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Protein

Lysozyme g

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei99 – 991By similarity
Active sitei112 – 1121By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH23. Glycoside Hydrolase Family 23.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme g (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase
Goose-type lysozyme
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 211185Lysozyme gPRO_0000012022Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 86By similarity
Disulfide bondi44 ↔ 55By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP27042.

Expressioni

Tissue specificityi

Granulocyte compartment of myelomonocytic cells.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027012.

Structurei

3D structure databases

ProteinModelPortaliP27042.
SMRiP27042. Positions 28-211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 23 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG74407.
HOGENOMiHOG000247036.
HOVERGENiHBG006299.
PhylomeDBiP27042.

Family and domain databases

InterProiIPR002152. Glyco_hydro_23.
IPR023346. Lysozyme-like_dom.
IPR008258. TGlycosylase-like_SLT.
[Graphical view]
PfamiPF01464. SLT. 1 hit.
[Graphical view]
PIRSFiPIRSF001065. Lysozyme_g. 1 hit.
PRINTSiPR00749. LYSOZYMEG.
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27042-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGKNDPMCL VLVLLGLTAL LGICQGGTGC YGSVSRIDTT GASCRTAKPE
60 70 80 90 100
GLSYCGVRAS RTIAERDLGS MNKYKVLIKR VGEALCIEPA VIAGIISRES
110 120 130 140 150
HAGKILKNGW GDRGNGFGLM QVDKRYHKIE GTWNGEAHIR QGTRILIDMV
160 170 180 190 200
KKIQRKFPRW TRDQQLKGGI SAYNAGVGNV RSYERMDIGT LHDDYSNDVV
210
ARAQYFKQHG Y
Length:211
Mass (Da):23,238
Last modified:August 1, 1992 - v1
Checksum:i8ECBE38AC9F67A9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61001 Genomic DNA. Translation: CAA43319.1.
X61002 mRNA. Translation: CAA43320.1.
X61197 mRNA. No translation available.
X61198 mRNA. Translation: CAB37929.1.
PIRiS18463.
RefSeqiNP_001001470.1. NM_001001470.1.
UniGeneiGga.3357.

Genome annotation databases

GeneIDi395708.
KEGGigga:395708.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61001 Genomic DNA. Translation: CAA43319.1.
X61002 mRNA. Translation: CAA43320.1.
X61197 mRNA. No translation available.
X61198 mRNA. Translation: CAB37929.1.
PIRiS18463.
RefSeqiNP_001001470.1. NM_001001470.1.
UniGeneiGga.3357.

3D structure databases

ProteinModelPortaliP27042.
SMRiP27042. Positions 28-211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027012.

Protein family/group databases

CAZyiGH23. Glycoside Hydrolase Family 23.

Proteomic databases

PaxDbiP27042.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395708.
KEGGigga:395708.

Organism-specific databases

CTDi254773.

Phylogenomic databases

eggNOGiNOG74407.
HOGENOMiHOG000247036.
HOVERGENiHBG006299.
PhylomeDBiP27042.

Miscellaneous databases

NextBioi20815778.
PROiP27042.

Family and domain databases

InterProiIPR002152. Glyco_hydro_23.
IPR023346. Lysozyme-like_dom.
IPR008258. TGlycosylase-like_SLT.
[Graphical view]
PfamiPF01464. SLT. 1 hit.
[Graphical view]
PIRSFiPIRSF001065. Lysozyme_g. 1 hit.
PRINTSiPR00749. LYSOZYMEG.
SUPFAMiSSF53955. SSF53955. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Goose-type lysozyme gene of the chicken: sequence, genomic organization and expression reveals major differences to chicken-type lysozyme gene."
    Nakano T., Graf T.
    Biochim. Biophys. Acta 1090:273-276(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Entry informationi

Entry nameiLYG_CHICK
AccessioniPrimary (citable) accession number: P27042
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 29, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Shows preference for N-acetylmuramic acid residues that are substituted with a peptide moiety. It acts only as a glycanohydrolase.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.