Ciliary neurotrophic factor receptor subunit alpha precursor

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Reviewed, UniProtKB/Swiss-Prot P26992 (CNTFR_HUMAN)

Last modified February 9, 2010. Version 101. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Ciliary neurotrophic factor receptor subunit alpha
      Short name=CNTF receptor subunit alpha
      Short name=CNTFR-alpha

Gene names

Name:

CNTFR

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Binds to CNTF. The alpha subunit provides the receptor specificity.
Subunit structure	Heterotrimer of the alpha subunit, LIFR and IL6ST.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor.
Tissue specificity	Nervous system and skeletal muscle.
Domain	The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
Sequence similarities	Belongs to the type I cytokine receptor family. Type 3 subfamily. Contains 2 fibronectin type-III domains. Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

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Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Immunoglobulin domain Repeat Signal
Molecular function	Receptor
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	ciliary neurotrophic factor-mediated signaling pathway Inferred from direct assay. Source: UniProtKB nervous system development Traceable author statement. Source: ProtInc
Cellular component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell extrinsic to membrane Ref.1 Traceable author statement. Source: ProtInc plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ciliary neurotrophic factor receptor activity Traceable author statement. Source: ProtInc receptor binding Ref.4 Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct
ABL1	P00519	1	EBI-743758,EBI-375543
CRK	P46108	1	EBI-743758,EBI-886
FYN	P06241	1	EBI-743758,EBI-515315
GRB2	P62993	1	EBI-743758,EBI-401755
NCK1	P16333	1	EBI-743758,EBI-389883

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 22

Potential

Chain

23 – 342

320

Ciliary neurotrophic factor receptor subunit alpha

PRO_0000010991

Propeptide

343 – 372

Removed in mature form Potential

PRO_0000010992

Regions

Domain

27 – 104

Ig-like C2-type

Domain

105 – 200

Fibronectin type-III 1

Domain

204 – 301

Fibronectin type-III 2

Motif

290 – 294

WSXWS motif

Amino acid modifications

Lipidation

342

GPI-anchor amidated serine Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

142

N-linked (GlcNAc...) Potential

Glycosylation

190

N-linked (GlcNAc...) Potential

Disulfide bond

46 ↔ 89

Potential

Secondary structure

372

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

P26992-1 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: B2F3F73DE8F8750E
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FASTA

372

40,633

        10         20         30         40         50         60 
MAAPVPWACC AVLAAAAAVV YAQRHSPQEA PHVQYERLGS DVTLPCGTAN WDAAVTWRVN 

        70         80         90        100        110        120 
GTDLAPDLLN GSQLVLHGLE LGHSGLYACF HRDSWHLRHQ VLLHVGLPPR EPVLSCRSNT 

       130        140        150        160        170        180 
YPKGFYCSWH LPTPTYIPNT FNVTVLHGSK IMVCEKDPAL KNRCHIRYMH LFSTIKYKVS 

       190        200        210        220        230        240 
ISVSNALGHN ATAITFDEFT IVKPDPPENV VARPVPSNPR RLEVTWQTPS TWPDPESFPL 

       250        260        270        280        290        300 
KFFLRYRPLI LDQWQHVELS DGTAHTITDA YAGKEYIIQV AAKDNEIGTW SDWSVAAHAT 

       310        320        330        340        350        360 
PWTEEPRHLT TEAQAAETTT STTSSLAPPP TTKICDPGEL GSGGGPSAPF LVSVPITLAL 

       370 
AAAAATASSL LI

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The receptor for ciliary neurotrophic factor." Davis S., Aldrich T.H., Valenzuela D.M., Wong V., Furth M.E., Squinto S.P., Yancopoulos G.D. Science 253:59-63(1991) [PubMed: 1648265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genomic organization and chromosomal localization of the human and mouse genes encoding the alpha receptor component for ciliary neurotrophic factor." Valenzuela D.M., Rojas E., le Beau M.M., Espinosa R., Brannan C.I., McClain J., Masiakowski P., Ip N.Y., Copeland N.G., Jenkins N.A., Yancopoulos G.D. Genomics 25:157-163(1995) [PubMed: 7774913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free associations among components of the CNTF receptor complex." Man D., He W., Sze K.H., Gong K., Smith D.K., Zhu G., Ip N.Y. J. Biol. Chem. 278:23285-23294(2003) [PubMed: 12707266] [Abstract] Cited for: STRUCTURE BY NMR OF 202-305.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M73238 mRNA. Translation: AAA35707.1.
L38025

L38024 Genomic DNA. Translation: AAA91337.1.
BC001492 mRNA. Translation: AAH01492.1.

IPI

IPI00003102.

PIR

UHHUCN. A40854.

RefSeq

NP_001833.1.
NP_671693.1.

UniGene

Hs.129966

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1UC6	NMR	-	A	202-305	[»]

SMR

P26992. Positions 29-304.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-5777N.

IntAct

P26992. 8 interactions.

STRING

P26992.

Proteomic databases

PRIDE

P26992.

Genome annotation databases

Ensembl

ENST00000351266; ENSP00000242338; ENSG00000122756; Homo sapiens. [Genome view]
ENST00000378980; ENSP00000368265; ENSG00000122756; Homo sapiens. [Genome view]

GeneID

1271.

KEGG

hsa:1271.

UCSC

uc003zup.1. human.

Organism-specific databases

CTD

1271.

GeneCards

GC09M034541.

H-InvDB

HIX0007996.

HGNC

HGNC:2170. CNTFR.

HPA

CAB025310.

MIM

118946. gene.

PharmGKB

PA26684.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG16448.

HOGENOM

HBG443531.

HOVERGEN

P26992.

InParanoid

P26992.

OMA

SWPDPES.

OrthoDB

EOG9ZGRZ2.

PhylomeDB

P26992.

Gene expression databases

ArrayExpress

P26992.

Bgee

P26992.

CleanEx

HS_CNTFR.

Genevestigator

P26992.

GermOnline

ENSG00000122756. Homo sapiens.

Family and domain databases

InterPro

IPR008957. Fibronectin_typ-III-like_fold.
IPR003961. FN_III.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
[Graphical view]

Gene3D

G3DSA:2.60.40.30. FN_III-like. 1 hit.
G3DSA:2.60.40.10. Ig-like_fold. 1 hit.

Pfam

PF00041. fn3. 1 hit.
[Graphical view]

SMART

SM00060. FN3. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]

PROSITE

PS50853. FN3. 2 hits.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

5147.

SOURCE

Search...

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Entry information

Entry name

CNTFR_HUMAN

Accession

Primary (citable) accession number: P26992

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	February 1, 1996
Last modified:	February 9, 2010
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents