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Protein

Natriuretic peptides A

Gene

NPPA

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone, Vasoactive

Names & Taxonomyi

Protein namesi
Recommended name:
Natriuretic peptides A
Alternative name(s):
Prepronatriodilatin
Cleaved into the following chain:
Alternative name(s):
Atrial natriuretic peptide
Short name:
ANP
Gene namesi
Name:NPPA
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25By similarityAdd BLAST25
PropeptideiPRO_000000149026 – 123CuratedAdd BLAST98
PeptideiPRO_0000001491124 – 151Atrial natriuretic factorBy similarityAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi130 ↔ 146By similarity

Post-translational modificationi

Cleaved by CORIN upon secretion to produce the functional hormone.By similarity
Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei123 – 124Cleavage; by CORINBy similarity2
Sitei130 – 131Cleavage; by MMEBy similarity2

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP27104.
PRIDEiP27104.

Expressioni

Gene expression databases

BgeeiENSECAG00000014892.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000012495.

Structurei

3D structure databases

SMRiP27104.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW5F. Eukaryota.
ENOG410ZUY6. LUCA.
GeneTreeiENSGT00510000048659.
HOGENOMiHOG000033937.
HOVERGENiHBG004227.
InParanoidiP27104.
KOiK12334.
OMAiCNSFRYR.
OrthoDBiEOG091G0SV3.
TreeFamiTF106304.

Family and domain databases

InterProiView protein in InterPro
IPR000663. Natr_peptide.
IPR030480. Natr_peptide_CS.
IPR002407. Natriuretic_peptide_atrial.
PfamiView protein in Pfam
PF00212. ANP. 1 hit.
PRINTSiPR00711. ANATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTiView protein in SMART
SM00183. NAT_PEP. 1 hit.
PROSITEiView protein in PROSITE
PS00263. NATRIURETIC_PEPTIDE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27104-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSFSTIMAS FLLFLAFQLQ GQTRANPVYG SVSNGDLMDF KNLLDRLEDK
60 70 80 90 100
MPLEDEVMPP QVLSDQSEEE RAALSPLPEV PPWTGEVNPA QRDGGALGRG
110 120 130 140 150
SWDSSDRSAL LKSKLRALLA APRSLRRSSC FGGRMDRIGA QSGLGCNSFR

YRR
Length:153
Mass (Da):16,825
Last modified:August 1, 1992 - v1
Checksum:iAFC19471DF564BD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58563 mRNA. Translation: CAA41443.1.
PIRiS14873.
RefSeqiNP_001075970.1. NM_001082501.2.
UniGeneiEca.12885.

Genome annotation databases

EnsembliENSECAT00000015536; ENSECAP00000012495; ENSECAG00000014892.
GeneIDi100034201.
KEGGiecb:100034201.

Similar proteinsi

Entry informationi

Entry nameiANF_HORSE
AccessioniPrimary (citable) accession number: P27104
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: August 30, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families