P27086 (MTA_COLVI) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 63.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Metallothionein A Short name=MTA |
| Organism | Colinus virginianus (Bobwhite quail) (Tetrao virginianus) |
| Taxonomic identifier | 9014 [NCBI] |
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Odontophoridae › Colinus |
Protein attributes
| Sequence length | 43 AA. |
| Sequence status | Fragment. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Metallothioneins have a high content of cysteine residues that bind various heavy metals. |
| Domain | Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines. |
| Sequence similarities | Belongs to the metallothionein superfamily. Type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Metal-binding Metal-thiolate cluster |
| Gene Ontology (GO) | |
| Molecular_function | metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | ‹1 – ›43 | ›43 | Metallothionein A | PRO_0000197263 | |||||
Regions | |||||||||
| Region | ‹1 – 16 | ›16 | Beta | ||||||
| Region | 17 – ›43 | ›27 | Alpha | ||||||
Sites | |||||||||
| Metal binding | 2 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 6 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 8 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 11 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 13 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 16 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 20 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 21 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 23 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 24 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 28 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 31 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 35 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 37 | 1 | Divalent metal cation; cluster A | ||||||
Experimental info | |||||||||
| Non-terminal residue | 1 | 1 | |||||||
| Non-terminal residue | 43 | 1 | |||||||
Sequences
References
| [1] | "Evolution of avian metallothionein: DNA sequence analyses of the turkey metallothionein gene and metallothionein cDNAs from pheasant and quail." Shartzer K.L., Kage K., Sobieski R.J., Andrews G.K. J. Mol. Evol. 36:255-262(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X62511 mRNA. Translation: CAA44370.1. |
| PIR | S18173. S33378. |
3D structure databases | |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Family and domain databases | |
| Gene3D | 4.10.10.10. 1 hit. |
| InterPro | IPR017854. Metalthion_dom. IPR023587. Metalthion_dom_vert. IPR003019. Metalthion_sfam_euk. IPR000006. Metalthion_vert. [Graphical view] |
| PANTHER | PTHR23299. PTHR23299. 1 hit. |
| Pfam | PF00131. Metallothio. 1 hit. [Graphical view] |
| PRINTS | PR00860. MTVERTEBRATE. |
| SUPFAM | SSF57868. Metallothionein_sfam. 1 hit. |
| PROSITE | PS00203. METALLOTHIONEIN_VRT. Partial match. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MTA_COLVI | ||||||||
| Accession | Primary (citable) accession number: P27086 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| Metallothioneins Classification of metallothioneins and list of entries |
| SIMILARITY comments Index of protein domains and families |