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Protein

Ornithine decarboxylase

Gene

ODC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.By similarity

Catalytic activityi

L-ornithine = putrescine + CO2.By similarity

Cofactori

pyridoxal 5'-phosphateBy similarity

Enzyme regulationi

Inhibited by antizymes (AZs) OAZ1, OAZ2 and OAZ3 in response to polyamine levels. AZs inhibit the assembly of the functional homodimer by binding to ODC monomers. Additionally, OAZ1 targets ODC monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.By similarity

Pathwayi: putrescine biosynthesis via L-ornithine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Ornithine decarboxylase (ODC1)
This subpathway is part of the pathway putrescine biosynthesis via L-ornithine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from L-ornithine, the pathway putrescine biosynthesis via L-ornithine pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei197Stacks against the aromatic ring of pyridoxal phosphate and stabilizes reaction intermediatesBy similarity1
Binding sitei200Pyridoxal phosphateBy similarity1
Binding sitei237Pyridoxal phosphate; via amino nitrogenBy similarity1
Active sitei360Proton donor; shared with dimeric partnerBy similarity1
Binding sitei361Substrate; shared with dimeric partnerBy similarity1
Binding sitei389Pyridoxal phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPolyamine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00535; UER00288

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine decarboxylase (EC:4.1.1.17)
Short name:
ODC
Gene namesi
Name:ODC1
Synonyms:ODC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3243912

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001498891 – 461Ornithine decarboxylaseAdd BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69N6-(pyridoxal phosphate)lysineBy similarity1
Modified residuei303Phosphoserine; by CK2By similarity1
Modified residuei360S-nitrosocysteineBy similarity1

Keywords - PTMi

Phosphoprotein, S-nitrosylation

Proteomic databases

PaxDbiP27117
PRIDEiP27117

Expressioni

Gene expression databases

BgeeiENSBTAG00000004256

Interactioni

Subunit structurei

Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005575

Chemistry databases

BindingDBiP27117

Structurei

3D structure databases

ProteinModelPortaliP27117
SMRiP27117
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni274 – 277Pyridoxal phosphate bindingBy similarity4
Regioni331 – 332Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0622 Eukaryota
COG0019 LUCA
GeneTreeiENSGT00390000011560
HOGENOMiHOG000274133
HOVERGENiHBG005456
InParanoidiP27117
KOiK01581
OMAiVVGYICE
OrthoDBiEOG091G0AJV
TreeFamiTF300760

Family and domain databases

Gene3Di2.40.37.102 hits
3.20.20.101 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR022643 De-COase2_C
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR022653 De-COase2_pyr-phos_BS
IPR000183 Orn/DAP/Arg_de-COase
IPR002433 Orn_de-COase
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PF00278 Orn_DAP_Arg_deC, 1 hit
PRINTSiPR01179 ODADCRBXLASE
PR01182 ORNDCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
PROSITEiView protein in PROSITE
PS00878 ODR_DC_2_1, 1 hit
PS00879 ODR_DC_2_2, 1 hit

Sequencei

Sequence statusi: Complete.

P27117-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSFSNEEFD CHFLDEGFTA KDILDQKINE VSYSDDKDAF YVADLGDILK
60 70 80 90 100
KHLRWLKALP RVTPFYAVKC NDSRTIVKTL AAIGTGFDCA SKTEIQLVQS
110 120 130 140 150
LGVPPERIIY ANPCKQVSQI KYAANNGVQM MTFDSEVELM KVARAHPKAK
160 170 180 190 200
LVLRIATDDS KAVCRLSVKF GATLKTSRLL LERAKELDID VIGVSFHVGS
210 220 230 240 250
GCTDPETFVQ AISDARCVFD MGAEVGFNMY LLDIGGGFPG SEDVKLKFEE
260 270 280 290 300
ITSVINPALD KYFPSDSGVR IIAEPGRYYV ASAFTLAVNI IAKKLVLKEQ
310 320 330 340 350
TGSDDEEEST DRTFMYYVND GVYGSFNCIL YDHAHVKPLL QKRPKPDEKY
360 370 380 390 400
YSSSIWGPTC DGLDRIVERC NLPEMHVGDW MLFENMGAYT VAAASTFNGF
410 420 430 440 450
QRPTIYYVMS GPTWQLMQQI RTQDFPPGVE EPDVGPLPVS CAWESGMKRH
460
SAACASTRIN V
Length:461
Mass (Da):51,346
Last modified:August 1, 1992 - v1
Checksum:i4E609B643E3B68FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92441 mRNA Translation: AAA92339.1
U36394 Genomic DNA Translation: AAA79849.1
U18531 Genomic DNA Translation: AAA86696.1
BC146218 mRNA Translation: AAI46219.1
RefSeqiNP_776555.1, NM_174130.2
XP_005212975.1, XM_005212918.2
XP_005212976.1, XM_005212919.3
XP_010808467.1, XM_010810165.2
UniGeneiBt.7133

Genome annotation databases

EnsembliENSBTAT00000005575; ENSBTAP00000005575; ENSBTAG00000004256
GeneIDi281365
KEGGibta:281365

Similar proteinsi

Entry informationi

Entry nameiDCOR_BOVIN
AccessioniPrimary (citable) accession number: P27117
Secondary accession number(s): A6H7E8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: February 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome