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P26997

- XYLA_THET8

UniProt

P26997 - XYLA_THET8

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Protein

Xylose isomerase

Gene

xylA

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei53 – 531By similarity
Active sitei56 – 561By similarity
Metal bindingi180 – 1801Magnesium 1By similarity
Metal bindingi216 – 2161Magnesium 1By similarity
Metal bindingi216 – 2161Magnesium 2By similarity
Metal bindingi219 – 2191Magnesium 2By similarity
Metal bindingi244 – 2441Magnesium 1By similarity
Metal bindingi254 – 2541Magnesium 2By similarity
Metal bindingi256 – 2561Magnesium 2By similarity
Metal bindingi286 – 2861Magnesium 1By similarity

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

SABIO-RKP26997.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387Xylose isomerasePRO_0000195816Add
BLAST

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1
387
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 83
Beta strandi10 – 134
Helixi14 – 174
Helixi35 – 4511
Beta strandi48 – 536
Helixi54 – 574
Helixi66 – 8116
Beta strandi87 – 893
Beta strandi93 – 953
Helixi96 – 1005
Helixi108 – 12821
Beta strandi132 – 1354
Beta strandi141 – 1433
Helixi145 – 1473
Helixi149 – 1513
Helixi153 – 17119
Beta strandi176 – 1794
Beta strandi183 – 19210
Helixi195 – 2028
Beta strandi205 – 2073
Helixi208 – 2103
Beta strandi211 – 2133
Helixi217 – 2226
Helixi227 – 23610
Beta strandi250 – 2534
Helixi264 – 27613
Helixi295 – 32026
Helixi323 – 33210
Helixi337 – 3404
Beta strandi343 – 3453
Helixi349 – 3568
Helixi361 – 3666
Helixi371 – 38212

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BXBX-ray2.20A/B/C/D1-387[»]
ProteinModelPortaliP26997.
SMRiP26997. Positions 1-387.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26997.

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26997-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYEPKPEHRF TFGLWTVGNV GRDPFGDAVR ERLDPVYVVH KLAELGAYGV
60 70 80 90 100
NLHDEDLIPR GTPPQERDQI VRRFKKALDE TGLKVPMVTA NLFSDPAFKD
110 120 130 140 150
GAFTSPDPWV RAYALRKSLE TMDLGAELGA EIYVVWPGRE GAEVEATGKA
160 170 180 190 200
RKVWDWVREA LNFMAAYAED QGYGYRFALE PKPNEPRGDI YFATVGSMLA
210 220 230 240 250
FIHTLDRPER FGLNPEFAHE TMAGLNFVHA VAQALDAGKL FHIDLNDQRM
260 270 280 290 300
SRFDQDLRFG SENLKAAFFL VDLLESSGYQ GPRHFDAHAL RTEDEEGVWA
310 320 330 340 350
FARGCMRTYL ILKERAEAFR EDPEVKELLA AYYQEDPAAL ALLGPYSREK
360 370 380
AEALKRAELP LEAKRRRGYA LERLDQLAVE YLLGVRG
Length:387
Mass (Da):43,907
Last modified:August 1, 1992 - v1
Checksum:iB2ED05466E4C88CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D90256 Genomic DNA. Translation: BAA14301.1.
RefSeqiWP_014677651.1. NC_017767.1.
YP_006250271.1. NC_017767.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D90256 Genomic DNA. Translation: BAA14301.1 .
RefSeqi WP_014677651.1. NC_017767.1.
YP_006250271.1. NC_017767.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BXB X-ray 2.20 A/B/C/D 1-387 [» ]
ProteinModelPortali P26997.
SMRi P26997. Positions 1-387.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

SABIO-RK P26997.

Miscellaneous databases

EvolutionaryTracei P26997.

Family and domain databases

Gene3Di 3.20.20.150. 1 hit.
HAMAPi MF_00455. Xylose_isom_A.
InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view ]
Pfami PF01261. AP_endonuc_2. 1 hit.
[Graphical view ]
PRINTSi PR00688. XYLOSISMRASE.
SUPFAMi SSF51658. SSF51658. 1 hit.
TIGRFAMsi TIGR02631. xylA_Arthro. 1 hit.
PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Xylose (glucose) isomerase gene from the thermophile Thermus thermophilus: cloning, sequencing, and comparison with other thermostable xylose isomerases."
    Dekker K., Yamagata H., Sakaguchi K., Udaka S.
    J. Bacteriol. 173:3078-3083(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Crystal structures of thermostable xylose isomerases from Thermus caldophilus and Thermus thermophilus: possible structural determinants of thermostability."
    Chang C., Park B.C., Lee D.-S., Suh S.W.
    J. Mol. Biol. 288:623-634(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).

Entry informationi

Entry nameiXYLA_THET8
AccessioniPrimary (citable) accession number: P26997
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3