Reviewed,
UniProtKB/Swiss-Prot P26992 (CNTFR_HUMAN)
Last modified
February 9, 2010.
Version 101.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ciliary neurotrophic factor receptor subunit alpha Short name=CNTF receptor subunit alpha Short name=CNTFR-alpha | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 372 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Binds to CNTF. The alpha subunit provides the receptor specificity. |
| Subunit structure | Heterotrimer of the alpha subunit, LIFR and IL6ST. |
| Subcellular location | |
| Tissue specificity | Nervous system and skeletal muscle. |
| Domain | The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. |
| Sequence similarities | Belongs to the type I cytokine receptor family. Type 3 subfamily. Contains 2 fibronectin type-III domains. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Domain | Immunoglobulin domain Repeat Signal |
| Molecular function | Receptor |
| PTM | Disulfide bond GPI-anchor Glycoprotein Lipoprotein |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Biological process | ciliary neurotrophic factor-mediated signaling pathway Inferred from direct assay. Source: UniProtKB nervous system developmentTraceable author statement. Source: ProtInc |
| Cellular component | anchored to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell extrinsic to membrane Ref.1Traceable author statement. Source: ProtInc plasma membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ciliary neurotrophic factor receptor activity Traceable author statement. Source: ProtInc receptor binding Ref.4Inferred from physical interaction. Source: UniProtKB |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| ABL1 | P00519 | 1 | EBI-743758,EBI-375543 | |
| CRK | P46108 | 1 | EBI-743758,EBI-886 | |
| FYN | P06241 | 1 | EBI-743758,EBI-515315 | |
| GRB2 | P62993 | 1 | EBI-743758,EBI-401755 | |
| NCK1 | P16333 | 1 | EBI-743758,EBI-389883 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 22 | 22 | Potential | ||||||||||||||||||||||||||
| Chain | 23 – 342 | 320 | Ciliary neurotrophic factor receptor subunit alpha | PRO_0000010991 | |||||||||||||||||||||||||
| Propeptide | 343 – 372 | 30 | Removed in mature form Potential | PRO_0000010992 | |||||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||||
| Domain | 27 – 104 | 78 | Ig-like C2-type | ||||||||||||||||||||||||||
| Domain | 105 – 200 | 96 | Fibronectin type-III 1 | ||||||||||||||||||||||||||
| Domain | 204 – 301 | 98 | Fibronectin type-III 2 | ||||||||||||||||||||||||||
| Motif | 290 – 294 | 5 | WSXWS motif | ||||||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||||||
| Lipidation | 342 | 1 | GPI-anchor amidated serine Potential | ||||||||||||||||||||||||||
| Glycosylation | 60 | 1 | N-linked (GlcNAc...) Potential | ||||||||||||||||||||||||||
| Glycosylation | 70 | 1 | N-linked (GlcNAc...) Potential | ||||||||||||||||||||||||||
| Glycosylation | 142 | 1 | N-linked (GlcNAc...) Potential | ||||||||||||||||||||||||||
| Glycosylation | 190 | 1 | N-linked (GlcNAc...) Potential | ||||||||||||||||||||||||||
| Disulfide bond | 46 ↔ 89 | Potential | |||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||
| Beta strand | 208 – 214 | 7 | |||||||||||||||||||||||||||
| Beta strand | 222 – 227 | 6 | |||||||||||||||||||||||||||
| Turn | 235 – 239 | 5 | |||||||||||||||||||||||||||
| Beta strand | 242 – 251 | 10 | |||||||||||||||||||||||||||
| Beta strand | 257 – 261 | 5 | |||||||||||||||||||||||||||
| Beta strand | 263 – 267 | 5 | |||||||||||||||||||||||||||
| Beta strand | 272 – 274 | 3 | |||||||||||||||||||||||||||
| Beta strand | 276 – 281 | 6 | |||||||||||||||||||||||||||
| Beta strand | 284 – 287 | 4 | |||||||||||||||||||||||||||
| Beta strand | 295 – 299 | 5 | |||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The receptor for ciliary neurotrophic factor." Davis S., Aldrich T.H., Valenzuela D.M., Wong V., Furth M.E., Squinto S.P., Yancopoulos G.D. Science 253:59-63(1991) [PubMed: 1648265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Genomic organization and chromosomal localization of the human and mouse genes encoding the alpha receptor component for ciliary neurotrophic factor." Valenzuela D.M., Rojas E., le Beau M.M., Espinosa R., Brannan C.I., McClain J., Masiakowski P., Ip N.Y., Copeland N.G., Jenkins N.A., Yancopoulos G.D. Genomics 25:157-163(1995) [PubMed: 7774913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [4] | "Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free associations among components of the CNTF receptor complex." Man D., He W., Sze K.H., Gong K., Smith D.K., Zhu G., Ip N.Y. J. Biol. Chem. 278:23285-23294(2003) [PubMed: 12707266] [Abstract] Cited for: STRUCTURE BY NMR OF 202-305. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | M73238 mRNA. Translation: AAA35707.1. L38025 L38024 Genomic DNA. Translation: AAA91337.1. BC001492 mRNA. Translation: AAH01492.1. | ||||||||||||
| IPI | IPI00003102. | ||||||||||||
| PIR | UHHUCN. A40854. | ||||||||||||
| RefSeq | NP_001833.1. NP_671693.1. | ||||||||||||
| UniGene | Hs.129966 | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| SMR | P26992. Positions 29-304. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| DIP | DIP-5777N. | ||||||||||||
| IntAct | P26992. 8 interactions. | ||||||||||||
| STRING | P26992. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | P26992. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000351266; ENSP00000242338; ENSG00000122756; Homo sapiens. [Genome view] ENST00000378980; ENSP00000368265; ENSG00000122756; Homo sapiens. [Genome view] | ||||||||||||
| GeneID | 1271. | ||||||||||||
| KEGG | hsa:1271. | ||||||||||||
| UCSC | uc003zup.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 1271. | ||||||||||||
| GeneCards | GC09M034541. | ||||||||||||
| H-InvDB | HIX0007996. | ||||||||||||
| HGNC | HGNC:2170. CNTFR. | ||||||||||||
| HPA | CAB025310. | ||||||||||||
| MIM | 118946. gene. | ||||||||||||
| PharmGKB | PA26684. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | prNOG16448. | ||||||||||||
| HOGENOM | HBG443531. | ||||||||||||
| HOVERGEN | P26992. | ||||||||||||
| InParanoid | P26992. | ||||||||||||
| OMA | SWPDPES. | ||||||||||||
| OrthoDB | EOG9ZGRZ2. | ||||||||||||
| PhylomeDB | P26992. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | P26992. | ||||||||||||
| Bgee | P26992. | ||||||||||||
| CleanEx | HS_CNTFR. | ||||||||||||
| Genevestigator | P26992. | ||||||||||||
| GermOnline | ENSG00000122756. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR008957. Fibronectin_typ-III-like_fold. IPR003961. FN_III. IPR003530. Hematopoietin_rcpt_L_F3_CS. IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003598. Ig_sub2. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:2.60.40.30. FN_III-like. 1 hit. G3DSA:2.60.40.10. Ig-like_fold. 1 hit. | ||||||||||||
| Pfam | PF00041. fn3. 1 hit. [Graphical view] | ||||||||||||
| SMART | SM00060. FN3. 1 hit. SM00408. IGc2. 1 hit. [Graphical view] | ||||||||||||
| PROSITE | PS50853. FN3. 2 hits. PS01354. HEMATOPO_REC_L_F3. 1 hit. PS50835. IG_LIKE. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 5147. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | CNTFR_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P26992 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 9 Human chromosome 9: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


