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Reviewed, UniProtKB/Swiss-Prot P27038 (AVR2A_MOUSE)

Last modified July 22, 2008. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Activin receptor type-2A
    EC=2.7.11.30
Alternative name(s):
    Activin receptor type IIA
      Short name(s)=ACTR-IIA
Gene names
Name: Acvr2a
Synonyms: Acvr2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactor

Magnesium or manganese By similarity.

Subunit structure

Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Brain, testis, intestine, liver and kidney.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 protein kinase domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

BMP7P180751EBI-1036102,EBI-1035195From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 513494Activin receptor type-2A

Regions

Topological domain20 – 135116Extracellular Potential
Transmembrane136 – 16126 Potential
Topological domain162 – 513352Cytoplasmic Potential
Domain192 – 485294Protein kinase
Nucleotide binding198 – 2069ATP By similarity

Sites

Active site3221Proton acceptor By similarity
Binding site2191ATP By similarity

Amino acid modifications

Glycosylation431N-linked (GlcNAc...)
Glycosylation661N-linked (GlcNAc...)
Disulfide bond30 ↔ 60
Disulfide bond50 ↔ 78
Disulfide bond85 ↔ 104
Disulfide bond91 ↔ 103
Disulfide bond105 ↔ 110

Secondary structure

.................... 513
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P27038-1 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 475CD292506BAC61

FASTA51357,890
        10         20         30         40         50         60 
MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWERD RTNQTGVEPC YGDKDKRRHC 

        70         80         90        100        110        120 
FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV YFCCCEGNMC NEKFSYFPEM 

       130        140        150        160        170        180 
EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP 

       190        200        210        220        230        240 
PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 

       250        260        270        280        290        300 
MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 

       310        320        330        340        350        360 
AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 

       370        380        390        400        410        420 
GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG 

       430        440        450        460        470        480 
QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT 

       490        500        510 
QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL 

« Hide

References

[1]"Expression cloning of an activin receptor, a predicted transmembrane serine kinase."
Mathews L.S., Vale W.W.
Cell 65:973-982(1991) [PubMed: 1646080] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase."
Greenwald J., Fischer W.H., Vale W.W., Choe S.
Nat. Struct. Biol. 6:18-22(1999) [PubMed: 9886286] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 25-121.
[3]"The disulfide bond arrangement in the extracellular domain of the activin type II receptor."
Fischer W.H., Greenwald J., Park M., Craig A.G., Choe S., Vale W.
J. Protein Chem. 18:437-446(1999) [PubMed: 10449041] [Abstract]
Cited for: DISULFIDE BONDS IN EXTRACELLULAR DOMAIN.
[4]"Identification and characterization of a PDZ protein that interacts with activin types II receptors."
Shoji H., Tsuchida K., Kishi H., Yamakawa N., Matsuzaki T., Liu Z., Nakamura T., Sugino H.
J. Biol. Chem. 275:5485-5492(2000) [PubMed: 10681527] [Abstract]
Cited for: INTERACTION WITH AIP1, IDENTIFICATION IN A COMPLEX WITH ACVR1B; AIP1 AND SMAD3.

Cross-references

Sequence databases

M65287 mRNA. Translation: AAA37171.1.
PIRA39896.
RefSeqNP_031422.3.
UniGeneMm.314338

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1BTEX-ray1.50A/B25-121[»]
1LX5X-ray3.30B20-121[»]
2GOOX-ray2.20C/F20-121[»]
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:5825N.
IntActP27038.

PTM databases

PhosphoSiteP27038.

Genome annotation databases

EnsemblENSMUSG00000052155. Mus musculus. [Contig view]
GeneID11480.
KEGGmmu:11480.

Organism-specific databases

MGIMGI:102806. Acvr2a.

Phylogenomic databases

HOGENOMP27038.
HOVERGENP27038.

Gene expression databases

ArrayExpressP27038.
CleanExMM_ACVR2A.
GermOnlineENSMUSG00000052155. Mus musculus.

Family and domain databases

InterProIPR000333. Activin_II_recpt.
IPR015768. Activin_II_recpt_C.
IPR000472. Activin_rcpt.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_bd_CS.
IPR017442. Se/Thr_pkinase-rel.
IPR008271. Ser_thr_pkin_AS.
[Graphical view]
PANTHERPTHR23255:SF10. Activin_II_recpt_C. 1 hit.
PfamPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSPR00653. ACTIVIN2R.
ProDomPD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00107. PROTEIN_KINASE_ATP. False negative.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
BLOCKSSearch...

Other Resources

LinkHubP27038.
SOURCESearch...
ProtoNetSearch...

Entry information

Entry nameAVR2A_MOUSE
AccessionPrimary (citable) accession number: P27038
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: July 22, 2008
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents