Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Activin receptor type-2A

Gene

Acvr2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (PubMed:23527555).1 Publication

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei219ATPPROSITE-ProRule annotation1
Active sitei322Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi198 – 206ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • activin-activated receptor activity Source: Ensembl
  • activin binding Source: MGI
  • ATP binding Source: UniProtKB-KW
  • BMP receptor activity Source: UniProtKB
  • coreceptor activity Source: MGI
  • growth factor binding Source: MGI
  • inhibin binding Source: BHF-UCL
  • metal ion binding Source: UniProtKB-KW
  • PDZ domain binding Source: UniProtKB
  • protein self-association Source: MGI
  • protein serine/threonine kinase activity Source: MGI
  • receptor signaling protein serine/threonine kinase activity Source: InterPro

GO - Biological processi

  • activin receptor signaling pathway Source: MGI
  • anterior/posterior pattern specification Source: MGI
  • BMP signaling pathway Source: UniProtKB
  • cellular response to BMP stimulus Source: MGI
  • determination of left/right symmetry Source: MGI
  • embryonic skeletal system development Source: MGI
  • gastrulation with mouth forming second Source: MGI
  • male gonad development Source: MGI
  • mesoderm development Source: MGI
  • penile erection Source: MGI
  • positive regulation of activin receptor signaling pathway Source: MGI
  • positive regulation of bone mineralization Source: MGI
  • positive regulation of erythrocyte differentiation Source: MGI
  • positive regulation of osteoblast differentiation Source: MGI
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
  • positive regulation of protein phosphorylation Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of BMP signaling pathway Source: MGI
  • regulation of nitric-oxide synthase activity Source: MGI
  • regulation of signal transduction Source: MGI
  • Sertoli cell proliferation Source: MGI
  • spermatogenesis Source: MGI
  • sperm ejaculation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 3474.
ReactomeiR-MMU-1181150. Signaling by NODAL.
R-MMU-1502540. Signaling by Activin.
R-MMU-201451. Signaling by BMP.

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-2A (EC:2.7.11.30)
Alternative name(s):
Activin receptor type IIA
Short name:
ACTR-IIA
Gene namesi
Name:Acvr2a
Synonyms:Acvr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:102806. Acvr2a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 135ExtracellularSequence analysisAdd BLAST116
Transmembranei136 – 161HelicalSequence analysisAdd BLAST26
Topological domaini162 – 513CytoplasmicSequence analysisAdd BLAST352

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002439920 – 513Activin receptor type-2AAdd BLAST494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 601 Publication
Glycosylationi43N-linked (GlcNAc...)1
Disulfide bondi50 ↔ 781 Publication
Glycosylationi66N-linked (GlcNAc...)1
Disulfide bondi85 ↔ 1041 Publication
Disulfide bondi91 ↔ 1031 Publication
Disulfide bondi105 ↔ 1101 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP27038.
PaxDbiP27038.
PRIDEiP27038.

PTM databases

iPTMnetiP27038.
PhosphoSitePlusiP27038.

Expressioni

Tissue specificityi

Brain, testis, intestine, liver and kidney.

Gene expression databases

BgeeiENSMUSG00000052155.
CleanExiMM_ACVR2A.
ExpressionAtlasiP27038. baseline and differential.
GenevisibleiP27038. MM.

Interactioni

Subunit structurei

Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3.1 Publication

GO - Molecular functioni

  • activin binding Source: MGI
  • growth factor binding Source: MGI
  • inhibin binding Source: BHF-UCL
  • PDZ domain binding Source: UniProtKB
  • protein self-association Source: MGI

Protein-protein interaction databases

BioGridi197955. 2 interactors.
DIPiDIP-5825N.
IntActiP27038. 1 interactor.
STRINGi10090.ENSMUSP00000067305.

Structurei

Secondary structure

1513
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 34Combined sources6
Helixi37 – 40Combined sources4
Beta strandi44 – 49Combined sources6
Beta strandi59 – 67Combined sources9
Beta strandi70 – 79Combined sources10
Helixi83 – 85Combined sources3
Beta strandi88 – 93Combined sources6
Beta strandi95 – 97Combined sources3
Beta strandi99 – 105Combined sources7
Helixi110 – 112Combined sources3
Beta strandi113 – 116Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BTEX-ray1.50A/B25-121[»]
1LX5X-ray3.30B20-121[»]
2GOOX-ray2.20C/F20-121[»]
ProteinModelPortaliP27038.
SMRiP27038.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27038.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini192 – 485Protein kinasePROSITE-ProRule annotationAdd BLAST294

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3653. Eukaryota.
ENOG410XS2Z. LUCA.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000231495.
HOVERGENiHBG054502.
InParanoidiP27038.
KOiK04670.
OMAiSCYGDKD.
OrthoDBiEOG091G03YO.
PhylomeDBiP27038.
TreeFamiTF352876.

Family and domain databases

InterProiIPR000472. Activin_recp.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27038-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWERD RTNQTGVEPC
60 70 80 90 100
YGDKDKRRHC FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV
110 120 130 140 150
YFCCCEGNMC NEKFSYFPEM EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI
160 170 180 190 200
AGIVICAFWV YRHHKMAYPP VLVPTQDPGP PPPSPLLGLK PLQLLEVKAR
210 220 230 240 250
GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG MKHENILQFI
260 270 280 290 300
GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL
310 320 330 340 350
AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG
360 370 380 390 400
KSAGDTHGQV GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR
410 420 430 440 450
CTAADGPVDE YMLPFEEEIG QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG
460 470 480 490 500
MAMLCETIEE CWDHDAEARL SAGCVGERIT QMQRLTNIIT TEDIVTVVTM
510
VTNVDFPPKE SSL
Length:513
Mass (Da):57,890
Last modified:August 1, 1992 - v1
Checksum:i475CD292506BAC61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65287 mRNA. Translation: AAA37171.1.
CCDSiCCDS16021.1.
PIRiA39896.
RefSeqiNP_031422.3. NM_007396.4.
UniGeneiMm.314338.

Genome annotation databases

EnsembliENSMUST00000063886; ENSMUSP00000067305; ENSMUSG00000052155.
GeneIDi11480.
KEGGimmu:11480.
UCSCiuc008jpn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65287 mRNA. Translation: AAA37171.1.
CCDSiCCDS16021.1.
PIRiA39896.
RefSeqiNP_031422.3. NM_007396.4.
UniGeneiMm.314338.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BTEX-ray1.50A/B25-121[»]
1LX5X-ray3.30B20-121[»]
2GOOX-ray2.20C/F20-121[»]
ProteinModelPortaliP27038.
SMRiP27038.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi197955. 2 interactors.
DIPiDIP-5825N.
IntActiP27038. 1 interactor.
STRINGi10090.ENSMUSP00000067305.

PTM databases

iPTMnetiP27038.
PhosphoSitePlusiP27038.

Proteomic databases

MaxQBiP27038.
PaxDbiP27038.
PRIDEiP27038.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063886; ENSMUSP00000067305; ENSMUSG00000052155.
GeneIDi11480.
KEGGimmu:11480.
UCSCiuc008jpn.2. mouse.

Organism-specific databases

CTDi92.
MGIiMGI:102806. Acvr2a.

Phylogenomic databases

eggNOGiKOG3653. Eukaryota.
ENOG410XS2Z. LUCA.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000231495.
HOVERGENiHBG054502.
InParanoidiP27038.
KOiK04670.
OMAiSCYGDKD.
OrthoDBiEOG091G03YO.
PhylomeDBiP27038.
TreeFamiTF352876.

Enzyme and pathway databases

BRENDAi2.7.10.2. 3474.
ReactomeiR-MMU-1181150. Signaling by NODAL.
R-MMU-1502540. Signaling by Activin.
R-MMU-201451. Signaling by BMP.

Miscellaneous databases

ChiTaRSiAcvr2a. mouse.
EvolutionaryTraceiP27038.
PROiP27038.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052155.
CleanExiMM_ACVR2A.
ExpressionAtlasiP27038. baseline and differential.
GenevisibleiP27038. MM.

Family and domain databases

InterProiIPR000472. Activin_recp.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAVR2A_MOUSE
AccessioniPrimary (citable) accession number: P27038
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 2, 2016
This is version 169 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.