P27117 (DCOR_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine decarboxylase
Short name=ODC
EC=4.1.1.17

Gene names

Name:	ODC1
Synonyms:	ODC

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	461 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	L-ornithine = putrescine + CO2.
Cofactor	Pyridoxal phosphate.
Pathway	Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family.

Ontologies

Keywords
Biological process	Polyamine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	polyamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ornithine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 461	461	Ornithine decarboxylase		PRO_0000149889
Sites
	Active site	360	1	Proton donor; shared with dimeric partner By similarity
Amino acid modifications
	Modified residue	69	1	N6-(pyridoxal phosphate)lysine By similarity
	Modified residue	303	1	Phosphoserine; by CK2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	P27117 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 4E609B643E3B68FA	FASTA	461	51,346
	10 20 30 40 50 60 MNSFSNEEFD CHFLDEGFTA KDILDQKINE VSYSDDKDAF YVADLGDILK KHLRWLKALP 70 80 90 100 110 120 RVTPFYAVKC NDSRTIVKTL AAIGTGFDCA SKTEIQLVQS LGVPPERIIY ANPCKQVSQI 130 140 150 160 170 180 KYAANNGVQM MTFDSEVELM KVARAHPKAK LVLRIATDDS KAVCRLSVKF GATLKTSRLL 190 200 210 220 230 240 LERAKELDID VIGVSFHVGS GCTDPETFVQ AISDARCVFD MGAEVGFNMY LLDIGGGFPG 250 260 270 280 290 300 SEDVKLKFEE ITSVINPALD KYFPSDSGVR IIAEPGRYYV ASAFTLAVNI IAKKLVLKEQ 310 320 330 340 350 360 TGSDDEEEST DRTFMYYVND GVYGSFNCIL YDHAHVKPLL QKRPKPDEKY YSSSIWGPTC 370 380 390 400 410 420 DGLDRIVERC NLPEMHVGDW MLFENMGAYT VAAASTFNGF QRPTIYYVMS GPTWQLMQQI 430 440 450 460 RTQDFPPGVE EPDVGPLPVS CAWESGMKRH SAACASTRIN V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a bovine ornithine decarboxylase cDNA and its use in the detection of restriction fragment length polymorphisms in Holsteins." Yao J., Zadworny D., Kuhnlein U., Hayes J.F. Genome 38:325-331(1995) [PubMed: 7774801] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Holstein. Tissue: Liver.
[2]	"Bovine ornithine decarboxylase gene: cloning, structure and polymorphisms." Yao J., Zadworny D., Aggrey S.E., Kuhnlein U., Hayes J.F. DNA Seq. 8:203-213(1998) [PubMed: 10520448] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M92441 mRNA. Translation: AAA92339.1. U36394 Genomic DNA. Translation: AAA79849.1. U18531 Genomic DNA. Translation: AAA86696.1. BC146218 mRNA. Translation: AAI46219.1.
IPI	IPI00698809.
RefSeq	NP_776555.1. NM_174130.2.
UniGene	Bt.7133.
3D structure databases
ProteinModelPortal	P27117.
SMR	P27117. Positions 7-421.
ModBase	Search...
Protein-protein interaction databases
STRING	P27117.
Proteomic databases
PRIDE	P27117.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000005575; ENSBTAP00000005575; ENSBTAG00000004256.
GeneID	281365.
KEGG	bta:281365.
Organism-specific databases
CTD	4953.
Phylogenomic databases
eggNOG	maNOG05169.
GeneTree	ENSGT00390000011560.
HOVERGEN	HBG005456.
InParanoid	P27117.
OMA	AXITSVI.
OrthoDB	EOG4ZGPC6.
PhylomeDB	P27117.
Family and domain databases
InterPro	IPR009006. Ala_racemase/Decarboxylase_C. IPR022643. De-COase2_C. IPR022657. De-COase2_CS. IPR022644. De-COase2_N. IPR022653. De-COase2_pyr-phos_BS. IPR000183. Orn/DAP/Arg_de-COase. IPR002433. Orn_de-COase. [Graphical view]
Gene3D	G3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 1 hit.
KO	K01581.
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PRINTS	PR01179. ODADCRBXLASE. PR01182. ORNDCRBXLASE.
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
PROSITE	PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCOR_BOVIN

Accession

Primary (citable) accession number: P27117
Secondary accession number(s): A6H7E8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	November 16, 2011
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program