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P27087 (MTB_COLVI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length43 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals.

Domain

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similarities

Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
   LigandMetal-binding
Metal-thiolate cluster
Gene Ontology (GO)
   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›43›43Metallothionein B
PRO_0000197264

Regions

Region‹1 – 16›16Beta
Region17 – ›43›27Alpha

Sites

Metal binding21Divalent metal cation; cluster B
Metal binding61Divalent metal cation; cluster B
Metal binding81Divalent metal cation; cluster B
Metal binding111Divalent metal cation; cluster B
Metal binding131Divalent metal cation; cluster B
Metal binding161Divalent metal cation; cluster B
Metal binding201Divalent metal cation; cluster A
Metal binding211Divalent metal cation; cluster A
Metal binding231Divalent metal cation; cluster A
Metal binding241Divalent metal cation; cluster A
Metal binding281Divalent metal cation; cluster A
Metal binding311Divalent metal cation; cluster A
Metal binding351Divalent metal cation; cluster A
Metal binding371Divalent metal cation; cluster A

Experimental info

Non-terminal residue11
Non-terminal residue431

Sequences

Sequence LengthMass (Da)Tools
P27087 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 1612EB40EE6EB875

FASTA434,429
        10         20         30         40 
SCAGSCKCKN CRCRSCRKSC CSCCPAGCNN CVKGCVCKEP ASS 

« Hide

References

[1]"Evolution of avian metallothionein: DNA sequence analyses of the turkey metallothionein gene and metallothionein cDNAs from pheasant and quail."
Shartzer K.L., Kage K., Sobieski R.J., Andrews G.K.
J. Mol. Evol. 36:255-262(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X62512 mRNA. Translation: CAA44371.1.
PIRS18174. S33379.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D4.10.10.10. 1 hit.
InterProIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
[Graphical view]
PANTHERPTHR23299. PTHR23299. 1 hit.
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSPR00860. MTVERTEBRATE.
SUPFAMSSF57868. SSF57868. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMTB_COLVI
AccessionPrimary (citable) accession number: P27087
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Metallothioneins

Classification of metallothioneins and list of entries