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Protein

Transforming growth factor beta-2

Gene

Tgfb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.

GO - Molecular functioni

GO - Biological processi

  • activation of protein kinase activity Source: UniProtKB
  • ascending aorta morphogenesis Source: BHF-UCL
  • atrial septum morphogenesis Source: BHF-UCL
  • atrial septum primum morphogenesis Source: BHF-UCL
  • atrioventricular valve morphogenesis Source: BHF-UCL
  • axon guidance Source: MGI
  • blood vessel development Source: MGI
  • blood vessel remodeling Source: MGI
  • cardiac epithelial to mesenchymal transition Source: UniProtKB
  • cardiac left ventricle morphogenesis Source: DFLAT
  • cardiac muscle cell proliferation Source: UniProtKB
  • cardiac right ventricle morphogenesis Source: BHF-UCL
  • cardioblast differentiation Source: UniProtKB
  • cartilage condensation Source: MGI
  • catagen Source: UniProtKB
  • cell-cell junction organization Source: UniProtKB
  • cell cycle arrest Source: UniProtKB
  • cell death Source: UniProtKB
  • cell growth Source: InterPro
  • cell migration Source: UniProtKB
  • cell morphogenesis Source: UniProtKB
  • collagen fibril organization Source: UniProtKB
  • cranial skeletal system development Source: BHF-UCL
  • dopamine biosynthetic process Source: UniProtKB
  • embryonic digestive tract development Source: AgBase
  • embryonic limb morphogenesis Source: BHF-UCL
  • endocardial cushion fusion Source: BHF-UCL
  • endocardial cushion morphogenesis Source: BHF-UCL
  • epithelial to mesenchymal transition Source: UniProtKB
  • extracellular matrix organization Source: MGI
  • extrinsic apoptotic signaling pathway Source: BHF-UCL
  • eye development Source: UniProtKB
  • face morphogenesis Source: UniProtKB
  • glial cell migration Source: UniProtKB
  • hair follicle development Source: UniProtKB
  • hair follicle morphogenesis Source: UniProtKB
  • heart development Source: UniProtKB
  • heart morphogenesis Source: UniProtKB
  • heart valve morphogenesis Source: BHF-UCL
  • hemopoiesis Source: UniProtKB
  • inner ear development Source: BHF-UCL
  • kidney development Source: BHF-UCL
  • male gonad development Source: BHF-UCL
  • membranous septum morphogenesis Source: BHF-UCL
  • negative regulation of alkaline phosphatase activity Source: UniProtKB
  • negative regulation of cartilage development Source: MGI
  • negative regulation of cell growth Source: AgBase
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of epithelial cell proliferation Source: UniProtKB
  • negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
  • negative regulation of gene expression Source: UniProtKB
  • negative regulation of keratinocyte differentiation Source: UniProtKB
  • negative regulation of macrophage cytokine production Source: UniProtKB
  • negative regulation of Ras protein signal transduction Source: BHF-UCL
  • neural retina development Source: BHF-UCL
  • neural tube closure Source: BHF-UCL
  • neuron development Source: UniProtKB
  • neuron fate commitment Source: MGI
  • neutrophil chemotaxis Source: UniProtKB
  • outflow tract morphogenesis Source: DFLAT
  • outflow tract septum morphogenesis Source: BHF-UCL
  • palate development Source: BHF-UCL
  • pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  • pharyngeal arch artery morphogenesis Source: BHF-UCL
  • positive regulation of activation-induced cell death of T cells Source: MGI
  • positive regulation of cardioblast differentiation Source: UniProtKB
  • positive regulation of catagen Source: UniProtKB
  • positive regulation of cell adhesion mediated by integrin Source: UniProtKB
  • positive regulation of cell cycle Source: UniProtKB
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of cell growth Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of epithelial cell migration Source: UniProtKB
  • positive regulation of epithelial to mesenchymal transition Source: UniProtKB
  • positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
  • positive regulation of extracellular matrix disassembly Source: UniProtKB
  • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of GTP binding Source: UniProtKB
  • positive regulation of heart contraction Source: UniProtKB
  • positive regulation of immune response Source: UniProtKB
  • positive regulation of integrin biosynthetic process Source: UniProtKB
  • positive regulation of neuron apoptotic process Source: UniProtKB
  • positive regulation of ossification Source: AgBase
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
  • positive regulation of protein localization to nucleus Source: UniProtKB
  • positive regulation of protein secretion Source: UniProtKB
  • positive regulation of stress-activated MAPK cascade Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
  • pulmonary valve morphogenesis Source: BHF-UCL
  • regulation of actin cytoskeleton organization Source: UniProtKB
  • regulation of apoptotic process Source: MGI
  • regulation of apoptotic process involved in outflow tract morphogenesis Source: BHF-UCL
  • regulation of cell proliferation Source: GO_Central
  • regulation of extracellular matrix organization Source: MGI
  • regulation of MAPK cascade Source: GO_Central
  • regulation of transforming growth factor beta2 production Source: UniProtKB
  • response to drug Source: UniProtKB
  • response to hypoxia Source: UniProtKB
  • response to progesterone Source: UniProtKB
  • response to wounding Source: AgBase
  • salivary gland morphogenesis Source: AgBase
  • signal transduction by protein phosphorylation Source: UniProtKB
  • skeletal system development Source: BHF-UCL
  • SMAD protein import into nucleus Source: UniProtKB
  • SMAD protein signal transduction Source: GO_Central
  • somatic stem cell division Source: UniProtKB
  • substantia propria of cornea development Source: BHF-UCL
  • transforming growth factor beta receptor signaling pathway Source: UniProtKB
  • uterus development Source: BHF-UCL
  • ventricular septum morphogenesis Source: BHF-UCL
  • ventricular trabecula myocardium morphogenesis Source: BHF-UCL
  • wound healing Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-2129379. Molecules associated with elastic fibres.

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming growth factor beta-2
Short name:
TGF-beta-2
Cleaved into the following chain:
Gene namesi
Name:Tgfb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98726. Tgfb2.

Subcellular locationi

GO - Cellular componenti

  • axon Source: UniProtKB
  • endosome Source: UniProtKB
  • extracellular matrix Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: MGI
  • neuronal cell body Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003378621 – 302Latency-associated peptideAdd BLAST282
ChainiPRO_0000033787303 – 414Transforming growth factor beta-2Add BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...)Sequence analysis1
Glycosylationi140N-linked (GlcNAc...)Sequence analysis1
Glycosylationi241N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi309 ↔ 318By similarity
Disulfide bondi317 ↔ 380By similarity
Disulfide bondi346 ↔ 411By similarity
Disulfide bondi350 ↔ 413By similarity
Disulfide bondi379InterchainBy similarity

Post-translational modificationi

The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP27090.
PaxDbiP27090.
PeptideAtlasiP27090.
PRIDEiP27090.

PTM databases

PhosphoSitePlusiP27090.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039239.
CleanExiMM_TGFB2.
ExpressionAtlasiP27090. baseline and differential.
GenevisibleiP27090. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked (By similarity). Heterodimers with TGFB1 and with TGFB3 have been found in bone (By similarity). Interacts with ASPN (By similarity). Interacts with the serine proteases HTRA1 and HTRA3. Latency-associated peptide interacts with NREP; the interaction results in a decrease in TGFB2 autoinduction. Interacts with MFAP5.By similarity4 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204160. 2 interactors.
IntActiP27090. 1 interactor.
MINTiMINT-4121010.
STRINGi10090.ENSMUSP00000043849.

Structurei

3D structure databases

ProteinModelPortaliP27090.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000119112.
HOGENOMiHOG000290198.
HOVERGENiHBG074115.
InParanoidiP27090.
KOiK13376.
TreeFamiTF318514.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR016319. TGF-beta.
IPR015615. TGF-beta-rel.
IPR003940. TGFb2.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 2 hits.
PTHR11848:SF141. PTHR11848:SF141. 2 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PIRSFiPIRSF001787. TGF-beta. 1 hit.
PRINTSiPR01423. TGFBETA.
PR01425. TGFBETA2.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHYCVLSTFL LLHLVPVALS LSTCSTLDMD QFMRKRIEAI RGQILSKLKL
60 70 80 90 100
TSPPEDYPEP DEVPPEVISI YNSTRDLLQE KASRRAAACE RERSDEEYYA
110 120 130 140 150
KEVYKIDMPS HLPSENAIPP TFYRPYFRIV RFDVSTMEKN ASNLVKAEFR
160 170 180 190 200
VFRLQNPKAR VAEQRIELYQ ILKSKDLTSP TQRYIDSKVV KTRAEGEWLS
210 220 230 240 250
FDVTDAVQEW LHHKDRNLGF KISLHCPCCT FVPSNNYIIP NKSEELEARF
260 270 280 290 300
AGIDGTSTYA SGDQKTIKST RKKTSGKTPH LLLMLLPSYR LESQQSSRRK
310 320 330 340 350
KRALDAAYCF RNVQDNCCLR PLYIDFKRDL GWKWIHEPKG YNANFCAGAC
360 370 380 390 400
PYLWSSDTQH TKVLSLYNTI NPEASASPCC VSQDLEPLTI LYYIGNTPKI
410
EQLSNMIVKS CKCS
Length:414
Mass (Da):47,589
Last modified:July 27, 2011 - v2
Checksum:iDB37A7C38881F286
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95 – 96DE → EQ in CAA40672 (PubMed:2797004).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57413 mRNA. Translation: CAA40672.1.
BC011170 mRNA. Translation: AAH11170.1.
CCDSiCCDS15601.1.
PIRiA40148. WFMSB2.
RefSeqiNP_033393.2. NM_009367.4.
UniGeneiMm.18213.

Genome annotation databases

EnsembliENSMUST00000045288; ENSMUSP00000043849; ENSMUSG00000039239.
GeneIDi21808.
KEGGimmu:21808.
UCSCiuc007dzo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57413 mRNA. Translation: CAA40672.1.
BC011170 mRNA. Translation: AAH11170.1.
CCDSiCCDS15601.1.
PIRiA40148. WFMSB2.
RefSeqiNP_033393.2. NM_009367.4.
UniGeneiMm.18213.

3D structure databases

ProteinModelPortaliP27090.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204160. 2 interactors.
IntActiP27090. 1 interactor.
MINTiMINT-4121010.
STRINGi10090.ENSMUSP00000043849.

PTM databases

PhosphoSitePlusiP27090.

Proteomic databases

MaxQBiP27090.
PaxDbiP27090.
PeptideAtlasiP27090.
PRIDEiP27090.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045288; ENSMUSP00000043849; ENSMUSG00000039239.
GeneIDi21808.
KEGGimmu:21808.
UCSCiuc007dzo.2. mouse.

Organism-specific databases

CTDi7042.
MGIiMGI:98726. Tgfb2.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000119112.
HOGENOMiHOG000290198.
HOVERGENiHBG074115.
InParanoidiP27090.
KOiK13376.
TreeFamiTF318514.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-2129379. Molecules associated with elastic fibres.

Miscellaneous databases

ChiTaRSiTgfb2. mouse.
PROiP27090.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039239.
CleanExiMM_TGFB2.
ExpressionAtlasiP27090. baseline and differential.
GenevisibleiP27090. MM.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR016319. TGF-beta.
IPR015615. TGF-beta-rel.
IPR003940. TGFb2.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 2 hits.
PTHR11848:SF141. PTHR11848:SF141. 2 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PIRSFiPIRSF001787. TGF-beta. 1 hit.
PRINTSiPR01423. TGFBETA.
PR01425. TGFBETA2.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTGFB2_MOUSE
AccessioniPrimary (citable) accession number: P27090
Secondary accession number(s): Q91VP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.