P27040 (AVR2B_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 136.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Activin receptor type-2B EC=2.7.11.30 Alternative name(s): Activin receptor type IIB Short name=ACTR-IIB | ||
| Gene names |
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| Organism | Mus musculus (Mouse) [Reference proteome] | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 536 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor By similarity. |
| Catalytic activity | ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. |
| Cofactor | Magnesium or manganese By similarity. |
| Subunit structure | Forms an activin receptor complex with activin type II receptors such as ACVR1B By similarity. Interacts with VPS39 By similarity. |
| Subcellular location | Cell membrane; Single-pass type I membrane protein By similarity. |
| Post-translational modification | Phosphorylated. Constitutive phosphorylation is in part catalyzed by its own kinase activity By similarity. |
| Sequence similarities | Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain. |
Ontologies
Alternative products
| This entry describes 4 isoforms produced by alternative splicing. [Align] [Select] Note: ActR-IIB1 and ActR-IIB2 have similar but higher affinities for activin A than ActR-II, ActR-IIB3 and ActR-IIB4. | ||||||
| Isoform ActR-IIB1 (identifier: P27040-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform ActR-IIB2 (identifier: P27040-2) The sequence of this isoform differs from the canonical sequence as follows: 175-198: Missing. | ||||||
| Isoform ActR-IIB3 (identifier: P27040-3) The sequence of this isoform differs from the canonical sequence as follows: 124-131: Missing. | ||||||
| Isoform ActR-IIB4 (identifier: P27040-4) The sequence of this isoform differs from the canonical sequence as follows: 124-131: Missing. 175-198: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 18 | 18 | Potential | ||||||||||||||||||||||||
| Chain | 19 – 536 | 518 | Activin receptor type-2B | PRO_0000024405 | |||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||
| Topological domain | 19 – 137 | 119 | Extracellular Potential | ||||||||||||||||||||||||
| Transmembrane | 138 – 158 | 21 | Helical; Potential | ||||||||||||||||||||||||
| Topological domain | 159 – 536 | 378 | Cytoplasmic Potential | ||||||||||||||||||||||||
| Domain | 214 – 504 | 291 | Protein kinase | ||||||||||||||||||||||||
| Nucleotide binding | 220 – 228 | 9 | ATP By similarity | ||||||||||||||||||||||||
Sites | |||||||||||||||||||||||||||
| Active site | 345 | 1 | Proton acceptor By similarity | ||||||||||||||||||||||||
| Binding site | 241 | 1 | ATP By similarity | ||||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||||
| Glycosylation | 42 | 1 | N-linked (GlcNAc...) Potential | ||||||||||||||||||||||||
| Glycosylation | 65 | 1 | N-linked (GlcNAc...) Potential | ||||||||||||||||||||||||
| Disulfide bond | 29 ↔ 59 | ||||||||||||||||||||||||||
| Disulfide bond | 49 ↔ 77 | ||||||||||||||||||||||||||
| Disulfide bond | 84 ↔ 103 | ||||||||||||||||||||||||||
| Disulfide bond | 90 ↔ 102 | ||||||||||||||||||||||||||
| Disulfide bond | 104 ↔ 109 | ||||||||||||||||||||||||||
Natural variations | |||||||||||||||||||||||||||
| Alternative sequence | 124 – 131 | 8 | Missing in isoform ActR-IIB3 and isoform ActR-IIB4. | VSP_004951 | |||||||||||||||||||||||
| Alternative sequence | 175 – 198 | 24 | Missing in isoform ActR-IIB2 and isoform ActR-IIB4. | VSP_004952 | |||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||
| Beta strand | 28 – 33 | 6 | |||||||||||||||||||||||||
| Turn | 34 – 40 | 7 | |||||||||||||||||||||||||
| Beta strand | 43 – 48 | 6 | |||||||||||||||||||||||||
| Beta strand | 57 – 66 | 10 | |||||||||||||||||||||||||
| Beta strand | 69 – 79 | 11 | |||||||||||||||||||||||||
| Helix | 82 – 84 | 3 | |||||||||||||||||||||||||
| Beta strand | 88 – 92 | 5 | |||||||||||||||||||||||||
| Beta strand | 93 – 96 | 4 | |||||||||||||||||||||||||
| Beta strand | 98 – 106 | 9 | |||||||||||||||||||||||||
| Turn | 107 – 110 | 4 | |||||||||||||||||||||||||
| Beta strand | 111 – 115 | 5 | |||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors." Attisano L., Wrana J.L., Cheifetz S., Massague J. Cell 68:97-108(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ACTR-IIB1; ACTR-IIB2; ACTR-IIB3 AND ACTR-IIB4). Strain: BALB/c. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ACTR-IIB2). Tissue: Jaw. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | M84120 mRNA. Translation: AAA37172.1. BC106189 mRNA. Translation: AAI06190.1. | ||||||||||||||||||
| IPI | IPI00114037. IPI00222110. IPI00222111. IPI00222112. | ||||||||||||||||||
| PIR | A40829. B40829. C40829. D40829. | ||||||||||||||||||
| RefSeq | NP_031423.1. NM_007397.2. | ||||||||||||||||||
| UniGene | Mm.390239. | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||||||||
| ProteinModelPortal | P27040. | ||||||||||||||||||
| SMR | P27040. Positions 24-116, 214-536. | ||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||
| DIP | DIP-5799N. | ||||||||||||||||||
| MINT | MINT-2842249. | ||||||||||||||||||
| STRING | 10090.ENSMUSP00000035093. | ||||||||||||||||||
PTM databases | |||||||||||||||||||
| PhosphoSite | P27040. | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PRIDE | P27040. | ||||||||||||||||||
Protocols and materials databases | |||||||||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| Ensembl | ENSMUST00000035093; ENSMUSP00000035093; ENSMUSG00000061393. ENSMUST00000165044; ENSMUSP00000126108; ENSMUSG00000061393. | ||||||||||||||||||
| GeneID | 11481. | ||||||||||||||||||
| KEGG | mmu:11481. | ||||||||||||||||||
| UCSC | uc009sax.1. mouse. uc009say.1. mouse. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| CTD | 93. | ||||||||||||||||||
| MGI | MGI:87912. Acvr2b. | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| eggNOG | COG0515. | ||||||||||||||||||
| GeneTree | ENSGT00560000076906. | ||||||||||||||||||
| HOGENOM | HOG000231495. | ||||||||||||||||||
| HOVERGEN | HBG054502. | ||||||||||||||||||
| InParanoid | P27040. | ||||||||||||||||||
| KO | K13596. | ||||||||||||||||||
| OMA | KKMRPAI. | ||||||||||||||||||
| OrthoDB | EOG4XPQFN. | ||||||||||||||||||
Enzyme and pathway databases | |||||||||||||||||||
| BRENDA | 2.7.10.2. 3474. | ||||||||||||||||||
| Reactome | REACT_127416. Developmental Biology. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| Bgee | P27040. | ||||||||||||||||||
| CleanEx | MM_ACVR2B. | ||||||||||||||||||
| Genevestigator | P27040. | ||||||||||||||||||
| GermOnline | ENSMUSG00000061393. Mus musculus. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR000333. Activin_II/TGFBeta-II_recpt. IPR015768. Activin_II_recpt. IPR000472. Activin_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view] | ||||||||||||||||||
| PANTHER | PTHR23255:SF10. PTHR23255:SF10. 1 hit. | ||||||||||||||||||
| Pfam | PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view] | ||||||||||||||||||
| PRINTS | PR00653. ACTIVIN2R. | ||||||||||||||||||
| SUPFAM | SSF56112. Kinase_like. 1 hit. | ||||||||||||||||||
| PROSITE | PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other | |||||||||||||||||||
| EvolutionaryTrace | P27040. | ||||||||||||||||||
| NextBio | 278832. | ||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||
Entry information
| Entry name | AVR2B_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P27040 Secondary accession number(s): Q3KQI1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |