ID   PHON_SALTY              Reviewed;         250 AA.
AC   P26976;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   16-JUN-2009, entry version 72.
DE   RecName: Full=Non-specific acid phosphatase;
DE            Short=NSAP;
DE            EC=3.1.3.2;
DE   Flags: Precursor;
GN   Name=phoN; OrderedLocusNames=STM4319;
OS   Salmonella typhimurium.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90371;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023;
RX   MEDLINE=92224869; PubMed=1339343;
RA   Groisman E.A., Saier M.H. Jr., Ochman H.;
RT   "Horizontal transfer of a phosphatase gene as evidence for mosaic
RT   structure of the Salmonella genome.";
RL   EMBO J. 11:1309-1316(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   MEDLINE=92041557; PubMed=1938882;
RA   Kasahara M., Nakata A., Shinagawa H.;
RT   "Molecular analysis of the Salmonella typhimurium phoN gene, which
RT   encodes nonspecific acid phosphatase.";
RL   J. Bacteriol. 173:6760-6765(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   MEDLINE=21534948; PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M.,
RA   Waterston R., Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium
RT   LT2.";
RL   Nature 413:852-856(2001).
CC   -!- CATALYTIC ACTIVITY: A phosphate monoester + H(2)O = an alcohol +
CC       phosphate.
CC   -!- SUBUNIT: Homodimer (Probable).
CC   -!- SUBCELLULAR LOCATION: Periplasm.
CC   -!- SIMILARITY: Belongs to the class A bacterial acid phosphatase
CC       family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA41760.1; Type=Frameshift; Positions=229;
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DR   EMBL; X63599; CAA45144.1; -; Genomic_DNA.
DR   EMBL; X59036; CAA41760.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AE008902; AAL23143.1; -; Genomic_DNA.
DR   PIR; S20958; A41330.
DR   RefSeq; NP_463184.1; -.
DR   HSSP; Q9S1A6; 1IW8.
DR   SMR; P26976; 23-241.
DR   GeneID; 1255845; -.
DR   GenomeReviews; AE006468_GR; STM4319.
DR   KEGG; stm:STM4319; -.
DR   NMPDR; fig|99287.1.peg.4157; -.
DR   HOGENOM; P26976; -.
DR   OMA; P26976; SPRWKQA.
DR   BioCyc; STYP99287:STM4319-MON; -.
DR   BRENDA; 3.1.3.2; 2.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR   GO; GO:0003993; F:acid phosphatase activity; IEA:EC.
DR   InterPro; IPR011158; Acid_Pase_ClassA.
DR   InterPro; IPR001011; Acid_Pase_classA_bac.
DR   InterPro; IPR018296; Acid_Pase_classA_bac_CS.
DR   InterPro; IPR016118; P_Acid_Pase/Cl_peroxidase_N.
DR   InterPro; IPR000326; P_Acid_Pase_2/haloperoxidase.
DR   Gene3D; G3DSA:1.20.144.10; P_Acid_Pase/Cl_peroxidase_N; 1.
DR   Pfam; PF01569; PAP2; 1.
DR   PIRSF; PIRSF000897; Acid_Ptase_ClsA; 1.
DR   PRINTS; PR00483; BACPHPHTASE.
DR   ProDom; PD009838; Bac_AcPataseA; 1.
DR   SMART; SM00014; acidPPc; 1.
DR   PROSITE; PS01157; ACID_PHOSPH_CL_A; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Periplasm; Signal.
FT   SIGNAL        1     20       Potential.
FT   CHAIN        21    250       Non-specific acid phosphatase.
FT                                /FTId=PRO_0000024002.
SQ   SEQUENCE   250 AA;  28382 MW;  CFE8DA409BD57573 CRC64;
     MKSRYLVFFL PLIVAKYTSA ETVQPFHSPE ESVNSQFYLP PPPGNDDPAY RYDKEAYFKG
     YAIKGSPRWK QAAEDADVSV ENIARIFSPV VGAKINPKDT PETWNMLKNL LTMGGYYATA
     SAKKYYMRTR PFVLFNHSTC RPEDENTLRK NGSYPSGHTA YGTLLALVLS EARPERAQEL
     ARRGWEFGQS RVICGAHWQS DVDAGRYVGA VEFARLQTIP AFQKSLAKVR EELNDKNNLL
     SKEDHPKLNY
//