ID   SYST_SOLLC              Reviewed;         200 AA.
AC   P27058;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   24-JAN-2024, entry version 86.
DE   RecName: Full=Systemin;
DE   Flags: Precursor;
OS   Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC   Solanum subgen. Lycopersicon.
OX   NCBI_TaxID=4081;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   TISSUE=Leaf;
RX   PubMed=1549783; DOI=10.1126/science.1549783;
RA   McGurl B., Pearce G., Orozco-Cardenas M., Ryan C.A.;
RT   "Structure, expression, and antisense inhibition of the systemin precursor
RT   gene.";
RL   Science 255:1570-1573(1992).
RN   [2]
RP   PROTEIN SEQUENCE OF 179-196.
RA   Pearce G., Strydom D., Johnson S., Ryan C.A.;
RT   "A polypeptide from tomato leaves induces wound-inducible proteinase
RT   inhibitor proteins.";
RL   Science 253:895-898(1991).
RN   [3]
RP   FUNCTION.
RX   PubMed=10708853; DOI=10.1016/s0167-4838(99)00269-1;
RA   Ryan C.A.;
RT   "The systemin signaling pathway: differential activation of plant defensive
RT   genes.";
RL   Biochim. Biophys. Acta 1477:112-121(2000).
CC   -!- FUNCTION: Activates a lipid-based signal transduction pathway in which
CC       linolenic acid is converted to jasmonic acid, a potent activator of
CC       defense gene transcription, including proteinase inhibitor.
CC       {ECO:0000269|PubMed:10708853}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- TISSUE SPECIFICITY: All organs except the roots. Transported out of
CC       wounds to distal tissues.
CC   -!- INDUCTION: By wounding; in leaves.
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DR   EMBL; M84800; AAA34182.1; -; Genomic_DNA.
DR   EMBL; M84801; AAA34184.1; -; mRNA.
DR   PIR; T07149; T07149.
DR   RefSeq; NP_001296096.1; NM_001309167.1.
DR   AlphaFoldDB; P27058; -.
DR   SMR; P27058; -.
DR   PaxDb; 4081-Solyc05g051750-2-1; -.
DR   GeneID; 543989; -.
DR   KEGG; sly:543989; -.
DR   InParanoid; P27058; -.
DR   OrthoDB; 782839at2759; -.
DR   Proteomes; UP000004994; Unplaced.
DR   ExpressionAtlas; P27058; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   DisProt; DP01969; -.
DR   InterPro; IPR009966; Prosystemin/Systemin.
DR   Pfam; PF07376; Prosystemin; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Direct protein sequencing; Hormone; Reference proteome; Repeat.
FT   PROPEP          1..178
FT                   /evidence="ECO:0000269|Ref.2"
FT                   /id="PRO_0000022461"
FT   PEPTIDE         179..196
FT                   /note="Systemin"
FT                   /id="PRO_0000022462"
FT   PROPEP          197..200
FT                   /id="PRO_0000022463"
FT   REPEAT          3..8
FT                   /note="1; truncated"
FT   REPEAT          37..45
FT                   /note="2"
FT   REPEAT          80..88
FT                   /note="3"
FT   REPEAT          117..125
FT                   /note="4"
FT   REPEAT          145..153
FT                   /note="5"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          106..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          178..200
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        106..153
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   200 AA;  22999 MW;  FA251D94BAA9C5A9 CRC64;
     MGTPSYDIKN KGDDMQEEPK VKLHHEKGGD EKEKIIEKET PSQDINNKDT ISSYVLRDDT
     QEIPKMEHEE GGYVKEKIVE KETISQYIIK IEGDDDAQEK LKVEYEEEEY EKEKIVEKET
     PSQDINNKGD DAQEKPKVEH EEGDDKETPS QDIIKMEGEG ALEITKVVCE KIIVREDLAV
     QSKPPSKRDP PKMQTDNNKL
//