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Protein

Erythrocyte band 7 integral membrane protein

Gene

STOM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.

GO - Molecular functioni

  • RNA polymerase binding Source: AgBase

GO - Biological processi

  • mitophagy in response to mitochondrial depolarization Source: ParkinsonsUK-UCL
  • positive regulation by host of viral genome replication Source: Ensembl
  • positive regulation of defense response to virus by host Source: ParkinsonsUK-UCL
  • positive regulation of protein targeting to membrane Source: Ensembl
  • protein homooligomerization Source: UniProtKB
  • regulation of acid-sensing ion channel activity Source: Ensembl
  • xenophagy Source: ParkinsonsUK-UCL
Complete GO annotation...

Protein family/group databases

TCDBi8.A.21.1.1. the stomatin/podocin/band 7/nephrosis.2/spfh (stomatin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Erythrocyte band 7 integral membrane protein
Alternative name(s):
Protein 7.2b
Stomatin
Gene namesi
Name:STOM
Synonyms:BND7, EPB72
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:3383. STOM.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525CytoplasmicSequence analysisAdd
BLAST
Intramembranei26 – 5429Sequence analysisAdd
BLAST
Topological domaini55 – 288234CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • cytoplasm Source: HPA
  • cytoskeleton Source: UniProtKB
  • endoplasmic reticulum Source: AgBase
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • melanosome Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
  • membrane raft Source: UniProtKB
  • mitochondrion Source: AgBase
  • perinuclear region of cytoplasm Source: Ensembl
  • vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi182 – 1821T → A: No effect on oligomerization. 1 Publication
Mutagenesisi185 – 1851W → A: Complete loss of oligomerization. 1 Publication
Mutagenesisi252 – 2521Y → A: Complete loss of oligomerization. 1 Publication
Mutagenesisi263 – 2631K → A: Reduced oligomerization and lipid raft association.
Mutagenesisi264 – 2641N → A: Reduced oligomerization and lipid raft association.
Mutagenesisi265 – 2651S → A: Oligomerization reduced to 18%. Reduced lipid raft association.
Mutagenesisi266 – 2661T → A: Complete loss of oligomerization. Reduced lipid raft association.
Mutagenesisi267 – 2671I → A: Complete loss of oligomerization and lipid raft association.
Mutagenesisi268 – 2681V → A: Complete loss of oligomerization and lipid raft association.
Mutagenesisi269 – 2691F → A: Complete loss of oligomerization and lipid raft association.
Mutagenesisi270 – 2701P → A: Complete loss of oligomerization. No effect on lipid raft association.
Mutagenesisi271 – 2711L → A: Complete loss of oligomerization. Reduced lipid raft association.
Mutagenesisi272 – 2721P → A: Oligomerization reduced to 18%. Reduced lipid raft association.
Mutagenesisi273 – 2731I → A: Complete loss of oligomerization. Reduced lipid raft association.
Mutagenesisi274 – 2741D → A: Reduced oligomerization and lipid raft association.
Mutagenesisi275 – 2751M → A: Reduced oligomerization and lipid raft association.
Mutagenesisi276 – 2761L → A: Reduced oligomerization and lipid raft association.

Organism-specific databases

PharmGKBiPA27816.

Polymorphism and mutation databases

DMDMi114823.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Erythrocyte band 7 integral membrane proteinPRO_0000094027Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101Phosphoserine; by PKACombined sources1 Publication
Modified residuei18 – 181PhosphoserineCombined sources
Lipidationi30 – 301S-palmitoyl cysteine1 Publication
Lipidationi87 – 871S-palmitoyl cysteine; partial1 Publication
Modified residuei161 – 1611PhosphoserineBy similarity
Modified residuei244 – 2441PhosphoserineCombined sources

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiP27105.
MaxQBiP27105.
PaxDbiP27105.
PeptideAtlasiP27105.
PRIDEiP27105.

PTM databases

iPTMnetiP27105.
PhosphoSiteiP27105.
SwissPalmiP27105.

Expressioni

Tissue specificityi

Detected in erythrocytes (at protein level). Widely expressed.2 Publications

Gene expression databases

BgeeiENSG00000148175.
CleanExiHS_STOM.
ExpressionAtlasiP27105. baseline and differential.
GenevisibleiP27105. HS.

Organism-specific databases

HPAiHPA010961.
HPA011419.

Interactioni

Subunit structurei

Homodimer and higher order homooligomer. The homodimer is banana-shaped. Interacts with ASIC1, ASIC2 and ASIC3 (By similarity). Interacts with LANCL1. Interacts with SLC2A1 and SLC4A1. Identified in large complexes with SLC40A1, SLC14A1, SLC29A1 and AQP1.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9WMX23EBI-1211440,EBI-9005440From a different organism.
DVL3Q929973EBI-1211440,EBI-739789

GO - Molecular functioni

  • RNA polymerase binding Source: AgBase

Protein-protein interaction databases

BioGridi108354. 84 interactions.
IntActiP27105. 23 interactions.
MINTiMINT-5004156.
STRINGi9606.ENSP00000286713.

Structurei

3D structure databases

ProteinModelPortaliP27105.
SMRiP27105. Positions 94-255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni265 – 2739Required for homooligomerization
Regioni267 – 2693Required for lipid raft association
Regioni273 – 28715Interaction with LANCL1Add
BLAST

Sequence similaritiesi

Belongs to the band 7/mec-2 family.Curated

Phylogenomic databases

eggNOGiKOG2621. Eukaryota.
COG0330. LUCA.
GeneTreeiENSGT00550000074454.
HOGENOMiHOG000049075.
HOVERGENiHBG004815.
InParanoidiP27105.
KOiK17286.
OMAiIIPEYER.
OrthoDBiEOG091G0G9K.
PhylomeDBiP27105.
TreeFamiTF105750.

Family and domain databases

InterProiIPR001107. Band_7.
IPR018080. Band_7/stomatin-like_CS.
IPR028515. Stomatin.
IPR001972. Stomatin_fam.
[Graphical view]
PANTHERiPTHR10264. PTHR10264. 1 hit.
PTHR10264:SF86. PTHR10264:SF86. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
PRINTSiPR00721. STOMATIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.
PROSITEiPS01270. BAND_7. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P27105-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEKRHTRDS EAQRLPDSFK DSPSKGLGPC GWILVAFSFL FTVITFPISI
60 70 80 90 100
WMCIKIIKEY ERAIIFRLGR ILQGGAKGPG LFFILPCTDS FIKVDMRTIS
110 120 130 140 150
FDIPPQEILT KDSVTISVDG VVYYRVQNAT LAVANITNAD SATRLLAQTT
160 170 180 190 200
LRNVLGTKNL SQILSDREEI AHNMQSTLDD ATDAWGIKVE RVEIKDVKLP
210 220 230 240 250
VQLQRAMAAE AEASREARAK VIAAEGEMNA SRALKEASMV ITESPAALQL
260 270 280
RYLQTLTTIA AEKNSTIVFP LPIDMLQGII GAKHSHLG
Length:288
Mass (Da):31,731
Last modified:January 23, 2007 - v3
Checksum:i5FEDA92230D99A24
GO
Isoform 2 (identifier: P27105-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-219: Missing.

Note: No experimental confirmation available.
Show »
Length:123
Mass (Da):13,475
Checksum:i794017BC3ABB59EF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61H → D in AAA58432 (PubMed:8825639).Curated
Sequence conflicti244 – 2441S → Y in AAH10703 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei55 – 219165Missing in isoform 2. 1 PublicationVSP_044669Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60067 mRNA. Translation: CAA42671.1.
M81635 mRNA. Translation: AAA58432.1.
X85116, X85117 Genomic DNA. Translation: CAA59436.1.
U33931
, U33925, U33926, U33927, U33928, U33929, U33930 Genomic DNA. Translation: AAC50296.1. Sequence problems.
CR542100 mRNA. Translation: CAG46897.1.
AL359644, AL161784 Genomic DNA. Translation: CAH70728.1.
AL359644, AL161784 Genomic DNA. Translation: CAH70729.1.
AL161784, AL359644 Genomic DNA. Translation: CAH72706.1.
AL161784, AL359644 Genomic DNA. Translation: CAH72707.1.
BC010703 mRNA. Translation: AAH10703.1.
BI603242 mRNA. No translation available.
CCDSiCCDS6830.1. [P27105-1]
CCDS6831.1. [P27105-2]
PIRiS17659.
RefSeqiNP_004090.4. NM_004099.5. [P27105-1]
NP_937837.1. NM_198194.2. [P27105-2]
UniGeneiHs.253903.

Genome annotation databases

EnsembliENST00000286713; ENSP00000286713; ENSG00000148175. [P27105-1]
ENST00000347359; ENSP00000339607; ENSG00000148175. [P27105-2]
GeneIDi2040.
KEGGihsa:2040.
UCSCiuc004blh.5. human. [P27105-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60067 mRNA. Translation: CAA42671.1.
M81635 mRNA. Translation: AAA58432.1.
X85116, X85117 Genomic DNA. Translation: CAA59436.1.
U33931
, U33925, U33926, U33927, U33928, U33929, U33930 Genomic DNA. Translation: AAC50296.1. Sequence problems.
CR542100 mRNA. Translation: CAG46897.1.
AL359644, AL161784 Genomic DNA. Translation: CAH70728.1.
AL359644, AL161784 Genomic DNA. Translation: CAH70729.1.
AL161784, AL359644 Genomic DNA. Translation: CAH72706.1.
AL161784, AL359644 Genomic DNA. Translation: CAH72707.1.
BC010703 mRNA. Translation: AAH10703.1.
BI603242 mRNA. No translation available.
CCDSiCCDS6830.1. [P27105-1]
CCDS6831.1. [P27105-2]
PIRiS17659.
RefSeqiNP_004090.4. NM_004099.5. [P27105-1]
NP_937837.1. NM_198194.2. [P27105-2]
UniGeneiHs.253903.

3D structure databases

ProteinModelPortaliP27105.
SMRiP27105. Positions 94-255.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108354. 84 interactions.
IntActiP27105. 23 interactions.
MINTiMINT-5004156.
STRINGi9606.ENSP00000286713.

Protein family/group databases

TCDBi8.A.21.1.1. the stomatin/podocin/band 7/nephrosis.2/spfh (stomatin) family.

PTM databases

iPTMnetiP27105.
PhosphoSiteiP27105.
SwissPalmiP27105.

Polymorphism and mutation databases

DMDMi114823.

Proteomic databases

EPDiP27105.
MaxQBiP27105.
PaxDbiP27105.
PeptideAtlasiP27105.
PRIDEiP27105.

Protocols and materials databases

DNASUi2040.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286713; ENSP00000286713; ENSG00000148175. [P27105-1]
ENST00000347359; ENSP00000339607; ENSG00000148175. [P27105-2]
GeneIDi2040.
KEGGihsa:2040.
UCSCiuc004blh.5. human. [P27105-1]

Organism-specific databases

CTDi2040.
GeneCardsiSTOM.
HGNCiHGNC:3383. STOM.
HPAiHPA010961.
HPA011419.
MIMi133090. gene.
neXtProtiNX_P27105.
PharmGKBiPA27816.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2621. Eukaryota.
COG0330. LUCA.
GeneTreeiENSGT00550000074454.
HOGENOMiHOG000049075.
HOVERGENiHBG004815.
InParanoidiP27105.
KOiK17286.
OMAiIIPEYER.
OrthoDBiEOG091G0G9K.
PhylomeDBiP27105.
TreeFamiTF105750.

Miscellaneous databases

ChiTaRSiSTOM. human.
GeneWikiiStomatin.
GenomeRNAii2040.
PROiP27105.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148175.
CleanExiHS_STOM.
ExpressionAtlasiP27105. baseline and differential.
GenevisibleiP27105. HS.

Family and domain databases

InterProiIPR001107. Band_7.
IPR018080. Band_7/stomatin-like_CS.
IPR028515. Stomatin.
IPR001972. Stomatin_fam.
[Graphical view]
PANTHERiPTHR10264. PTHR10264. 1 hit.
PTHR10264:SF86. PTHR10264:SF86. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
PRINTSiPR00721. STOMATIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.
PROSITEiPS01270. BAND_7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTOM_HUMAN
AccessioniPrimary (citable) accession number: P27105
Secondary accession number(s): B1AM77
, Q14087, Q15609, Q5VX96, Q96FK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 166 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.