P26987 (SAM22_SOYBN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Stress-induced protein SAM22 Alternative name(s): Starvation-associated message 22 Allergen=Gly m 4
Organism	Glycine max (Soybean) (Glycine hispida) [Reference proteome]
Taxonomic identifier	3847 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Fabales › Fabaceae › Papilionoideae › Phaseoleae › Glycine

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Allergenic properties	Causes an allergic reaction in human. Gly m 4 is the major soy allergen for patients allergic to birch pollen with soy allergy. Ref.2
Sequence similarities	Belongs to the BetVI family.

Ontologies

Keywords
Biological process	Plant defense
Disease	Allergen
Molecular function	Pathogenesis-related protein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response Inferred from electronic annotation. Source: UniProtKB-KW response to biotic stimulus Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 158

158

Stress-induced protein SAM22

PRO_0000154170

Secondary structure

1

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158

Helix Strand Turn

Details...

Beta strand

3 – 14

12

Helix

16 – 24

9

Helix

27 – 34

8

Beta strand

38 – 49

12

Beta strand

53 – 60

8

Beta strand

63 – 75

13

Turn

76 – 79

4

Beta strand

80 – 88

9

Beta strand

93 – 96

4

Beta strand

98 – 103

6

Beta strand

110 – 121

12

Beta strand

123 – 125

3

Helix

130 – 153

24

Sequences

	Sequence		Length	Mass (Da)
	P26987 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 9FA5167221DC929C	FASTA	158	16,772
	10 20 30 40 50 60 MGVFTFEDEI NSPVAPATLY KALVTDADNV IPKALDSFKS VENVEGNGGP GTIKKITFLE 70 80 90 100 110 120 DGETKFVLHK IESIDEANLG YSYSVVGGAA LPDTAEKITF DSKLVAGPNG GSAGKLTVKY 130 140 150 ETKGDAEPNQ DELKTGKAKA DALFKAIEAY LLAHPDYN

References

[1]	"Characterization of a stress-induced, developmentally regulated gene family from soybean." Crowell D., John M.E., Russell D., Amasino R.M. Plant Mol. Biol. 18:459-466(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Mandarin.
[2]	"Soybean allergy in patients allergic to birch pollen: clinical investigation and molecular characterization of allergens." Mittag D., Vieths S., Vogel L., Becker W.M., Rihs H.P., Helbling A., Wuthrich B., Ballmer-Weber B.K. J. Allergy Clin. Immunol. 113:148-154(2004) [PubMed] [Europe PMC] [Abstract] Cited for: ALLERGEN.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X60043 mRNA. Translation: CAA42646.1.

PIR

S20518.

RefSeq

NP_001236038.1. NM_001249109.2.

UniGene

Gma.3926.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2K7H	NMR	-	A	2-158	[»]

ProteinModelPortal

P26987.

SMR

P26987. Positions 2-158.

ModBase

Search...

Protein family/group databases

Allergome

3297. Gly m 4.0101.
749. Gly m 4.

Proteomic databases

ProMEX

P26987.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblPlants

GLYMA07G37240.2; GLYMA07G37240.2; GLYMA07G37240.

GeneID

547915.

KEGG

gmx:547915.

Gene expression databases

Genevestigator

P26987.

Family and domain databases

Gene3D

3.30.530.20. 1 hit.

InterPro

IPR024949. Bet_v_I_allergen.
IPR000916. Bet_v_I_dom.
IPR023393. START-like_dom.
[Graphical view]

Pfam

PF00407. Bet_v_1. 1 hit.
[Graphical view]

PRINTS

PR00634. BETALLERGEN.

PROSITE

PS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P26987.

Entry information

Entry name

SAM22_SOYBN

Accession

Primary (citable) accession number: P26987

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program