Reviewed, UniProtKB/Swiss-Prot P27042 (LYG_CHICK)

Names and origin

Protein names	Recommended name:     Lysozyme g     EC=3.2.1.17 Alternative name(s):     1,4-beta-N-acetylmuramidase     Goose-type lysozyme
Organism	Gallus gallus (Chicken)
Taxonomic identifier	9031 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Subcellular location	Secreted.
Tissue specificity	Granulocyte compartment of myelomonocytic cells.
Miscellaneous	Shows preference for N-acetylmuramic acid residues that are substituted with a peptide moiety. It acts only as a glycanohydrolase.
Sequence similarities	Belongs to the glycosyl hydrolase 23 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 211	185	Lysozyme g		PRO_0000012022
Sites
	Active site	99	1	By similarity
	Active site	112	1	By similarity
Amino acid modifications
	Disulfide bond	30 ↔ 86		By similarity
	Disulfide bond	44 ↔ 55		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P27042-1 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 8ECBE38AC9F67A9E	FASTA	211	23,238
	10 20 30 40 50 60 MLGKNDPMCL VLVLLGLTAL LGICQGGTGC YGSVSRIDTT GASCRTAKPE GLSYCGVRAS 70 80 90 100 110 120 RTIAERDLGS MNKYKVLIKR VGEALCIEPA VIAGIISRES HAGKILKNGW GDRGNGFGLM 130 140 150 160 170 180 QVDKRYHKIE GTWNGEAHIR QGTRILIDMV KKIQRKFPRW TRDQQLKGGI SAYNAGVGNV 190 200 210 RSYERMDIGT LHDDYSNDVV ARAQYFKQHG Y

References

[1]	"Goose-type lysozyme gene of the chicken: sequence, genomic organization and expression reveals major differences to chicken-type lysozyme gene." Nakano T., Graf T. Biochim. Biophys. Acta 1090:273-276(1991) [PubMed: 1932124] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	X61001 Genomic DNA. Translation: CAA43319.1. X61002 mRNA. Translation: CAA43320.1. X61197 mRNA. No translation available. X61198 mRNA. Translation: CAB37929.1.
IPI	IPI00573323.
PIR	S18463.
RefSeq	NP_001001470.1.
UniGene	Gga.3357
3D structure databases
HSSP	HSSP built from PDB template 1GBS based on UniProtKB P00717.
SMR	P27042. Positions 28-211.
ModBase	Search...
Protein family/group databases
CAZy	GH23. Glycoside Hydrolase Family 23.
Genome annotation databases
Ensembl	ENSGALG00000016761. Gallus gallus. [Contig view]
GeneID	395708.
KEGG	gga:395708.
Phylogenomic databases
HOGENOM	P27042.
HOVERGEN	P27042.
Enzyme and pathway databases
BRENDA	3.2.1.17. 4.
Family and domain databases
InterPro	IPR002152. Glyco_hydro_23. IPR008258. Lytic_TGlycosylase-like_cat. [Graphical view]
Pfam	PF01464. SLT. 1 hit. [Graphical view]
PIRSF	PIRSF001065. Lysozyme_g. 1 hit.
PRINTS	PR00749. LYSOZYMEG.
ProtoNet	Search...

Entry information

Entry name

LYG_CHICK

Accession

Primary (citable) accession number: P27042

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	June 16, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)