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Protein

Activin receptor type-2B

Gene

Acvr2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor (By similarity).By similarity

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei241ATPPROSITE-ProRule annotation1
Active sitei345Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi220 – 228ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • activin binding Source: MGI
  • ATP binding Source: UniProtKB-KW
  • growth factor binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine/tyrosine kinase activity Source: MGI
  • protein serine/threonine kinase activity Source: MGI
  • receptor signaling protein serine/threonine kinase activity Source: InterPro
  • transmembrane receptor protein serine/threonine kinase activity Source: InterPro

GO - Biological processi

  • activation of protein kinase activity Source: MGI
  • activin receptor signaling pathway Source: MGI
  • anterior/posterior pattern specification Source: MGI
  • artery development Source: BHF-UCL
  • blood vessel remodeling Source: BHF-UCL
  • BMP signaling pathway Source: MGI
  • determination of left/right symmetry Source: MGI
  • embryonic foregut morphogenesis Source: MGI
  • gastrulation with mouth forming second Source: MGI
  • heart development Source: MGI
  • insulin secretion Source: MGI
  • kidney development Source: MGI
  • lung development Source: MGI
  • lymphangiogenesis Source: BHF-UCL
  • lymphatic endothelial cell differentiation Source: BHF-UCL
  • mesoderm development Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • odontogenesis of dentin-containing tooth Source: MGI
  • organ growth Source: MGI
  • palate development Source: MGI
  • pancreas development Source: MGI
  • pattern specification process Source: MGI
  • positive regulation of activin receptor signaling pathway Source: MGI
  • positive regulation of bone mineralization Source: MGI
  • positive regulation of osteoblast differentiation Source: MGI
  • post-embryonic development Source: MGI
  • regulation of signal transduction Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • response to glucose Source: MGI
  • retina vasculature development in camera-type eye Source: BHF-UCL
  • signal transduction Source: MGI
  • skeletal system development Source: MGI
  • skeletal system morphogenesis Source: MGI
  • venous blood vessel development Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 3474.
ReactomeiR-MMU-1181150. Signaling by NODAL.
R-MMU-1502540. Signaling by Activin.
R-MMU-201451. Signaling by BMP.

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-2B (EC:2.7.11.30)
Alternative name(s):
Activin receptor type IIB
Short name:
ACTR-IIB
Gene namesi
Name:Acvr2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:87912. Acvr2b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 137ExtracellularSequence analysisAdd BLAST119
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 536CytoplasmicSequence analysisAdd BLAST378

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000002440519 – 536Activin receptor type-2BAdd BLAST518

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 59By similarity
Glycosylationi42N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi49 ↔ 77By similarity
Glycosylationi65N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi84 ↔ 103By similarity
Disulfide bondi90 ↔ 102By similarity
Disulfide bondi104 ↔ 109By similarity

Post-translational modificationi

Phosphorylated. Constitutive phosphorylation is in part catalyzed by its own kinase activity (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP27040.
PaxDbiP27040.
PRIDEiP27040.

PTM databases

PhosphoSitePlusiP27040.

Expressioni

Gene expression databases

BgeeiENSMUSG00000061393.
CleanExiMM_ACVR2B.
GenevisibleiP27040. MM.

Interactioni

Subunit structurei

Forms an activin receptor complex with activin type II receptors such as ACVR1B. Interacts with VPS39.By similarity

GO - Molecular functioni

  • activin binding Source: MGI
  • growth factor binding Source: MGI

Protein-protein interaction databases

BioGridi197956. 1 interactor.
DIPiDIP-5799N.
IntActiP27040. 1 interactor.
MINTiMINT-2842249.
STRINGi10090.ENSMUSP00000126108.

Structurei

Secondary structure

1536
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi28 – 33Combined sources6
Turni34 – 40Combined sources7
Beta strandi43 – 48Combined sources6
Beta strandi57 – 66Combined sources10
Beta strandi69 – 79Combined sources11
Helixi82 – 84Combined sources3
Beta strandi88 – 92Combined sources5
Beta strandi93 – 96Combined sources4
Beta strandi98 – 106Combined sources9
Turni107 – 110Combined sources4
Beta strandi111 – 115Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S4YX-ray2.30A/C23-120[»]
2H64X-ray1.92C19-117[»]
ProteinModelPortaliP27040.
SMRiP27040.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27040.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini214 – 504Protein kinasePROSITE-ProRule annotationAdd BLAST291

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3653. Eukaryota.
ENOG410XS2Z. LUCA.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000231495.
HOVERGENiHBG054502.
InParanoidiP27040.
KOiK13596.
OMAiILLAFWM.
OrthoDBiEOG091G03YO.
PhylomeDBiP27040.
TreeFamiTF352876.

Family and domain databases

InterProiIPR000472. Activin_recp.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: ActR-IIB1 and ActR-IIB2 have similar but higher affinities for activin A than ActR-II, ActR-IIB3 and ActR-IIB4.
Isoform ActR-IIB1 (identifier: P27040-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTAPWAALAL LWGSLCAGSG RGEAETRECI YYNANWELER TNQSGLERCE
60 70 80 90 100
GEQDKRLHCY ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVY
110 120 130 140 150
FCCCEGNFCN ERFTHLPEPG GPEVTYEPPP TAPTLLTVLA YSLLPIGGLS
160 170 180 190 200
LIVLLAFWMY RHRKPPYGHV DIHEVRQCQR WAGRRDGCAD SFKPLPFQDP
210 220 230 240 250
GPPPPSPLVG LKPLQLLEIK ARGRFGCVWK AQLMNDFVAV KIFPLQDKQS
260 270 280 290 300
WQSEREIFST PGMKHENLLQ FIAAEKRGSN LEVELWLITA FHDKGSLTDY
310 320 330 340 350
LKGNIITWNE LCHVAETMSR GLSYLHEDVP WCRGEGHKPS IAHRDFKSKN
360 370 380 390 400
VLLKSDLTAV LADFGLAVRF EPGKPPGDTH GQVGTRRYMA PEVLEGAINF
410 420 430 440 450
QRDAFLRIDM YAMGLVLWEL VSRCKAADGP VDEYMLPFEE EIGQHPSLEE
460 470 480 490 500
LQEVVVHKKM RPTIKDHWLK HPGLAQLCVT IEECWDHDAE ARLSAGCVEE
510 520 530
RVSLIRRSVN GTTSDCLVSL VTSVTNVDLL PKESSI
Length:536
Mass (Da):60,542
Last modified:August 1, 1992 - v1
Checksum:iBF1C8CAC974BF5E2
GO
Isoform ActR-IIB2 (identifier: P27040-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     175-198: Missing.

Show »
Length:512
Mass (Da):57,738
Checksum:iF8C53AE6D0825D7A
GO
Isoform ActR-IIB3 (identifier: P27040-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-131: Missing.

Show »
Length:528
Mass (Da):59,657
Checksum:i1559B59DEAF7733B
GO
Isoform ActR-IIB4 (identifier: P27040-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-131: Missing.
     175-198: Missing.

Show »
Length:504
Mass (Da):56,853
Checksum:i42A315009EE8C17A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004951124 – 131Missing in isoform ActR-IIB3 and isoform ActR-IIB4. 1 Publication8
Alternative sequenceiVSP_004952175 – 198Missing in isoform ActR-IIB2 and isoform ActR-IIB4. 2 PublicationsAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84120 mRNA. Translation: AAA37172.1.
BC106189 mRNA. Translation: AAI06190.1.
CCDSiCCDS23615.1. [P27040-1]
PIRiA40829.
B40829.
C40829.
D40829.
RefSeqiNP_001300686.1. NM_001313757.1. [P27040-2]
NP_031423.1. NM_007397.3. [P27040-1]
XP_006511989.1. XM_006511926.3. [P27040-4]
UniGeneiMm.390239.
Mm.8940.

Genome annotation databases

EnsembliENSMUST00000035093; ENSMUSP00000035093; ENSMUSG00000061393. [P27040-3]
ENSMUST00000165044; ENSMUSP00000126108; ENSMUSG00000061393. [P27040-1]
GeneIDi11481.
KEGGimmu:11481.
UCSCiuc009sax.1. mouse. [P27040-1]
uc009say.1. mouse. [P27040-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84120 mRNA. Translation: AAA37172.1.
BC106189 mRNA. Translation: AAI06190.1.
CCDSiCCDS23615.1. [P27040-1]
PIRiA40829.
B40829.
C40829.
D40829.
RefSeqiNP_001300686.1. NM_001313757.1. [P27040-2]
NP_031423.1. NM_007397.3. [P27040-1]
XP_006511989.1. XM_006511926.3. [P27040-4]
UniGeneiMm.390239.
Mm.8940.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S4YX-ray2.30A/C23-120[»]
2H64X-ray1.92C19-117[»]
ProteinModelPortaliP27040.
SMRiP27040.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi197956. 1 interactor.
DIPiDIP-5799N.
IntActiP27040. 1 interactor.
MINTiMINT-2842249.
STRINGi10090.ENSMUSP00000126108.

PTM databases

PhosphoSitePlusiP27040.

Proteomic databases

MaxQBiP27040.
PaxDbiP27040.
PRIDEiP27040.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035093; ENSMUSP00000035093; ENSMUSG00000061393. [P27040-3]
ENSMUST00000165044; ENSMUSP00000126108; ENSMUSG00000061393. [P27040-1]
GeneIDi11481.
KEGGimmu:11481.
UCSCiuc009sax.1. mouse. [P27040-1]
uc009say.1. mouse. [P27040-2]

Organism-specific databases

CTDi93.
MGIiMGI:87912. Acvr2b.

Phylogenomic databases

eggNOGiKOG3653. Eukaryota.
ENOG410XS2Z. LUCA.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000231495.
HOVERGENiHBG054502.
InParanoidiP27040.
KOiK13596.
OMAiILLAFWM.
OrthoDBiEOG091G03YO.
PhylomeDBiP27040.
TreeFamiTF352876.

Enzyme and pathway databases

BRENDAi2.7.10.2. 3474.
ReactomeiR-MMU-1181150. Signaling by NODAL.
R-MMU-1502540. Signaling by Activin.
R-MMU-201451. Signaling by BMP.

Miscellaneous databases

EvolutionaryTraceiP27040.
PROiP27040.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061393.
CleanExiMM_ACVR2B.
GenevisibleiP27040. MM.

Family and domain databases

InterProiIPR000472. Activin_recp.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAVR2B_MOUSE
AccessioniPrimary (citable) accession number: P27040
Secondary accession number(s): Q3KQI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 2, 2016
This is version 167 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.