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Protein

Promotilin

Gene

MLN

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Promotilin
Cleaved into the following 2 chains:
Gene namesi
Name:MLN
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Add
BLAST
Chaini26 – 133108PromotilinPRO_0000342174Add
BLAST
Peptidei26 – 4722MotilinPRO_0000019190Add
BLAST
Peptidei50 – 13384Motilin-associated peptidePRO_0000019191Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Interactioni

Chemistry

BindingDBiP27114.

Family & Domainsi

Sequence similaritiesi

Belongs to the motilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000108883.
HOVERGENiHBG003618.
InParanoidiP27114.
KOiK05265.

Family and domain databases

InterProiIPR006737. Motilin_assoc.
IPR006738. Motilin_ghrelin.
IPR015662. Promotilin.
[Graphical view]
PANTHERiPTHR14156. PTHR14156. 1 hit.
PfamiPF04643. Motilin_assoc. 1 hit.
PF04644. Motilin_ghrelin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSRKAVAAL LLVHVTAMLA SQTEAFVPIF TYSELQRMQE RERNRGHKKS
60 70 80 90 100
LSVQQRSDAA AAPRPAEPTL EEENGRMQLT APVEIGMRMN SRQLEKYRAA
110 120 130
LEAAERAVHP DAPSRPCWPA GGESGWSGEP SPT
Length:133
Mass (Da):14,667
Last modified:August 1, 1992 - v1
Checksum:i878195E28D45AAC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63860 mRNA. Translation: CAA45342.1.
PIRiS24315.
RefSeqiNP_001095169.1. NM_001101699.1.
UniGeneiOcu.3265.

Genome annotation databases

GeneIDi100009276.
KEGGiocu:100009276.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63860 mRNA. Translation: CAA45342.1.
PIRiS24315.
RefSeqiNP_001095169.1. NM_001101699.1.
UniGeneiOcu.3265.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiP27114.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009276.
KEGGiocu:100009276.

Organism-specific databases

CTDi4295.

Phylogenomic databases

HOGENOMiHOG000108883.
HOVERGENiHBG003618.
InParanoidiP27114.
KOiK05265.

Family and domain databases

InterProiIPR006737. Motilin_assoc.
IPR006738. Motilin_ghrelin.
IPR015662. Promotilin.
[Graphical view]
PANTHERiPTHR14156. PTHR14156. 1 hit.
PfamiPF04643. Motilin_assoc. 1 hit.
PF04644. Motilin_ghrelin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The isolation and characterization of rabbit motilin precursor cDNA."
    Banfield D.K., Macgillivray R.T.A., Brown J.C., McIntosh C.H.S.
    Biochim. Biophys. Acta 1131:341-344(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiMOTI_RABIT
AccessioniPrimary (citable) accession number: P27114
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 11, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.