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Protein

Promotilin

Gene

MLN

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Promotilin
Cleaved into the following 2 chains:
Gene namesi
Name:MLN
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Add BLAST25
ChainiPRO_000034217426 – 133PromotilinAdd BLAST108
PeptideiPRO_000001919026 – 47MotilinAdd BLAST22
PeptideiPRO_000001919150 – 133Motilin-associated peptideAdd BLAST84

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PRIDEiP27114.

Interactioni

Chemistry databases

BindingDBiP27114.

Family & Domainsi

Sequence similaritiesi

Belongs to the motilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000108883.
HOVERGENiHBG003618.
InParanoidiP27114.
KOiK05265.

Family and domain databases

InterProiView protein in InterPro
IPR006737. Motilin_assoc.
IPR006738. Motilin_ghrelin.
IPR015662. Promotilin.
PANTHERiPTHR14156. PTHR14156. 1 hit.
PfamiView protein in Pfam
PF04643. Motilin_assoc. 1 hit.
PF04644. Motilin_ghrelin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSRKAVAAL LLVHVTAMLA SQTEAFVPIF TYSELQRMQE RERNRGHKKS
60 70 80 90 100
LSVQQRSDAA AAPRPAEPTL EEENGRMQLT APVEIGMRMN SRQLEKYRAA
110 120 130
LEAAERAVHP DAPSRPCWPA GGESGWSGEP SPT
Length:133
Mass (Da):14,667
Last modified:August 1, 1992 - v1
Checksum:i878195E28D45AAC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63860 mRNA. Translation: CAA45342.1.
PIRiS24315.
RefSeqiNP_001095169.1. NM_001101699.1.
UniGeneiOcu.3265.

Genome annotation databases

GeneIDi100009276.
KEGGiocu:100009276.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63860 mRNA. Translation: CAA45342.1.
PIRiS24315.
RefSeqiNP_001095169.1. NM_001101699.1.
UniGeneiOcu.3265.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiP27114.

Proteomic databases

PRIDEiP27114.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009276.
KEGGiocu:100009276.

Organism-specific databases

CTDi4295.

Phylogenomic databases

HOGENOMiHOG000108883.
HOVERGENiHBG003618.
InParanoidiP27114.
KOiK05265.

Family and domain databases

InterProiView protein in InterPro
IPR006737. Motilin_assoc.
IPR006738. Motilin_ghrelin.
IPR015662. Promotilin.
PANTHERiPTHR14156. PTHR14156. 1 hit.
PfamiView protein in Pfam
PF04643. Motilin_assoc. 1 hit.
PF04644. Motilin_ghrelin. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMOTI_RABIT
AccessioniPrimary (citable) accession number: P27114
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 5, 2016
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.