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P27042

- LYG_CHICK

UniProt

P27042 - LYG_CHICK

Protein

Lysozyme g

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei99 – 991By similarity
    Active sitei112 – 1121By similarity

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell wall macromolecule catabolic process Source: InterPro
    2. cytolysis Source: UniProtKB-KW
    3. defense response to bacterium Source: UniProtKB-KW
    4. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH23. Glycoside Hydrolase Family 23.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysozyme g (EC:3.2.1.17)
    Alternative name(s):
    1,4-beta-N-acetylmuramidase
    Goose-type lysozyme
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 211185Lysozyme gPRO_0000012022Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 86By similarity
    Disulfide bondi44 ↔ 55By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP27042.

    Expressioni

    Tissue specificityi

    Granulocyte compartment of myelomonocytic cells.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000027012.

    Structurei

    3D structure databases

    ProteinModelPortaliP27042.
    SMRiP27042. Positions 28-211.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 23 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG74407.
    HOGENOMiHOG000247036.
    HOVERGENiHBG006299.
    InParanoidiP27042.
    PhylomeDBiP27042.

    Family and domain databases

    InterProiIPR002152. Glyco_hydro_23.
    IPR023346. Lysozyme-like_dom.
    IPR008258. TGlycosylase-like_SLT.
    [Graphical view]
    PfamiPF01464. SLT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001065. Lysozyme_g. 1 hit.
    PRINTSiPR00749. LYSOZYMEG.
    SUPFAMiSSF53955. SSF53955. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P27042-1 [UniParc]FASTAAdd to Basket

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    MLGKNDPMCL VLVLLGLTAL LGICQGGTGC YGSVSRIDTT GASCRTAKPE    50
    GLSYCGVRAS RTIAERDLGS MNKYKVLIKR VGEALCIEPA VIAGIISRES 100
    HAGKILKNGW GDRGNGFGLM QVDKRYHKIE GTWNGEAHIR QGTRILIDMV 150
    KKIQRKFPRW TRDQQLKGGI SAYNAGVGNV RSYERMDIGT LHDDYSNDVV 200
    ARAQYFKQHG Y 211
    Length:211
    Mass (Da):23,238
    Last modified:August 1, 1992 - v1
    Checksum:i8ECBE38AC9F67A9E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61001 Genomic DNA. Translation: CAA43319.1.
    X61002 mRNA. Translation: CAA43320.1.
    X61197 mRNA. No translation available.
    X61198 mRNA. Translation: CAB37929.1.
    PIRiS18463.
    RefSeqiNP_001001470.1. NM_001001470.1.
    UniGeneiGga.3357.

    Genome annotation databases

    GeneIDi395708.
    KEGGigga:395708.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61001 Genomic DNA. Translation: CAA43319.1 .
    X61002 mRNA. Translation: CAA43320.1 .
    X61197 mRNA. No translation available.
    X61198 mRNA. Translation: CAB37929.1 .
    PIRi S18463.
    RefSeqi NP_001001470.1. NM_001001470.1.
    UniGenei Gga.3357.

    3D structure databases

    ProteinModelPortali P27042.
    SMRi P27042. Positions 28-211.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000027012.

    Protein family/group databases

    CAZyi GH23. Glycoside Hydrolase Family 23.

    Proteomic databases

    PaxDbi P27042.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 395708.
    KEGGi gga:395708.

    Organism-specific databases

    CTDi 254773.

    Phylogenomic databases

    eggNOGi NOG74407.
    HOGENOMi HOG000247036.
    HOVERGENi HBG006299.
    InParanoidi P27042.
    PhylomeDBi P27042.

    Miscellaneous databases

    NextBioi 20815778.

    Family and domain databases

    InterProi IPR002152. Glyco_hydro_23.
    IPR023346. Lysozyme-like_dom.
    IPR008258. TGlycosylase-like_SLT.
    [Graphical view ]
    Pfami PF01464. SLT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001065. Lysozyme_g. 1 hit.
    PRINTSi PR00749. LYSOZYMEG.
    SUPFAMi SSF53955. SSF53955. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Goose-type lysozyme gene of the chicken: sequence, genomic organization and expression reveals major differences to chicken-type lysozyme gene."
      Nakano T., Graf T.
      Biochim. Biophys. Acta 1090:273-276(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

    Entry informationi

    Entry nameiLYG_CHICK
    AccessioniPrimary (citable) accession number: P27042
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Shows preference for N-acetylmuramic acid residues that are substituted with a peptide moiety. It acts only as a glycanohydrolase.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3