Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P27112 (ATP4A_RABIT)

Last modified June 16, 2009. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Potassium-transporting ATPase alpha chain 1
    EC=3.6.3.10
Alternative name(s):
    Proton pump
    Gastric H(+)/K(+) ATPase subunit alpha
Gene names
Name: ATP4A
OrganismOryctolagus cuniculus (Rabbit)
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Hide | Top

Protein attributes

Sequence length1035 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

Hide | Top

General annotation (Comments)

Function

Catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. Responsible for acid production in the stomach.

Catalytic activity

ATP + H2O + H+(In) + K+(Out) = ADP + phosphate + H+(Out) + K+(In).

Subunit structure

Composed of two subunits: alpha (catalytic) and beta.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 10351034Potassium-transporting ATPase alpha chain 1
PRO_0000046256

Regions

Topological domain2 – 9897Cytoplasmic Potential
Transmembrane99 – 11921 Potential
Topological domain120 – 14223Lumenal Potential
Transmembrane143 – 16321 Potential
Topological domain164 – 299136Cytoplasmic Potential
Transmembrane300 – 31920 Potential
Topological domain320 – 33112Lumenal Potential
Transmembrane332 – 34918 Potential
Topological domain350 – 783434Cytoplasmic Potential
Transmembrane784 – 80320 Potential
Topological domain804 – 81310Lumenal Potential
Transmembrane814 – 83421 Potential
Topological domain835 – 85420Cytoplasmic Potential
Transmembrane855 – 87723 Potential
Topological domain878 – 92952Lumenal Potential
Transmembrane930 – 94920 Potential
Topological domain950 – 96314Cytoplasmic Potential
Transmembrane964 – 98219 Potential
Topological domain983 – 99715Lumenal Potential
Transmembrane998 – 101821 Potential
Topological domain1019 – 103517Cytoplasmic Potential

Sites

Active site38714-aspartylphosphate intermediate By similarity
Metal binding7281Magnesium By similarity
Metal binding7321Magnesium By similarity

Amino acid modifications

Modified residue9541Phosphoserine; by PKA By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
P27112-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: FCD600AC142CC14A

FASTA1,035114,202
        10         20         30         40         50         60 
MGKADNYELY SVELGPGPGG DMAAKMSKKK KAGGGGGKRK EKLENMKKEM EINDHQLSVA 

        70         80         90        100        110        120 
ELEQKYQTSA TKGLSARLAA ELLLRDGPNA LRPPRGTPEY VKFARQLAGG LQCLMWVAAA 

       130        140        150        160        170        180 
ICLIAFAIQA SEGDLTTDDN LYLALALIAV VVVTGCFGYY QEFKSTNIIA SFKNLVPQQA 

       190        200        210        220        230        240 
TVIRDGDKFQ INADQLVVGD LVEMKGGDRV PADIRILAAQ GCKVDNSSLT GESEPQTRSP 

       250        260        270        280        290        300 
ECTHESPLET RNIAFFSTMC LEGTAQGLVV NTGDRTIIGR IASLASGVEN EKTPIAIEIE 

       310        320        330        340        350        360 
HFVDIIAGLA ILFGATFFVV AMCIGYTFLR AMVFFMAIVV AYVPEGLLAT VTVCLSLTAK 

       370        380        390        400        410        420 
RLASKNCVVK NLEAVETLGS TSVICSDKTG TLTQNRMTVS HLWFDNHIHT ADTTEDQSGQ 

       430        440        450        460        470        480 
TFDQSSETWR ALCRVLTLCN RAAFKSGQDA VPVPKRIVIG DASETALLKF SELTLGNAMG 

       490        500        510        520        530        540 
YRDRFPKVCE IPFNSTNKFQ LSIHTLEDPR DPRHLLVMKG APERVLERCS SILIKGQELP 

       550        560        570        580        590        600 
LDEQWREAFQ TAYLSLGGLG ERVLGFCHLY LSEKDYPPGY AFDVEAMNFP SSGLCFAGLV 

       610        620        630        640        650        660 
SMIDPPRATV PDAVLKCRTA GIRVIMVTGD HPITAKAIAA SVGIISEGSE TVEDIAARLR 

       670        680        690        700        710        720 
VPVDQVNRKD ARACVINGMQ LKDMDPSELV EALRTHPEMV FARTSPQQKL VIVESCQRLG 

       730        740        750        760        770        780 
AIVAVTGDGV NDSPALKKAD IGVAMGIAGS DAAKNAADMI LLDDNFASIV TGVEQGRLIF 

       790        800        810        820        830        840 
DNLKKSIAYT LTKNIPELTP YLIYITVSVP LPLGCITILF IELCTDIFPS VSLAYEKAES 

       850        860        870        880        890        900 
DIMHLRPRNP KRDRLVNEPL AAYSYFQIGA IQSFAGFTDY FTAMAQEGWF PLLCVGLRPQ 

       910        920        930        940        950        960 
WEDHHLQDLQ DSYGQEWTFG QRLYQQYTCY TVFFISIEMC QIADVLIRKT RRLSAFQQGF 

       970        980        990       1000       1010       1020 
FRNRILVIAI VFQVCIGCFL CYCPGMPNIF NFMPIRFQWW LVPMPFGLLI FVYDEIRKLG 

      1030 
VRCCPGSWWD QELYY

« Hide

Hide | Top

References

[1]"cDNA cloning and membrane topology of the rabbit gastric H+/K(+)-ATPase alpha-subunit."
Bamberg K., Mercier F., Reuben M.A., Kobayashi Y., Munson K.B., Sachs G.
Biochim. Biophys. Acta 1131:69-77(1992) [PubMed: 1316171] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: New Zealand white.

Hide | Top

Cross-references

Sequence databases

X64694 mRNA. Translation: CAA45927.1.
PIRS23406.
RefSeqNP_001095171.1.
UniGeneOcu.3252

3D structure databases

HSSPHSSP built from PDB template 1IWC based on UniProtKB P19156.
ModBaseSearch...

Genome annotation databases

GeneID100009279.

Phylogenomic databases

HOVERGENP27112.

Enzyme and pathway databases

BRENDA3.6.3.10. 255.

Family and domain databases

InterProIPR008250. ATPase_P-typ_ATPase-assoc-reg.
IPR005775. ATPase_P-typ_cation-ex_asu_euk.
IPR006069. ATPase_P-typ_cation-exchng_asu.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR015127. ATPase_P-typ_H/K-transp_N.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_phosphor_site.
IPR005834. Dehalogen-like_hydro.
[Graphical view]
PANTHERPTHR11939. ATPase_P. 1 hit.
PfamPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF09040. H-K_ATPase_N. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00121. NAKATPASE.
TIGRFAMsTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 4 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Hide | Top

Entry information

Entry nameATP4A_RABIT
AccessionPrimary (citable) accession number: P27112
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: June 16, 2009
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents