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P27039 (AVR2A_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Activin receptor type-2A

EC=2.7.11.30
Alternative name(s):
Activin receptor type IIA
Short name=ACTR-IIA
Gene names
Name:acvr2a
Synonyms:acvr2
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length514 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for activin A, activin B and inhibin A. Involved in transmembrane signaling.

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 514494Activin receptor type-2A
PRO_0000024402

Regions

Topological domain21 – 136116Extracellular Potential
Transmembrane137 – 16226Helical; Potential
Topological domain163 – 514352Cytoplasmic Potential
Domain193 – 486294Protein kinase
Nucleotide binding199 – 2079ATP By similarity

Sites

Active site3231Proton acceptor By similarity
Binding site2201ATP By similarity

Amino acid modifications

Glycosylation461N-linked (GlcNAc...) Potential
Glycosylation671N-linked (GlcNAc...) Potential
Glycosylation881N-linked (GlcNAc...) Potential
Disulfide bond31 ↔ 61 By similarity
Disulfide bond51 ↔ 79 By similarity
Disulfide bond86 ↔ 105 By similarity
Disulfide bond92 ↔ 104 By similarity
Disulfide bond106 ↔ 111 By similarity

Sequences

Sequence LengthMass (Da)Tools
P27039 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 9FA4B4D7F9756C26

FASTA51457,904
        10         20         30         40         50         60 
MGAATKLAFA VFLISCSSAG SILGRSETKE CIYYNANWEK DKTNSNGTEI CYGDNDKRKH 

        70         80         90        100        110        120 
CFATWKNISG SIEIVKQGCW LDDINCYNKS KCTEKKDSPD VFFCCCEGNY CNEKFYHSPE 

       130        140        150        160        170        180 
MEVTQPTSNP VTTKPPLFNT LLYSLVPIMV VAVIVLFSFW MYRHHKLAYP PVLVPTQDPG 

       190        200        210        220        230        240 
PPPPSPLLGL KPLQLLEVKA RGRFGCVWKA QLLNETVAVK IFPVQDKLSW QNEYEIYSLP 

       250        260        270        280        290        300 
GMKHENILYF IGAEKRGTNL DTDLWLITAF HEKGSLTDYL KANVVSWNEL CLIAETMARG 

       310        320        330        340        350        360 
LSHLHEDIPG LKDGHKPAVA HRDIKSKNVL LKNNLTACIA DFGLALKFEA GKSAGDTHGQ 

       370        380        390        400        410        420 
VGTRRYMAPE VLEGAINFQR DAFLRIDMYA FGLVLWELAS RCTASDGPVD EYMLPFEEEV 

       430        440        450        460        470        480 
GQHPSLEDMQ EVVVHKKKRP ILRECWQKHA GMAMLCETIE ECWDHDAEAR LSAGCVEERI 

       490        500        510 
IQMQKLTNII TTEDIVTVVT MVTNVDFPPK ESSL 

« Hide

References

« Hide 'large scale' references
[1]"Activin receptor mRNA is expressed early in Xenopus embryogenesis and the level of the expression affects the body axis formation."
Kondo M., Tashiro K., Fujii G., Asano M., Miyoshi R., Yamada R., Muramatsu M., Shiokawa K.
Biochem. Biophys. Res. Commun. 181:684-690(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S70930 mRNA. Translation: AAB20638.1.
BC066770 mRNA. Translation: AAH66770.1.
PIRJQ1317.
RefSeqNP_001084061.1. NM_001090592.1.
UniGeneXl.1080.

3D structure databases

ProteinModelPortalP27039.
SMRP27039. Positions 27-120, 193-480.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID399283.
KEGGxla:399283.

Organism-specific databases

CTD92.
XenbaseXB-GENE-865037. acvr2a.

Phylogenomic databases

HOVERGENHBG054502.
KOK04670.

Enzyme and pathway databases

BRENDA2.7.10.2. 6726.

Family and domain databases

InterProIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERPTHR23255:SF10. PTHR23255:SF10. 1 hit.
PfamPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSPR00653. ACTIVIN2R.
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAVR2A_XENLA
AccessionPrimary (citable) accession number: P27039
Secondary accession number(s): Q5D043
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families