Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Muellerian-inhibiting factor

Gene

Amh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.

Miscellaneous

Although it does not compete with EGF for receptor binding sites, MIS can inhibit the autophosphorylation of the EGF receptor in vitro.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor
Biological processDifferentiation, Gonadal differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Muellerian-inhibiting factor
Alternative name(s):
Anti-Muellerian hormone
Short name:
AMH
Muellerian-inhibiting substance
Short name:
MIS
Gene namesi
Name:Amh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:88006 Amh

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000033749? – 555Muellerian-inhibiting factor
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000003374821 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi326N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi410N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi457 ↔ 521By similarity
Disulfide bondi483 ↔ 552By similarity
Disulfide bondi487 ↔ 554By similarity
Disulfide bondi520InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP27106
PRIDEiP27106

PTM databases

iPTMnetiP27106
PhosphoSitePlusiP27106

Expressioni

Tissue specificityi

Sertoli cells of fetal testes, and testes just after birth, but absent in adult testes. In female, AMH is expressed after birth in the granulosa cells of the follicle. AMH expression is dependent on the degree of follicular maturation and not on the age of the ovary.

Gene expression databases

CleanExiMM_AMH

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043153

Structurei

3D structure databases

ProteinModelPortaliP27106
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
HOGENOMiHOG000113593
HOVERGENiHBG006358
InParanoidiP27106
PhylomeDBiP27106

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR006799 AMH_N
IPR029034 Cystine-knot_cytokine
IPR021203 Muellerian-inhibiting_factor
IPR001839 TGF-b_C
IPR017948 TGFb_CS
PANTHERiPTHR15009 PTHR15009, 1 hit
PfamiView protein in Pfam
PF04709 AMH_N, 1 hit
PF00019 TGF_beta, 1 hit
PIRSFiPIRSF037270 Muellerian-inhibiting_factor, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27106-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGPHLSPLV LLLATMGAVL QPEAVENLAT NTRGLIFLED ELWPPSSPPE
60 70 80 90 100
PLCLVTVRGE GNTSRASLRV VGGLNSYEYA FLEAVQESRW GPQDLATFGV
110 120 130 140 150
SSTDSQATLP ALQRLGAWLG ETGEQQLLVL HLAEVIWEPE LLLKFQEPPP
160 170 180 190 200
GGASRWEQAL LVLYSGPGPQ VTVTGTGLRG TQNLCPTRDT RYLVLTVDFP
210 220 230 240 250
AGAWSGFGLI LTLQPSREGA TLSIDQLQAF LFGSDSRCFT RMTPTLVVLP
260 270 280 290 300
PAEPSPQPAH GQLDTMPFPQ PGLSLEPEAL PHSADPFLET LTRLVRALRG
310 320 330 340 350
PLTQASNTQL ALDPGALASF PQGLVNLSDP AALGRLLDWE EPLLLLLSPT
360 370 380 390 400
AATEREPIRL HGPASAPWAA GLQRRVAVEL QAAASELRDL PGLPPTAPPL
410 420 430 440 450
LARLLALCPN DSRSSGDPLR ALLLLKALQG LRAEWHGREG RGRTRAQRGD
460 470 480 490 500
KGQDGPCALR ELSVDLRAER SVLIPETYQA NNCQGACRWP QSDRNPRYGN
510 520 530 540 550
HVVLLLKMQA RGAALGRLPC CVPTAYAGKL LISLSEERIS ADHVPNMVAT

ECGCR
Length:555
Mass (Da):59,778
Last modified:August 1, 1992 - v1
Checksum:iD6A3A20C50306E29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63240 Genomic DNA Translation: CAA44912.1
X83733 Genomic DNA Translation: CAC10450.1
PIRiS20100
UniGeneiMm.376094

Similar proteinsi

Entry informationi

Entry nameiMIS_MOUSE
AccessioniPrimary (citable) accession number: P27106
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health