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Protein

Ciliary neurotrophic factor receptor subunit alpha

Gene

CNTFR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to CNTF. The alpha subunit provides the receptor specificity.

GO - Molecular functioni

  • ciliary neurotrophic factor receptor activity Source: ProtInc
  • cytokine binding Source: HGNC
  • receptor binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000122756-MONOMER.
ReactomeiR-HSA-6788467. IL-6-type cytokine receptor ligand interactions.
SignaLinkiP26992.
SIGNORiP26992.

Names & Taxonomyi

Protein namesi
Recommended name:
Ciliary neurotrophic factor receptor subunit alpha
Short name:
CNTF receptor subunit alpha
Short name:
CNTFR-alpha
Gene namesi
Name:CNTFR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:2170. CNTFR.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • apical plasma membrane Source: CACAO
  • ciliary neurotrophic factor receptor complex Source: BHF-UCL
  • CNTFR-CLCF1 complex Source: BHF-UCL
  • extrinsic component of membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1271.
OpenTargetsiENSG00000122756.
PharmGKBiPA26684.

Polymorphism and mutation databases

BioMutaiCNTFR.
DMDMi1352099.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001099123 – 342Ciliary neurotrophic factor receptor subunit alphaAdd BLAST320
PropeptideiPRO_0000010992343 – 372Removed in mature formSequence analysisAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 89PROSITE-ProRule annotation
Glycosylationi60N-linked (GlcNAc...)Sequence analysis1
Glycosylationi70N-linked (GlcNAc...)Sequence analysis1
Glycosylationi142N-linked (GlcNAc...)Sequence analysis1
Glycosylationi190N-linked (GlcNAc...)Sequence analysis1
Lipidationi342GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiP26992.
PaxDbiP26992.
PeptideAtlasiP26992.
PRIDEiP26992.

Expressioni

Tissue specificityi

Nervous system and skeletal muscle.

Gene expression databases

BgeeiENSG00000122756.
CleanExiHS_CNTFR.
ExpressionAtlasiP26992. baseline and differential.
GenevisibleiP26992. HS.

Organism-specific databases

HPAiCAB025310.
HPA036635.

Interactioni

Subunit structurei

Heterotrimer of the alpha subunit, LIFR and IL6ST.

Binary interactionsi

WithEntry#Exp.IntActNotes
CNTFP2644112EBI-743758,EBI-1050897

GO - Molecular functioni

  • cytokine binding Source: HGNC
  • receptor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi107671. 8 interactors.
DIPiDIP-5777N.
IntActiP26992. 10 interactors.
STRINGi9606.ENSP00000242338.

Structurei

Secondary structure

1372
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi208 – 214Combined sources7
Beta strandi222 – 227Combined sources6
Turni235 – 239Combined sources5
Beta strandi242 – 251Combined sources10
Beta strandi257 – 261Combined sources5
Beta strandi263 – 267Combined sources5
Beta strandi272 – 274Combined sources3
Beta strandi276 – 281Combined sources6
Beta strandi284 – 287Combined sources4
Beta strandi295 – 299Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UC6NMR-A202-305[»]
ProteinModelPortaliP26992.
SMRiP26992.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26992.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 104Ig-like C2-typeAdd BLAST78
Domaini108 – 205Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST98
Domaini206 – 306Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST101

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi290 – 294WSXWS motif5

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IH2U. Eukaryota.
ENOG4110HUW. LUCA.
GeneTreeiENSGT00530000063103.
HOGENOMiHOG000171060.
HOVERGENiHBG051048.
InParanoidiP26992.
KOiK05059.
OMAiQETPHVQ.
OrthoDBiEOG091G0B8P.
PhylomeDBiP26992.
TreeFamiTF331210.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26992-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPVPWACC AVLAAAAAVV YAQRHSPQEA PHVQYERLGS DVTLPCGTAN
60 70 80 90 100
WDAAVTWRVN GTDLAPDLLN GSQLVLHGLE LGHSGLYACF HRDSWHLRHQ
110 120 130 140 150
VLLHVGLPPR EPVLSCRSNT YPKGFYCSWH LPTPTYIPNT FNVTVLHGSK
160 170 180 190 200
IMVCEKDPAL KNRCHIRYMH LFSTIKYKVS ISVSNALGHN ATAITFDEFT
210 220 230 240 250
IVKPDPPENV VARPVPSNPR RLEVTWQTPS TWPDPESFPL KFFLRYRPLI
260 270 280 290 300
LDQWQHVELS DGTAHTITDA YAGKEYIIQV AAKDNEIGTW SDWSVAAHAT
310 320 330 340 350
PWTEEPRHLT TEAQAAETTT STTSSLAPPP TTKICDPGEL GSGGGPSAPF
360 370
LVSVPITLAL AAAAATASSL LI
Length:372
Mass (Da):40,633
Last modified:February 1, 1996 - v2
Checksum:iB2F3F73DE8F8750E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73238 mRNA. Translation: AAA35707.1.
L38025
, L38022, L38023, L38024 Genomic DNA. Translation: AAA91337.1.
BT019824 mRNA. Translation: AAV38627.1.
AL160270 Genomic DNA. Translation: CAI13159.1.
CH471071 Genomic DNA. Translation: EAW58445.1.
CH471071 Genomic DNA. Translation: EAW58446.1.
CH471071 Genomic DNA. Translation: EAW58447.1.
CH471071 Genomic DNA. Translation: EAW58448.1.
BC001492 mRNA. Translation: AAH01492.1.
CCDSiCCDS6558.1.
PIRiA40854. UHHUCN.
RefSeqiNP_001193940.1. NM_001207011.1.
NP_001833.1. NM_001842.4.
NP_671693.1. NM_147164.2.
XP_016869752.1. XM_017014263.1.
XP_016869753.1. XM_017014264.1.
XP_016869754.1. XM_017014265.1.
UniGeneiHs.129966.

Genome annotation databases

EnsembliENST00000351266; ENSP00000242338; ENSG00000122756.
ENST00000378980; ENSP00000368265; ENSG00000122756.
ENST00000610543; ENSP00000480451; ENSG00000122756.
GeneIDi1271.
KEGGihsa:1271.
UCSCiuc003zup.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73238 mRNA. Translation: AAA35707.1.
L38025
, L38022, L38023, L38024 Genomic DNA. Translation: AAA91337.1.
BT019824 mRNA. Translation: AAV38627.1.
AL160270 Genomic DNA. Translation: CAI13159.1.
CH471071 Genomic DNA. Translation: EAW58445.1.
CH471071 Genomic DNA. Translation: EAW58446.1.
CH471071 Genomic DNA. Translation: EAW58447.1.
CH471071 Genomic DNA. Translation: EAW58448.1.
BC001492 mRNA. Translation: AAH01492.1.
CCDSiCCDS6558.1.
PIRiA40854. UHHUCN.
RefSeqiNP_001193940.1. NM_001207011.1.
NP_001833.1. NM_001842.4.
NP_671693.1. NM_147164.2.
XP_016869752.1. XM_017014263.1.
XP_016869753.1. XM_017014264.1.
XP_016869754.1. XM_017014265.1.
UniGeneiHs.129966.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UC6NMR-A202-305[»]
ProteinModelPortaliP26992.
SMRiP26992.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107671. 8 interactors.
DIPiDIP-5777N.
IntActiP26992. 10 interactors.
STRINGi9606.ENSP00000242338.

Polymorphism and mutation databases

BioMutaiCNTFR.
DMDMi1352099.

Proteomic databases

EPDiP26992.
PaxDbiP26992.
PeptideAtlasiP26992.
PRIDEiP26992.

Protocols and materials databases

DNASUi1271.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000351266; ENSP00000242338; ENSG00000122756.
ENST00000378980; ENSP00000368265; ENSG00000122756.
ENST00000610543; ENSP00000480451; ENSG00000122756.
GeneIDi1271.
KEGGihsa:1271.
UCSCiuc003zup.2. human.

Organism-specific databases

CTDi1271.
DisGeNETi1271.
GeneCardsiCNTFR.
HGNCiHGNC:2170. CNTFR.
HPAiCAB025310.
HPA036635.
MIMi118946. gene.
neXtProtiNX_P26992.
OpenTargetsiENSG00000122756.
PharmGKBiPA26684.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH2U. Eukaryota.
ENOG4110HUW. LUCA.
GeneTreeiENSGT00530000063103.
HOGENOMiHOG000171060.
HOVERGENiHBG051048.
InParanoidiP26992.
KOiK05059.
OMAiQETPHVQ.
OrthoDBiEOG091G0B8P.
PhylomeDBiP26992.
TreeFamiTF331210.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000122756-MONOMER.
ReactomeiR-HSA-6788467. IL-6-type cytokine receptor ligand interactions.
SignaLinkiP26992.
SIGNORiP26992.

Miscellaneous databases

ChiTaRSiCNTFR. human.
EvolutionaryTraceiP26992.
GenomeRNAii1271.
PROiP26992.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122756.
CleanExiHS_CNTFR.
ExpressionAtlasiP26992. baseline and differential.
GenevisibleiP26992. HS.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNTFR_HUMAN
AccessioniPrimary (citable) accession number: P26992
Secondary accession number(s): Q5U050
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 161 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.