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P27041

- AVR2B_XENLA

UniProt

P27041 - AVR2B_XENLA

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Protein

Activin receptor type-2B

Gene
acvr2b
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for activin A, activin B and inhibin A. Involved in transmembrane signaling.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei216 – 2161ATP By similarity
Active sitei320 – 3201Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi195 – 2039ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. receptor signaling protein serine/threonine kinase activity Source: InterPro
  3. transforming growth factor beta-activated receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 6726.

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-2B (EC:2.7.11.30)
Alternative name(s):
Activin receptor type IIB
Short name:
ACTR-IIB
Gene namesi
Name:acvr2b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-484252. acvr2b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 136116Extracellular Reviewed predictionAdd
BLAST
Transmembranei137 – 15721Helical; Reviewed predictionAdd
BLAST
Topological domaini158 – 511354Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 511491Activin receptor type-2BPRO_0000024407Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 61 By similarity
Glycosylationi43 – 431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi67 – 671N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi86 ↔ 105 By similarity
Disulfide bondi92 ↔ 104 By similarity
Disulfide bondi106 ↔ 111 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP27041.
SMRiP27041. Positions 26-119, 189-483.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini189 – 477289Protein kinaseAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG054502.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27041-1 [UniParc]FASTAAdd to Basket

« Hide

MGASVALTFL LLLATFRAGS GHDEVETREC IYYNANWELE KTNQSGVERL    50
VEGKKDKRLH CYASWRNNSG FIELVKKGCW LDDFNCYDRQ ECIAKEENPQ 100
VFFCCCEGNY CNKKFTHLPE VETFDPKPQP SASVLNILIY SLLPIVGLSM 150
AILLAFWMYR HRKPSYGHVE INEDPGLPPP SPLVGLKPLQ LLDIKARGRF 200
GCVWKARLLN EYVAVKIFPV QDKQSWQCEK EIFTTPGMKH ENLLEFIAAE 250
KRGSNLEMEL WLITAFHDKG SLTDYLKGNL VSWNELCHIT ETMARGLAYL 300
HEDVPRCKGE GHKPAIAHRD FKSKNVLLRN DLTAILADFG LAVRFEPGKP 350
PGDTHGQVGT RRYMAPEVLE GAINFQRDSF LRIDMYAMGL VLWEIVSRCT 400
AADGPVDEYL LPFEEEIGQH PSLEDLQEVV VHKKIRPVFK DHWLKHPGLA 450
QLCVTIEECW DHDAEARLSA GCVEERISQI RKSVNGTTSD CLVSIVTSVT 500
NVDLPPKESS I 511
Length:511
Mass (Da):57,936
Last modified:August 1, 1992 - v1
Checksum:iA87F1E6BC78C92F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M88594 mRNA. Translation: AAB00480.1.
RefSeqiNP_001084049.1. NM_001090580.1.
UniGeneiXl.1053.

Genome annotation databases

GeneIDi399277.
KEGGixla:399277.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M88594 mRNA. Translation: AAB00480.1 .
RefSeqi NP_001084049.1. NM_001090580.1.
UniGenei Xl.1053.

3D structure databases

ProteinModelPortali P27041.
SMRi P27041. Positions 26-119, 189-483.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 399277.
KEGGi xla:399277.

Organism-specific databases

CTDi 93.
Xenbasei XB-GENE-484252. acvr2b.

Phylogenomic databases

HOVERGENi HBG054502.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 6726.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
PRINTSi PR00653. ACTIVIN2R.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of a second type of activin receptor and functional characterization in Xenopus embryos."
    Mathews L.S., Vale W.W., Kintner C.R.
    Science 255:1702-1705(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAVR2B_XENLA
AccessioniPrimary (citable) accession number: P27041
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: June 11, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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