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P27121 (DCOR_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ornithine decarboxylase
Short name=ODC
EC=4.1.1.17
Gene names
Name:spe-1
ORF Names:B13M13.130, NCU01271
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora

Protein attributes

Sequence length484 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

L-ornithine = putrescine + CO2.

Cofactor

Pyridoxal phosphate.

Enzyme regulation

ODC synthesis is enhanced postranscriptionally by an excess of putrescine. This polyamine-mediated control is unique to N.crassa.

Pathway

Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family.

Caution

It is uncertain whether Met-1 or Met-3 is the initiator.

Ontologies

Keywords
   Biological processPolyamine biosynthesis
   LigandPyridoxal phosphate
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processpolyamine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionornithine decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 484484Ornithine decarboxylase
PRO_0000149906

Sites

Active site4221Proton donor; shared with dimeric partner By similarity

Amino acid modifications

Modified residue1141N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P27121 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 3554F4315EA44A6F

FASTA48453,301
        10         20         30         40         50         60 
MVMPTVVSDR MGTIDFIDYT NNHVFSKCQT DSLNTVNNGS LKHDDYLHGL ANGKLVAKQM 

        70         80         90        100        110        120 
IGDALRQRVE SIDSEFCEPG DEDTFFVADL GEVYRQHLRW KLNLPRVKPF YAVKCHPDER 

       130        140        150        160        170        180 
LLQLLAALGT GFDCASKAEI EQVLRMGVDP SRIIYAQPCK TNSYLRYVAQ QGVRQMTFDN 

       190        200        210        220        230        240 
ADELRKIARL YPDAELFLRI LTDDSSSLCR FSMKFGASLD STDGLLGLAR QLGLNVVGVS 

       250        260        270        280        290        300 
FHVGSGASDP TAFLKAVQDA HVVFQQAAAY GYSLKTLDVG GGFCSDDSFE QMANVLRAAL 

       310        320        330        340        350        360 
DEYFPAHTGV NLIAEPGRYY ASSAFTLACN IIARRTIQDG SAVSVSDSSS MSDDGSVNNG 

       370        380        390        400        410        420 
DARYMVYVND GLYGNFSSIM FDHQHPVAKI LRAGGRTMYN SVAAHESSAE DAIEYSIWGP 

       430        440        450        460        470        480 
TCDGIDRITE SIRFREILDV GDWLYFEDMG AYTKCSATTF NGFSNEHDVI YVCSEPGAMA 


LLGL

« Hide

References

« Hide 'large scale' references
[1]"Ornithine decarboxylase gene of Neurospora crassa: isolation, sequence, and polyamine-mediated regulation of its mRNA."
Williams L.J., Barnett G.R., Ristow J.L., Pitkin J., Perriere M., Davis R.H.
Mol. Cell. Biol. 12:347-359(1992) [PubMed: 1530878] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: 74-ORS-6a / FGSC 4200.
[2]"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
Nucleic Acids Res. 31:1944-1954(2003) [PubMed: 12655011] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[3]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed: 12712197] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M68969 mRNA. Translation: AAA33604.1.
M68970 Genomic DNA. Translation: AAA33605.1.
L16920 Genomic DNA. Translation: AAA33614.1.
BX842618 Genomic DNA. Translation: CAE76122.1.
AABX02000014 Genomic DNA. Translation: EAA31513.1.
PIRA42065.
RefSeqXP_960749.1. XM_955656.2.
UniGeneNcr.5302.

3D structure databases

ProteinModelPortalP27121.
ModBaseSearch...

Protein-protein interaction databases

STRINGP27121.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000004012; EFNCRP00000004012; EFNCRG00000004007.
GeneID3876899.
KEGGncr:NCU01271.
NMPDRfig|5141.1.peg.4697.

Phylogenomic databases

eggNOGfuNOG06852.
GeneTreeEFGT00050000003448.
OMAMNCILFD.
OrthoDBEOG47SWPC.

Enzyme and pathway databases

BioCycNCRA-XX3-01:NCRA-XX3-01-004981-MONOMER.

Family and domain databases

InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
[Graphical view]
Gene3DG3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 1 hit.
KOK01581.
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMSSF50621. Racem_decarbox_C. 1 hit.
PROSITEPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCOR_NEUCR
AccessionPrimary (citable) accession number: P27121
Secondary accession number(s): Q7S7C1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: December 14, 2011
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents