Reviewed,
UniProtKB/Swiss-Prot P27039 (AVR2A_XENLA)
Last modified
October 13, 2009.
Version 76.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Activin receptor type-2A EC=2.7.11.30 Alternative name(s): Activin receptor type IIA Short name=ACTR-IIA | ||||
| Gene names |
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| Organism | Xenopus laevis (African clawed frog) | ||||
| Taxonomic identifier | 8355 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Protein attributes
| Sequence length | 514 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Receptor for activin A, activin B and inhibin A. Involved in transmembrane signaling. |
| Catalytic activity | ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. |
| Subcellular location | |
| Sequence similarities | Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Signal Transmembrane |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Receptor Serine/threonine-protein kinase Transferase |
| PTM | Disulfide bond Glycoprotein |
| Gene Ontology (GO) | |
| Biological process | activin receptor signaling pathway Inferred from electronic annotation. Source: InterPro protein amino acid phosphorylationInferred from electronic annotation. Source: InterPro |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW activin receptor activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 20 | 20 | Potential | ||||||||
| Chain | 21 – 514 | 494 | Activin receptor type-2A | PRO_0000024402 | |||||||
Regions | |||||||||||
| Topological domain | 21 – 136 | 116 | Extracellular Potential | ||||||||
| Transmembrane | 137 – 162 | 26 | Potential | ||||||||
| Topological domain | 163 – 514 | 352 | Cytoplasmic Potential | ||||||||
| Domain | 193 – 486 | 294 | Protein kinase | ||||||||
| Nucleotide binding | 199 – 207 | 9 | ATP By similarity | ||||||||
Sites | |||||||||||
| Active site | 323 | 1 | Proton acceptor By similarity | ||||||||
| Binding site | 220 | 1 | ATP By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 46 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 67 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 88 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 31 ↔ 61 | By similarity | |||||||||
| Disulfide bond | 51 ↔ 79 | By similarity | |||||||||
| Disulfide bond | 86 ↔ 105 | By similarity | |||||||||
| Disulfide bond | 92 ↔ 104 | By similarity | |||||||||
| Disulfide bond | 106 ↔ 111 | By similarity | |||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Activin receptor mRNA is expressed early in Xenopus embryogenesis and the level of the expression affects the body axis formation." Kondo M., Tashiro K., Fujii G., Asano M., Miyoshi R., Yamada R., Muramatsu M., Shiokawa K. Biochem. Biophys. Res. Commun. 181:684-690(1991) [PubMed: 1661587] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | NIH - Xenopus Gene Collection (XGC) project Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo. |
Cross-references
Sequence databases | |
|---|---|
| S70930 mRNA. Translation: AAB20638.1. BC066770 mRNA. Translation: AAH66770.1. | |
| PIR | JQ1317. |
| RefSeq | NP_001084061.1. |
| UniGene | Xl.1080 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1BTE based on UniProtKB P27038. |
| SMR | P27039. Positions 27-120. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 399283. |
| KEGG | xla:399283. |
Organism-specific databases | |
| CTD | 399283. |
| Xenbase | XB-FEAT-484011. acvr2a. |
Phylogenomic databases | |
| HOVERGEN | P27039. |
Enzyme and pathway databases | |
| BRENDA | 2.7.10.2. 648. 2.7.11.30. 648. |
Family and domain databases | |
| InterPro | IPR000333. Activin_II_recpt. IPR015768. Activin_II_recpt_C. IPR000472. Activin_rcpt. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. [Graphical view] |
| PANTHER | PTHR23255:SF10. Activin_II_recpt_C. 1 hit. |
| Pfam | PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view] |
| PRINTS | PR00653. ACTIVIN2R. |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AVR2A_XENLA | ||||||||
| Accession | Primary (citable) accession number: P27039 Secondary accession number(s): Q5D043 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Xenopus annotation project | ||||||||

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