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Protein

Activin receptor type-2A

Gene

acvr2a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for activin A, activin B and inhibin A. Involved in transmembrane signaling.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei220ATPPROSITE-ProRule annotation1
Active sitei323Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi199 – 207ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 6725.

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-2A (EC:2.7.11.30)
Alternative name(s):
Activin receptor type IIA
Short name:
ACTR-IIA
Gene namesi
Name:acvr2a
Synonyms:acvr2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865037. acvr2a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 136ExtracellularSequence analysisAdd BLAST116
Transmembranei137 – 162HelicalSequence analysisAdd BLAST26
Topological domaini163 – 514CytoplasmicSequence analysisAdd BLAST352

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002440221 – 514Activin receptor type-2AAdd BLAST494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 61By similarity
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi51 ↔ 79By similarity
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi86 ↔ 105By similarity
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi92 ↔ 104By similarity
Disulfide bondi106 ↔ 111By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP27039.
SMRiP27039.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini193 – 486Protein kinasePROSITE-ProRule annotationAdd BLAST294

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG054502.
KOiK04670.

Family and domain databases

InterProiView protein in InterPro
IPR000472. Activin_recp.
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiView protein in Pfam
PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PRINTSiPR00653. ACTIVIN2R.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27039-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAATKLAFA VFLISCSSAG SILGRSETKE CIYYNANWEK DKTNSNGTEI
60 70 80 90 100
CYGDNDKRKH CFATWKNISG SIEIVKQGCW LDDINCYNKS KCTEKKDSPD
110 120 130 140 150
VFFCCCEGNY CNEKFYHSPE MEVTQPTSNP VTTKPPLFNT LLYSLVPIMV
160 170 180 190 200
VAVIVLFSFW MYRHHKLAYP PVLVPTQDPG PPPPSPLLGL KPLQLLEVKA
210 220 230 240 250
RGRFGCVWKA QLLNETVAVK IFPVQDKLSW QNEYEIYSLP GMKHENILYF
260 270 280 290 300
IGAEKRGTNL DTDLWLITAF HEKGSLTDYL KANVVSWNEL CLIAETMARG
310 320 330 340 350
LSHLHEDIPG LKDGHKPAVA HRDIKSKNVL LKNNLTACIA DFGLALKFEA
360 370 380 390 400
GKSAGDTHGQ VGTRRYMAPE VLEGAINFQR DAFLRIDMYA FGLVLWELAS
410 420 430 440 450
RCTASDGPVD EYMLPFEEEV GQHPSLEDMQ EVVVHKKKRP ILRECWQKHA
460 470 480 490 500
GMAMLCETIE ECWDHDAEAR LSAGCVEERI IQMQKLTNII TTEDIVTVVT
510
MVTNVDFPPK ESSL
Length:514
Mass (Da):57,904
Last modified:August 1, 1992 - v1
Checksum:i9FA4B4D7F9756C26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S70930 mRNA. Translation: AAB20638.1.
BC066770 mRNA. Translation: AAH66770.1.
PIRiJQ1317.
RefSeqiNP_001084061.1. NM_001090592.1.
UniGeneiXl.1080.

Genome annotation databases

GeneIDi399283.
KEGGixla:399283.

Similar proteinsi

Entry informationi

Entry nameiAVR2A_XENLA
AccessioniPrimary (citable) accession number: P27039
Secondary accession number(s): Q5D043
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 22, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families