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Protein

ADP-ribosylation factor 6

Gene

ARF6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. May contribute to the regulation of dendritic branching, filopodia extension and dendritic spine development (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 27GTPBy similarity8
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi122 – 125GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDifferentiation, ER-Golgi transport, Neurogenesis, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-8854214. TBC/RABGAPs.
R-GGA-8856828. Clathrin-mediated endocytosis.
R-GGA-8875656. MET receptor recycling.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor 6
Gene namesi
Name:ARF6
Synonyms:CPS1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cell projection, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002074032 – 175ADP-ribosylation factor 6Add BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PRIDEiP26990.

Expressioni

Developmental stagei

In 3 days embryos.

Gene expression databases

BgeeiENSGALG00000026944.
ExpressionAtlasiP26990. baseline.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP26990. 2 interactors.
MINTiMINT-6824981.

Structurei

3D structure databases

ProteinModelPortaliP26990.
SMRiP26990.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

HOVERGENiHBG002073.
InParanoidiP26990.
KOiK07941.
OrthoDBiEOG091G0OXD.
PhylomeDBiP26990.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
PfamiView protein in Pfam
PF00025. Arf. 1 hit.
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51417. ARF. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26990-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKVLSKIFG NKEMRILMLG LDAAGKTTIL YKLKLGQSVT TIPTVGFNVE
60 70 80 90 100
TVTYKNVKFN VWDVGGQDKI RPLWRHYYTG TQGLIFVVDC ADRDRIDEAR
110 120 130 140 150
QELHRIINDR EMRDAIILIF ANKQDLPDAM KPHEIQEKLG LTRIRDRNWY
160 170
VQPSCATTGD GLYEGLTWLT SNYKS
Length:175
Mass (Da):20,096
Last modified:January 23, 2007 - v3
Checksum:i49E68E09AEA52B98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03682 Genomic DNA. Translation: CAA27317.1.
PIRiI50632.
RefSeqiNP_001075174.1. NM_001081705.1.
UniGeneiGga.2511.

Genome annotation databases

EnsembliENSGALT00000045497; ENSGALP00000041604; ENSGALG00000026944.
GeneIDi428927.
KEGGigga:428927.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03682 Genomic DNA. Translation: CAA27317.1.
PIRiI50632.
RefSeqiNP_001075174.1. NM_001081705.1.
UniGeneiGga.2511.

3D structure databases

ProteinModelPortaliP26990.
SMRiP26990.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP26990. 2 interactors.
MINTiMINT-6824981.

Proteomic databases

PRIDEiP26990.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000045497; ENSGALP00000041604; ENSGALG00000026944.
GeneIDi428927.
KEGGigga:428927.

Organism-specific databases

CTDi382.

Phylogenomic databases

HOVERGENiHBG002073.
InParanoidiP26990.
KOiK07941.
OrthoDBiEOG091G0OXD.
PhylomeDBiP26990.

Enzyme and pathway databases

ReactomeiR-GGA-8854214. TBC/RABGAPs.
R-GGA-8856828. Clathrin-mediated endocytosis.
R-GGA-8875656. MET receptor recycling.

Miscellaneous databases

PROiPR:P26990.

Gene expression databases

BgeeiENSGALG00000026944.
ExpressionAtlasiP26990. baseline.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
PfamiView protein in Pfam
PF00025. Arf. 1 hit.
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51417. ARF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARF6_CHICK
AccessioniPrimary (citable) accession number: P26990
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.