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P27087

- MTB_COLVI

UniProt

P27087 - MTB_COLVI

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Protein
Metallothionein B
Gene
N/A
Organism
Colinus virginianus (Northern bobwhite) (Tetrao virginianus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi2 – 21Divalent metal cation; cluster B
Metal bindingi6 – 61Divalent metal cation; cluster B
Metal bindingi8 – 81Divalent metal cation; cluster B
Metal bindingi11 – 111Divalent metal cation; cluster B
Metal bindingi13 – 131Divalent metal cation; cluster B
Metal bindingi16 – 161Divalent metal cation; cluster B
Metal bindingi20 – 201Divalent metal cation; cluster A
Metal bindingi21 – 211Divalent metal cation; cluster A
Metal bindingi23 – 231Divalent metal cation; cluster A
Metal bindingi24 – 241Divalent metal cation; cluster A
Metal bindingi28 – 281Divalent metal cation; cluster A
Metal bindingi31 – 311Divalent metal cation; cluster A
Metal bindingi35 – 351Divalent metal cation; cluster A
Metal bindingi37 – 371Divalent metal cation; cluster A

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein B
Short name:
MTB
OrganismiColinus virginianus (Northern bobwhite) (Tetrao virginianus)
Taxonomic identifieri9014 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesOdontophoridaeColinus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›43›43Metallothionein B
PRO_0000197264Add
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni‹1 – 16›16Beta
Add
BLAST
Regioni17 – ›43›27Alpha
Add
BLAST

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.

Sequencei

Sequence statusi: Fragment.

P27087-1 [UniParc]FASTAAdd to Basket

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SCAGSCKCKN CRCRSCRKSC CSCCPAGCNN CVKGCVCKEP ASS          43
Length:43
Mass (Da):4,429
Last modified:August 1, 1992 - v1
Checksum:i1612EB40EE6EB875
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei43 – 431

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X62512 mRNA. Translation: CAA44371.1.
PIRiS33379. S18174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X62512 mRNA. Translation: CAA44371.1 .
PIRi S33379. S18174.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 4.10.10.10. 1 hit.
InterProi IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
[Graphical view ]
PANTHERi PTHR23299. PTHR23299. 1 hit.
Pfami PF00131. Metallothio. 1 hit.
[Graphical view ]
PRINTSi PR00860. MTVERTEBRATE.
SUPFAMi SSF57868. SSF57868. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Evolution of avian metallothionein: DNA sequence analyses of the turkey metallothionein gene and metallothionein cDNAs from pheasant and quail."
    Shartzer K.L., Kage K., Sobieski R.J., Andrews G.K.
    J. Mol. Evol. 36:255-262(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiMTB_COLVI
AccessioniPrimary (citable) accession number: P27087
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: July 9, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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