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P27041 (AVR2B_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Activin receptor type-2B
EC=2.7.11.30
Alternative name(s):
Activin receptor type IIB
Short name=ACTR-IIB
Gene names
Name:acvr2b
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length511 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for activin A, activin B and inhibin A. Involved in transmembrane signaling.

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 511491Activin receptor type-2B
PRO_0000024407

Regions

Topological domain21 – 136116Extracellular Potential
Transmembrane137 – 15721Helical; Potential
Topological domain158 – 511354Cytoplasmic Potential
Domain189 – 477289Protein kinase
Nucleotide binding195 – 2039ATP By similarity

Sites

Active site3201Proton acceptor By similarity
Binding site2161ATP By similarity

Amino acid modifications

Glycosylation431N-linked (GlcNAc...) Potential
Glycosylation671N-linked (GlcNAc...) Potential
Disulfide bond30 ↔ 61 By similarity
Disulfide bond86 ↔ 105 By similarity
Disulfide bond92 ↔ 104 By similarity
Disulfide bond106 ↔ 111 By similarity

Sequences

Sequence LengthMass (Da)Tools
P27041 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: A87F1E6BC78C92F0

FASTA51157,936
        10         20         30         40         50         60 
MGASVALTFL LLLATFRAGS GHDEVETREC IYYNANWELE KTNQSGVERL VEGKKDKRLH 

        70         80         90        100        110        120 
CYASWRNNSG FIELVKKGCW LDDFNCYDRQ ECIAKEENPQ VFFCCCEGNY CNKKFTHLPE 

       130        140        150        160        170        180 
VETFDPKPQP SASVLNILIY SLLPIVGLSM AILLAFWMYR HRKPSYGHVE INEDPGLPPP 

       190        200        210        220        230        240 
SPLVGLKPLQ LLDIKARGRF GCVWKARLLN EYVAVKIFPV QDKQSWQCEK EIFTTPGMKH 

       250        260        270        280        290        300 
ENLLEFIAAE KRGSNLEMEL WLITAFHDKG SLTDYLKGNL VSWNELCHIT ETMARGLAYL 

       310        320        330        340        350        360 
HEDVPRCKGE GHKPAIAHRD FKSKNVLLRN DLTAILADFG LAVRFEPGKP PGDTHGQVGT 

       370        380        390        400        410        420 
RRYMAPEVLE GAINFQRDSF LRIDMYAMGL VLWEIVSRCT AADGPVDEYL LPFEEEIGQH 

       430        440        450        460        470        480 
PSLEDLQEVV VHKKIRPVFK DHWLKHPGLA QLCVTIEECW DHDAEARLSA GCVEERISQI 

       490        500        510 
RKSVNGTTSD CLVSIVTSVT NVDLPPKESS I

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References

[1]"Cloning of a second type of activin receptor and functional characterization in Xenopus embryos."
Mathews L.S., Vale W.W., Kintner C.R.
Science 255:1702-1705(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M88594 mRNA. Translation: AAB00480.1.
RefSeqNP_001084049.1. NM_001090580.1.
UniGeneXl.1053.

3D structure databases

ProteinModelPortalP27041.
SMRP27041. Positions 26-119, 189-483.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID399277.
KEGGxla:399277.

Organism-specific databases

CTD93.
XenbaseXB-GENE-484252. acvr2b.

Phylogenomic databases

HOVERGENHBG054502.

Enzyme and pathway databases

BRENDA2.7.10.2. 6726.

Family and domain databases

InterProIPR000333. Activin_II/TGFBeta-II_recpt.
IPR015768. Activin_II_recpt.
IPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERPTHR23255:SF10. PTHR23255:SF10. 1 hit.
PfamPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSPR00653. ACTIVIN2R.
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. False negative.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAVR2B_XENLA
AccessionPrimary (citable) accession number: P27041
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 3, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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