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P27039

- AVR2A_XENLA

UniProt

P27039 - AVR2A_XENLA

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Protein

Activin receptor type-2A

Gene

acvr2a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for activin A, activin B and inhibin A. Involved in transmembrane signaling.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei220 – 2201ATPPROSITE-ProRule annotation
Active sitei323 – 3231Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi199 – 2079ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. receptor signaling protein serine/threonine kinase activity Source: InterPro
  3. transforming growth factor beta-activated receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 6726.

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-2A (EC:2.7.11.30)
Alternative name(s):
Activin receptor type IIA
Short name:
ACTR-IIA
Gene namesi
Name:acvr2a
Synonyms:acvr2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865037. acvr2a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 136116ExtracellularSequence AnalysisAdd
BLAST
Transmembranei137 – 16226HelicalSequence AnalysisAdd
BLAST
Topological domaini163 – 514352CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 514494Activin receptor type-2APRO_0000024402Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 61By similarity
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi51 ↔ 79By similarity
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi86 ↔ 105By similarity
Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi92 ↔ 104By similarity
Disulfide bondi106 ↔ 111By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP27039.
SMRiP27039. Positions 27-120, 193-480.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini193 – 486294Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG054502.
KOiK04670.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27039-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGAATKLAFA VFLISCSSAG SILGRSETKE CIYYNANWEK DKTNSNGTEI
60 70 80 90 100
CYGDNDKRKH CFATWKNISG SIEIVKQGCW LDDINCYNKS KCTEKKDSPD
110 120 130 140 150
VFFCCCEGNY CNEKFYHSPE MEVTQPTSNP VTTKPPLFNT LLYSLVPIMV
160 170 180 190 200
VAVIVLFSFW MYRHHKLAYP PVLVPTQDPG PPPPSPLLGL KPLQLLEVKA
210 220 230 240 250
RGRFGCVWKA QLLNETVAVK IFPVQDKLSW QNEYEIYSLP GMKHENILYF
260 270 280 290 300
IGAEKRGTNL DTDLWLITAF HEKGSLTDYL KANVVSWNEL CLIAETMARG
310 320 330 340 350
LSHLHEDIPG LKDGHKPAVA HRDIKSKNVL LKNNLTACIA DFGLALKFEA
360 370 380 390 400
GKSAGDTHGQ VGTRRYMAPE VLEGAINFQR DAFLRIDMYA FGLVLWELAS
410 420 430 440 450
RCTASDGPVD EYMLPFEEEV GQHPSLEDMQ EVVVHKKKRP ILRECWQKHA
460 470 480 490 500
GMAMLCETIE ECWDHDAEAR LSAGCVEERI IQMQKLTNII TTEDIVTVVT
510
MVTNVDFPPK ESSL
Length:514
Mass (Da):57,904
Last modified:August 1, 1992 - v1
Checksum:i9FA4B4D7F9756C26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S70930 mRNA. Translation: AAB20638.1.
BC066770 mRNA. Translation: AAH66770.1.
PIRiJQ1317.
RefSeqiNP_001084061.1. NM_001090592.1.
UniGeneiXl.1080.

Genome annotation databases

GeneIDi399283.
KEGGixla:399283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S70930 mRNA. Translation: AAB20638.1 .
BC066770 mRNA. Translation: AAH66770.1 .
PIRi JQ1317.
RefSeqi NP_001084061.1. NM_001090592.1.
UniGenei Xl.1080.

3D structure databases

ProteinModelPortali P27039.
SMRi P27039. Positions 27-120, 193-480.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 399283.
KEGGi xla:399283.

Organism-specific databases

CTDi 92.
Xenbasei XB-GENE-865037. acvr2a.

Phylogenomic databases

HOVERGENi HBG054502.
KOi K04670.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 6726.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
PRINTSi PR00653. ACTIVIN2R.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Activin receptor mRNA is expressed early in Xenopus embryogenesis and the level of the expression affects the body axis formation."
    Kondo M., Tashiro K., Fujii G., Asano M., Miyoshi R., Yamada R., Muramatsu M., Shiokawa K.
    Biochem. Biophys. Res. Commun. 181:684-690(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiAVR2A_XENLA
AccessioniPrimary (citable) accession number: P27039
Secondary accession number(s): Q5D043
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 1, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3