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P27090

- TGFB2_MOUSE

UniProt

P27090 - TGFB2_MOUSE

Protein

Transforming growth factor beta-2

Gene

Tgfb2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.

    GO - Molecular functioni

    1. beta-amyloid binding Source: UniProtKB
    2. growth factor activity Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. protein homodimerization activity Source: UniProtKB
    5. receptor binding Source: UniProtKB
    6. receptor signaling protein serine/threonine kinase activity Source: UniProtKB
    7. transforming growth factor beta receptor binding Source: UniProtKB
    8. type II transforming growth factor beta receptor binding Source: UniProtKB

    GO - Biological processi

    1. activation of protein kinase activity Source: UniProtKB
    2. axon guidance Source: MGI
    3. blood vessel development Source: MGI
    4. blood vessel remodeling Source: MGI
    5. cardiac epithelial to mesenchymal transition Source: UniProtKB
    6. cardiac left ventricle morphogenesis Source: DFLAT
    7. cardiac muscle cell proliferation Source: UniProtKB
    8. cardiac right ventricle morphogenesis Source: DFLAT
    9. cardioblast differentiation Source: UniProtKB
    10. cartilage condensation Source: MGI
    11. catagen Source: UniProtKB
    12. cell-cell junction organization Source: UniProtKB
    13. cell cycle arrest Source: UniProtKB
    14. cell death Source: UniProtKB
    15. cell growth Source: InterPro
    16. cell migration Source: UniProtKB
    17. cell morphogenesis Source: UniProtKB
    18. collagen fibril organization Source: UniProtKB
    19. dopamine biosynthetic process Source: UniProtKB
    20. embryonic digestive tract development Source: Ensembl
    21. epithelial to mesenchymal transition Source: UniProtKB
    22. extracellular matrix organization Source: MGI
    23. extrinsic apoptotic signaling pathway Source: BHF-UCL
    24. eye development Source: UniProtKB
    25. face morphogenesis Source: UniProtKB
    26. glial cell migration Source: UniProtKB
    27. hair follicle development Source: UniProtKB
    28. hair follicle morphogenesis Source: UniProtKB
    29. heart development Source: UniProtKB
    30. heart morphogenesis Source: UniProtKB
    31. heart valve morphogenesis Source: MGI
    32. hemopoiesis Source: UniProtKB
    33. menstrual cycle phase Source: Ensembl
    34. negative regulation of alkaline phosphatase activity Source: UniProtKB
    35. negative regulation of cartilage development Source: MGI
    36. negative regulation of cell growth Source: Ensembl
    37. negative regulation of cell proliferation Source: UniProtKB
    38. negative regulation of epithelial cell proliferation Source: UniProtKB
    39. negative regulation of keratinocyte differentiation Source: UniProtKB
    40. negative regulation of macrophage cytokine production Source: UniProtKB
    41. neuron development Source: UniProtKB
    42. neuron fate commitment Source: MGI
    43. neutrophil chemotaxis Source: UniProtKB
    44. outflow tract morphogenesis Source: DFLAT
    45. pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
    46. positive regulation of activation-induced cell death of T cells Source: MGI
    47. positive regulation of cardioblast differentiation Source: UniProtKB
    48. positive regulation of catagen Source: UniProtKB
    49. positive regulation of cell adhesion mediated by integrin Source: UniProtKB
    50. positive regulation of cell cycle Source: UniProtKB
    51. positive regulation of cell division Source: UniProtKB-KW
    52. positive regulation of cell growth Source: UniProtKB
    53. positive regulation of cell proliferation Source: UniProtKB
    54. positive regulation of epithelial cell migration Source: UniProtKB
    55. positive regulation of epithelial to mesenchymal transition Source: UniProtKB
    56. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
    57. positive regulation of gene expression Source: UniProtKB
    58. positive regulation of heart contraction Source: UniProtKB
    59. positive regulation of immune response Source: UniProtKB
    60. positive regulation of integrin biosynthetic process Source: UniProtKB
    61. positive regulation of neuron apoptotic process Source: UniProtKB
    62. positive regulation of ossification Source: Ensembl
    63. positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
    64. positive regulation of protein secretion Source: UniProtKB
    65. positive regulation of stress-activated MAPK cascade Source: UniProtKB
    66. protein phosphorylation Source: UniProtKB
    67. regulation of apoptotic process Source: MGI
    68. regulation of extracellular matrix organization Source: MGI
    69. regulation of transforming growth factor beta2 production Source: UniProtKB
    70. response to drug Source: UniProtKB
    71. response to hypoxia Source: UniProtKB
    72. response to progesterone Source: UniProtKB
    73. salivary gland morphogenesis Source: Ensembl
    74. signal transduction by phosphorylation Source: UniProtKB
    75. skeletal system development Source: MGI
    76. SMAD protein import into nucleus Source: UniProtKB
    77. somatic stem cell division Source: UniProtKB
    78. transforming growth factor beta receptor signaling pathway Source: UniProtKB
    79. ventricular septum morphogenesis Source: DFLAT
    80. wound healing Source: UniProtKB

    Keywords - Molecular functioni

    Growth factor, Mitogen

    Enzyme and pathway databases

    ReactomeiREACT_196606. ECM proteoglycans.
    REACT_198998. Molecules associated with elastic fibres.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transforming growth factor beta-2
    Short name:
    TGF-beta-2
    Cleaved into the following chain:
    Gene namesi
    Name:Tgfb2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:98726. Tgfb2.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: UniProtKB
    2. endosome Source: UniProt
    3. extracellular matrix Source: UniProtKB
    4. extracellular region Source: UniProtKB
    5. extracellular space Source: MGI
    6. neuronal cell body Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 302282Latency-associated peptidePRO_0000033786Add
    BLAST
    Chaini303 – 414112Transforming growth factor beta-2PRO_0000033787Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi309 ↔ 318By similarity
    Disulfide bondi317 ↔ 380By similarity
    Disulfide bondi346 ↔ 411By similarity
    Disulfide bondi350 ↔ 413By similarity
    Disulfide bondi379 – 379InterchainBy similarity

    Post-translational modificationi

    The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP27090.
    PRIDEiP27090.

    PTM databases

    PhosphoSiteiP27090.

    Expressioni

    Gene expression databases

    ArrayExpressiP27090.
    BgeeiP27090.
    CleanExiMM_TGFB2.
    GenevestigatoriP27090.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked By similarity. Heterodimers with TGFB1 and with TGFB3 have been found in bone By similarity. Interacts with ASPN By similarity. Interacts with the serine proteases HTRA1 and HTRA3. Latency-associated peptide interacts with NREP; the interaction results in a decrease in TGFB2 autoinduction.By similarity3 Publications

    Protein-protein interaction databases

    BioGridi204160. 2 interactions.
    IntActiP27090. 1 interaction.
    MINTiMINT-4121010.

    Structurei

    3D structure databases

    ProteinModelPortaliP27090.
    SMRiP27090. Positions 21-414.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG269146.
    GeneTreeiENSGT00620000087687.
    HOGENOMiHOG000290198.
    HOVERGENiHBG074115.
    InParanoidiQ91VP5.
    KOiK13376.
    OMAiENAIPPT.
    OrthoDBiEOG70GMFT.
    TreeFamiTF318514.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR016319. TGF-beta.
    IPR015615. TGF-beta-rel.
    IPR003940. TGFb2.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001787. TGF-beta. 1 hit.
    PRINTSiPR01423. TGFBETA.
    PR01425. TGFBETA2.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P27090-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHYCVLSTFL LLHLVPVALS LSTCSTLDMD QFMRKRIEAI RGQILSKLKL    50
    TSPPEDYPEP DEVPPEVISI YNSTRDLLQE KASRRAAACE RERSDEEYYA 100
    KEVYKIDMPS HLPSENAIPP TFYRPYFRIV RFDVSTMEKN ASNLVKAEFR 150
    VFRLQNPKAR VAEQRIELYQ ILKSKDLTSP TQRYIDSKVV KTRAEGEWLS 200
    FDVTDAVQEW LHHKDRNLGF KISLHCPCCT FVPSNNYIIP NKSEELEARF 250
    AGIDGTSTYA SGDQKTIKST RKKTSGKTPH LLLMLLPSYR LESQQSSRRK 300
    KRALDAAYCF RNVQDNCCLR PLYIDFKRDL GWKWIHEPKG YNANFCAGAC 350
    PYLWSSDTQH TKVLSLYNTI NPEASASPCC VSQDLEPLTI LYYIGNTPKI 400
    EQLSNMIVKS CKCS 414
    Length:414
    Mass (Da):47,589
    Last modified:July 27, 2011 - v2
    Checksum:iDB37A7C38881F286
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti95 – 962DE → EQ in CAA40672. (PubMed:2797004)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57413 mRNA. Translation: CAA40672.1.
    BC011170 mRNA. Translation: AAH11170.1.
    CCDSiCCDS15601.1.
    PIRiA40148. WFMSB2.
    RefSeqiNP_033393.2. NM_009367.3.
    UniGeneiMm.18213.

    Genome annotation databases

    EnsembliENSMUST00000045288; ENSMUSP00000043849; ENSMUSG00000039239.
    GeneIDi21808.
    KEGGimmu:21808.
    UCSCiuc007dzo.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57413 mRNA. Translation: CAA40672.1 .
    BC011170 mRNA. Translation: AAH11170.1 .
    CCDSi CCDS15601.1.
    PIRi A40148. WFMSB2.
    RefSeqi NP_033393.2. NM_009367.3.
    UniGenei Mm.18213.

    3D structure databases

    ProteinModelPortali P27090.
    SMRi P27090. Positions 21-414.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204160. 2 interactions.
    IntActi P27090. 1 interaction.
    MINTi MINT-4121010.

    PTM databases

    PhosphoSitei P27090.

    Proteomic databases

    PaxDbi P27090.
    PRIDEi P27090.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000045288 ; ENSMUSP00000043849 ; ENSMUSG00000039239 .
    GeneIDi 21808.
    KEGGi mmu:21808.
    UCSCi uc007dzo.2. mouse.

    Organism-specific databases

    CTDi 7042.
    MGIi MGI:98726. Tgfb2.

    Phylogenomic databases

    eggNOGi NOG269146.
    GeneTreei ENSGT00620000087687.
    HOGENOMi HOG000290198.
    HOVERGENi HBG074115.
    InParanoidi Q91VP5.
    KOi K13376.
    OMAi ENAIPPT.
    OrthoDBi EOG70GMFT.
    TreeFami TF318514.

    Enzyme and pathway databases

    Reactomei REACT_196606. ECM proteoglycans.
    REACT_198998. Molecules associated with elastic fibres.

    Miscellaneous databases

    ChiTaRSi TGFB2. mouse.
    NextBioi 301190.
    PROi P27090.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P27090.
    Bgeei P27090.
    CleanExi MM_TGFB2.
    Genevestigatori P27090.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR016319. TGF-beta.
    IPR015615. TGF-beta-rel.
    IPR003940. TGFb2.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001787. TGF-beta. 1 hit.
    PRINTSi PR01423. TGFBETA.
    PR01425. TGFBETA2.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine transforming growth factor-beta 2 cDNA sequence and expression in adult tissues and embryos."
      Miller D.A., Lee A., Pelton R.W., Chen E.Y., Moses H.L., Derynck R.
      Mol. Endocrinol. 3:1108-1114(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.
    3. "P311 binds to the latency associated protein and downregulates the expression of TGF-beta1 and TGF-beta2."
      Paliwal S., Shi J., Dhru U., Zhou Y., Schuger L.
      Biochem. Biophys. Res. Commun. 315:1104-1109(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NREP.
    4. "Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling."
      Tocharus J., Tsuchiya A., Kajikawa M., Ueta Y., Oka C., Kawaichi M.
      Dev. Growth Differ. 46:257-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HTRA3.
    5. Cited for: INTERACTION WITH HTRA1.

    Entry informationi

    Entry nameiTGFB2_MOUSE
    AccessioniPrimary (citable) accession number: P27090
    Secondary accession number(s): Q91VP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3