Activin receptor type-2A precursor - Xenopus laevis (African clawed frog)

Contribute

Send feedback

Read comments (?) or add your own

P27039 (AVR2A_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 97. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Activin receptor type-2A
EC=2.7.11.30

Alternative name(s):
Activin receptor type IIA
Short name=ACTR-IIA

Gene names

Name:	acvr2a
Synonyms:	acvr2

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	514 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for activin A, activin B and inhibin A. Involved in transmembrane signaling.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological_process	signal transduction by phosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW activin-activated receptor activity Inferred from electronic annotation. Source: InterPro receptor signaling protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro transforming growth factor beta-activated receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 20

Potential

Chain

21 – 514

494

Activin receptor type-2A

PRO_0000024402

Regions

Topological domain

21 – 136

116

Extracellular Potential

Transmembrane

137 – 162

Helical; Potential

Topological domain

163 – 514

352

Cytoplasmic Potential

Domain

193 – 486

294

Protein kinase

Nucleotide binding

199 – 207

ATP By similarity

Sites

Active site

323

Proton acceptor By similarity

Binding site

220

ATP By similarity

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

31 ↔ 61

By similarity

Disulfide bond

51 ↔ 79

By similarity

Disulfide bond

86 ↔ 105

By similarity

Disulfide bond

92 ↔ 104

By similarity

Disulfide bond

106 ↔ 111

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P27039 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 9FA4B4D7F9756C26
Show »

FASTA

514

57,904

        10         20         30         40         50         60 
MGAATKLAFA VFLISCSSAG SILGRSETKE CIYYNANWEK DKTNSNGTEI CYGDNDKRKH 

        70         80         90        100        110        120 
CFATWKNISG SIEIVKQGCW LDDINCYNKS KCTEKKDSPD VFFCCCEGNY CNEKFYHSPE 

       130        140        150        160        170        180 
MEVTQPTSNP VTTKPPLFNT LLYSLVPIMV VAVIVLFSFW MYRHHKLAYP PVLVPTQDPG 

       190        200        210        220        230        240 
PPPPSPLLGL KPLQLLEVKA RGRFGCVWKA QLLNETVAVK IFPVQDKLSW QNEYEIYSLP 

       250        260        270        280        290        300 
GMKHENILYF IGAEKRGTNL DTDLWLITAF HEKGSLTDYL KANVVSWNEL CLIAETMARG 

       310        320        330        340        350        360 
LSHLHEDIPG LKDGHKPAVA HRDIKSKNVL LKNNLTACIA DFGLALKFEA GKSAGDTHGQ 

       370        380        390        400        410        420 
VGTRRYMAPE VLEGAINFQR DAFLRIDMYA FGLVLWELAS RCTASDGPVD EYMLPFEEEV 

       430        440        450        460        470        480 
GQHPSLEDMQ EVVVHKKKRP ILRECWQKHA GMAMLCETIE ECWDHDAEAR LSAGCVEERI 

       490        500        510 
IQMQKLTNII TTEDIVTVVT MVTNVDFPPK ESSL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Activin receptor mRNA is expressed early in Xenopus embryogenesis and the level of the expression affects the body axis formation." Kondo M., Tashiro K., Fujii G., Asano M., Miyoshi R., Yamada R., Muramatsu M., Shiokawa K. Biochem. Biophys. Res. Commun. 181:684-690(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	NIH - Xenopus Gene Collection (XGC) project Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S70930 mRNA. Translation: AAB20638.1. BC066770 mRNA. Translation: AAH66770.1.
PIR	JQ1317.
RefSeq	NP_001084061.1. NM_001090592.1.
UniGene	Xl.1080.
3D structure databases
ProteinModelPortal	P27039.
SMR	P27039. Positions 27-120, 193-480.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	399283.
KEGG	xla:399283.
Organism-specific databases
CTD	92.
Xenbase	XB-GENE-865037. acvr2a.
Phylogenomic databases
HOVERGEN	HBG054502.
KO	K04670.
Enzyme and pathway databases
BRENDA	2.7.10.2. 6726.
Family and domain databases
InterPro	IPR000333. Activin_II/TGFBeta-II_recpt. IPR015768. Activin_II_recpt. IPR000472. Activin_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
PANTHER	PTHR23255:SF10. PTHR23255:SF10. 1 hit.
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
PRINTS	PR00653. ACTIVIN2R.
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AVR2A_XENLA

Accession

Primary (citable) accession number: P27039
Secondary accession number(s): Q5D043

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	April 3, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents