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Protein

HTH-type transcriptional regulator CynR

Gene

cynR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR-cynTSX intergenic region.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi18 – 37H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:PD00291.
ECOL316407:JW5894-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator CynR
Alternative name(s):
Cyn operon transcriptional activator
Gene namesi
Name:cynR
Ordered Locus Names:b0338, JW5894
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11421. cynR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001056121 – 299HTH-type transcriptional regulator CynRAdd BLAST299

Proteomic databases

PaxDbiP27111.
PRIDEiP27111.

Expressioni

Inductioni

Negatively autoregulated.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4259814. 1 interactor.
DIPiDIP-9364N.
STRINGi511145.b0338.

Structurei

Secondary structure

1299
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi93 – 97Combined sources5
Helixi99 – 102Combined sources4
Turni103 – 105Combined sources3
Helixi106 – 116Combined sources11
Beta strandi122 – 126Combined sources5
Helixi129 – 137Combined sources9
Beta strandi142 – 149Combined sources8
Beta strandi155 – 170Combined sources16
Helixi174 – 177Combined sources4
Beta strandi179 – 181Combined sources3
Helixi183 – 188Combined sources6
Beta strandi190 – 194Combined sources5
Helixi199 – 210Combined sources12
Beta strandi216 – 222Combined sources7
Helixi224 – 233Combined sources10
Beta strandi237 – 241Combined sources5
Helixi243 – 247Combined sources5
Beta strandi251 – 258Combined sources8
Beta strandi262 – 270Combined sources9
Helixi277 – 290Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HXRX-ray2.05A/B63-299[»]
3HFUX-ray2.60A/B/C/D63-299[»]
ProteinModelPortaliP27111.
SMRiP27111.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27111.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 58HTH lysR-typePROSITE-ProRule annotationAdd BLAST58

Sequence similaritiesi

Contains 1 HTH lysR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105DND. Bacteria.
ENOG410YUCG. LUCA.
HOGENOMiHOG000233514.
InParanoidiP27111.
KOiK11921.
OMAiYLMPRMI.
PhylomeDBiP27111.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRHINYFL AVAEHGSFTR AASALHVSQP ALSQQIRQLE ESLGVPLFDR
60 70 80 90 100
SGRTIRLTDA GEVWRQYASR ALQELGAGKR AIHDVADLTR GSLRIAVTPT
110 120 130 140 150
FTSYFIGPLM ADFYARYPSI TLQLQEMSQE KIEDMLCRDE LDVGIAFAPV
160 170 180 190 200
HSPELEAIPL LTESLALVVA QHHPLAVHEQ VALSRLHDEK LVLLSAEFAT
210 220 230 240 250
REQIDHYCEK AGLHPQVVIE ANSISAVLEL IRRTSLSTLL PAAIATQHDG
260 270 280 290
LKAISLAPPL LERTAVLLRR KNSWQTAAAK AFLHMALDKC AVVGGNESR
Length:299
Mass (Da):32,961
Last modified:November 13, 2007 - v5
Checksum:i5649F6FF2437624A
GO

Sequence cautioni

The sequence AAB18062 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93053 Genomic DNA. Translation: AAA23628.1.
U73857 Genomic DNA. Translation: AAB18062.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73441.3.
AP009048 Genomic DNA. Translation: BAE76120.1.
PIRiA41900.
RefSeqiNP_414872.3. NC_000913.3.
WP_000952503.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73441; AAC73441; b0338.
BAE76120; BAE76120; BAE76120.
GeneIDi945001.
KEGGiecj:JW5894.
eco:b0338.
PATRICi32115809. VBIEscCol129921_0346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93053 Genomic DNA. Translation: AAA23628.1.
U73857 Genomic DNA. Translation: AAB18062.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73441.3.
AP009048 Genomic DNA. Translation: BAE76120.1.
PIRiA41900.
RefSeqiNP_414872.3. NC_000913.3.
WP_000952503.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HXRX-ray2.05A/B63-299[»]
3HFUX-ray2.60A/B/C/D63-299[»]
ProteinModelPortaliP27111.
SMRiP27111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259814. 1 interactor.
DIPiDIP-9364N.
STRINGi511145.b0338.

Proteomic databases

PaxDbiP27111.
PRIDEiP27111.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73441; AAC73441; b0338.
BAE76120; BAE76120; BAE76120.
GeneIDi945001.
KEGGiecj:JW5894.
eco:b0338.
PATRICi32115809. VBIEscCol129921_0346.

Organism-specific databases

EchoBASEiEB1391.
EcoGeneiEG11421. cynR.

Phylogenomic databases

eggNOGiENOG4105DND. Bacteria.
ENOG410YUCG. LUCA.
HOGENOMiHOG000233514.
InParanoidiP27111.
KOiK11921.
OMAiYLMPRMI.
PhylomeDBiP27111.

Enzyme and pathway databases

BioCyciEcoCyc:PD00291.
ECOL316407:JW5894-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP27111.
PROiP27111.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYNR_ECOLI
AccessioniPrimary (citable) accession number: P27111
Secondary accession number(s): Q2MC86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: November 13, 2007
Last modified: November 2, 2016
This is version 131 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.