P27016 (SCR18_OMMSL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: S-crystallin SL18
Organism	Ommastrephes sloanei (Arrow squid) (Sloane's squid)
Taxonomic identifier	215440 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Mollusca › Cephalopoda › Coleoidea › Neocoleoidea › Decapodiformes › Teuthida › Oegopsina › Ommastrephidae › Nototodarus

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	S-crystallins are structural components of squids and octopi eye lens. Contains relatively little if any GST activity.
Tissue specificity	Lens.
Sequence similarities	Belongs to the GST superfamily. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Eye lens protein
Gene Ontology (GO)
Molecular_function	structural constituent of eye lens Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	S-crystallin SL18		PRO_0000186001
Regions
	Domain	2 – 80	79	GST N-terminal
	Domain	185 – 308	124	GST C-terminal

Sequences

	Sequence		Length	Mass (Da)
	P27016 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: C97B3793257271B6	FASTA	308	36,431
	10 20 30 40 50 60 MPKYTLYYFN SRGRAEICRM LFAAANIPYN DVRIDYSEWD IYRSKMPGSC LPVLEINDSI 70 80 90 100 110 120 QIPQTMAIAR YLARQFGFYG KHHLDMARVD FICDSFYDIF NDYMRMYHDQ KGRVMFELMS 130 140 150 160 170 180 QMREWYAARN ENSGYEECYM QPSMAPSAQM SQEVDNSDTL ADCSEMRSQD SMVEPPSQKL 190 200 210 220 230 240 SPELESQSSL CSERPQCGPP DPMMGSDFER LSFNEGRMLE MRRRYDETCR RVLPFLEGTL 250 260 270 280 290 300 KQRYGGDRYF MGEYMTMCDL MCYCALENPL LDNAYLLHPY PKLRGLRDRV SRNQRINSYF TLRNYTDF

References

[1]	"Characterization of squid crystallin genes. Comparison with mammalian glutathione S-transferase genes." Tomarev S.I., Zinovieva R.D., Piatigorsky J. J. Biol. Chem. 267:8604-8612(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M74326 mRNA. Translation: AAA29404.1.
PIR	S14892.
3D structure databases
ProteinModelPortal	P27016.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.20.1050.10. 2 hits. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR003083. S-crystallin. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PRINTS	PR01269. SCRYSTALLIN.
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SCR18_OMMSL

Accession

Primary (citable) accession number: P27016

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)