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P27042 (LYG_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysozyme g

EC=3.2.1.17
Alternative name(s):
1,4-beta-N-acetylmuramidase
Goose-type lysozyme
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Subcellular location

Secreted.

Tissue specificity

Granulocyte compartment of myelomonocytic cells.

Miscellaneous

Shows preference for N-acetylmuramic acid residues that are substituted with a peptide moiety. It acts only as a glycanohydrolase.

Sequence similarities

Belongs to the glycosyl hydrolase 23 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 211185Lysozyme g
PRO_0000012022

Sites

Active site991 By similarity
Active site1121 By similarity

Amino acid modifications

Disulfide bond30 ↔ 86 By similarity
Disulfide bond44 ↔ 55 By similarity

Sequences

Sequence LengthMass (Da)Tools
P27042 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 8ECBE38AC9F67A9E

FASTA21123,238
        10         20         30         40         50         60 
MLGKNDPMCL VLVLLGLTAL LGICQGGTGC YGSVSRIDTT GASCRTAKPE GLSYCGVRAS 

        70         80         90        100        110        120 
RTIAERDLGS MNKYKVLIKR VGEALCIEPA VIAGIISRES HAGKILKNGW GDRGNGFGLM 

       130        140        150        160        170        180 
QVDKRYHKIE GTWNGEAHIR QGTRILIDMV KKIQRKFPRW TRDQQLKGGI SAYNAGVGNV 

       190        200        210 
RSYERMDIGT LHDDYSNDVV ARAQYFKQHG Y 

« Hide

References

[1]"Goose-type lysozyme gene of the chicken: sequence, genomic organization and expression reveals major differences to chicken-type lysozyme gene."
Nakano T., Graf T.
Biochim. Biophys. Acta 1090:273-276(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X61001 Genomic DNA. Translation: CAA43319.1.
X61002 mRNA. Translation: CAA43320.1.
X61197 mRNA. No translation available.
X61198 mRNA. Translation: CAB37929.1.
PIRS18463.
RefSeqNP_001001470.1. NM_001001470.1.
UniGeneGga.3357.

3D structure databases

ProteinModelPortalP27042.
SMRP27042. Positions 28-211.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000027012.

Protein family/group databases

CAZyGH23. Glycoside Hydrolase Family 23.

Proteomic databases

PaxDbP27042.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID395708.
KEGGgga:395708.

Organism-specific databases

CTD254773.

Phylogenomic databases

eggNOGNOG74407.
HOGENOMHOG000247036.
HOVERGENHBG006299.
InParanoidP27042.
PhylomeDBP27042.

Family and domain databases

InterProIPR002152. Glyco_hydro_23.
IPR023346. Lysozyme-like_dom.
IPR008258. TGlycosylase-like_SLT.
[Graphical view]
PfamPF01464. SLT. 1 hit.
[Graphical view]
PIRSFPIRSF001065. Lysozyme_g. 1 hit.
PRINTSPR00749. LYSOZYMEG.
SUPFAMSSF53955. SSF53955. 1 hit.
ProtoNetSearch...

Other

NextBio20815778.

Entry information

Entry nameLYG_CHICK
AccessionPrimary (citable) accession number: P27042
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries