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P26978

- PUR9_SALTY

UniProt

P26978 - PUR9_SALTY

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciSENT99287:GCTI-4206-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:STM4176
ORF Names:STMF1.30
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Bifunctional purine biosynthesis protein PurHPRO_0000192120Add
BLAST

Proteomic databases

PaxDbiP26978.
PRIDEiP26978.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM4176.

Structurei

3D structure databases

ProteinModelPortaliP26978.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.By similarity

Sequence similaritiesi

Belongs to the PurH family.Curated

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.
PhylomeDBiP26978.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

P26978-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQQRRPVRRA LLSVSDKAGI IEFAQALSAR GVELLSTGGT ARLLAEKGLP
60 70 80 90 100
VTEVSDYTGF PEMMDGRVKT LHPKVHGGIL GRRGQDDAIM EQHHIAPIDM
110 120 130 140 150
VVVNLYPFAE TVAREGCSLE DAVENIDIGG PTMVRSAAKN HKDVAIVVKS
160 170 180 190 200
SDYDAIIKEM DANEGSLTLD TRFDLAIKAF EHTAAYDSMI ANYFGSMVPA
210 220 230 240 250
YHGESKEAAG RFPRTLNLNF IKKQDMRYGE NSHQQAAFYI EENVKEASVA
260 270 280 290 300
TAQQVQGKAL SYNNIADTDA ALECVKEFNE PACVIVKHAN PCGVAVSTTI
310 320 330 340 350
LDAYDRAYKT DPTSAFGGII AFNRELDAET AQAIISRQFV EVIIAPSATE
360 370 380 390 400
EALKITAAKQ NVRVLTCGQW AQRVPGLDFK RVNGGLLVQD RDLGMVSEAE
410 420 430 440 450
LRVVSKRQPT EQELRDALFC WKVAKFVKSN AIVYAKENMT IGIGAGQMSR
460 470 480 490 500
VYSAKIAGIK AADEGLEVKG SAMASDAFFP FRDGIDAAAA VGVSCVIQPG
510 520
GSIRDDEVIA AADEHGIAMI FTDMRHFRH
Length:529
Mass (Da):57,467
Last modified:August 29, 2001 - v2
Checksum:i5D713504AD644778
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti302 – 3032DA → EP in AAA27197. (PubMed:1954258)Curated
Sequence conflicti399 – 3991A → R in AAA27197. (PubMed:1954258)Curated
Sequence conflicti418 – 4181L → W in AAA27197. (PubMed:1954258)Curated
Sequence conflicti494 – 4941S → T in AAA27197. (PubMed:1954258)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF170176 Genomic DNA. Translation: AAF33520.1.
AE006468 Genomic DNA. Translation: AAL23004.1.
M66160 Genomic DNA. Translation: AAA27197.1.
PIRiS18488. DTEBPH.
RefSeqiNP_463045.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL23004; AAL23004; STM4176.
GeneIDi1255702.
KEGGistm:STM4176.
PATRICi32387237. VBISalEnt20916_4390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF170176 Genomic DNA. Translation: AAF33520.1 .
AE006468 Genomic DNA. Translation: AAL23004.1 .
M66160 Genomic DNA. Translation: AAA27197.1 .
PIRi S18488. DTEBPH.
RefSeqi NP_463045.1. NC_003197.1.

3D structure databases

ProteinModelPortali P26978.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM4176.

Proteomic databases

PaxDbi P26978.
PRIDEi P26978.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL23004 ; AAL23004 ; STM4176 .
GeneIDi 1255702.
KEGGi stm:STM4176.
PATRICi 32387237. VBISalEnt20916_4390.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.
PhylomeDBi P26978.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci SENT99287:GCTI-4206-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  2. "Nucleotide sequence analysis of purH and purD genes from Salmonella typhimurium."
    Chopra A.K., Peterson J.W., Prasad R.
    Biochim. Biophys. Acta 1090:351-354(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-529.

Entry informationi

Entry nameiPUR9_SALTY
AccessioniPrimary (citable) accession number: P26978
Secondary accession number(s): Q9L9H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 29, 2001
Last modified: October 1, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3