Reviewed,
UniProtKB/Swiss-Prot P27041 (AVR2B_XENLA)
Last modified
July 22, 2008.
Version 66.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Activin receptor type-2B EC=2.7.11.30 Alternative name(s): Activin receptor type IIB Short name=ACTR-IIB | ||
| Gene names |
| ||
| Organism | Xenopus laevis (African clawed frog) | ||
| Taxonomic identifier | 8355 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Protein attributes
| Sequence length | 511 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Receptor for activin A, activin B and inhibin A. Involved in transmembrane signaling. |
| Catalytic activity | ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. |
| Subcellular location | |
| Sequence similarities | Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Signal Transmembrane |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Receptor Serine/threonine-protein kinase Transferase |
| PTM | Glycoprotein |
Gene Ontology (GO) | |
| None. [Check GOA] | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||||
Molecule processing | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 20 | 20 | Potential | |||||||
| Chain | 21 – 511 | 491 | Activin receptor type-2B | |||||||
Regions | ||||||||||
| Topological domain | 21 – 136 | 116 | Extracellular Potential | |||||||
| Transmembrane | 137 – 157 | 21 | Potential | |||||||
| Topological domain | 158 – 511 | 354 | Cytoplasmic Potential | |||||||
| Domain | 189 – 477 | 289 | Protein kinase | |||||||
| Nucleotide binding | 195 – 203 | 9 | ATP By similarity | |||||||
Sites | ||||||||||
| Active site | 320 | 1 | Proton acceptor By similarity | |||||||
| Binding site | 216 | 1 | ATP By similarity | |||||||
Amino acid modifications | ||||||||||
| Glycosylation | 43 | 1 | N-linked (GlcNAc...) Potential | |||||||
| Glycosylation | 67 | 1 | N-linked (GlcNAc...) Potential | |||||||
| Disulfide bond | 30 ↔ 61 | By similarity | ||||||||
| Disulfide bond | 86 ↔ 105 | By similarity | ||||||||
| Disulfide bond | 92 ↔ 104 | By similarity | ||||||||
| Disulfide bond | 106 ↔ 111 | By similarity | ||||||||
Sequences
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References
| [1] | "Cloning of a second type of activin receptor and functional characterization in Xenopus embryos." Mathews L.S., Vale W.W., Kintner C.R. Science 255:1702-1705(1992) [PubMed: 1313188] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
Cross-references
Sequence databases | |
|---|---|
| M88594 mRNA. Translation: AAB00480.1. | |
| RefSeq | NP_001084049.1. |
| UniGene | Xl.1053 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1BTE based on UniProtKB P27038. |
| SMR | P27041. Positions 26-119. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 399277. |
| KEGG | xla:399277. |
Phylogenomic databases | |
| HOVERGEN | P27041. |
Family and domain databases | |
| InterPro | IPR000333. Activin_II_recpt. IPR015768. Activin_II_recpt_C. IPR000472. Activin_rcpt. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. [Graphical view] |
| PANTHER | PTHR23255:SF10. Activin_II_recpt_C. 1 hit. |
| Pfam | PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view] |
| PRINTS | PR00653. ACTIVIN2R. |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| BLOCKS | Search... |
Other Resources | |
| ProtoNet | Search... |
Entry information
| Entry name | AVR2B_XENLA | ||||||||
| Accession | Primary (citable) accession number: P27041 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Xenopus annotation project | ||||||||

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