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P27118 (DCOR_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ornithine decarboxylase
Short name=ODC
EC=4.1.1.17
Gene names
Name:ODC1
Synonyms:ODC
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length450 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

L-ornithine = putrescine + CO2.

Cofactor

Pyridoxal phosphate.

Pathway

Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.

Subunit structure

Homodimer.

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family.

Ontologies

Keywords
   Biological processPolyamine biosynthesis
   LigandPyridoxal phosphate
   Molecular functionDecarboxylase
Lyase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processpolyamine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionornithine decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 450›450Ornithine decarboxylase
PRO_0000149895

Sites

Active site3501Proton donor; shared with dimeric partner By similarity

Amino acid modifications

Modified residue591N6-(pyridoxal phosphate)lysine By similarity
Modified residue2931Phosphoserine; by CK2 By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P27118 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 5EAC75DF3D17AD2C

FASTA45049,735
        10         20         30         40         50         60 
FTFLDEGFTA KDILDQKINE VSSSDDKDAF YVADLGDIVK KHMRWHKALP RVTPFYAVKC 

        70         80         90        100        110        120 
NDSEAVVKTL AVLGAGFDCA SKTEIQLVQS IGVPPERIIY ANPCKQLSQI KHAANSGVRM 

       130        140        150        160        170        180 
MTFDSEVELM KIARPHPKAK LLLRITTDDS KAVCRLSVKF GATLKTSRLL LERAKELDLA 

       190        200        210        220        230        240 
IVGVSFHVGS GCTDPETFVQ AISDARCVFD MGAELGFNMY LLDIGGGFPG SEDVKLKFEE 

       250        260        270        280        290        300 
ITSVINPALD KYFPLDSEVT IIAEPGRYYV ASAFTLAVNI IAKKIVSKEQ TGSDDEDDVN 

       310        320        330        340        350        360 
DKTLMYYVND GVYGSFNCIL YDHAHVKPVL QKRPKPDDGC YSCSIWGPTC DGLDRIVERC 

       370        380        390        400        410        420 
NMPELQVGDW ILFENMGAYT VAAASTFNGF QRPTIHYVMS RPAWQLMQQI KEQEFLAEVE 

       430        440        450 
EQDVASLPLS CACESGIEYP ATCASASINV

« Hide

References

[1]"Molecular cloning and sequence analysis of a chicken ornithine decarboxylase cDNA."
Johnson R., Bulfield G.
Anim. Genet. 23:403-409(1992) [PubMed: 1416246] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: White leghorn.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X64710 mRNA. Translation: CAA45965.1.
IPIIPI00578714.
PIRDCCHO. A48386.
RefSeqNP_001161238.1. NM_001167766.1.
UniGeneGga.4340.

3D structure databases

ProteinModelPortalP27118.
SMRP27118. Positions 3-411.
ModBaseSearch...

Protein-protein interaction databases

STRINGP27118.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID421937.
KEGGgga:421937.

Organism-specific databases

CTD4953.

Phylogenomic databases

eggNOGveNOG11746.
GeneTreeENSGT00390000011560.
HOGENOMHBG672375.
HOVERGENHBG005456.
InParanoidP27118.
OrthoDBEOG4ZGPC6.
PhylomeDBP27118.

Family and domain databases

InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
[Graphical view]
Gene3DG3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 1 hit.
KOK01581.
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMSSF50621. Racem_decarbox_C. 1 hit.
PROSITEPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCOR_CHICK
AccessionPrimary (citable) accession number: P27118
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 16, 2011
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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