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Protein

Protein S100-A10

Gene

S100A10

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.By similarity

Miscellaneous

Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-GGA-75205 Dissolution of Fibrin Clot

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A10
Alternative name(s):
Calpactin I light chain
Calpactin-1 light chain
Cellular ligand of annexin II
S100 calcium-binding protein A10
p10 protein
p11
Gene namesi
Name:S100A10
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001440072 – 97Protein S100-A10Add BLAST96

Proteomic databases

PRIDEiP27003

Expressioni

Gene expression databases

BgeeiENSGALG00000028774
ExpressionAtlasiP27003 baseline and differential

Interactioni

Subunit structurei

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP27003
SMRiP27003
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni60 – 71Ancestral calcium siteAdd BLAST12

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00760000119034
HOVERGENiHBG001479
InParanoidiP27003
KOiK17274
OrthoDBiEOG091G10QT
PhylomeDBiP27003

Family and domain databases

CDDicd05024 S-100A10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR028476 S100-A10
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PANTHERiPTHR11639:SF74 PTHR11639:SF74, 1 hit
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27003-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSQMEHAME TLMFTFHKYA GDKNYLSKED LRALMEKEFP GFLENQRDPM
60 70 80 90
ALDKIMKDLD QCRDGKVGFQ SFFSLVAGLT IACNDYFVVH MKQKGRK
Length:97
Mass (Da):11,290
Last modified:January 23, 2007 - v2
Checksum:i4CF79C4F856971AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M38592 mRNA Translation: AAA48690.1
PIRiJH0663
RefSeqiNP_990837.1, NM_205506.2
XP_015135488.1, XM_015280002.1
UniGeneiGga.11321

Genome annotation databases

EnsembliENSGALT00000042661; ENSGALP00000041652; ENSGALG00000028774
ENSGALT00000088809; ENSGALP00000061767; ENSGALG00000028774
GeneIDi396506
KEGGigga:396506

Similar proteinsi

Entry informationi

Entry nameiS10AA_CHICK
AccessioniPrimary (citable) accession number: P27003
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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