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Protein

Transforming growth factor beta-2

Gene

Tgfb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.

GO - Molecular functioni

GO - Biological processi

  • activation of protein kinase activity Source: UniProtKB
  • axon guidance Source: MGI
  • blood vessel development Source: MGI
  • blood vessel remodeling Source: MGI
  • cardiac epithelial to mesenchymal transition Source: UniProtKB
  • cardiac left ventricle morphogenesis Source: DFLAT
  • cardiac muscle cell proliferation Source: UniProtKB
  • cardiac right ventricle morphogenesis Source: DFLAT
  • cardioblast differentiation Source: UniProtKB
  • cartilage condensation Source: MGI
  • catagen Source: UniProtKB
  • cell-cell junction organization Source: UniProtKB
  • cell cycle arrest Source: UniProtKB
  • cell death Source: UniProtKB
  • cell growth Source: InterPro
  • cell migration Source: UniProtKB
  • cell morphogenesis Source: UniProtKB
  • collagen fibril organization Source: UniProtKB
  • dopamine biosynthetic process Source: UniProtKB
  • embryonic digestive tract development Source: AgBase
  • epithelial to mesenchymal transition Source: UniProtKB
  • extracellular matrix organization Source: MGI
  • extrinsic apoptotic signaling pathway Source: BHF-UCL
  • eye development Source: UniProtKB
  • face morphogenesis Source: UniProtKB
  • glial cell migration Source: UniProtKB
  • hair follicle development Source: UniProtKB
  • hair follicle morphogenesis Source: UniProtKB
  • heart development Source: UniProtKB
  • heart morphogenesis Source: UniProtKB
  • heart valve morphogenesis Source: MGI
  • hemopoiesis Source: UniProtKB
  • negative regulation of alkaline phosphatase activity Source: UniProtKB
  • negative regulation of cartilage development Source: MGI
  • negative regulation of cell growth Source: AgBase
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of epithelial cell proliferation Source: UniProtKB
  • negative regulation of keratinocyte differentiation Source: UniProtKB
  • negative regulation of macrophage cytokine production Source: UniProtKB
  • neuron development Source: UniProtKB
  • neuron fate commitment Source: MGI
  • neutrophil chemotaxis Source: UniProtKB
  • outflow tract morphogenesis Source: DFLAT
  • pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  • positive regulation of activation-induced cell death of T cells Source: MGI
  • positive regulation of cardioblast differentiation Source: UniProtKB
  • positive regulation of catagen Source: UniProtKB
  • positive regulation of cell adhesion mediated by integrin Source: UniProtKB
  • positive regulation of cell cycle Source: UniProtKB
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of cell growth Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of epithelial cell migration Source: UniProtKB
  • positive regulation of epithelial to mesenchymal transition Source: UniProtKB
  • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of heart contraction Source: UniProtKB
  • positive regulation of immune response Source: UniProtKB
  • positive regulation of integrin biosynthetic process Source: UniProtKB
  • positive regulation of neuron apoptotic process Source: UniProtKB
  • positive regulation of ossification Source: AgBase
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
  • positive regulation of protein secretion Source: UniProtKB
  • positive regulation of stress-activated MAPK cascade Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
  • regulation of apoptotic process Source: MGI
  • regulation of cell proliferation Source: GO_Central
  • regulation of extracellular matrix organization Source: MGI
  • regulation of MAPK cascade Source: GO_Central
  • regulation of transforming growth factor beta2 production Source: UniProtKB
  • response to drug Source: UniProtKB
  • response to hypoxia Source: UniProtKB
  • response to progesterone Source: UniProtKB
  • response to wounding Source: AgBase
  • salivary gland morphogenesis Source: AgBase
  • signal transduction by protein phosphorylation Source: UniProtKB
  • skeletal system development Source: MGI
  • SMAD protein import into nucleus Source: UniProtKB
  • SMAD protein signal transduction Source: GO_Central
  • somatic stem cell division Source: UniProtKB
  • transforming growth factor beta receptor signaling pathway Source: UniProtKB
  • ventricular septum morphogenesis Source: DFLAT
  • wound healing Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Enzyme and pathway databases

ReactomeiREACT_307071. Platelet degranulation.
REACT_332220. Molecules associated with elastic fibres.
REACT_354321. ECM proteoglycans.

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming growth factor beta-2
Short name:
TGF-beta-2
Cleaved into the following chain:
Gene namesi
Name:Tgfb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98726. Tgfb2.

Subcellular locationi

GO - Cellular componenti

  • axon Source: UniProtKB
  • endosome Source: UniProtKB
  • extracellular matrix Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: MGI
  • neuronal cell body Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 302282Latency-associated peptidePRO_0000033786Add
BLAST
Chaini303 – 414112Transforming growth factor beta-2PRO_0000033787Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi309 ↔ 318By similarity
Disulfide bondi317 ↔ 380By similarity
Disulfide bondi346 ↔ 411By similarity
Disulfide bondi350 ↔ 413By similarity
Disulfide bondi379 – 379InterchainBy similarity

Post-translational modificationi

The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP27090.
PaxDbiP27090.
PRIDEiP27090.

PTM databases

PhosphoSiteiP27090.

Expressioni

Gene expression databases

BgeeiP27090.
CleanExiMM_TGFB2.
ExpressionAtlasiP27090. baseline and differential.
GenevisibleiP27090. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked (By similarity). Heterodimers with TGFB1 and with TGFB3 have been found in bone (By similarity). Interacts with ASPN (By similarity). Interacts with the serine proteases HTRA1 and HTRA3. Latency-associated peptide interacts with NREP; the interaction results in a decrease in TGFB2 autoinduction. Interacts with MFAP5.By similarity4 Publications

Protein-protein interaction databases

BioGridi204160. 2 interactions.
IntActiP27090. 1 interaction.
MINTiMINT-4121010.
STRINGi10090.ENSMUSP00000043849.

Structurei

3D structure databases

ProteinModelPortaliP27090.
SMRiP27090. Positions 21-414.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG269146.
GeneTreeiENSGT00760000119112.
HOGENOMiHOG000290198.
HOVERGENiHBG074115.
InParanoidiP27090.
KOiK13376.
OrthoDBiEOG70GMFT.
TreeFamiTF318514.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR016319. TGF-beta.
IPR015615. TGF-beta-rel.
IPR003940. TGFb2.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PIRSFiPIRSF001787. TGF-beta. 1 hit.
PRINTSiPR01423. TGFBETA.
PR01425. TGFBETA2.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHYCVLSTFL LLHLVPVALS LSTCSTLDMD QFMRKRIEAI RGQILSKLKL
60 70 80 90 100
TSPPEDYPEP DEVPPEVISI YNSTRDLLQE KASRRAAACE RERSDEEYYA
110 120 130 140 150
KEVYKIDMPS HLPSENAIPP TFYRPYFRIV RFDVSTMEKN ASNLVKAEFR
160 170 180 190 200
VFRLQNPKAR VAEQRIELYQ ILKSKDLTSP TQRYIDSKVV KTRAEGEWLS
210 220 230 240 250
FDVTDAVQEW LHHKDRNLGF KISLHCPCCT FVPSNNYIIP NKSEELEARF
260 270 280 290 300
AGIDGTSTYA SGDQKTIKST RKKTSGKTPH LLLMLLPSYR LESQQSSRRK
310 320 330 340 350
KRALDAAYCF RNVQDNCCLR PLYIDFKRDL GWKWIHEPKG YNANFCAGAC
360 370 380 390 400
PYLWSSDTQH TKVLSLYNTI NPEASASPCC VSQDLEPLTI LYYIGNTPKI
410
EQLSNMIVKS CKCS
Length:414
Mass (Da):47,589
Last modified:July 27, 2011 - v2
Checksum:iDB37A7C38881F286
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 962DE → EQ in CAA40672 (PubMed:2797004).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57413 mRNA. Translation: CAA40672.1.
BC011170 mRNA. Translation: AAH11170.1.
CCDSiCCDS15601.1.
PIRiA40148. WFMSB2.
RefSeqiNP_033393.2. NM_009367.3.
UniGeneiMm.18213.

Genome annotation databases

EnsembliENSMUST00000045288; ENSMUSP00000043849; ENSMUSG00000039239.
GeneIDi21808.
KEGGimmu:21808.
UCSCiuc007dzo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57413 mRNA. Translation: CAA40672.1.
BC011170 mRNA. Translation: AAH11170.1.
CCDSiCCDS15601.1.
PIRiA40148. WFMSB2.
RefSeqiNP_033393.2. NM_009367.3.
UniGeneiMm.18213.

3D structure databases

ProteinModelPortaliP27090.
SMRiP27090. Positions 21-414.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204160. 2 interactions.
IntActiP27090. 1 interaction.
MINTiMINT-4121010.
STRINGi10090.ENSMUSP00000043849.

PTM databases

PhosphoSiteiP27090.

Proteomic databases

MaxQBiP27090.
PaxDbiP27090.
PRIDEiP27090.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045288; ENSMUSP00000043849; ENSMUSG00000039239.
GeneIDi21808.
KEGGimmu:21808.
UCSCiuc007dzo.2. mouse.

Organism-specific databases

CTDi7042.
MGIiMGI:98726. Tgfb2.

Phylogenomic databases

eggNOGiNOG269146.
GeneTreeiENSGT00760000119112.
HOGENOMiHOG000290198.
HOVERGENiHBG074115.
InParanoidiP27090.
KOiK13376.
OrthoDBiEOG70GMFT.
TreeFamiTF318514.

Enzyme and pathway databases

ReactomeiREACT_307071. Platelet degranulation.
REACT_332220. Molecules associated with elastic fibres.
REACT_354321. ECM proteoglycans.

Miscellaneous databases

ChiTaRSiTgfb2. mouse.
NextBioi301190.
PROiP27090.
SOURCEiSearch...

Gene expression databases

BgeeiP27090.
CleanExiMM_TGFB2.
ExpressionAtlasiP27090. baseline and differential.
GenevisibleiP27090. MM.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR016319. TGF-beta.
IPR015615. TGF-beta-rel.
IPR003940. TGFb2.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PIRSFiPIRSF001787. TGF-beta. 1 hit.
PRINTSiPR01423. TGFBETA.
PR01425. TGFBETA2.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Murine transforming growth factor-beta 2 cDNA sequence and expression in adult tissues and embryos."
    Miller D.A., Lee A., Pelton R.W., Chen E.Y., Moses H.L., Derynck R.
    Mol. Endocrinol. 3:1108-1114(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. "P311 binds to the latency associated protein and downregulates the expression of TGF-beta1 and TGF-beta2."
    Paliwal S., Shi J., Dhru U., Zhou Y., Schuger L.
    Biochem. Biophys. Res. Commun. 315:1104-1109(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NREP.
  4. "Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling."
    Tocharus J., Tsuchiya A., Kajikawa M., Ueta Y., Oka C., Kawaichi M.
    Dev. Growth Differ. 46:257-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HTRA3.
  5. Cited for: INTERACTION WITH HTRA1.
  6. Cited for: INTERACTION WITH MFAP5.

Entry informationi

Entry nameiTGFB2_MOUSE
AccessioniPrimary (citable) accession number: P27090
Secondary accession number(s): Q91VP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: July 27, 2011
Last modified: July 22, 2015
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.