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Protein

ADP-ribosylation factor 6

Gene

ARF6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. May contribute to the regulation of dendritic branching, filopodia extension and dendritic spine development (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 27GTPBy similarity8
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi122 – 125GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDifferentiation, ER-Golgi transport, Neurogenesis, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-8854214. TBC/RABGAPs.
R-GGA-8856828. Clathrin-mediated endocytosis.
R-GGA-8875656. MET receptor recycling.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor 6
Gene namesi
Name:ARF6
Synonyms:CPS1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 5

Subcellular locationi

  • Cytoplasmcytosol By similarity
  • Cell membrane By similarity; Lipid-anchor By similarity
  • Endosome membrane By similarity; Lipid-anchor By similarity
  • Recycling endosome membrane By similarity; Lipid-anchor By similarity
  • Cell projectionfilopodium membrane By similarity; Lipid-anchor By similarity
  • Cell projectionruffle By similarity
  • Cleavage furrow By similarity
  • MidbodyMidbody ring By similarity
  • Golgi apparatus By similarity

  • Note: Distributed uniformly on the plasma membrane, as well as throughout the cytoplasm during metaphase. Subsequently concentrated at patches in the equatorial region at the onset of cytokinesis, and becomes distributed in the equatorial region concurrent with cleavage furrow ingression. In late stages of cytokinesis, concentrates at the midbody ring/Flemming body. After abscission of the intercellular bridge, incorporated into one of the daughter cells as a midbody remnant and localizes to punctate structures beneath the plasma membrane (By similarity). Recruited to the cell membrane in association with CYTH2 and ARL4C. Colocalizes with DAB2IP at the plasma membrane and endocytic vesicles. Myristoylation is required for proper localization to membranes (By similarity).By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002074032 – 175ADP-ribosylation factor 6Add BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PRIDEiP26990.

Expressioni

Developmental stagei

In 3 days embryos.

Gene expression databases

BgeeiENSGALG00000026944.
ExpressionAtlasiP26990. baseline.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP26990. 2 interactors.
MINTiMINT-6824981.

Structurei

3D structure databases

ProteinModelPortaliP26990.
SMRiP26990.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

HOVERGENiHBG002073.
InParanoidiP26990.
KOiK07941.
OrthoDBiEOG091G0OXD.
PhylomeDBiP26990.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
PfamiView protein in Pfam
PF00025. Arf. 1 hit.
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51417. ARF. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26990-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKVLSKIFG NKEMRILMLG LDAAGKTTIL YKLKLGQSVT TIPTVGFNVE
60 70 80 90 100
TVTYKNVKFN VWDVGGQDKI RPLWRHYYTG TQGLIFVVDC ADRDRIDEAR
110 120 130 140 150
QELHRIINDR EMRDAIILIF ANKQDLPDAM KPHEIQEKLG LTRIRDRNWY
160 170
VQPSCATTGD GLYEGLTWLT SNYKS
Length:175
Mass (Da):20,096
Last modified:January 23, 2007 - v3
Checksum:i49E68E09AEA52B98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03682 Genomic DNA. Translation: CAA27317.1.
PIRiI50632.
RefSeqiNP_001075174.1. NM_001081705.1.
UniGeneiGga.2511.

Genome annotation databases

EnsembliENSGALT00000045497; ENSGALP00000041604; ENSGALG00000026944.
GeneIDi428927.
KEGGigga:428927.

Similar proteinsi

Entry informationi

Entry nameiARF6_CHICK
AccessioniPrimary (citable) accession number: P26990
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families