Reviewed, UniProtKB/Swiss-Prot P27049 (BTG2_RAT)

Names and origin

Protein names

Recommended name:
    Protein BTG2
Alternative name(s):
    BTG family member 2
    NGF-inducible anti-proliferative protein PC3

Gene names

Name:	Btg2
Synonyms:	Pc3

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Modulates transcription regulation mediated by ESR1 By similarity. Anti-proliferative protein. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors.
Subunit structure	Binds the CCR4-NOT complex By similarity. Interacts with PRKCABP.
Tissue specificity	In brain at embryonic day 13.5, placenta, amnion, and spleen, which are proliferating and/or differentiating.
Induction	By nerve growth factor. At lower levels by epidermal growth factor and membrane depolarization. At much lower levels by fibroblast growth factor and interleukin 6.
Sequence similarities	Belongs to the BTG family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Gene Ontology (GO)
Biological process	negative regulation of apoptosis Inferred from direct assay. Source: MGI neuron differentiation Inferred from direct assay. Source: MGI positive regulation of anti-apoptosis Inferred from mutant phenotype. Source: RGD regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW response to electrical stimulus Inferred from expression pattern. Source: RGD response to mechanical stimulus Inferred from expression pattern. Source: RGD response to organic cyclic substance Inferred from expression pattern. Source: RGD response to organic nitrogen Inferred from expression pattern. Source: RGD response to peptide hormone stimulus Inferred from expression pattern. Source: RGD transcription Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Ref.5 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Pick1	Q9EP80	2	EBI-78953,EBI-77728

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 158	158	Protein BTG2		PRO_0000143806

Sequences

	Sequence		Length	Mass (Da)
	P27049-1 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: F9105D73C3CDF24A	FASTA	158	17,728
	10 20 30 40 50 60 MSHGKRTDML PEIAAAVGFL TSLLRTRGCV SEQRLKVFSR ALQDALTDHY KHHWFPEKPS 70 80 90 100 110 120 KGSGYRCIRI NHKMDPIISK VASQIGLSQP QLHQLLPSEL TLWVDPYEVS YRIGEDGSIC 130 140 150 VLYEEAPVAT SYGLLTCKNQ MMLGRSSPSK NYVMTVSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization." Bradbury A., Possenti R., Shooter E.M., Tirone F. Proc. Natl. Acad. Sci. U.S.A. 88:3353-3357(1991) [PubMed: 1849653] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[3]	"Developmental expression of PC3 gene is correlated with neuronal cell birthday." Iacopetti P., Barsacchi G., Tirone F., Maffei L., Cremisi F. Mech. Dev. 47:127-137(1994) [PubMed: 7811636] [Abstract] Cited for: CHARACTERIZATION.
[4]	"Overexpression of the nerve growth factor-inducible PC3 immediate early gene is associated with growth inhibition." Montagnoli A., Guardavaccaro D., Starace G., Tirone F. Cell Growth Differ. 7:1327-1336(1996) [PubMed: 8891336] [Abstract] Cited for: CHARACTERIZATION.
[5]	"Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1." Lin W.-J., Chang Y.-F., Wang W.-L., Huang C.-Y.F. Biochem. J. 354:635-643(2001) [PubMed: 11237868] [Abstract] Cited for: INTERACTION WITH PRKCABP.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M60921 mRNA. Translation: AAB49567.1. BC072493 mRNA. Translation: AAH72493.1.
IPI	IPI00193262.
PIR	A40443.
RefSeq	NP_058955.1.
UniGene	Rn.27923
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P27049. 2 interactions.
Genome annotation databases
Ensembl	ENSRNOG00000003300. Rattus norvegicus. [Contig view]
GeneID	29619.
KEGG	rno:29619.
Organism-specific databases
RGD	2225. Btg2.
Phylogenomic databases
HOVERGEN	P27049.
OMA	P27049. SKVASQI.
Gene expression databases
ArrayExpress	P27049.
GermOnline	ENSRNOG00000003300. Rattus norvegicus.
Family and domain databases
InterPro	IPR002087. Anti_prolifrtn. [Graphical view]
Pfam	PF07742. BTG. 1 hit. [Graphical view]
PRINTS	PR00310. ANTIPRLFBTG1.
SMART	SM00099. btg1. 1 hit. [Graphical view]
PROSITE	PS00960. BTG_1. 1 hit. PS01203. BTG_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	609818.

Entry information

Entry name

BTG2_RAT

Accession

Primary (citable) accession number: P27049

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	June 16, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)