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P27042

- LYG_CHICK

UniProt

P27042 - LYG_CHICK

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Protein

Lysozyme g

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei99 – 991 By similarity
Active sitei112 – 1121 By similarity

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH23. Glycoside Hydrolase Family 23.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme g (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase
Goose-type lysozyme
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed predictionAdd
BLAST
Chaini27 – 211185Lysozyme gPRO_0000012022Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 86 By similarity
Disulfide bondi44 ↔ 55 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP27042.

Expressioni

Tissue specificityi

Granulocyte compartment of myelomonocytic cells.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027012.

Structurei

3D structure databases

ProteinModelPortaliP27042.
SMRiP27042. Positions 28-211.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG74407.
HOGENOMiHOG000247036.
HOVERGENiHBG006299.
InParanoidiP27042.
PhylomeDBiP27042.

Family and domain databases

InterProiIPR002152. Glyco_hydro_23.
IPR023346. Lysozyme-like_dom.
IPR008258. TGlycosylase-like_SLT.
[Graphical view]
PfamiPF01464. SLT. 1 hit.
[Graphical view]
PIRSFiPIRSF001065. Lysozyme_g. 1 hit.
PRINTSiPR00749. LYSOZYMEG.
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27042-1 [UniParc]FASTAAdd to Basket

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MLGKNDPMCL VLVLLGLTAL LGICQGGTGC YGSVSRIDTT GASCRTAKPE    50
GLSYCGVRAS RTIAERDLGS MNKYKVLIKR VGEALCIEPA VIAGIISRES 100
HAGKILKNGW GDRGNGFGLM QVDKRYHKIE GTWNGEAHIR QGTRILIDMV 150
KKIQRKFPRW TRDQQLKGGI SAYNAGVGNV RSYERMDIGT LHDDYSNDVV 200
ARAQYFKQHG Y 211
Length:211
Mass (Da):23,238
Last modified:August 1, 1992 - v1
Checksum:i8ECBE38AC9F67A9E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61001 Genomic DNA. Translation: CAA43319.1.
X61002 mRNA. Translation: CAA43320.1.
X61197 mRNA. No translation available.
X61198 mRNA. Translation: CAB37929.1.
PIRiS18463.
RefSeqiNP_001001470.1. NM_001001470.1.
UniGeneiGga.3357.

Genome annotation databases

GeneIDi395708.
KEGGigga:395708.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61001 Genomic DNA. Translation: CAA43319.1 .
X61002 mRNA. Translation: CAA43320.1 .
X61197 mRNA. No translation available.
X61198 mRNA. Translation: CAB37929.1 .
PIRi S18463.
RefSeqi NP_001001470.1. NM_001001470.1.
UniGenei Gga.3357.

3D structure databases

ProteinModelPortali P27042.
SMRi P27042. Positions 28-211.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000027012.

Protein family/group databases

CAZyi GH23. Glycoside Hydrolase Family 23.

Proteomic databases

PaxDbi P27042.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395708.
KEGGi gga:395708.

Organism-specific databases

CTDi 254773.

Phylogenomic databases

eggNOGi NOG74407.
HOGENOMi HOG000247036.
HOVERGENi HBG006299.
InParanoidi P27042.
PhylomeDBi P27042.

Miscellaneous databases

NextBioi 20815778.

Family and domain databases

InterProi IPR002152. Glyco_hydro_23.
IPR023346. Lysozyme-like_dom.
IPR008258. TGlycosylase-like_SLT.
[Graphical view ]
Pfami PF01464. SLT. 1 hit.
[Graphical view ]
PIRSFi PIRSF001065. Lysozyme_g. 1 hit.
PRINTSi PR00749. LYSOZYMEG.
SUPFAMi SSF53955. SSF53955. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Goose-type lysozyme gene of the chicken: sequence, genomic organization and expression reveals major differences to chicken-type lysozyme gene."
    Nakano T., Graf T.
    Biochim. Biophys. Acta 1090:273-276(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Entry informationi

Entry nameiLYG_CHICK
AccessioniPrimary (citable) accession number: P27042
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Shows preference for N-acetylmuramic acid residues that are substituted with a peptide moiety. It acts only as a glycanohydrolase.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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