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P27033

- GUNC_CELJU

UniProt

P27033 - GUNC_CELJU

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Protein

Endoglucanase C

Gene
celC, cel5A, CJA_1462
Organism
Cellvibrio japonicus (strain Ueda107) (Pseudomonas fluorescens subsp. cellulosa)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei502 – 5021Proton donor By similarity
Active sitei652 – 6521Nucleophile By similarity

GO - Molecular functioni

  1. cellulase activity Source: UniProtKB-EC
  2. cellulose binding Source: InterPro

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

BioCyciCJAP498211:GHIT-1456-MONOMER.

Protein family/group databases

CAZyiCBM10. Carbohydrate-Binding Module Family 10.
CBM2. Carbohydrate-Binding Module Family 2.
GH5. Glycoside Hydrolase Family 5.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase C (EC:3.2.1.4)
Alternative name(s):
Cellodextrinase C
Cellulase C
Endo-1,4-beta-glucanase C
Short name:
EGC
Gene namesi
Name:celC
Synonyms:cel5A
Ordered Locus Names:CJA_1462
OrganismiCellvibrio japonicus (strain Ueda107) (Pseudomonas fluorescens subsp. cellulosa)
Taxonomic identifieri498211 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeCellvibrio
ProteomesiUP000001036: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 37371 PublicationAdd
BLAST
Chaini38 – 747710Endoglucanase CPRO_0000007865Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi39 ↔ 133 By similarity
Disulfide bondi183 ↔ 214 By similarity
Disulfide bondi193 ↔ 208 By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi498211.CJA_1462.

Structurei

3D structure databases

ProteinModelPortaliP27033.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 13699CBM2Add
BLAST
Domaini182 – 20928CBM10Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni280 – 747468CatalyticAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi137 – 17943Ser-rich (linker)Add
BLAST
Compositional biasi227 – 27953Ser-rich (linker)Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000066200.
OMAiRTIQQTM.
OrthoDBiEOG6PS5R7.

Family and domain databases

Gene3Di2.30.32.30. 1 hit.
2.60.40.290. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR008965. Carb-bd_dom.
IPR012291. CBD_carb-bd_dom.
IPR002883. CBM10/Dockerin_dom.
IPR018366. CBM2_CS.
IPR009031. CBM_fam10.
IPR001919. Cellulose-bd_dom_fam2_bac.
IPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02013. CBM_10. 1 hit.
PF00553. CBM_2. 1 hit.
PF00150. Cellulase. 1 hit.
[Graphical view]
SMARTiSM00637. CBD_II. 1 hit.
SM01064. CBM_10. 1 hit.
[Graphical view]
SUPFAMiSSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 2 hits.
SSF57615. SSF57615. 1 hit.
PROSITEiPS51173. CBM2. 1 hit.
PS00561. CBM2_A. 1 hit.
PS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27033-1 [UniParc]FASTAAdd to Basket

« Hide

MGHVTSPSKR YPASFKRAGS ILGVSIALAA FSNVAAAGCE YVVTNSWGSG    50
FTAAIRITNS TSSVINGWNV SWQYNSNRVT NLWNANLSGS NPYSASNLSW 100
NGTIQPGQTV EFGFQGVTNS GTVESPTVNG AACTGGTSSS VSSSSVVSSS 150
SSSRSSVSSS SVVSSSSSVV SSSSSSVVSG GQCNWYGTLY PLCVSTTSGW 200
GYENNRSCIS PSTCSAQPAP YGIVGGSSSP SSISSSSVRS SSSSSVVPPS 250
SSSSSSVPSS SSSSVSSSSV VSSSSSSVSV PGTGVFRVNT QGNLTKDGQL 300
LPARCGNWFG LEGRHEPSND ADNPSGAPME LYAGNMWWVN NSQGSGRTIQ 350
QTMTELKQQG ITMLRLPIAP QTLDANDPQG RSPNLKNHQS IRQSNARQAL 400
EDFIKLADQN DIQIFIDIHS CSNYVGWRAG RLDARPPYVD ANRVGYDFTR 450
EEYSCSATNN PSSVTRIHAY DKQKWLANLR EIAGLSAKLG VSNLIGIDVF 500
NEPYDYTWAE WKGMVEEAYQ AINEVNPNML IIVEGISANA NTQDGTPDTS 550
VPVPHGSTDL NPNWGENLYE AGANPPNIPK DRLLFSPHTY GPSVFVQRQF 600
MDPAQTECAG LEGDEAAQAR CRIVINPTVL EQGWEEHFGY LRELGYGILI 650
GEFGGNMDWP GAKSSQADRN AWSHITTNVD QQWQQAAASY FKRKGINACY 700
WSMNPESADT MGWYLTPWDP VTANDMWGQW TGFDPRKTQL LHNMWGL 747
Length:747
Mass (Da):80,098
Last modified:April 20, 2010 - v2
Checksum:i2A1D90E2612D361A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851A → P in CAA43597. 1 Publication
Sequence conflicti181 – 1811G → GG in CAA43597. 1 Publication
Sequence conflicti262 – 2621S → C in CAA43597. 1 Publication
Sequence conflicti291 – 2911Q → K in CAA43597. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61299 Genomic DNA. Translation: CAA43597.1.
CP000934 Genomic DNA. Translation: ACE82870.1.
PIRiS19652.
RefSeqiYP_001981949.1. NC_010995.1.

Genome annotation databases

EnsemblBacteriaiACE82870; ACE82870; CJA_1462.
GeneIDi6413622.
KEGGicja:CJA_1462.
PATRICi21326306. VBICelJap122165_1442.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61299 Genomic DNA. Translation: CAA43597.1 .
CP000934 Genomic DNA. Translation: ACE82870.1 .
PIRi S19652.
RefSeqi YP_001981949.1. NC_010995.1.

3D structure databases

ProteinModelPortali P27033.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 498211.CJA_1462.

Protein family/group databases

CAZyi CBM10. Carbohydrate-Binding Module Family 10.
CBM2. Carbohydrate-Binding Module Family 2.
GH5. Glycoside Hydrolase Family 5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACE82870 ; ACE82870 ; CJA_1462 .
GeneIDi 6413622.
KEGGi cja:CJA_1462.
PATRICi 21326306. VBICelJap122165_1442.

Phylogenomic databases

HOGENOMi HOG000066200.
OMAi RTIQQTM.
OrthoDBi EOG6PS5R7.

Enzyme and pathway databases

BioCyci CJAP498211:GHIT-1456-MONOMER.

Family and domain databases

Gene3Di 2.30.32.30. 1 hit.
2.60.40.290. 1 hit.
3.20.20.80. 2 hits.
InterProi IPR008965. Carb-bd_dom.
IPR012291. CBD_carb-bd_dom.
IPR002883. CBM10/Dockerin_dom.
IPR018366. CBM2_CS.
IPR009031. CBM_fam10.
IPR001919. Cellulose-bd_dom_fam2_bac.
IPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF02013. CBM_10. 1 hit.
PF00553. CBM_2. 1 hit.
PF00150. Cellulase. 1 hit.
[Graphical view ]
SMARTi SM00637. CBD_II. 1 hit.
SM01064. CBM_10. 1 hit.
[Graphical view ]
SUPFAMi SSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 2 hits.
SSF57615. SSF57615. 1 hit.
PROSITEi PS51173. CBM2. 1 hit.
PS00561. CBM2_A. 1 hit.
PS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The cellodextrinase from Pseudomonas fluorescens subsp. cellulosa consists of multiple functional domains."
    Ferreira L.M.A., Hazlewood G.P., Barker P.J., Gilbert H.J.
    Biochem. J. 279:793-799(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 38-47.
  2. "Insights into plant cell wall degradation from the genome sequence of the soil bacterium Cellvibrio japonicus."
    DeBoy R.T., Mongodin E.F., Fouts D.E., Tailford L.E., Khouri H., Emerson J.B., Mohamoud Y., Watkins K., Henrissat B., Gilbert H.J., Nelson K.E.
    J. Bacteriol. 190:5455-5463(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ueda107.

Entry informationi

Entry nameiGUNC_CELJU
AccessioniPrimary (citable) accession number: P27033
Secondary accession number(s): B3PDK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: April 20, 2010
Last modified: May 14, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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