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Protein

HTH-type transcriptional regulator CynR

Gene

cynR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR-cynTSX intergenic region.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi18 – 3720H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:PD00291.
ECOL316407:JW5894-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator CynR
Alternative name(s):
Cyn operon transcriptional activator
Gene namesi
Name:cynR
Ordered Locus Names:b0338, JW5894
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11421. cynR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299HTH-type transcriptional regulator CynRPRO_0000105612Add
BLAST

Proteomic databases

PaxDbiP27111.

Expressioni

Inductioni

Negatively autoregulated.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4259814. 1 interaction.
DIPiDIP-9364N.
STRINGi511145.b0338.

Structurei

Secondary structure

1
299
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi93 – 975Combined sources
Helixi99 – 1024Combined sources
Turni103 – 1053Combined sources
Helixi106 – 11611Combined sources
Beta strandi122 – 1265Combined sources
Helixi129 – 1379Combined sources
Beta strandi142 – 1498Combined sources
Beta strandi155 – 17016Combined sources
Helixi174 – 1774Combined sources
Beta strandi179 – 1813Combined sources
Helixi183 – 1886Combined sources
Beta strandi190 – 1945Combined sources
Helixi199 – 21012Combined sources
Beta strandi216 – 2227Combined sources
Helixi224 – 23310Combined sources
Beta strandi237 – 2415Combined sources
Helixi243 – 2475Combined sources
Beta strandi251 – 2588Combined sources
Beta strandi262 – 2709Combined sources
Helixi277 – 29014Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HXRX-ray2.05A/B63-299[»]
3HFUX-ray2.60A/B/C/D63-299[»]
ProteinModelPortaliP27111.
SMRiP27111. Positions 1-292.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27111.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5858HTH lysR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH lysR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105DND. Bacteria.
ENOG410YUCG. LUCA.
HOGENOMiHOG000233514.
InParanoidiP27111.
KOiK11921.
OMAiYLMPRMI.
PhylomeDBiP27111.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRHINYFL AVAEHGSFTR AASALHVSQP ALSQQIRQLE ESLGVPLFDR
60 70 80 90 100
SGRTIRLTDA GEVWRQYASR ALQELGAGKR AIHDVADLTR GSLRIAVTPT
110 120 130 140 150
FTSYFIGPLM ADFYARYPSI TLQLQEMSQE KIEDMLCRDE LDVGIAFAPV
160 170 180 190 200
HSPELEAIPL LTESLALVVA QHHPLAVHEQ VALSRLHDEK LVLLSAEFAT
210 220 230 240 250
REQIDHYCEK AGLHPQVVIE ANSISAVLEL IRRTSLSTLL PAAIATQHDG
260 270 280 290
LKAISLAPPL LERTAVLLRR KNSWQTAAAK AFLHMALDKC AVVGGNESR
Length:299
Mass (Da):32,961
Last modified:November 13, 2007 - v5
Checksum:i5649F6FF2437624A
GO

Sequence cautioni

The sequence AAB18062 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93053 Genomic DNA. Translation: AAA23628.1.
U73857 Genomic DNA. Translation: AAB18062.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73441.3.
AP009048 Genomic DNA. Translation: BAE76120.1.
PIRiA41900.
RefSeqiNP_414872.3. NC_000913.3.
WP_000952503.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73441; AAC73441; b0338.
BAE76120; BAE76120; BAE76120.
GeneIDi945001.
KEGGiecj:JW5894.
eco:b0338.
PATRICi32115809. VBIEscCol129921_0346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93053 Genomic DNA. Translation: AAA23628.1.
U73857 Genomic DNA. Translation: AAB18062.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73441.3.
AP009048 Genomic DNA. Translation: BAE76120.1.
PIRiA41900.
RefSeqiNP_414872.3. NC_000913.3.
WP_000952503.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HXRX-ray2.05A/B63-299[»]
3HFUX-ray2.60A/B/C/D63-299[»]
ProteinModelPortaliP27111.
SMRiP27111. Positions 1-292.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259814. 1 interaction.
DIPiDIP-9364N.
STRINGi511145.b0338.

Proteomic databases

PaxDbiP27111.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73441; AAC73441; b0338.
BAE76120; BAE76120; BAE76120.
GeneIDi945001.
KEGGiecj:JW5894.
eco:b0338.
PATRICi32115809. VBIEscCol129921_0346.

Organism-specific databases

EchoBASEiEB1391.
EcoGeneiEG11421. cynR.

Phylogenomic databases

eggNOGiENOG4105DND. Bacteria.
ENOG410YUCG. LUCA.
HOGENOMiHOG000233514.
InParanoidiP27111.
KOiK11921.
OMAiYLMPRMI.
PhylomeDBiP27111.

Enzyme and pathway databases

BioCyciEcoCyc:PD00291.
ECOL316407:JW5894-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP27111.
PROiP27111.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYNR_ECOLI
AccessioniPrimary (citable) accession number: P27111
Secondary accession number(s): Q2MC86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: November 13, 2007
Last modified: September 7, 2016
This is version 129 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.