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Protein

RNA polymerase sigma-54 factor

Gene

rpoN

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of enzymes involved in arginine catabolism. The open complex (sigma-54 and core RNA polymerase) serves as the receptor for the receipt of the melting signal from the remotely bound activator protein GlnG(NtrC).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi366 – 385H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Nucleotidyltransferase, Sigma factor, Transferase
Biological processArginine metabolism, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase sigma-54 factor
Gene namesi
Name:rpoN
Synonyms:glnF, ntrA
Ordered Locus Names:STM3320
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • protein-DNA complex Source: CollecTF

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002055301 – 477RNA polymerase sigma-54 factorAdd BLAST477

Proteomic databases

PaxDbiP26979.
PRIDEiP26979.

Expressioni

Gene expression databases

CollecTFiEXPREG_000009e0.

Interactioni

Protein-protein interaction databases

MINTiMINT-1506804.
STRINGi99287.STM3320.

Structurei

3D structure databases

ProteinModelPortaliP26979.
SMRiP26979.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi454 – 462RPON box9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 39Gln-richAdd BLAST37

Sequence similaritiesi

Belongs to the sigma-54 factor family.Curated

Phylogenomic databases

eggNOGiENOG4105DTW. Bacteria.
COG1508. LUCA.
HOGENOMiHOG000071905.
KOiK03092.
OMAiVTTQKFM.
PhylomeDBiP26979.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR000394. RNA_pol_sigma_54.
IPR007046. RNA_pol_sigma_54_core-bd.
IPR007634. RNA_pol_sigma_54_DNA-bd.
IPR036388. WH-like_DNA-bd_sf.
PANTHERiPTHR32248. PTHR32248. 1 hit.
PfamiView protein in Pfam
PF00309. Sigma54_AID. 1 hit.
PF04963. Sigma54_CBD. 1 hit.
PF04552. Sigma54_DBD. 1 hit.
PIRSFiPIRSF000774. RpoN. 1 hit.
PRINTSiPR00045. SIGMA54FCT.
TIGRFAMsiTIGR02395. rpoN_sigma. 1 hit.
PROSITEiView protein in PROSITE
PS00717. SIGMA54_1. 1 hit.
PS00718. SIGMA54_2. 1 hit.
PS50044. SIGMA54_3. 1 hit.

Sequencei

Sequence statusi: Complete.

P26979-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQGLQLRLS QQLAMTPQLQ QAIRLLQLST LELQQELQQA LENNPLLEQT
60 70 80 90 100
DLHDEIDTQQ PQDNDPLDTA DALEQKEMPE ELPLDASWDE IYTAGTPSGP
110 120 130 140 150
SGDYIDDELP VYQGETTQSL QDYLMWQVEL TPFSDTDRAI ATSIVDAVDD
160 170 180 190 200
TGYLTVSLDE IRESMGDVEV DLDEVEAVLK RIQRFDPVGV AAKDLRDCLL
210 220 230 240 250
IQLSQFDKST PWLEEARLII CDHLDLLANH DFRTLMRVTR LKEEVLKEAV
260 270 280 290 300
NLIQSLDPRP GQSIQTGEPE YVIPDVLVRK HNGRWTVELN SDSIPRLQIN
310 320 330 340 350
QHYAAMCNSA RNDADSQFIR SNLQDAKWLI KSLESRNDTL LRVSRCIVEQ
360 370 380 390 400
QQAFFEQGEE YMKPMVLADI AQAVEMHEST ISRVTTQKYL HSPRGIFELK
410 420 430 440 450
YFFSSHVNTE GGGEASSTAI RALVKKLIAA ENPAKPLSDS KLTSLLSEQG
460 470
IMVARRTVAK YRESLSIPPS NQRKQLV
Length:477
Mass (Da):53,988
Last modified:August 1, 1992 - v1
Checksum:i5077B24BA8BAC8FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68571 Genomic DNA. Translation: AAA27224.1.
AE006468 Genomic DNA. Translation: AAL22189.1.
PIRiA41026.
RefSeqiNP_462230.1. NC_003197.2.
WP_000809020.1. NC_003197.2.

Genome annotation databases

EnsemblBacteriaiAAL22189; AAL22189; STM3320.
GeneIDi1254843.
KEGGistm:STM3320.
PATRICifig|99287.12.peg.3521.

Similar proteinsi

Entry informationi

Entry nameiRP54_SALTY
AccessioniPrimary (citable) accession number: P26979
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 25, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families