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Protein

Activin receptor type-2A

Gene

acvr2a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for activin A, activin B and inhibin A. Involved in transmembrane signaling.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei220ATPPROSITE-ProRule annotation1
Active sitei323Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi199 – 207ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 6725.

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-2A (EC:2.7.11.30)
Alternative name(s):
Activin receptor type IIA
Short name:
ACTR-IIA
Gene namesi
Name:acvr2a
Synonyms:acvr2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865037. acvr2a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 136ExtracellularSequence analysisAdd BLAST116
Transmembranei137 – 162HelicalSequence analysisAdd BLAST26
Topological domaini163 – 514CytoplasmicSequence analysisAdd BLAST352

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002440221 – 514Activin receptor type-2AAdd BLAST494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 61By similarity
Glycosylationi46N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi51 ↔ 79By similarity
Glycosylationi67N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi86 ↔ 105By similarity
Glycosylationi88N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi92 ↔ 104By similarity
Disulfide bondi106 ↔ 111By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP27039.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini193 – 486Protein kinasePROSITE-ProRule annotationAdd BLAST294

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG054502.
KOiK04670.

Family and domain databases

InterProiIPR000472. Activin_recp.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27039-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAATKLAFA VFLISCSSAG SILGRSETKE CIYYNANWEK DKTNSNGTEI
60 70 80 90 100
CYGDNDKRKH CFATWKNISG SIEIVKQGCW LDDINCYNKS KCTEKKDSPD
110 120 130 140 150
VFFCCCEGNY CNEKFYHSPE MEVTQPTSNP VTTKPPLFNT LLYSLVPIMV
160 170 180 190 200
VAVIVLFSFW MYRHHKLAYP PVLVPTQDPG PPPPSPLLGL KPLQLLEVKA
210 220 230 240 250
RGRFGCVWKA QLLNETVAVK IFPVQDKLSW QNEYEIYSLP GMKHENILYF
260 270 280 290 300
IGAEKRGTNL DTDLWLITAF HEKGSLTDYL KANVVSWNEL CLIAETMARG
310 320 330 340 350
LSHLHEDIPG LKDGHKPAVA HRDIKSKNVL LKNNLTACIA DFGLALKFEA
360 370 380 390 400
GKSAGDTHGQ VGTRRYMAPE VLEGAINFQR DAFLRIDMYA FGLVLWELAS
410 420 430 440 450
RCTASDGPVD EYMLPFEEEV GQHPSLEDMQ EVVVHKKKRP ILRECWQKHA
460 470 480 490 500
GMAMLCETIE ECWDHDAEAR LSAGCVEERI IQMQKLTNII TTEDIVTVVT
510
MVTNVDFPPK ESSL
Length:514
Mass (Da):57,904
Last modified:August 1, 1992 - v1
Checksum:i9FA4B4D7F9756C26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S70930 mRNA. Translation: AAB20638.1.
BC066770 mRNA. Translation: AAH66770.1.
PIRiJQ1317.
RefSeqiNP_001084061.1. NM_001090592.1.
UniGeneiXl.1080.

Genome annotation databases

GeneIDi399283.
KEGGixla:399283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S70930 mRNA. Translation: AAB20638.1.
BC066770 mRNA. Translation: AAH66770.1.
PIRiJQ1317.
RefSeqiNP_001084061.1. NM_001090592.1.
UniGeneiXl.1080.

3D structure databases

ProteinModelPortaliP27039.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399283.
KEGGixla:399283.

Organism-specific databases

CTDi92.
XenbaseiXB-GENE-865037. acvr2a.

Phylogenomic databases

HOVERGENiHBG054502.
KOiK04670.

Enzyme and pathway databases

BRENDAi2.7.10.2. 6725.

Family and domain databases

InterProiIPR000472. Activin_recp.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAVR2A_XENLA
AccessioniPrimary (citable) accession number: P27039
Secondary accession number(s): Q5D043
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 5, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.