KEGGiecj:JW3878.
eco:b3907.
PATRICi32123325. VBIEscCol129921_4023.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85158 Genomic DNA. Translation: AAA24529.1.
X60699 Genomic DNA. Translation: CAA43109.1.
L19201 Genomic DNA. Translation: AAB03040.1.
U00096 Genomic DNA. Translation: AAC76889.1.
AP009048 Genomic DNA. Translation: BAE77402.1.
PIRiB42436.
RefSeqiNP_418343.1. NC_000913.3.
WP_000063526.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP27125.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263535. 4 interactors.
STRINGi511145.b3907.

Protein family/group databases

TCDBi2.A.7.6.1. the drug/metabolite transporter (dmt) superfamily.

Proteomic databases

PaxDbiP27125.
PRIDEiP27125.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76889; AAC76889; b3907.
BAE77402; BAE77402; BAE77402.
GeneIDi948398.
KEGGiecj:JW3878.
eco:b3907.
PATRICi32123325. VBIEscCol129921_4023.

Organism-specific databases

EchoBASEiEB1289.
EcoGeneiEG11313. rhaT.

Phylogenomic databases

eggNOGiENOG4107YRA. Bacteria.
COG0697. LUCA.
HOGENOMiHOG000274531.
InParanoidiP27125.
KOiK02856.
OMAiQFFFYGM.
PhylomeDBiP27125.

Enzyme and pathway databases

BioCyciEcoCyc:RHAT-MONOMER.
ECOL316407:JW3878-MONOMER.
MetaCyc:RHAT-MONOMER.

Miscellaneous databases

PROiP27125.

Family and domain databases

HAMAPiMF_01532. RhaT. 1 hit.
InterProiIPR004673. L-rhamnose-proton_sym_RhaT.
[Graphical view]
PfamiPF06379. RhaT. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00776. RhaT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRHAT_ECOLI
AccessioniPrimary (citable) accession number: P27125
Secondary accession number(s): Q2M8K4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.