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P27038

- AVR2A_MOUSE

UniProt

P27038 - AVR2A_MOUSE

Protein

Activin receptor type-2A

Gene

Acvr2a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 149 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei219 – 2191ATPPROSITE-ProRule annotation
    Active sitei322 – 3221Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi198 – 2069ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. activin-activated receptor activity Source: Ensembl
    2. activin binding Source: MGI
    3. ATP binding Source: UniProtKB-KW
    4. coreceptor activity Source: Ensembl
    5. growth factor binding Source: MGI
    6. inhibin binding Source: BHF-UCL
    7. metal ion binding Source: UniProtKB-KW
    8. PDZ domain binding Source: UniProtKB
    9. protein binding Source: UniProtKB
    10. protein self-association Source: MGI
    11. protein serine/threonine kinase activity Source: Reactome
    12. receptor signaling protein serine/threonine kinase activity Source: InterPro
    13. transforming growth factor beta-activated receptor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. BMP signaling pathway Source: MGI
    3. determination of left/right symmetry Source: MGI
    4. embryonic skeletal system development Source: MGI
    5. gastrulation with mouth forming second Source: MGI
    6. male gonad development Source: MGI
    7. mesoderm development Source: MGI
    8. penile erection Source: MGI
    9. positive regulation of activin receptor signaling pathway Source: Ensembl
    10. positive regulation of bone mineralization Source: Ensembl
    11. positive regulation of erythrocyte differentiation Source: Ensembl
    12. positive regulation of osteoblast differentiation Source: Ensembl
    13. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    14. positive regulation of protein phosphorylation Source: MGI
    15. regulation of BMP signaling pathway Source: MGI
    16. regulation of nitric-oxide synthase activity Source: MGI
    17. regulation of signal transduction Source: MGI
    18. Sertoli cell proliferation Source: MGI
    19. spermatogenesis Source: MGI
    20. sperm ejaculation Source: MGI

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 3474.
    ReactomeiREACT_216258. Signaling by Activin.
    REACT_220505. Signaling by BMP.
    REACT_220645. Signaling by NODAL.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Activin receptor type-2A (EC:2.7.11.30)
    Alternative name(s):
    Activin receptor type IIA
    Short name:
    ACTR-IIA
    Gene namesi
    Name:Acvr2a
    Synonyms:Acvr2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:102806. Acvr2a.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProtKB
    2. cytoplasm Source: Ensembl
    3. inhibin-betaglycan-ActRII complex Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 513494Activin receptor type-2APRO_0000024399Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 601 Publication
    Glycosylationi43 – 431N-linked (GlcNAc...)
    Disulfide bondi50 ↔ 781 Publication
    Glycosylationi66 – 661N-linked (GlcNAc...)
    Disulfide bondi85 ↔ 1041 Publication
    Disulfide bondi91 ↔ 1031 Publication
    Disulfide bondi105 ↔ 1101 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP27038.
    PRIDEiP27038.

    PTM databases

    PhosphoSiteiP27038.

    Expressioni

    Tissue specificityi

    Brain, testis, intestine, liver and kidney.

    Gene expression databases

    ArrayExpressiP27038.
    BgeeiP27038.
    CleanExiMM_ACVR2A.
    GenevestigatoriP27038.

    Interactioni

    Subunit structurei

    Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3.1 Publication

    Protein-protein interaction databases

    BioGridi197955. 2 interactions.
    DIPiDIP-5825N.
    IntActiP27038. 1 interaction.

    Structurei

    Secondary structure

    1
    513
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi29 – 346
    Helixi37 – 404
    Beta strandi44 – 496
    Beta strandi59 – 679
    Beta strandi70 – 7910
    Helixi83 – 853
    Beta strandi88 – 936
    Beta strandi95 – 973
    Beta strandi99 – 1057
    Helixi110 – 1123
    Beta strandi113 – 1164

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BTEX-ray1.50A/B25-121[»]
    1LX5X-ray3.30B20-121[»]
    2GOOX-ray2.20C/F20-121[»]
    ProteinModelPortaliP27038.
    SMRiP27038. Positions 26-119, 191-486.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP27038.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 135116ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini162 – 513352CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei136 – 16126HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini192 – 485294Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00560000076906.
    HOGENOMiHOG000231495.
    HOVERGENiHBG054502.
    InParanoidiP27038.
    KOiK04670.
    OMAiEDPGNWI.
    OrthoDBiEOG7JHM5B.
    PhylomeDBiP27038.
    TreeFamiTF352876.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    PRINTSiPR00653. ACTIVIN2R.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P27038-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWERD RTNQTGVEPC    50
    YGDKDKRRHC FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV 100
    YFCCCEGNMC NEKFSYFPEM EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI 150
    AGIVICAFWV YRHHKMAYPP VLVPTQDPGP PPPSPLLGLK PLQLLEVKAR 200
    GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG MKHENILQFI 250
    GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 300
    AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG 350
    KSAGDTHGQV GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR 400
    CTAADGPVDE YMLPFEEEIG QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG 450
    MAMLCETIEE CWDHDAEARL SAGCVGERIT QMQRLTNIIT TEDIVTVVTM 500
    VTNVDFPPKE SSL 513
    Length:513
    Mass (Da):57,890
    Last modified:August 1, 1992 - v1
    Checksum:i475CD292506BAC61
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M65287 mRNA. Translation: AAA37171.1.
    CCDSiCCDS16021.1.
    PIRiA39896.
    RefSeqiNP_031422.3. NM_007396.4.
    UniGeneiMm.314338.

    Genome annotation databases

    EnsembliENSMUST00000063886; ENSMUSP00000067305; ENSMUSG00000052155.
    GeneIDi11480.
    KEGGimmu:11480.
    UCSCiuc008jpn.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M65287 mRNA. Translation: AAA37171.1 .
    CCDSi CCDS16021.1.
    PIRi A39896.
    RefSeqi NP_031422.3. NM_007396.4.
    UniGenei Mm.314338.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BTE X-ray 1.50 A/B 25-121 [» ]
    1LX5 X-ray 3.30 B 20-121 [» ]
    2GOO X-ray 2.20 C/F 20-121 [» ]
    ProteinModelPortali P27038.
    SMRi P27038. Positions 26-119, 191-486.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 197955. 2 interactions.
    DIPi DIP-5825N.
    IntActi P27038. 1 interaction.

    PTM databases

    PhosphoSitei P27038.

    Proteomic databases

    PaxDbi P27038.
    PRIDEi P27038.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000063886 ; ENSMUSP00000067305 ; ENSMUSG00000052155 .
    GeneIDi 11480.
    KEGGi mmu:11480.
    UCSCi uc008jpn.2. mouse.

    Organism-specific databases

    CTDi 92.
    MGIi MGI:102806. Acvr2a.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00560000076906.
    HOGENOMi HOG000231495.
    HOVERGENi HBG054502.
    InParanoidi P27038.
    KOi K04670.
    OMAi EDPGNWI.
    OrthoDBi EOG7JHM5B.
    PhylomeDBi P27038.
    TreeFami TF352876.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 3474.
    Reactomei REACT_216258. Signaling by Activin.
    REACT_220505. Signaling by BMP.
    REACT_220645. Signaling by NODAL.

    Miscellaneous databases

    ChiTaRSi ACVR2A. mouse.
    EvolutionaryTracei P27038.
    NextBioi 278828.
    PROi P27038.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P27038.
    Bgeei P27038.
    CleanExi MM_ACVR2A.
    Genevestigatori P27038.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PRINTSi PR00653. ACTIVIN2R.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression cloning of an activin receptor, a predicted transmembrane serine kinase."
      Mathews L.S., Vale W.W.
      Cell 65:973-982(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase."
      Greenwald J., Fischer W.H., Vale W.W., Choe S.
      Nat. Struct. Biol. 6:18-22(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 25-121.
    3. "The disulfide bond arrangement in the extracellular domain of the activin type II receptor."
      Fischer W.H., Greenwald J., Park M., Craig A.G., Choe S., Vale W.
      J. Protein Chem. 18:437-446(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS IN EXTRACELLULAR DOMAIN.
    4. "Identification and characterization of a PDZ protein that interacts with activin types II receptors."
      Shoji H., Tsuchida K., Kishi H., Yamakawa N., Matsuzaki T., Liu Z., Nakamura T., Sugino H.
      J. Biol. Chem. 275:5485-5492(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AIP1, IDENTIFICATION IN A COMPLEX WITH ACVR1B; AIP1 AND SMAD3.

    Entry informationi

    Entry nameiAVR2A_MOUSE
    AccessioniPrimary (citable) accession number: P27038
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 149 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3