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P26976 (PHON_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Non-specific acid phosphatase

Short name=NSAP
EC=3.1.3.2
Gene names
Name:phoN
Ordered Locus Names:STM4319
OrganismSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]
Taxonomic identifier99287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Subunit structure

Homodimer Probable.

Subcellular location

Periplasm.

Sequence similarities

Belongs to the class A bacterial acid phosphatase family.

Sequence caution

The sequence CAA41760.1 differs from that shown. Reason: Frameshift at position 229.

Ontologies

Keywords
   Cellular componentPeriplasm
   DomainSignal
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentmembrane

Inferred from electronic annotation. Source: InterPro

outer membrane-bounded periplasmic space

Inferred from electronic annotation. Source: InterPro

   Molecular_functionacid phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 250230Non-specific acid phosphatase
PRO_0000024002

Sequences

Sequence LengthMass (Da)Tools
P26976 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: CFE8DA409BD57573

FASTA25028,382
        10         20         30         40         50         60 
MKSRYLVFFL PLIVAKYTSA ETVQPFHSPE ESVNSQFYLP PPPGNDDPAY RYDKEAYFKG 

        70         80         90        100        110        120 
YAIKGSPRWK QAAEDADVSV ENIARIFSPV VGAKINPKDT PETWNMLKNL LTMGGYYATA 

       130        140        150        160        170        180 
SAKKYYMRTR PFVLFNHSTC RPEDENTLRK NGSYPSGHTA YGTLLALVLS EARPERAQEL 

       190        200        210        220        230        240 
ARRGWEFGQS RVICGAHWQS DVDAGRYVGA VEFARLQTIP AFQKSLAKVR EELNDKNNLL 

       250 
SKEDHPKLNY 

« Hide

References

« Hide 'large scale' references
[1]"Horizontal transfer of a phosphatase gene as evidence for mosaic structure of the Salmonella genome."
Groisman E.A., Saier M.H. Jr., Ochman H.
EMBO J. 11:1309-1316(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023.
[2]"Molecular analysis of the Salmonella typhimurium phoN gene, which encodes nonspecific acid phosphatase."
Kasahara M., Nakata A., Shinagawa H.
J. Bacteriol. 173:6760-6765(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: LT2.
[3]"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2."
McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. expand/collapse author list , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K.
Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X63599 Genomic DNA. Translation: CAA45144.1.
X59036 Genomic DNA. Translation: CAA41760.1. Frameshift.
AE006468 Genomic DNA. Translation: AAL23143.1.
PIRA41330. S20958.
RefSeqNP_463184.1. NC_003197.1.

3D structure databases

ProteinModelPortalP26976.
SMRP26976. Positions 23-241.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING99287.STM4319.

Proteomic databases

PaxDbP26976.
PRIDEP26976.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL23143; AAL23143; STM4319.
GeneID1255845.
KEGGstm:STM4319.
PATRIC32387549. VBISalEnt20916_4542.

Phylogenomic databases

eggNOGCOG0671.
HOGENOMHOG000233901.
KOK09474.
OMATPRWELA.
OrthoDBEOG6H1Q3K.
ProtClustDBCLSK894555.

Enzyme and pathway databases

BioCycSENT99287:GCTI-4350-MONOMER.
SABIO-RKP26976.

Family and domain databases

Gene3D1.20.144.10. 1 hit.
InterProIPR011158. Acid_Pase_ClassA.
IPR001011. Acid_Pase_classA_bac.
IPR018296. Acid_Pase_classA_bac_CS.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamPF01569. PAP2. 1 hit.
[Graphical view]
PIRSFPIRSF000897. Acid_Ptase_ClsA. 1 hit.
PRINTSPR00483. BACPHPHTASE.
SMARTSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMSSF48317. SSF48317. 1 hit.
PROSITEPS01157. ACID_PHOSPH_CL_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePHON_SALTY
AccessionPrimary (citable) accession number: P26976
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families