##gff-version 3 P27008 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Chain 2 1014 . . . ID=PRO_0000211321;Note=Poly [ADP-ribose] polymerase 1 P27008 UniProtKB Chain 2 214 . . . ID=PRO_0000456365;Note=Poly [ADP-ribose] polymerase 1%2C processed N-terminus;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Chain 215 1014 . . . ID=PRO_0000456366;Note=Poly [ADP-ribose] polymerase 1%2C processed C-terminus;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Domain 225 360 . . . Note=PADR1 zinc-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01351 P27008 UniProtKB Domain 386 477 . . . Note=BRCT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00033 P27008 UniProtKB Domain 542 638 . . . Note=WGR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01321 P27008 UniProtKB Domain 662 779 . . . Note=PARP alpha-helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00398 P27008 UniProtKB Domain 788 1014 . . . Note=PARP catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00397 P27008 UniProtKB Zinc finger 9 93 . . . Note=PARP-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00264 P27008 UniProtKB Zinc finger 113 203 . . . Note=PARP-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00264 P27008 UniProtKB Region 291 333 . . . Note=Zinc ribbon;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01351 P27008 UniProtKB Region 357 387 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P27008 UniProtKB Region 374 524 . . . Note=Automodification domain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Region 496 519 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P27008 UniProtKB Motif 207 209 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Motif 221 226 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Active site 988 988 . . . Note=For poly [ADP-ribose] polymerase activity;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Binding site 21 21 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00264 P27008 UniProtKB Binding site 24 24 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00264 P27008 UniProtKB Binding site 53 53 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00264 P27008 UniProtKB Binding site 56 56 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00264 P27008 UniProtKB Binding site 125 125 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00264 P27008 UniProtKB Binding site 128 128 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00264 P27008 UniProtKB Binding site 159 159 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00264 P27008 UniProtKB Binding site 162 162 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00264 P27008 UniProtKB Binding site 296 296 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01351 P27008 UniProtKB Binding site 299 299 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01351 P27008 UniProtKB Binding site 312 312 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01351 P27008 UniProtKB Binding site 322 322 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01351 P27008 UniProtKB Binding site 862 864 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9UGN5 P27008 UniProtKB Binding site 871 871 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9UGN5 P27008 UniProtKB Binding site 878 878 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9UGN5 P27008 UniProtKB Binding site 904 904 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9UGN5 P27008 UniProtKB Site 214 215 . . . Note=Cleavage%3B by caspase-3 and caspase-7;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Modified residue 2 2 . . . Note=N-acetylalanine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Modified residue 41 41 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Modified residue 97 97 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Modified residue 105 105 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Modified residue 131 131 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Modified residue 177 177 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Modified residue 179 179 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Modified residue 185 185 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Modified residue 275 275 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Modified residue 278 278 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Modified residue 388 388 . . . Note=PolyADP-ribosyl aspartic acid;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Modified residue 408 408 . . . Note=PolyADP-ribosyl glutamic acid;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27008 UniProtKB Modified residue 414 414 . . . Note=PolyADP-ribosyl glutamic acid;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27008 UniProtKB Modified residue 436 436 . . . Note=PolyADP-ribosyl glutamic acid;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27008 UniProtKB Modified residue 438 438 . . . Note=PolyADP-ribosyl glutamic acid;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27008 UniProtKB Modified residue 445 445 . . . Note=PolyADP-ribosyl glutamic acid;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27008 UniProtKB Modified residue 446 446 . . . Note=PolyADP-ribosyl glutamic acid;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27008 UniProtKB Modified residue 457 457 . . . Note=PolyADP-ribosyl glutamic acid;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27008 UniProtKB Modified residue 485 485 . . . Note=PolyADP-ribosyl glutamic acid;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27008 UniProtKB Modified residue 489 489 . . . Note=PolyADP-ribosyl glutamic acid;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Modified residue 492 492 . . . Note=PolyADP-ribosyl glutamic acid;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Modified residue 500 500 . . . Note=ADP-ribosylserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Modified residue 504 504 . . . Note=ADP-ribosylserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Modified residue 507 507 . . . Note=ADP-ribosylserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Modified residue 513 513 . . . Note=PolyADP-ribosyl glutamic acid;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27008 UniProtKB Modified residue 514 514 . . . Note=PolyADP-ribosyl glutamic acid;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27008 UniProtKB Modified residue 519 519 . . . Note=ADP-ribosylserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Modified residue 520 520 . . . Note=PolyADP-ribosyl glutamic acid;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27008 UniProtKB Modified residue 521 521 . . . Note=N6-(ADP-ribosyl)lysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Modified residue 594 594 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Modified residue 600 600 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Modified residue 621 621 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Modified residue 782 782 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Modified residue 786 786 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Cross-link 192 192 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Cross-link 203 203 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Cross-link 203 203 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Cross-link 250 250 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Cross-link 468 468 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Cross-link 487 487 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Cross-link 487 487 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Cross-link 512 512 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Cross-link 528 528 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Cross-link 748 748 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Cross-link 748 748 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09874 P27008 UniProtKB Sequence conflict 639 639 . . . Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 P27008 UniProtKB Sequence conflict 642 642 . . . Note=E->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 P27008 UniProtKB Sequence conflict 753 753 . . . Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 P27008 UniProtKB Beta strand 394 398 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LE0 P27008 UniProtKB Helix 406 416 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LE0 P27008 UniProtKB Beta strand 422 424 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LE0 P27008 UniProtKB Beta strand 427 431 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LE0 P27008 UniProtKB Helix 434 439 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LE0 P27008 UniProtKB Helix 442 449 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LE0 P27008 UniProtKB Beta strand 453 455 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LE0 P27008 UniProtKB Helix 458 465 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LE0 P27008 UniProtKB Helix 470 476 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LE0