Reviewed, UniProtKB/Swiss-Prot P27119 (DCOR_MUSPA)

Names and origin

Protein names

Recommended name:
    Ornithine decarboxylase
      Short name=ODC
    EC=4.1.1.17

Gene names

Name:	Odc1
Synonyms:	Odc

Organism

Mus pahari (Shrew mouse)

Taxonomic identifier

10093 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	461 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-ornithine = putrescine + CO2.
Cofactor	Pyridoxal phosphate.
Pathway	Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family.

Ontologies

Keywords
Biological process	Polyamine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	polyamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ornithine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 461	461	Ornithine decarboxylase		PRO_0000149893
Sites
	Active site	360	1	Proton donor; shared with dimeric partner By similarity
Amino acid modifications
	Modified residue	69	1	N6-(pyridoxal phosphate)lysine By similarity
	Modified residue	303	1	Phosphoserine; by CK2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	P27119-1 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 61ABBCBEEC7BFB92	FASTA	461	51,203
	10 20 30 40 50 60 MSSFTKEEFD CHILDEGFTA KDILDQKINE VSSSDDKDAF YVADLGDILK KHLRWLKALP 70 80 90 100 110 120 RVTPFYAVKC NDSRAIVSTL AATGTGFDCA SKTEIQLVQG LGVPPERIIY ANPCKQVSQI 130 140 150 160 170 180 KYAASSGVQM MTFDSEIELM KVARAHPKAK LVLRIATDDS KAVCRLSVKF GATLKTSRLL 190 200 210 220 230 240 LERAKELNID VIGVSFHVGS GCTDPETFVQ AVSDARCVFD MGTEVGFSMY LLDIGGGFPG 250 260 270 280 290 300 SEDTKLKFEE ITSVINPALD KYFPSDSGVR IIAEPGRYYV ASAFTLAVNI IAKKTVWKEQ 310 320 330 340 350 360 PGSDDEDESN EQTFMYYVND GVYGSFNCIL YDHAHVKALL QKRPKPDEKY YSSSIWGPTC 370 380 390 400 410 420 DGLDRIVERC NLPEMHVGDW MLFENMGAYT VAAASTFNGF QRPNIYYVMS RPMWQLMKRI 430 440 450 460 QSHGFPPEVE EQDDGTLPMS CAQESGMDHH SAACASARIN V

References

[1]	"Alterations in mRNA translation as a mechanism for the modification of enzyme synthesis during evolution. The ornithine decarboxylase model." Johannes G., Berger F.G. J. Biol. Chem. 267:10108-10115(1992) [PubMed: 1374399] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M87223 mRNA. Translation: AAA39847.1.
PIR	I55356.
3D structure databases
HSSP	HSSP built from PDB template 7ODC based on UniProtKB P00860.
SMR	P27119. Positions 2-418.
ModBase	Search...
Organism-specific databases
MGI	MGI:97402. Odc1.
Phylogenomic databases
HOVERGEN	P27119.
Enzyme and pathway databases
BRENDA	4.1.1.17. 292995.
Family and domain databases
InterPro	IPR000183. De-COase2. IPR002433. Orn_de-COase. [Graphical view]
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PRINTS	PR01179. ODADCRBXLASE. PR01182. ORNDCRBXLASE.
PROSITE	PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCOR_MUSPA

Accession

Primary (citable) accession number: P27119

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	June 16, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)