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P27041

- AVR2B_XENLA

UniProt

P27041 - AVR2B_XENLA

Protein

Activin receptor type-2B

Gene

acvr2b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Receptor for activin A, activin B and inhibin A. Involved in transmembrane signaling.

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei216 – 2161ATPPROSITE-ProRule annotation
    Active sitei320 – 3201Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi195 – 2039ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. receptor signaling protein serine/threonine kinase activity Source: InterPro
    3. transforming growth factor beta-activated receptor activity Source: InterPro

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 6726.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Activin receptor type-2B (EC:2.7.11.30)
    Alternative name(s):
    Activin receptor type IIB
    Short name:
    ACTR-IIB
    Gene namesi
    Name:acvr2b
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-484252. acvr2b.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 511491Activin receptor type-2BPRO_0000024407Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 61By similarity
    Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi86 ↔ 105By similarity
    Disulfide bondi92 ↔ 104By similarity
    Disulfide bondi106 ↔ 111By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP27041.
    SMRiP27041. Positions 26-119, 189-483.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 136116ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini158 – 511354CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei137 – 15721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini189 – 477289Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG054502.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    PRINTSiPR00653. ACTIVIN2R.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P27041-1 [UniParc]FASTAAdd to Basket

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    MGASVALTFL LLLATFRAGS GHDEVETREC IYYNANWELE KTNQSGVERL    50
    VEGKKDKRLH CYASWRNNSG FIELVKKGCW LDDFNCYDRQ ECIAKEENPQ 100
    VFFCCCEGNY CNKKFTHLPE VETFDPKPQP SASVLNILIY SLLPIVGLSM 150
    AILLAFWMYR HRKPSYGHVE INEDPGLPPP SPLVGLKPLQ LLDIKARGRF 200
    GCVWKARLLN EYVAVKIFPV QDKQSWQCEK EIFTTPGMKH ENLLEFIAAE 250
    KRGSNLEMEL WLITAFHDKG SLTDYLKGNL VSWNELCHIT ETMARGLAYL 300
    HEDVPRCKGE GHKPAIAHRD FKSKNVLLRN DLTAILADFG LAVRFEPGKP 350
    PGDTHGQVGT RRYMAPEVLE GAINFQRDSF LRIDMYAMGL VLWEIVSRCT 400
    AADGPVDEYL LPFEEEIGQH PSLEDLQEVV VHKKIRPVFK DHWLKHPGLA 450
    QLCVTIEECW DHDAEARLSA GCVEERISQI RKSVNGTTSD CLVSIVTSVT 500
    NVDLPPKESS I 511
    Length:511
    Mass (Da):57,936
    Last modified:August 1, 1992 - v1
    Checksum:iA87F1E6BC78C92F0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M88594 mRNA. Translation: AAB00480.1.
    RefSeqiNP_001084049.1. NM_001090580.1.
    UniGeneiXl.1053.

    Genome annotation databases

    GeneIDi399277.
    KEGGixla:399277.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M88594 mRNA. Translation: AAB00480.1 .
    RefSeqi NP_001084049.1. NM_001090580.1.
    UniGenei Xl.1053.

    3D structure databases

    ProteinModelPortali P27041.
    SMRi P27041. Positions 26-119, 189-483.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 399277.
    KEGGi xla:399277.

    Organism-specific databases

    CTDi 93.
    Xenbasei XB-GENE-484252. acvr2b.

    Phylogenomic databases

    HOVERGENi HBG054502.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 6726.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PRINTSi PR00653. ACTIVIN2R.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a second type of activin receptor and functional characterization in Xenopus embryos."
      Mathews L.S., Vale W.W., Kintner C.R.
      Science 255:1702-1705(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiAVR2B_XENLA
    AccessioniPrimary (citable) accession number: P27041
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3