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P27041

- AVR2B_XENLA

UniProt

P27041 - AVR2B_XENLA

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Protein

Activin receptor type-2B

Gene

acvr2b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for activin A, activin B and inhibin A. Involved in transmembrane signaling.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei216 – 2161ATPPROSITE-ProRule annotation
Active sitei320 – 3201Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi195 – 2039ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. receptor signaling protein serine/threonine kinase activity Source: InterPro
  3. transforming growth factor beta-activated receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 6726.

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-2B (EC:2.7.11.30)
Alternative name(s):
Activin receptor type IIB
Short name:
ACTR-IIB
Gene namesi
Name:acvr2b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-484252. acvr2b.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 511491Activin receptor type-2BPRO_0000024407Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 61By similarity
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi86 ↔ 105By similarity
Disulfide bondi92 ↔ 104By similarity
Disulfide bondi106 ↔ 111By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP27041.
SMRiP27041. Positions 26-119, 189-483.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 136116ExtracellularSequence AnalysisAdd
BLAST
Topological domaini158 – 511354CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei137 – 15721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini189 – 477289Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG054502.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27041-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGASVALTFL LLLATFRAGS GHDEVETREC IYYNANWELE KTNQSGVERL
60 70 80 90 100
VEGKKDKRLH CYASWRNNSG FIELVKKGCW LDDFNCYDRQ ECIAKEENPQ
110 120 130 140 150
VFFCCCEGNY CNKKFTHLPE VETFDPKPQP SASVLNILIY SLLPIVGLSM
160 170 180 190 200
AILLAFWMYR HRKPSYGHVE INEDPGLPPP SPLVGLKPLQ LLDIKARGRF
210 220 230 240 250
GCVWKARLLN EYVAVKIFPV QDKQSWQCEK EIFTTPGMKH ENLLEFIAAE
260 270 280 290 300
KRGSNLEMEL WLITAFHDKG SLTDYLKGNL VSWNELCHIT ETMARGLAYL
310 320 330 340 350
HEDVPRCKGE GHKPAIAHRD FKSKNVLLRN DLTAILADFG LAVRFEPGKP
360 370 380 390 400
PGDTHGQVGT RRYMAPEVLE GAINFQRDSF LRIDMYAMGL VLWEIVSRCT
410 420 430 440 450
AADGPVDEYL LPFEEEIGQH PSLEDLQEVV VHKKIRPVFK DHWLKHPGLA
460 470 480 490 500
QLCVTIEECW DHDAEARLSA GCVEERISQI RKSVNGTTSD CLVSIVTSVT
510
NVDLPPKESS I
Length:511
Mass (Da):57,936
Last modified:August 1, 1992 - v1
Checksum:iA87F1E6BC78C92F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M88594 mRNA. Translation: AAB00480.1.
RefSeqiNP_001084049.1. NM_001090580.1.
UniGeneiXl.1053.

Genome annotation databases

GeneIDi399277.
KEGGixla:399277.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M88594 mRNA. Translation: AAB00480.1 .
RefSeqi NP_001084049.1. NM_001090580.1.
UniGenei Xl.1053.

3D structure databases

ProteinModelPortali P27041.
SMRi P27041. Positions 26-119, 189-483.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 399277.
KEGGi xla:399277.

Organism-specific databases

CTDi 93.
Xenbasei XB-GENE-484252. acvr2b.

Phylogenomic databases

HOVERGENi HBG054502.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 6726.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
PRINTSi PR00653. ACTIVIN2R.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of a second type of activin receptor and functional characterization in Xenopus embryos."
    Mathews L.S., Vale W.W., Kintner C.R.
    Science 255:1702-1705(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAVR2B_XENLA
AccessioniPrimary (citable) accession number: P27041
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 1, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3