Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P27037

- AVR2A_HUMAN

UniProt

P27037 - AVR2A_HUMAN

Protein

Activin receptor type-2A

Gene

ACVR2A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 157 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei219 – 2191ATPPROSITE-ProRule annotation
    Active sitei322 – 3221Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi198 – 2069ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. coreceptor activity Source: BHF-UCL
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: UniProtKB
    5. protein serine/threonine kinase activity Source: Reactome
    6. receptor signaling protein serine/threonine kinase activity Source: InterPro
    7. transforming growth factor beta-activated receptor activity Source: InterPro
    8. transmembrane receptor protein serine/threonine kinase activity Source: ProtInc

    GO - Biological processi

    1. activin receptor signaling pathway Source: GOC
    2. anterior/posterior pattern specification Source: Ensembl
    3. BMP signaling pathway Source: BHF-UCL
    4. cellular response to BMP stimulus Source: BHF-UCL
    5. determination of left/right symmetry Source: Ensembl
    6. embryonic skeletal system development Source: Ensembl
    7. gastrulation with mouth forming second Source: Ensembl
    8. mesoderm development Source: Ensembl
    9. penile erection Source: Ensembl
    10. positive regulation of activin receptor signaling pathway Source: HGNC
    11. positive regulation of bone mineralization Source: BHF-UCL
    12. positive regulation of erythrocyte differentiation Source: HGNC
    13. positive regulation of osteoblast differentiation Source: BHF-UCL
    14. positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
    15. positive regulation of protein phosphorylation Source: MGI
    16. regulation of BMP signaling pathway Source: Ensembl
    17. regulation of nitric-oxide synthase activity Source: Ensembl
    18. Sertoli cell proliferation Source: Ensembl
    19. spermatogenesis Source: Ensembl
    20. sperm ejaculation Source: Ensembl
    21. transmembrane receptor protein serine/threonine kinase signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 2681.
    ReactomeiREACT_111057. Signaling by NODAL.
    REACT_111059. Regulation of signaling by NODAL.
    REACT_12034. Signaling by BMP.
    REACT_150238. Signaling by Activin.
    SignaLinkiP27037.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Activin receptor type-2A (EC:2.7.11.30)
    Alternative name(s):
    Activin receptor type IIA
    Short name:
    ACTR-IIA
    Short name:
    ACTRIIA
    Gene namesi
    Name:ACVR2A
    Synonyms:ACVR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:173. ACVR2A.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. cytoplasm Source: HGNC
    3. inhibin-betaglycan-ActRII complex Source: BHF-UCL
    4. integral component of plasma membrane Source: ProtInc
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24494.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 513494Activin receptor type-2APRO_0000024398Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 60By similarity
    Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi50 ↔ 78By similarity
    Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi85 ↔ 104By similarity
    Disulfide bondi91 ↔ 103By similarity
    Disulfide bondi105 ↔ 110By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP27037.
    PaxDbiP27037.
    PRIDEiP27037.

    PTM databases

    PhosphoSiteiP27037.

    Expressioni

    Gene expression databases

    ArrayExpressiP27037.
    BgeeiP27037.
    CleanExiHS_ACVR2A.
    GenevestigatoriP27037.

    Organism-specific databases

    HPAiHPA046997.

    Interactioni

    Subunit structurei

    Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi106607. 17 interactions.
    DIPiDIP-520N.
    IntActiP27037. 1 interaction.
    MINTiMINT-122188.
    STRINGi9606.ENSP00000241416.

    Structurei

    Secondary structure

    1
    513
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi191 – 1999
    Beta strandi205 – 2117
    Beta strandi214 – 2218
    Helixi223 – 2253
    Helixi226 – 23611
    Beta strandi249 – 2568
    Beta strandi258 – 26811
    Helixi275 – 2817
    Helixi286 – 30318
    Beta strandi307 – 3104
    Beta strandi313 – 3153
    Beta strandi317 – 3193
    Beta strandi327 – 3304
    Beta strandi336 – 3383
    Beta strandi345 – 3473
    Helixi363 – 3653
    Helixi368 – 3714
    Helixi379 – 39820
    Beta strandi404 – 4063
    Helixi416 – 4194
    Helixi425 – 4328
    Helixi443 – 4464
    Helixi449 – 46113
    Helixi466 – 4683
    Helixi472 – 48514

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3Q4TX-ray1.96A/B191-488[»]
    3SOCX-ray1.95A/B191-488[»]
    4ASXX-ray2.05A/B191-488[»]
    ProteinModelPortaliP27037.
    SMRiP27037. Positions 26-119, 191-486.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP27037.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 135116ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini162 – 513352CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei136 – 16126HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini192 – 485294Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000231495.
    HOVERGENiHBG054502.
    InParanoidiP27037.
    KOiK04670.
    OMAiEDPGNWI.
    OrthoDBiEOG7JHM5B.
    PhylomeDBiP27037.
    TreeFamiTF352876.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    PRINTSiPR00653. ACTIVIN2R.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P27037-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWEKD RTNQTGVEPC    50
    YGDKDKRRHC FATWKNISGS IEIVKQGCWL DDINCYDRTD CVEKKDSPEV 100
    YFCCCEGNMC NEKFSYFPEM EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI 150
    AGIVICAFWV YRHHKMAYPP VLVPTQDPGP PPPSPLLGLK PLQLLEVKAR 200
    GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG MKHENILQFI 250
    GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 300
    AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG 350
    KSAGDTHGQV GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR 400
    CTAADGPVDE YMLPFEEEIG QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG 450
    MAMLCETIEE CWDHDAEARL SAGCVGERIT QMQRLTNIIT TEDIVTVVTM 500
    VTNVDFPPKE SSL 513
    Length:513
    Mass (Da):57,848
    Last modified:August 1, 1992 - v1
    Checksum:iA89822E880979618
    GO
    Isoform 2 (identifier: P27037-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-108: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:405
    Mass (Da):45,713
    Checksum:iF0D4F7B18BD200AB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti13 – 131L → V in BAA06548. 1 PublicationCurated
    Sequence conflicti204 – 2063GCV → PSL in BAA06548. 1 PublicationCurated
    Sequence conflicti348 – 3481E → V in BAA06548. 1 PublicationCurated
    Sequence conflicti507 – 5071P → L in AAH67417. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti258 – 2581S → R.1 Publication
    Corresponds to variant rs34917571 [ dbSNP | Ensembl ].
    VAR_032809
    Natural varianti306 – 3061D → N in a gastric adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_032810
    Natural varianti367 – 3671A → T Found in a clear cell renal carcinoma case; somatic mutation. 1 Publication
    VAR_064692

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 108108Missing in isoform 2. 1 PublicationVSP_054689Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63128 mRNA. Translation: CAA44839.1.
    M93415 mRNA. Translation: AAA35504.1.
    X62381 mRNA. Translation: CAA44245.1.
    D31770 mRNA. Translation: BAA06548.1.
    AK301629 mRNA. Translation: BAG63114.1.
    AK314124 mRNA. Translation: BAG36815.1.
    AC009480 Genomic DNA. Translation: AAX93050.1.
    CH471058 Genomic DNA. Translation: EAX11561.1.
    CH471058 Genomic DNA. Translation: EAX11562.1.
    BC067418 mRNA. Translation: AAH67418.1.
    BC067417 mRNA. Translation: AAH67417.1.
    BC069707 mRNA. Translation: AAH69707.1.
    CCDSiCCDS33301.1. [P27037-1]
    CCDS63030.1. [P27037-2]
    PIRiJQ1486.
    RefSeqiNP_001265508.1. NM_001278579.1. [P27037-1]
    NP_001265509.1. NM_001278580.1. [P27037-2]
    NP_001607.1. NM_001616.4. [P27037-1]
    UniGeneiHs.470174.

    Genome annotation databases

    EnsembliENST00000241416; ENSP00000241416; ENSG00000121989. [P27037-1]
    ENST00000404590; ENSP00000384338; ENSG00000121989. [P27037-1]
    ENST00000535787; ENSP00000439988; ENSG00000121989. [P27037-2]
    GeneIDi92.
    KEGGihsa:92.
    UCSCiuc002twg.3. human. [P27037-1]

    Polymorphism databases

    DMDMi114722.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology
    CGP resequencing studies

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63128 mRNA. Translation: CAA44839.1 .
    M93415 mRNA. Translation: AAA35504.1 .
    X62381 mRNA. Translation: CAA44245.1 .
    D31770 mRNA. Translation: BAA06548.1 .
    AK301629 mRNA. Translation: BAG63114.1 .
    AK314124 mRNA. Translation: BAG36815.1 .
    AC009480 Genomic DNA. Translation: AAX93050.1 .
    CH471058 Genomic DNA. Translation: EAX11561.1 .
    CH471058 Genomic DNA. Translation: EAX11562.1 .
    BC067418 mRNA. Translation: AAH67418.1 .
    BC067417 mRNA. Translation: AAH67417.1 .
    BC069707 mRNA. Translation: AAH69707.1 .
    CCDSi CCDS33301.1. [P27037-1 ]
    CCDS63030.1. [P27037-2 ]
    PIRi JQ1486.
    RefSeqi NP_001265508.1. NM_001278579.1. [P27037-1 ]
    NP_001265509.1. NM_001278580.1. [P27037-2 ]
    NP_001607.1. NM_001616.4. [P27037-1 ]
    UniGenei Hs.470174.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3Q4T X-ray 1.96 A/B 191-488 [» ]
    3SOC X-ray 1.95 A/B 191-488 [» ]
    4ASX X-ray 2.05 A/B 191-488 [» ]
    ProteinModelPortali P27037.
    SMRi P27037. Positions 26-119, 191-486.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106607. 17 interactions.
    DIPi DIP-520N.
    IntActi P27037. 1 interaction.
    MINTi MINT-122188.
    STRINGi 9606.ENSP00000241416.

    Chemistry

    BindingDBi P27037.
    ChEMBLi CHEMBL5616.
    GuidetoPHARMACOLOGYi 1791.

    PTM databases

    PhosphoSitei P27037.

    Polymorphism databases

    DMDMi 114722.

    Proteomic databases

    MaxQBi P27037.
    PaxDbi P27037.
    PRIDEi P27037.

    Protocols and materials databases

    DNASUi 92.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000241416 ; ENSP00000241416 ; ENSG00000121989 . [P27037-1 ]
    ENST00000404590 ; ENSP00000384338 ; ENSG00000121989 . [P27037-1 ]
    ENST00000535787 ; ENSP00000439988 ; ENSG00000121989 . [P27037-2 ]
    GeneIDi 92.
    KEGGi hsa:92.
    UCSCi uc002twg.3. human. [P27037-1 ]

    Organism-specific databases

    CTDi 92.
    GeneCardsi GC02P148602.
    HGNCi HGNC:173. ACVR2A.
    HPAi HPA046997.
    MIMi 102581. gene.
    neXtProti NX_P27037.
    PharmGKBi PA24494.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000231495.
    HOVERGENi HBG054502.
    InParanoidi P27037.
    KOi K04670.
    OMAi EDPGNWI.
    OrthoDBi EOG7JHM5B.
    PhylomeDBi P27037.
    TreeFami TF352876.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 2681.
    Reactomei REACT_111057. Signaling by NODAL.
    REACT_111059. Regulation of signaling by NODAL.
    REACT_12034. Signaling by BMP.
    REACT_150238. Signaling by Activin.
    SignaLinki P27037.

    Miscellaneous databases

    EvolutionaryTracei P27037.
    GeneWikii ACVR2A.
    GenomeRNAii 92.
    NextBioi 347.
    PROi P27037.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P27037.
    Bgeei P27037.
    CleanExi HS_ACVR2A.
    Genevestigatori P27037.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PRINTSi PR00653. ACTIVIN2R.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the human activin receptor cDNA reveals high evolutionary conservation."
      Matzuk M.M., Bradley A.
      Biochim. Biophys. Acta 1130:105-108(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. "Molecular cloning and binding properties of the human type II activin receptor."
      Donaldson C.J., Mathews L.S., Vale W.W.
      Biochem. Biophys. Res. Commun. 184:310-316(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Testis.
    3. Geiser A.G.
      Submitted (DEC-1991) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Mammary gland.
    4. Iimura T., Oida S.
      Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Colon and Hippocampus.
    6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    9. "Crystal structure of activin receptor type-IIa (ACVR2A) kinase domain in complex with dorsomorphin."
      Structural genomics consortium (SGC)
      Submitted (FEB-2011) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) OF 191-488 IN COMPLEX WITH DORSOMORPHIN.
    10. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ARG-258 AND ASN-306.
    11. Cited for: VARIANT THR-367.

    Entry informationi

    Entry nameiAVR2A_HUMAN
    AccessioniPrimary (citable) accession number: P27037
    Secondary accession number(s): B2RAB8
    , B4DWQ2, D3DP85, Q53TH4, Q6NWV2, Q92474
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 157 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3