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Protein

Potassium-transporting ATPase alpha chain 1

Gene

ATP4A

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. Responsible for acid production in the stomach.

Catalytic activityi

ATP + H2O + H+(In) + K+(Out) = ADP + phosphate + H+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei387 – 38714-aspartylphosphate intermediateBy similarity
Metal bindingi728 – 7281MagnesiumBy similarity
Metal bindingi732 – 7321MagnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BRENDAi3.6.3.10. 1749.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase alpha chain 1 (EC:3.6.3.10)
Alternative name(s):
Gastric H(+)/K(+) ATPase subunit alpha
Proton pump
Gene namesi
Name:ATP4A
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 9897CytoplasmicSequence analysisAdd
BLAST
Transmembranei99 – 11921HelicalSequence analysisAdd
BLAST
Topological domaini120 – 14223LumenalSequence analysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence analysisAdd
BLAST
Topological domaini164 – 299136CytoplasmicSequence analysisAdd
BLAST
Transmembranei300 – 31920HelicalSequence analysisAdd
BLAST
Topological domaini320 – 33112LumenalSequence analysisAdd
BLAST
Transmembranei332 – 34918HelicalSequence analysisAdd
BLAST
Topological domaini350 – 783434CytoplasmicSequence analysisAdd
BLAST
Transmembranei784 – 80320HelicalSequence analysisAdd
BLAST
Topological domaini804 – 81310LumenalSequence analysis
Transmembranei814 – 83421HelicalSequence analysisAdd
BLAST
Topological domaini835 – 85420CytoplasmicSequence analysisAdd
BLAST
Transmembranei855 – 87723HelicalSequence analysisAdd
BLAST
Topological domaini878 – 92952LumenalSequence analysisAdd
BLAST
Transmembranei930 – 94920HelicalSequence analysisAdd
BLAST
Topological domaini950 – 96314CytoplasmicSequence analysisAdd
BLAST
Transmembranei964 – 98219HelicalSequence analysisAdd
BLAST
Topological domaini983 – 99715LumenalSequence analysisAdd
BLAST
Transmembranei998 – 101821HelicalSequence analysisAdd
BLAST
Topological domaini1019 – 103517CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 10351034Potassium-transporting ATPase alpha chain 1PRO_0000046256Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71PhosphotyrosineBy similarity
Modified residuei10 – 101PhosphotyrosineBy similarity
Modified residuei27 – 271PhosphoserineBy similarity
Modified residuei58 – 581PhosphoserineBy similarity
Modified residuei239 – 2391PhosphoserineBy similarity
Modified residuei286 – 2861PhosphoserineBy similarity
Modified residuei463 – 4631PhosphoserineBy similarity
Modified residuei601 – 6011PhosphoserineBy similarity
Modified residuei840 – 8401PhosphoserineBy similarity
Modified residuei954 – 9541Phosphoserine; by PKABy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP27112.

Interactioni

Subunit structurei

Composed of two subunits: alpha (catalytic) and beta.

Protein-protein interaction databases

BioGridi1172300. 1 interaction.
STRINGi9986.ENSOCUP00000025966.

Structurei

3D structure databases

ProteinModelPortaliP27112.
SMRiP27112. Positions 1-34, 37-1035.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0203. Eukaryota.
COG0474. LUCA.
HOGENOMiHOG000265622.
HOVERGENiHBG004298.
InParanoidiP27112.
KOiK01542.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR015127. ATPase_P-typ_H/K-transp_N.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF09040. H-K_ATPase_N. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27112-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKADNYELY SVELGPGPGG DMAAKMSKKK KAGGGGGKRK EKLENMKKEM
60 70 80 90 100
EINDHQLSVA ELEQKYQTSA TKGLSARLAA ELLLRDGPNA LRPPRGTPEY
110 120 130 140 150
VKFARQLAGG LQCLMWVAAA ICLIAFAIQA SEGDLTTDDN LYLALALIAV
160 170 180 190 200
VVVTGCFGYY QEFKSTNIIA SFKNLVPQQA TVIRDGDKFQ INADQLVVGD
210 220 230 240 250
LVEMKGGDRV PADIRILAAQ GCKVDNSSLT GESEPQTRSP ECTHESPLET
260 270 280 290 300
RNIAFFSTMC LEGTAQGLVV NTGDRTIIGR IASLASGVEN EKTPIAIEIE
310 320 330 340 350
HFVDIIAGLA ILFGATFFVV AMCIGYTFLR AMVFFMAIVV AYVPEGLLAT
360 370 380 390 400
VTVCLSLTAK RLASKNCVVK NLEAVETLGS TSVICSDKTG TLTQNRMTVS
410 420 430 440 450
HLWFDNHIHT ADTTEDQSGQ TFDQSSETWR ALCRVLTLCN RAAFKSGQDA
460 470 480 490 500
VPVPKRIVIG DASETALLKF SELTLGNAMG YRDRFPKVCE IPFNSTNKFQ
510 520 530 540 550
LSIHTLEDPR DPRHLLVMKG APERVLERCS SILIKGQELP LDEQWREAFQ
560 570 580 590 600
TAYLSLGGLG ERVLGFCHLY LSEKDYPPGY AFDVEAMNFP SSGLCFAGLV
610 620 630 640 650
SMIDPPRATV PDAVLKCRTA GIRVIMVTGD HPITAKAIAA SVGIISEGSE
660 670 680 690 700
TVEDIAARLR VPVDQVNRKD ARACVINGMQ LKDMDPSELV EALRTHPEMV
710 720 730 740 750
FARTSPQQKL VIVESCQRLG AIVAVTGDGV NDSPALKKAD IGVAMGIAGS
760 770 780 790 800
DAAKNAADMI LLDDNFASIV TGVEQGRLIF DNLKKSIAYT LTKNIPELTP
810 820 830 840 850
YLIYITVSVP LPLGCITILF IELCTDIFPS VSLAYEKAES DIMHLRPRNP
860 870 880 890 900
KRDRLVNEPL AAYSYFQIGA IQSFAGFTDY FTAMAQEGWF PLLCVGLRPQ
910 920 930 940 950
WEDHHLQDLQ DSYGQEWTFG QRLYQQYTCY TVFFISIEMC QIADVLIRKT
960 970 980 990 1000
RRLSAFQQGF FRNRILVIAI VFQVCIGCFL CYCPGMPNIF NFMPIRFQWW
1010 1020 1030
LVPMPFGLLI FVYDEIRKLG VRCCPGSWWD QELYY
Length:1,035
Mass (Da):114,202
Last modified:January 23, 2007 - v3
Checksum:iFCD600AC142CC14A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64694 mRNA. Translation: CAA45927.1.
PIRiS23406.
RefSeqiNP_001095171.1. NM_001101701.1.
UniGeneiOcu.3252.

Genome annotation databases

GeneIDi100009279.
KEGGiocu:100009279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64694 mRNA. Translation: CAA45927.1.
PIRiS23406.
RefSeqiNP_001095171.1. NM_001101701.1.
UniGeneiOcu.3252.

3D structure databases

ProteinModelPortaliP27112.
SMRiP27112. Positions 1-34, 37-1035.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1172300. 1 interaction.
STRINGi9986.ENSOCUP00000025966.

Proteomic databases

PRIDEiP27112.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009279.
KEGGiocu:100009279.

Organism-specific databases

CTDi495.

Phylogenomic databases

eggNOGiKOG0203. Eukaryota.
COG0474. LUCA.
HOGENOMiHOG000265622.
HOVERGENiHBG004298.
InParanoidiP27112.
KOiK01542.

Enzyme and pathway databases

BRENDAi3.6.3.10. 1749.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR015127. ATPase_P-typ_H/K-transp_N.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF09040. H-K_ATPase_N. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATP4A_RABIT
AccessioniPrimary (citable) accession number: P27112
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.