P26992 (CNTFR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ciliary neurotrophic factor receptor subunit alpha
Short name=CNTF receptor subunit alpha
Short name=CNTFR-alpha

Gene names

Name:

CNTFR

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to CNTF. The alpha subunit provides the receptor specificity.
Subunit structure	Heterotrimer of the alpha subunit, LIFR and IL6ST.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor.
Tissue specificity	Nervous system and skeletal muscle.
Domain	The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
Sequence similarities	Belongs to the type I cytokine receptor family. Type 3 subfamily. Contains 2 fibronectin type-III domains. Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Immunoglobulin domain Repeat Signal
Molecular function	Receptor
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	brainstem development Inferred from electronic annotation. Source: Compara negative regulation of neuron apoptotic process Inferred from electronic annotation. Source: Compara nervous system development Traceable author statement PubMed 7585948. Source: ProtInc positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara sex differentiation Inferred from electronic annotation. Source: Compara skeletal muscle organ development Inferred from electronic annotation. Source: Compara suckling behavior Inferred from electronic annotation. Source: Compara
Cellular_component	CNTFR-CLCF1 complex Inferred from direct assay PubMed 11285233. Source: BHF-UCL anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW extrinsic to membrane Traceable author statement Ref.1. Source: ProtInc plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ciliary neurotrophic factor receptor activity Traceable author statement PubMed 7585948. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 22

22

Potential

Chain

23 – 342

320

Ciliary neurotrophic factor receptor subunit alpha

PRO_0000010991

Propeptide

343 – 372

30

Removed in mature form Potential

PRO_0000010992

Regions

Domain

27 – 104

78

Ig-like C2-type

Domain

105 – 200

96

Fibronectin type-III 1

Domain

204 – 301

98

Fibronectin type-III 2

Motif

290 – 294

5

WSXWS motif

Amino acid modifications

Lipidation

342

1

GPI-anchor amidated serine Potential

Glycosylation

60

1

N-linked (GlcNAc...) Potential

Glycosylation

70

1

N-linked (GlcNAc...) Potential

Glycosylation

142

1

N-linked (GlcNAc...) Potential

Glycosylation

190

1

N-linked (GlcNAc...) Potential

Disulfide bond

46 ↔ 89

Potential

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

372

Helix Strand Turn

Details...

Beta strand

208 – 214

7

Beta strand

222 – 227

6

Turn

235 – 239

5

Beta strand

242 – 251

10

Beta strand

257 – 261

5

Beta strand

263 – 267

5

Beta strand

272 – 274

3

Beta strand

276 – 281

6

Beta strand

284 – 287

4

Beta strand

295 – 299

5

Sequences

	Sequence		Length	Mass (Da)
	P26992 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: B2F3F73DE8F8750E	FASTA	372	40,633
	10 20 30 40 50 60 MAAPVPWACC AVLAAAAAVV YAQRHSPQEA PHVQYERLGS DVTLPCGTAN WDAAVTWRVN 70 80 90 100 110 120 GTDLAPDLLN GSQLVLHGLE LGHSGLYACF HRDSWHLRHQ VLLHVGLPPR EPVLSCRSNT 130 140 150 160 170 180 YPKGFYCSWH LPTPTYIPNT FNVTVLHGSK IMVCEKDPAL KNRCHIRYMH LFSTIKYKVS 190 200 210 220 230 240 ISVSNALGHN ATAITFDEFT IVKPDPPENV VARPVPSNPR RLEVTWQTPS TWPDPESFPL 250 260 270 280 290 300 KFFLRYRPLI LDQWQHVELS DGTAHTITDA YAGKEYIIQV AAKDNEIGTW SDWSVAAHAT 310 320 330 340 350 360 PWTEEPRHLT TEAQAAETTT STTSSLAPPP TTKICDPGEL GSGGGPSAPF LVSVPITLAL 370 AAAAATASSL LI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The receptor for ciliary neurotrophic factor." Davis S., Aldrich T.H., Valenzuela D.M., Wong V., Furth M.E., Squinto S.P., Yancopoulos G.D. Science 253:59-63(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genomic organization and chromosomal localization of the human and mouse genes encoding the alpha receptor component for ciliary neurotrophic factor." Valenzuela D.M., Rojas E., le Beau M.M., Espinosa R., Brannan C.I., McClain J., Masiakowski P., Ip N.Y., Copeland N.G., Jenkins N.A., Yancopoulos G.D. Genomics 25:157-163(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[7]	"Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free associations among components of the CNTF receptor complex." Man D., He W., Sze K.H., Gong K., Smith D.K., Zhu G., Ip N.Y. J. Biol. Chem. 278:23285-23294(2003) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 202-305.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M73238 mRNA. Translation: AAA35707.1.
L38025 , L38022, L38023, L38024 Genomic DNA. Translation: AAA91337.1.
BT019824 mRNA. Translation: AAV38627.1.
AL160270 Genomic DNA. Translation: CAI13159.1.
CH471071 Genomic DNA. Translation: EAW58445.1.
CH471071 Genomic DNA. Translation: EAW58446.1.
CH471071 Genomic DNA. Translation: EAW58447.1.
CH471071 Genomic DNA. Translation: EAW58448.1.
BC001492 mRNA. Translation: AAH01492.1.

IPI

IPI00003102.

PIR

UHHUCN. A40854.

RefSeq

NP_001193940.1. NM_001207011.1.
NP_001833.1. NM_001842.4.
NP_671693.1. NM_147164.2.

UniGene

Hs.129966.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1UC6	NMR	-	A	202-305	[»]

ProteinModelPortal

P26992.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-5777N.

IntAct

P26992. 8 interactions.

STRING

9606.ENSP00000242338.

Polymorphism databases

DMDM

1352099.

Proteomic databases

PaxDb

P26992.

PRIDE

P26992.

Protocols and materials databases

DNASU

1271.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000351266; ENSP00000242338; ENSG00000122756.
ENST00000378980; ENSP00000368265; ENSG00000122756.

GeneID

1271.

KEGG

hsa:1271.

UCSC

uc003zup.2. human.

Organism-specific databases

CTD

1271.

GeneCards

GC09M034541.

HGNC

HGNC:2170. CNTFR.

HPA

CAB025310.

MIM

118946. gene.

neXtProt

NX_P26992.

PharmGKB

PA26684.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG42607.

HOGENOM

HOG000171060.

HOVERGEN

HBG051048.

InParanoid

P26992.

KO

K05059.

OMA

KYFLRYR.

OrthoDB

EOG4RBQMB.

PhylomeDB

P26992.

Gene expression databases

ArrayExpress

P26992.

Bgee

P26992.

CleanEx

HS_CNTFR.

Genevestigator

P26992.

GermOnline

ENSG00000122756. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 3 hits.

InterPro

IPR003961. Fibronectin_type3.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
[Graphical view]

Pfam

PF00041. fn3. 1 hit.
[Graphical view]

SMART

SM00060. FN3. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]

SUPFAM

SSF49265. FN_III-like. 2 hits.

PROSITE

PS50853. FN3. 2 hits.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P26992.

GenomeRNAi

1271.

NextBio

5147.

SOURCE

Search...

Entry information

Entry name

CNTFR_HUMAN

Accession

Primary (citable) accession number: P26992
Secondary accession number(s): Q5U050

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 130 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.