Reviewed, UniProtKB/Swiss-Prot P27041 (AVR2B_XENLA)

Names and origin

Protein names

Recommended name:
    Activin receptor type-2B
    EC=2.7.11.30
Alternative name(s):
    Activin receptor type IIB
      Short name=ACTR-IIB

Gene names

Name:

acvr2b

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	511 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for activin A, activin B and inhibin A. Involved in transmembrane signaling.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	activin receptor signaling pathway Inferred from electronic annotation. Source: InterPro protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW activin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 511	491	Activin receptor type-2B		PRO_0000024407
Regions
	Topological domain	21 – 136	116	Extracellular Potential
	Transmembrane	137 – 157	21	Potential
	Topological domain	158 – 511	354	Cytoplasmic Potential
	Domain	189 – 477	289	Protein kinase
	Nucleotide binding	195 – 203	9	ATP By similarity
Sites
	Active site	320	1	Proton acceptor By similarity
	Binding site	216	1	ATP By similarity
Amino acid modifications
	Glycosylation	43	1	N-linked (GlcNAc...) Potential
	Glycosylation	67	1	N-linked (GlcNAc...) Potential
	Disulfide bond	30 ↔ 61		By similarity
	Disulfide bond	86 ↔ 105		By similarity
	Disulfide bond	92 ↔ 104		By similarity
	Disulfide bond	106 ↔ 111		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P27041-1 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: A87F1E6BC78C92F0	FASTA	511	57,936
	10 20 30 40 50 60 MGASVALTFL LLLATFRAGS GHDEVETREC IYYNANWELE KTNQSGVERL VEGKKDKRLH 70 80 90 100 110 120 CYASWRNNSG FIELVKKGCW LDDFNCYDRQ ECIAKEENPQ VFFCCCEGNY CNKKFTHLPE 130 140 150 160 170 180 VETFDPKPQP SASVLNILIY SLLPIVGLSM AILLAFWMYR HRKPSYGHVE INEDPGLPPP 190 200 210 220 230 240 SPLVGLKPLQ LLDIKARGRF GCVWKARLLN EYVAVKIFPV QDKQSWQCEK EIFTTPGMKH 250 260 270 280 290 300 ENLLEFIAAE KRGSNLEMEL WLITAFHDKG SLTDYLKGNL VSWNELCHIT ETMARGLAYL 310 320 330 340 350 360 HEDVPRCKGE GHKPAIAHRD FKSKNVLLRN DLTAILADFG LAVRFEPGKP PGDTHGQVGT 370 380 390 400 410 420 RRYMAPEVLE GAINFQRDSF LRIDMYAMGL VLWEIVSRCT AADGPVDEYL LPFEEEIGQH 430 440 450 460 470 480 PSLEDLQEVV VHKKIRPVFK DHWLKHPGLA QLCVTIEECW DHDAEARLSA GCVEERISQI 490 500 510 RKSVNGTTSD CLVSIVTSVT NVDLPPKESS I

References

[1]	"Cloning of a second type of activin receptor and functional characterization in Xenopus embryos." Mathews L.S., Vale W.W., Kintner C.R. Science 255:1702-1705(1992) [PubMed: 1313188] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M88594 mRNA. Translation: AAB00480.1.
RefSeq	NP_001084049.1.
UniGene	Xl.1053
3D structure databases
HSSP	HSSP built from PDB template 1BTE based on UniProtKB P27038.
SMR	P27041. Positions 26-119.
ModBase	Search...
Genome annotation databases
GeneID	399277.
KEGG	xla:399277.
Organism-specific databases
CTD	399277.
Xenbase	XB-FEAT-484247. acvr2b.
Phylogenomic databases
HOVERGEN	P27041.
Enzyme and pathway databases
BRENDA	2.7.10.2. 648. 2.7.11.30. 648.
Family and domain databases
InterPro	IPR000333. Activin_II_recpt. IPR015768. Activin_II_recpt_C. IPR000472. Activin_rcpt. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. [Graphical view]
PANTHER	PTHR23255:SF10. Activin_II_recpt_C. 1 hit.
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
PRINTS	PR00653. ACTIVIN2R.
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AVR2B_XENLA

Accession

Primary (citable) accession number: P27041

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	October 13, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project