P26976 (PHON_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Non-specific acid phosphatase
Short name=NSAP
EC=3.1.3.2

Gene names

Name:	phoN
Ordered Locus Names:	STM4319

Organism

Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]

Taxonomic identifier

99287 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I › Salmonella typhimurium

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	A phosphate monoester + H2O = an alcohol + phosphate.
Subunit structure	Homodimer Probable.
Subcellular location	Periplasm.
Sequence similarities	Belongs to the class A bacterial acid phosphatase family.
Sequence caution	The sequence CAA41760.1 differs from that shown. Reason: Frameshift at position 229.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Signal
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	metabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	membrane Inferred from electronic annotation. Source: InterPro outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro
Molecular_function	acid phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 250	230	Non-specific acid phosphatase		PRO_0000024002

Sequences

	Sequence		Length	Mass (Da)
	P26976 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: CFE8DA409BD57573	FASTA	250	28,382
	10 20 30 40 50 60 MKSRYLVFFL PLIVAKYTSA ETVQPFHSPE ESVNSQFYLP PPPGNDDPAY RYDKEAYFKG 70 80 90 100 110 120 YAIKGSPRWK QAAEDADVSV ENIARIFSPV VGAKINPKDT PETWNMLKNL LTMGGYYATA 130 140 150 160 170 180 SAKKYYMRTR PFVLFNHSTC RPEDENTLRK NGSYPSGHTA YGTLLALVLS EARPERAQEL 190 200 210 220 230 240 ARRGWEFGQS RVICGAHWQS DVDAGRYVGA VEFARLQTIP AFQKSLAKVR EELNDKNNLL 250 SKEDHPKLNY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Horizontal transfer of a phosphatase gene as evidence for mosaic structure of the Salmonella genome." Groisman E.A., Saier M.H. Jr., Ochman H. EMBO J. 11:1309-1316(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023.
[2]	"Molecular analysis of the Salmonella typhimurium phoN gene, which encodes nonspecific acid phosphatase." Kasahara M., Nakata A., Shinagawa H. J. Bacteriol. 173:6760-6765(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LT2.
[3]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X63599 Genomic DNA. Translation: CAA45144.1. X59036 Genomic DNA. Translation: CAA41760.1. Frameshift. AE006468 Genomic DNA. Translation: AAL23143.1.
PIR	A41330. S20958.
RefSeq	NP_463184.1. NC_003197.1.
3D structure databases
ProteinModelPortal	P26976.
SMR	P26976. Positions 23-241.
ModBase	Search...
Protein-protein interaction databases
STRING	99287.STM4319.
Proteomic databases
PaxDb	P26976.
PRIDE	P26976.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL23143; AAL23143; STM4319.
GeneID	1255845.
KEGG	stm:STM4319.
PATRIC	32387549. VBISalEnt20916_4542.
Phylogenomic databases
eggNOG	COG0671.
HOGENOM	HOG000233901.
KO	K09474.
OMA	TPRWELA.
ProtClustDB	CLSK894555.
Enzyme and pathway databases
SABIO-RK	P26976.
Family and domain databases
Gene3D	1.20.144.10. 1 hit.
InterPro	IPR011158. Acid_Pase_ClassA. IPR001011. Acid_Pase_classA_bac. IPR018296. Acid_Pase_classA_bac_CS. IPR016118. P_Acid_Pase/Cl_peroxidase_N. IPR000326. P_Acid_Pase_2/haloperoxidase. [Graphical view]
Pfam	PF01569. PAP2. 1 hit. [Graphical view]
PIRSF	PIRSF000897. Acid_Ptase_ClsA. 1 hit.
PRINTS	PR00483. BACPHPHTASE.
SMART	SM00014. acidPPc. 1 hit. [Graphical view]
SUPFAM	SSF48317. AcPase_VanPerase. 1 hit.
PROSITE	PS01157. ACID_PHOSPH_CL_A. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PHON_SALTY

Accession

Primary (citable) accession number: P26976

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program