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P27038

- AVR2A_MOUSE

UniProt

P27038 - AVR2A_MOUSE

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Protein

Activin receptor type-2A

Gene

Acvr2a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Magnesium or manganese.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei219 – 2191ATPPROSITE-ProRule annotation
Active sitei322 – 3221Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi198 – 2069ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. activin-activated receptor activity Source: Ensembl
  2. activin binding Source: MGI
  3. ATP binding Source: UniProtKB-KW
  4. coreceptor activity Source: Ensembl
  5. growth factor binding Source: MGI
  6. inhibin binding Source: BHF-UCL
  7. metal ion binding Source: UniProtKB-KW
  8. PDZ domain binding Source: UniProtKB
  9. protein self-association Source: MGI
  10. protein serine/threonine kinase activity Source: Reactome
  11. receptor signaling protein serine/threonine kinase activity Source: InterPro
  12. transforming growth factor beta-activated receptor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. BMP signaling pathway Source: MGI
  3. cellular response to BMP stimulus Source: Ensembl
  4. determination of left/right symmetry Source: MGI
  5. embryonic skeletal system development Source: MGI
  6. gastrulation with mouth forming second Source: MGI
  7. male gonad development Source: MGI
  8. mesoderm development Source: MGI
  9. penile erection Source: MGI
  10. positive regulation of activin receptor signaling pathway Source: Ensembl
  11. positive regulation of bone mineralization Source: Ensembl
  12. positive regulation of erythrocyte differentiation Source: Ensembl
  13. positive regulation of osteoblast differentiation Source: Ensembl
  14. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  15. positive regulation of protein phosphorylation Source: MGI
  16. regulation of BMP signaling pathway Source: MGI
  17. regulation of nitric-oxide synthase activity Source: MGI
  18. regulation of signal transduction Source: MGI
  19. Sertoli cell proliferation Source: MGI
  20. spermatogenesis Source: MGI
  21. sperm ejaculation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 3474.
ReactomeiREACT_216258. Signaling by Activin.
REACT_220505. Signaling by BMP.
REACT_220645. Signaling by NODAL.

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-2A (EC:2.7.11.30)
Alternative name(s):
Activin receptor type IIA
Short name:
ACTR-IIA
Gene namesi
Name:Acvr2a
Synonyms:Acvr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:102806. Acvr2a.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. cytoplasm Source: Ensembl
  3. inhibin-betaglycan-ActRII complex Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 513494Activin receptor type-2APRO_0000024399Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 601 Publication
Glycosylationi43 – 431N-linked (GlcNAc...)
Disulfide bondi50 ↔ 781 Publication
Glycosylationi66 – 661N-linked (GlcNAc...)
Disulfide bondi85 ↔ 1041 Publication
Disulfide bondi91 ↔ 1031 Publication
Disulfide bondi105 ↔ 1101 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP27038.
PaxDbiP27038.
PRIDEiP27038.

PTM databases

PhosphoSiteiP27038.

Expressioni

Tissue specificityi

Brain, testis, intestine, liver and kidney.

Gene expression databases

BgeeiP27038.
CleanExiMM_ACVR2A.
ExpressionAtlasiP27038. baseline and differential.
GenevestigatoriP27038.

Interactioni

Subunit structurei

Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3.1 Publication

Protein-protein interaction databases

BioGridi197955. 2 interactions.
DIPiDIP-5825N.
IntActiP27038. 1 interaction.

Structurei

Secondary structure

1
513
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 346
Helixi37 – 404
Beta strandi44 – 496
Beta strandi59 – 679
Beta strandi70 – 7910
Helixi83 – 853
Beta strandi88 – 936
Beta strandi95 – 973
Beta strandi99 – 1057
Helixi110 – 1123
Beta strandi113 – 1164

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BTEX-ray1.50A/B25-121[»]
1LX5X-ray3.30B20-121[»]
2GOOX-ray2.20C/F20-121[»]
ProteinModelPortaliP27038.
SMRiP27038. Positions 26-119, 191-486.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27038.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 135116ExtracellularSequence AnalysisAdd
BLAST
Topological domaini162 – 513352CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei136 – 16126HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini192 – 485294Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000231495.
HOVERGENiHBG054502.
InParanoidiP27038.
KOiK04670.
OMAiEDPGNWI.
OrthoDBiEOG7JHM5B.
PhylomeDBiP27038.
TreeFamiTF352876.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27038-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWERD RTNQTGVEPC
60 70 80 90 100
YGDKDKRRHC FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV
110 120 130 140 150
YFCCCEGNMC NEKFSYFPEM EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI
160 170 180 190 200
AGIVICAFWV YRHHKMAYPP VLVPTQDPGP PPPSPLLGLK PLQLLEVKAR
210 220 230 240 250
GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG MKHENILQFI
260 270 280 290 300
GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL
310 320 330 340 350
AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG
360 370 380 390 400
KSAGDTHGQV GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR
410 420 430 440 450
CTAADGPVDE YMLPFEEEIG QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG
460 470 480 490 500
MAMLCETIEE CWDHDAEARL SAGCVGERIT QMQRLTNIIT TEDIVTVVTM
510
VTNVDFPPKE SSL
Length:513
Mass (Da):57,890
Last modified:August 1, 1992 - v1
Checksum:i475CD292506BAC61
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M65287 mRNA. Translation: AAA37171.1.
CCDSiCCDS16021.1.
PIRiA39896.
RefSeqiNP_031422.3. NM_007396.4.
UniGeneiMm.314338.

Genome annotation databases

EnsembliENSMUST00000063886; ENSMUSP00000067305; ENSMUSG00000052155.
GeneIDi11480.
KEGGimmu:11480.
UCSCiuc008jpn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M65287 mRNA. Translation: AAA37171.1 .
CCDSi CCDS16021.1.
PIRi A39896.
RefSeqi NP_031422.3. NM_007396.4.
UniGenei Mm.314338.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BTE X-ray 1.50 A/B 25-121 [» ]
1LX5 X-ray 3.30 B 20-121 [» ]
2GOO X-ray 2.20 C/F 20-121 [» ]
ProteinModelPortali P27038.
SMRi P27038. Positions 26-119, 191-486.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 197955. 2 interactions.
DIPi DIP-5825N.
IntActi P27038. 1 interaction.

PTM databases

PhosphoSitei P27038.

Proteomic databases

MaxQBi P27038.
PaxDbi P27038.
PRIDEi P27038.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000063886 ; ENSMUSP00000067305 ; ENSMUSG00000052155 .
GeneIDi 11480.
KEGGi mmu:11480.
UCSCi uc008jpn.2. mouse.

Organism-specific databases

CTDi 92.
MGIi MGI:102806. Acvr2a.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118876.
HOGENOMi HOG000231495.
HOVERGENi HBG054502.
InParanoidi P27038.
KOi K04670.
OMAi EDPGNWI.
OrthoDBi EOG7JHM5B.
PhylomeDBi P27038.
TreeFami TF352876.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 3474.
Reactomei REACT_216258. Signaling by Activin.
REACT_220505. Signaling by BMP.
REACT_220645. Signaling by NODAL.

Miscellaneous databases

ChiTaRSi ACVR2A. mouse.
EvolutionaryTracei P27038.
NextBioi 278828.
PROi P27038.
SOURCEi Search...

Gene expression databases

Bgeei P27038.
CleanExi MM_ACVR2A.
ExpressionAtlasi P27038. baseline and differential.
Genevestigatori P27038.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
PRINTSi PR00653. ACTIVIN2R.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression cloning of an activin receptor, a predicted transmembrane serine kinase."
    Mathews L.S., Vale W.W.
    Cell 65:973-982(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase."
    Greenwald J., Fischer W.H., Vale W.W., Choe S.
    Nat. Struct. Biol. 6:18-22(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 25-121.
  3. "The disulfide bond arrangement in the extracellular domain of the activin type II receptor."
    Fischer W.H., Greenwald J., Park M., Craig A.G., Choe S., Vale W.
    J. Protein Chem. 18:437-446(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS IN EXTRACELLULAR DOMAIN.
  4. "Identification and characterization of a PDZ protein that interacts with activin types II receptors."
    Shoji H., Tsuchida K., Kishi H., Yamakawa N., Matsuzaki T., Liu Z., Nakamura T., Sugino H.
    J. Biol. Chem. 275:5485-5492(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AIP1, IDENTIFICATION IN A COMPLEX WITH ACVR1B; AIP1 AND SMAD3.

Entry informationi

Entry nameiAVR2A_MOUSE
AccessioniPrimary (citable) accession number: P27038
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 29, 2014
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3