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Protein

Protein BTG2

Gene

Btg2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors. Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BTG2
Alternative name(s):
BTG family member 2
NGF-inducible anti-proliferative protein PC3
Gene namesi
Name:Btg2
Synonyms:Pc3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi2225 Btg2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001438061 – 158Protein BTG2Add BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei147Phosphoserine; by MAPK1 and MAPK3By similarity1
Modified residuei149Phosphoserine; by MAPK14By similarity1

Post-translational modificationi

Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and at Ser-149 by MAPK14, leading to PIN1-binding and mitochondrial depolarization.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP27049
PRIDEiP27049

Expressioni

Tissue specificityi

In brain at embryonic day 13.5, placenta, amnion, and spleen, which are proliferating and/or differentiating.

Inductioni

By nerve growth factor. At lower levels by epidermal growth factor and membrane depolarization. At much lower levels by fibroblast growth factor and interleukin 6.

Gene expression databases

BgeeiENSRNOG00000003300
GenevisibleiP27049 RN

Interactioni

Subunit structurei

Interacts with PRKCABP. Interacts with CNOT7 and CNOT8; indicative for an association with the CCR4-NOT complex. Interacts with PIN1, inducing mitochondrial depolarization.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Pick1Q9EP803EBI-78953,EBI-77728

Protein-protein interaction databases

BioGridi2482453 interactors.
IntActiP27049 2 interactors.
STRINGi10116.ENSRNOP00000004408

Structurei

3D structure databases

ProteinModelPortaliP27049
SMRiP27049
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiKOG4006 Eukaryota
ENOG410ZZC0 LUCA
GeneTreeiENSGT00550000074461
HOGENOMiHOG000290200
HOVERGENiHBG004907
InParanoidiP27049
KOiK14443
OMAiPSKNYIM
OrthoDBiEOG091G0RS0
PhylomeDBiP27049
TreeFamiTF105272

Family and domain databases

Gene3Di1.20.120.11201 hit
InterProiView protein in InterPro
IPR002087 Anti_prolifrtn
IPR036054 BTG-like_sf
IPR033328 BTG2
PANTHERiPTHR22978:SF29 PTHR22978:SF29, 1 hit
PfamiView protein in Pfam
PF07742 BTG, 1 hit
PRINTSiPR00310 ANTIPRLFBTG1
SMARTiView protein in SMART
SM00099 btg1, 1 hit
SUPFAMiSSF160696 SSF160696, 1 hit
PROSITEiView protein in PROSITE
PS00960 BTG_1, 1 hit
PS01203 BTG_2, 1 hit

Sequencei

Sequence statusi: Complete.

P27049-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHGKRTDML PEIAAAVGFL TSLLRTRGCV SEQRLKVFSR ALQDALTDHY
60 70 80 90 100
KHHWFPEKPS KGSGYRCIRI NHKMDPIISK VASQIGLSQP QLHQLLPSEL
110 120 130 140 150
TLWVDPYEVS YRIGEDGSIC VLYEEAPVAT SYGLLTCKNQ MMLGRSSPSK

NYVMTVSS
Length:158
Mass (Da):17,728
Last modified:August 1, 1992 - v1
Checksum:iF9105D73C3CDF24A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60921 mRNA Translation: AAB49567.1
BC072493 mRNA Translation: AAH72493.1
PIRiA40443
RefSeqiNP_058955.1, NM_017259.1
UniGeneiRn.27923

Genome annotation databases

EnsembliENSRNOT00000004408; ENSRNOP00000004408; ENSRNOG00000003300
GeneIDi29619
KEGGirno:29619
UCSCiRGD:2225 rat

Similar proteinsi

Entry informationi

Entry nameiBTG2_RAT
AccessioniPrimary (citable) accession number: P27049
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: March 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome