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Protein

Protein S100-A10

Gene

S100A10

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-GGA-75205. Dissolution of Fibrin Clot.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A10
Alternative name(s):
Calpactin I light chain
Calpactin-1 light chain
Cellular ligand of annexin II
S100 calcium-binding protein A10
p10 protein
p11
Gene namesi
Name:S100A10
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 9796Protein S100-A10PRO_0000144007Add
BLAST

Proteomic databases

PRIDEiP27003.

Expressioni

Gene expression databases

BgeeiENSGALG00000028774.
ExpressionAtlasiP27003. baseline.

Interactioni

Subunit structurei

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36.

Structurei

3D structure databases

ProteinModelPortaliP27003.
SMRiP27003. Positions 2-93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni60 – 7112Ancestral calcium siteAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG001479.
InParanoidiP27003.
KOiK17274.
OrthoDBiEOG091G10QT.
PhylomeDBiP27003.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR028476. S100-A10.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF74. PTHR11639:SF74. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27003-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSQMEHAME TLMFTFHKYA GDKNYLSKED LRALMEKEFP GFLENQRDPM
60 70 80 90
ALDKIMKDLD QCRDGKVGFQ SFFSLVAGLT IACNDYFVVH MKQKGRK
Length:97
Mass (Da):11,290
Last modified:January 23, 2007 - v2
Checksum:i4CF79C4F856971AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M38592 mRNA. Translation: AAA48690.1.
PIRiJH0663.
RefSeqiNP_990837.1. NM_205506.1.
XP_015135488.1. XM_015280002.1.
UniGeneiGga.11321.

Genome annotation databases

GeneIDi396506.
KEGGigga:396506.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M38592 mRNA. Translation: AAA48690.1.
PIRiJH0663.
RefSeqiNP_990837.1. NM_205506.1.
XP_015135488.1. XM_015280002.1.
UniGeneiGga.11321.

3D structure databases

ProteinModelPortaliP27003.
SMRiP27003. Positions 2-93.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP27003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396506.
KEGGigga:396506.

Organism-specific databases

CTDi6281.

Phylogenomic databases

HOVERGENiHBG001479.
InParanoidiP27003.
KOiK17274.
OrthoDBiEOG091G10QT.
PhylomeDBiP27003.

Enzyme and pathway databases

ReactomeiR-GGA-75205. Dissolution of Fibrin Clot.

Miscellaneous databases

PROiP27003.

Gene expression databases

BgeeiENSGALG00000028774.
ExpressionAtlasiP27003. baseline.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR028476. S100-A10.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF74. PTHR11639:SF74. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS10AA_CHICK
AccessioniPrimary (citable) accession number: P27003
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.