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Protein

Ornithine decarboxylase

Gene

ODC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Key enzyme of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine.By similarity

Catalytic activityi

L-ornithine = putrescine + CO2.

Cofactori

Enzyme regulationi

Inhibited by antizyme OAZ1, OAZ2 and OAZ3.By similarity

Pathwayi: putrescine biosynthesis via L-ornithine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Ornithine decarboxylase (ODC1)
This subpathway is part of the pathway putrescine biosynthesis via L-ornithine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from L-ornithine, the pathway putrescine biosynthesis via L-ornithine pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei360 – 3601Proton donor; shared with dimeric partnerBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00535; UER00288.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine decarboxylase (EC:4.1.1.17)
Short name:
ODC
Gene namesi
Name:ODC1
Synonyms:ODC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3243912.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Ornithine decarboxylasePRO_0000149889Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei69 – 691N6-(pyridoxal phosphate)lysineBy similarity
Modified residuei303 – 3031Phosphoserine; by CK2By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP27117.
PRIDEiP27117.

Interactioni

Subunit structurei

Monomer. Homodimer. Does not form a heterodimer with AZIN2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005575.

Chemistry

BindingDBiP27117.

Structurei

3D structure databases

ProteinModelPortaliP27117.
SMRiP27117. Positions 7-421.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0622. Eukaryota.
COG0019. LUCA.
GeneTreeiENSGT00390000011560.
HOGENOMiHOG000274133.
HOVERGENiHBG005456.
InParanoidiP27117.
KOiK01581.
OMAiVFCRILC.
OrthoDBiEOG73Z2T6.
TreeFamiTF300760.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27117-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSFSNEEFD CHFLDEGFTA KDILDQKINE VSYSDDKDAF YVADLGDILK
60 70 80 90 100
KHLRWLKALP RVTPFYAVKC NDSRTIVKTL AAIGTGFDCA SKTEIQLVQS
110 120 130 140 150
LGVPPERIIY ANPCKQVSQI KYAANNGVQM MTFDSEVELM KVARAHPKAK
160 170 180 190 200
LVLRIATDDS KAVCRLSVKF GATLKTSRLL LERAKELDID VIGVSFHVGS
210 220 230 240 250
GCTDPETFVQ AISDARCVFD MGAEVGFNMY LLDIGGGFPG SEDVKLKFEE
260 270 280 290 300
ITSVINPALD KYFPSDSGVR IIAEPGRYYV ASAFTLAVNI IAKKLVLKEQ
310 320 330 340 350
TGSDDEEEST DRTFMYYVND GVYGSFNCIL YDHAHVKPLL QKRPKPDEKY
360 370 380 390 400
YSSSIWGPTC DGLDRIVERC NLPEMHVGDW MLFENMGAYT VAAASTFNGF
410 420 430 440 450
QRPTIYYVMS GPTWQLMQQI RTQDFPPGVE EPDVGPLPVS CAWESGMKRH
460
SAACASTRIN V
Length:461
Mass (Da):51,346
Last modified:August 1, 1992 - v1
Checksum:i4E609B643E3B68FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92441 mRNA. Translation: AAA92339.1.
U36394 Genomic DNA. Translation: AAA79849.1.
U18531 Genomic DNA. Translation: AAA86696.1.
BC146218 mRNA. Translation: AAI46219.1.
RefSeqiNP_776555.1. NM_174130.2.
XP_005212975.1. XM_005212918.2.
XP_005212976.1. XM_005212919.3.
XP_010808467.1. XM_010810165.2.
UniGeneiBt.7133.

Genome annotation databases

EnsembliENSBTAT00000005575; ENSBTAP00000005575; ENSBTAG00000004256.
GeneIDi281365.
KEGGibta:281365.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92441 mRNA. Translation: AAA92339.1.
U36394 Genomic DNA. Translation: AAA79849.1.
U18531 Genomic DNA. Translation: AAA86696.1.
BC146218 mRNA. Translation: AAI46219.1.
RefSeqiNP_776555.1. NM_174130.2.
XP_005212975.1. XM_005212918.2.
XP_005212976.1. XM_005212919.3.
XP_010808467.1. XM_010810165.2.
UniGeneiBt.7133.

3D structure databases

ProteinModelPortaliP27117.
SMRiP27117. Positions 7-421.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005575.

Chemistry

BindingDBiP27117.
ChEMBLiCHEMBL3243912.

Proteomic databases

PaxDbiP27117.
PRIDEiP27117.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000005575; ENSBTAP00000005575; ENSBTAG00000004256.
GeneIDi281365.
KEGGibta:281365.

Organism-specific databases

CTDi4953.

Phylogenomic databases

eggNOGiKOG0622. Eukaryota.
COG0019. LUCA.
GeneTreeiENSGT00390000011560.
HOGENOMiHOG000274133.
HOVERGENiHBG005456.
InParanoidiP27117.
KOiK01581.
OMAiVFCRILC.
OrthoDBiEOG73Z2T6.
TreeFamiTF300760.

Enzyme and pathway databases

UniPathwayiUPA00535; UER00288.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a bovine ornithine decarboxylase cDNA and its use in the detection of restriction fragment length polymorphisms in Holsteins."
    Yao J., Zadworny D., Kuhnlein U., Hayes J.F.
    Genome 38:325-331(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Holstein.
    Tissue: Liver.
  2. "Bovine ornithine decarboxylase gene: cloning, structure and polymorphisms."
    Yao J., Zadworny D., Aggrey S.E., Kuhnlein U., Hayes J.F.
    DNA Seq. 8:203-213(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal skin.

Entry informationi

Entry nameiDCOR_BOVIN
AccessioniPrimary (citable) accession number: P27117
Secondary accession number(s): A6H7E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.