Reviewed, UniProtKB/Swiss-Prot P27039 (AVR2A_XENLA)

Names and origin

Protein names

Recommended name:
    Activin receptor type-2A
    EC=2.7.11.30
Alternative name(s):
    Activin receptor type IIA
      Short name=ACTR-IIA

Gene names

Name:	acvr2a
Synonyms:	acvr2

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	514 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for activin A, activin B and inhibin A. Involved in transmembrane signaling.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	activin receptor signaling pathway Inferred from electronic annotation. Source: InterPro protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW activin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 514	494	Activin receptor type-2A		PRO_0000024402
Regions
	Topological domain	21 – 136	116	Extracellular Potential
	Transmembrane	137 – 162	26	Potential
	Topological domain	163 – 514	352	Cytoplasmic Potential
	Domain	193 – 486	294	Protein kinase
	Nucleotide binding	199 – 207	9	ATP By similarity
Sites
	Active site	323	1	Proton acceptor By similarity
	Binding site	220	1	ATP By similarity
Amino acid modifications
	Glycosylation	46	1	N-linked (GlcNAc...) Potential
	Glycosylation	67	1	N-linked (GlcNAc...) Potential
	Glycosylation	88	1	N-linked (GlcNAc...) Potential
	Disulfide bond	31 ↔ 61		By similarity
	Disulfide bond	51 ↔ 79		By similarity
	Disulfide bond	86 ↔ 105		By similarity
	Disulfide bond	92 ↔ 104		By similarity
	Disulfide bond	106 ↔ 111		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P27039-1 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 9FA4B4D7F9756C26	FASTA	514	57,904
	10 20 30 40 50 60 MGAATKLAFA VFLISCSSAG SILGRSETKE CIYYNANWEK DKTNSNGTEI CYGDNDKRKH 70 80 90 100 110 120 CFATWKNISG SIEIVKQGCW LDDINCYNKS KCTEKKDSPD VFFCCCEGNY CNEKFYHSPE 130 140 150 160 170 180 MEVTQPTSNP VTTKPPLFNT LLYSLVPIMV VAVIVLFSFW MYRHHKLAYP PVLVPTQDPG 190 200 210 220 230 240 PPPPSPLLGL KPLQLLEVKA RGRFGCVWKA QLLNETVAVK IFPVQDKLSW QNEYEIYSLP 250 260 270 280 290 300 GMKHENILYF IGAEKRGTNL DTDLWLITAF HEKGSLTDYL KANVVSWNEL CLIAETMARG 310 320 330 340 350 360 LSHLHEDIPG LKDGHKPAVA HRDIKSKNVL LKNNLTACIA DFGLALKFEA GKSAGDTHGQ 370 380 390 400 410 420 VGTRRYMAPE VLEGAINFQR DAFLRIDMYA FGLVLWELAS RCTASDGPVD EYMLPFEEEV 430 440 450 460 470 480 GQHPSLEDMQ EVVVHKKKRP ILRECWQKHA GMAMLCETIE ECWDHDAEAR LSAGCVEERI 490 500 510 IQMQKLTNII TTEDIVTVVT MVTNVDFPPK ESSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Activin receptor mRNA is expressed early in Xenopus embryogenesis and the level of the expression affects the body axis formation." Kondo M., Tashiro K., Fujii G., Asano M., Miyoshi R., Yamada R., Muramatsu M., Shiokawa K. Biochem. Biophys. Res. Commun. 181:684-690(1991) [PubMed: 1661587] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	NIH - Xenopus Gene Collection (XGC) project Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	S70930 mRNA. Translation: AAB20638.1. BC066770 mRNA. Translation: AAH66770.1.
PIR	JQ1317.
RefSeq	NP_001084061.1.
UniGene	Xl.1080
3D structure databases
HSSP	HSSP built from PDB template 1BTE based on UniProtKB P27038.
SMR	P27039. Positions 27-120.
ModBase	Search...
Genome annotation databases
GeneID	399283.
KEGG	xla:399283.
Organism-specific databases
CTD	399283.
Xenbase	XB-FEAT-484011. acvr2a.
Phylogenomic databases
HOVERGEN	P27039.
Enzyme and pathway databases
BRENDA	2.7.10.2. 648. 2.7.11.30. 648.
Family and domain databases
InterPro	IPR000333. Activin_II_recpt. IPR015768. Activin_II_recpt_C. IPR000472. Activin_rcpt. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. [Graphical view]
PANTHER	PTHR23255:SF10. Activin_II_recpt_C. 1 hit.
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
PRINTS	PR00653. ACTIVIN2R.
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AVR2A_XENLA

Accession

Primary (citable) accession number: P27039
Secondary accession number(s): Q5D043

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	October 13, 2009
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project