P27120 (DCOR1_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine decarboxylase 1
Short name=ODC 1
Short name=xODC1
EC=4.1.1.17

Gene names

Name:	odc1-a
Synonyms:	odc, odc1

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	460 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	L-ornithine = putrescine + CO2.
Cofactor	Pyridoxal phosphate.
Enzyme regulation	Regulated post-translationally by polyamines.
Pathway	Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.
Developmental stage	Levels increase in the embryos 1.5-2 hours after fertilization and reach a maximum at 6 hours post-fertilization, then decrease to a very low level in early gastrulating embryos (12 hours post-fertilization). Ref.2
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family.

Ontologies

Keywords
Biological process	Polyamine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	polyamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ornithine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 460	460	Ornithine decarboxylase 1		PRO_0000149896
Sites
	Active site	361	1	Proton donor; shared with dimeric partner By similarity
Amino acid modifications
	Modified residue	69	1	N6-(pyridoxal phosphate)lysine By similarity
	Modified residue	303	1	Phosphoserine; by CK2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	P27120 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: CC6F87FD165877EE	FASTA	460	50,830
	10 20 30 40 50 60 MNSFSNDDFD FSFLEEGFSA RDIVEQKINE VSLSDDKDAF YVADFGDIVK KHVRWFKALP 70 80 90 100 110 120 RVTPFYAVKC NDGKAIVKTL SILGAGFDCA SKTEIQLVQS IGVSPERIIY ANPCKQVSQI 130 140 150 160 170 180 KYAASCGVEK MTFDSEVELM KVARNHPNAK LVLRIATDDS KAVCRLSVKF GATLKTSRLL 190 200 210 220 230 240 LERAKELNVD IIGVSFHVGS GCTDPQTYVQ AVSDARCVFD MGAELGFNMH LLDIGGGFPG 250 260 270 280 290 300 SEDVKLKFEE ITSVINPALD KYFPADSGVK IIAEPGRYYV ASSFTLAVNI IAKKVMVNEQ 310 320 330 340 350 360 SGSDDEEDAA NDKTLMYYVN DGVYGSFNCI LFDHAHVKPV LTKKPKPDEK FYSSSIWGPT 370 380 390 400 410 420 CDGLDRIVER FELPELQVGD WMLFENMGAY TVAAASTFNG FQRPTLYYVM SRPHWQLMHD 430 440 450 460 IKEHGILPEV PDLSALHVSC AQESGMELAP AVCTAASINV

References

[1]	"Post-transcriptional regulation of ornithine decarboxylase in Xenopus laevis oocytes." Bassez T., Paris J., Omilli F., Dorel C., Osborne H.B. Development 110:955-962(1990) [PubMed: 2088731] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Oocyte.
[2]	"Expression and post-transcriptional regulation of ornithine decarboxylase during early Xenopus development." Osborne H.B., Duval C., Ghoda L., Omilli F., Bassez T., Coffino P. Eur. J. Biochem. 202:575-581(1991) [PubMed: 1761057] [Abstract] Cited for: DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X56316 mRNA. Translation: CAA39760.1.
PIR	A43563.
UniGene	Xl.4223.
3D structure databases
ProteinModelPortal	P27120.
SMR	P27120. Positions 7-422.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
Xenbase	XB-GENE-856383. odc1.
Phylogenomic databases
HOVERGEN	HBG005456.
Family and domain databases
InterPro	IPR009006. Ala_racemase/Decarboxylase_C. IPR022643. De-COase2_C. IPR022657. De-COase2_CS. IPR022644. De-COase2_N. IPR022653. De-COase2_pyr-phos_BS. IPR000183. Orn/DAP/Arg_de-COase. IPR002433. Orn_de-COase. [Graphical view]
Gene3D	G3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 1 hit.
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PRINTS	PR01179. ODADCRBXLASE. PR01182. ORNDCRBXLASE.
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
PROSITE	PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCOR1_XENLA

Accession

Primary (citable) accession number: P27120

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	May 31, 2011
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program