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Protein

Protein BTG2

Gene

Btg2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors. Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-6804115. TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BTG2
Alternative name(s):
BTG family member 2
NGF-inducible anti-proliferative protein PC3
Gene namesi
Name:Btg2
Synonyms:Pc3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi2225. Btg2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 158158Protein BTG2PRO_0000143806Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei147 – 1471Phosphoserine; by MAPK1 and MAPK3By similarity
Modified residuei149 – 1491Phosphoserine; by MAPK14By similarity

Post-translational modificationi

Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and at Ser-149 by MAPK14, leading to PIN1-binding and mitochondrial depolarization.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP27049.
PRIDEiP27049.

Expressioni

Tissue specificityi

In brain at embryonic day 13.5, placenta, amnion, and spleen, which are proliferating and/or differentiating.

Inductioni

By nerve growth factor. At lower levels by epidermal growth factor and membrane depolarization. At much lower levels by fibroblast growth factor and interleukin 6.

Gene expression databases

BgeeiENSRNOG00000003300.
GenevisibleiP27049. RN.

Interactioni

Subunit structurei

Interacts with PRKCABP. Interacts with CNOT7 and CNOT8; indicative for an asscociation with the CCR4-NOT complex. Interacts with PIN1, inducing mitochondrial depolarization.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Pick1Q9EP803EBI-78953,EBI-77728

Protein-protein interaction databases

BioGridi248245. 2 interactions.
IntActiP27049. 2 interactions.
STRINGi10116.ENSRNOP00000004408.

Structurei

3D structure databases

ProteinModelPortaliP27049.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiKOG4006. Eukaryota.
ENOG410ZZC0. LUCA.
GeneTreeiENSGT00550000074461.
HOGENOMiHOG000290200.
HOVERGENiHBG004907.
InParanoidiP27049.
KOiK14443.
OMAiMLTCKNQ.
OrthoDBiEOG091G0RS0.
PhylomeDBiP27049.
TreeFamiTF105272.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
IPR033328. BTG2.
[Graphical view]
PANTHERiPTHR22978:SF29. PTHR22978:SF29. 1 hit.
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
SUPFAMiSSF160696. SSF160696. 1 hit.
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27049-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHGKRTDML PEIAAAVGFL TSLLRTRGCV SEQRLKVFSR ALQDALTDHY
60 70 80 90 100
KHHWFPEKPS KGSGYRCIRI NHKMDPIISK VASQIGLSQP QLHQLLPSEL
110 120 130 140 150
TLWVDPYEVS YRIGEDGSIC VLYEEAPVAT SYGLLTCKNQ MMLGRSSPSK

NYVMTVSS
Length:158
Mass (Da):17,728
Last modified:August 1, 1992 - v1
Checksum:iF9105D73C3CDF24A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60921 mRNA. Translation: AAB49567.1.
BC072493 mRNA. Translation: AAH72493.1.
PIRiA40443.
RefSeqiNP_058955.1. NM_017259.1.
UniGeneiRn.27923.

Genome annotation databases

EnsembliENSRNOT00000004408; ENSRNOP00000004408; ENSRNOG00000003300.
GeneIDi29619.
KEGGirno:29619.
UCSCiRGD:2225. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60921 mRNA. Translation: AAB49567.1.
BC072493 mRNA. Translation: AAH72493.1.
PIRiA40443.
RefSeqiNP_058955.1. NM_017259.1.
UniGeneiRn.27923.

3D structure databases

ProteinModelPortaliP27049.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248245. 2 interactions.
IntActiP27049. 2 interactions.
STRINGi10116.ENSRNOP00000004408.

Proteomic databases

PaxDbiP27049.
PRIDEiP27049.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004408; ENSRNOP00000004408; ENSRNOG00000003300.
GeneIDi29619.
KEGGirno:29619.
UCSCiRGD:2225. rat.

Organism-specific databases

CTDi7832.
RGDi2225. Btg2.

Phylogenomic databases

eggNOGiKOG4006. Eukaryota.
ENOG410ZZC0. LUCA.
GeneTreeiENSGT00550000074461.
HOGENOMiHOG000290200.
HOVERGENiHBG004907.
InParanoidiP27049.
KOiK14443.
OMAiMLTCKNQ.
OrthoDBiEOG091G0RS0.
PhylomeDBiP27049.
TreeFamiTF105272.

Enzyme and pathway databases

ReactomeiR-RNO-6804115. TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.

Miscellaneous databases

PROiP27049.

Gene expression databases

BgeeiENSRNOG00000003300.
GenevisibleiP27049. RN.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
IPR033328. BTG2.
[Graphical view]
PANTHERiPTHR22978:SF29. PTHR22978:SF29. 1 hit.
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
SUPFAMiSSF160696. SSF160696. 1 hit.
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBTG2_RAT
AccessioniPrimary (citable) accession number: P27049
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.