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P26997

- XYLA_THET8

UniProt

P26997 - XYLA_THET8

Protein

Xylose isomerase

Gene

xylA

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-xylopyranose = D-xylulose.

    Cofactori

    Binds 2 magnesium ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei53 – 531By similarity
    Active sitei56 – 561By similarity
    Metal bindingi180 – 1801Magnesium 1By similarity
    Metal bindingi216 – 2161Magnesium 1By similarity
    Metal bindingi216 – 2161Magnesium 2By similarity
    Metal bindingi219 – 2191Magnesium 2By similarity
    Metal bindingi244 – 2441Magnesium 1By similarity
    Metal bindingi254 – 2541Magnesium 2By similarity
    Metal bindingi256 – 2561Magnesium 2By similarity
    Metal bindingi286 – 2861Magnesium 1By similarity

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. xylose isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-xylose metabolic process Source: UniProtKB-HAMAP
    2. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism, Pentose shunt, Xylose metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    SABIO-RKP26997.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylose isomerase (EC:5.3.1.5)
    Gene namesi
    Name:xylA
    OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
    Taxonomic identifieri300852 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 387387Xylose isomerasePRO_0000195816Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.

    Structurei

    Secondary structure

    1
    387
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 83
    Beta strandi10 – 134
    Helixi14 – 174
    Helixi35 – 4511
    Beta strandi48 – 536
    Helixi54 – 574
    Helixi66 – 8116
    Beta strandi87 – 893
    Beta strandi93 – 953
    Helixi96 – 1005
    Helixi108 – 12821
    Beta strandi132 – 1354
    Beta strandi141 – 1433
    Helixi145 – 1473
    Helixi149 – 1513
    Helixi153 – 17119
    Beta strandi176 – 1794
    Beta strandi183 – 19210
    Helixi195 – 2028
    Beta strandi205 – 2073
    Helixi208 – 2103
    Beta strandi211 – 2133
    Helixi217 – 2226
    Helixi227 – 23610
    Beta strandi250 – 2534
    Helixi264 – 27613
    Helixi295 – 32026
    Helixi323 – 33210
    Helixi337 – 3404
    Beta strandi343 – 3453
    Helixi349 – 3568
    Helixi361 – 3666
    Helixi371 – 38212

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BXBX-ray2.20A/B/C/D1-387[»]
    ProteinModelPortaliP26997.
    SMRiP26997. Positions 1-387.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP26997.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the xylose isomerase family.Curated

    Family and domain databases

    Gene3Di3.20.20.150. 1 hit.
    HAMAPiMF_00455. Xylose_isom_A.
    InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013453. XylA_actinobac.
    IPR001998. Xylose_isomerase.
    [Graphical view]
    PfamiPF01261. AP_endonuc_2. 1 hit.
    [Graphical view]
    PRINTSiPR00688. XYLOSISMRASE.
    SUPFAMiSSF51658. SSF51658. 1 hit.
    TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
    PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P26997-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYEPKPEHRF TFGLWTVGNV GRDPFGDAVR ERLDPVYVVH KLAELGAYGV    50
    NLHDEDLIPR GTPPQERDQI VRRFKKALDE TGLKVPMVTA NLFSDPAFKD 100
    GAFTSPDPWV RAYALRKSLE TMDLGAELGA EIYVVWPGRE GAEVEATGKA 150
    RKVWDWVREA LNFMAAYAED QGYGYRFALE PKPNEPRGDI YFATVGSMLA 200
    FIHTLDRPER FGLNPEFAHE TMAGLNFVHA VAQALDAGKL FHIDLNDQRM 250
    SRFDQDLRFG SENLKAAFFL VDLLESSGYQ GPRHFDAHAL RTEDEEGVWA 300
    FARGCMRTYL ILKERAEAFR EDPEVKELLA AYYQEDPAAL ALLGPYSREK 350
    AEALKRAELP LEAKRRRGYA LERLDQLAVE YLLGVRG 387
    Length:387
    Mass (Da):43,907
    Last modified:August 1, 1992 - v1
    Checksum:iB2ED05466E4C88CE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D90256 Genomic DNA. Translation: BAA14301.1.
    RefSeqiWP_014677651.1. NC_017767.1.
    YP_006250271.1. NC_017767.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D90256 Genomic DNA. Translation: BAA14301.1 .
    RefSeqi WP_014677651.1. NC_017767.1.
    YP_006250271.1. NC_017767.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BXB X-ray 2.20 A/B/C/D 1-387 [» ]
    ProteinModelPortali P26997.
    SMRi P26997. Positions 1-387.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    SABIO-RK P26997.

    Miscellaneous databases

    EvolutionaryTracei P26997.

    Family and domain databases

    Gene3Di 3.20.20.150. 1 hit.
    HAMAPi MF_00455. Xylose_isom_A.
    InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013453. XylA_actinobac.
    IPR001998. Xylose_isomerase.
    [Graphical view ]
    Pfami PF01261. AP_endonuc_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00688. XYLOSISMRASE.
    SUPFAMi SSF51658. SSF51658. 1 hit.
    TIGRFAMsi TIGR02631. xylA_Arthro. 1 hit.
    PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Xylose (glucose) isomerase gene from the thermophile Thermus thermophilus: cloning, sequencing, and comparison with other thermostable xylose isomerases."
      Dekker K., Yamagata H., Sakaguchi K., Udaka S.
      J. Bacteriol. 173:3078-3083(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Crystal structures of thermostable xylose isomerases from Thermus caldophilus and Thermus thermophilus: possible structural determinants of thermostability."
      Chang C., Park B.C., Lee D.-S., Suh S.W.
      J. Mol. Biol. 288:623-634(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).

    Entry informationi

    Entry nameiXYLA_THET8
    AccessioniPrimary (citable) accession number: P26997
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3