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Protein

Xylose isomerase

Gene

xylA

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei53By similarity1
Active sitei56By similarity1
Metal bindingi180Magnesium 1By similarity1
Metal bindingi216Magnesium 1By similarity1
Metal bindingi216Magnesium 2By similarity1
Metal bindingi219Magnesium 2By similarity1
Metal bindingi244Magnesium 1By similarity1
Metal bindingi254Magnesium 2By similarity1
Metal bindingi256Magnesium 2By similarity1
Metal bindingi286Magnesium 1By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BRENDAi5.3.1.5. 2305.
SABIO-RKP26997.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001958161 – 387Xylose isomeraseAdd BLAST387

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1387
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 8Combined sources3
Beta strandi10 – 13Combined sources4
Helixi14 – 17Combined sources4
Helixi35 – 45Combined sources11
Beta strandi48 – 53Combined sources6
Helixi54 – 57Combined sources4
Helixi66 – 81Combined sources16
Beta strandi87 – 89Combined sources3
Beta strandi93 – 95Combined sources3
Helixi96 – 100Combined sources5
Helixi108 – 128Combined sources21
Beta strandi132 – 135Combined sources4
Beta strandi141 – 143Combined sources3
Helixi145 – 147Combined sources3
Helixi149 – 151Combined sources3
Helixi153 – 171Combined sources19
Beta strandi176 – 179Combined sources4
Beta strandi183 – 192Combined sources10
Helixi195 – 202Combined sources8
Beta strandi205 – 207Combined sources3
Helixi208 – 210Combined sources3
Beta strandi211 – 213Combined sources3
Helixi217 – 222Combined sources6
Helixi227 – 236Combined sources10
Beta strandi250 – 253Combined sources4
Helixi264 – 276Combined sources13
Helixi295 – 320Combined sources26
Helixi323 – 332Combined sources10
Helixi337 – 340Combined sources4
Beta strandi343 – 345Combined sources3
Helixi349 – 356Combined sources8
Helixi361 – 366Combined sources6
Helixi371 – 382Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BXBX-ray2.20A/B/C/D1-387[»]
ProteinModelPortaliP26997.
SMRiP26997.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26997.

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26997-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYEPKPEHRF TFGLWTVGNV GRDPFGDAVR ERLDPVYVVH KLAELGAYGV
60 70 80 90 100
NLHDEDLIPR GTPPQERDQI VRRFKKALDE TGLKVPMVTA NLFSDPAFKD
110 120 130 140 150
GAFTSPDPWV RAYALRKSLE TMDLGAELGA EIYVVWPGRE GAEVEATGKA
160 170 180 190 200
RKVWDWVREA LNFMAAYAED QGYGYRFALE PKPNEPRGDI YFATVGSMLA
210 220 230 240 250
FIHTLDRPER FGLNPEFAHE TMAGLNFVHA VAQALDAGKL FHIDLNDQRM
260 270 280 290 300
SRFDQDLRFG SENLKAAFFL VDLLESSGYQ GPRHFDAHAL RTEDEEGVWA
310 320 330 340 350
FARGCMRTYL ILKERAEAFR EDPEVKELLA AYYQEDPAAL ALLGPYSREK
360 370 380
AEALKRAELP LEAKRRRGYA LERLDQLAVE YLLGVRG
Length:387
Mass (Da):43,907
Last modified:August 1, 1992 - v1
Checksum:iB2ED05466E4C88CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90256 Genomic DNA. Translation: BAA14301.1.
RefSeqiWP_014677651.1. NC_017767.1.
YP_006250271.1. NC_017767.1.

Genome annotation databases

GeneIDi13916970.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90256 Genomic DNA. Translation: BAA14301.1.
RefSeqiWP_014677651.1. NC_017767.1.
YP_006250271.1. NC_017767.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BXBX-ray2.20A/B/C/D1-387[»]
ProteinModelPortaliP26997.
SMRiP26997.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13916970.

Enzyme and pathway databases

BRENDAi5.3.1.5. 2305.
SABIO-RKP26997.

Miscellaneous databases

EvolutionaryTraceiP26997.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXYLA_THET8
AccessioniPrimary (citable) accession number: P26997
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.