Reviewed, UniProtKB/Swiss-Prot P26976 (PHON_SALTY)

Names and origin

Protein names

Recommended name:
    Non-specific acid phosphatase
      Short name=NSAP
    EC=3.1.3.2

Gene names

Name:	phoN
Ordered Locus Names:	STM4319

Organism

Salmonella typhimurium [Complete proteome] [HAMAP]

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	A phosphate monoester + H2O = an alcohol + phosphate.
Subunit structure	Homodimer Probable.
Subcellular location	Periplasm.
Sequence similarities	Belongs to the class A bacterial acid phosphatase family.
Sequence caution	The sequence CAA41760.1 differs from that shown. Reason: Frameshift at position 229.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Signal
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	membrane Inferred from electronic annotation. Source: InterPro outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro
Molecular function	acid phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 250	230	Non-specific acid phosphatase		PRO_0000024002

Sequences

	Sequence		Length	Mass (Da)
	P26976-1 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: CFE8DA409BD57573	FASTA	250	28,382
	10 20 30 40 50 60 MKSRYLVFFL PLIVAKYTSA ETVQPFHSPE ESVNSQFYLP PPPGNDDPAY RYDKEAYFKG 70 80 90 100 110 120 YAIKGSPRWK QAAEDADVSV ENIARIFSPV VGAKINPKDT PETWNMLKNL LTMGGYYATA 130 140 150 160 170 180 SAKKYYMRTR PFVLFNHSTC RPEDENTLRK NGSYPSGHTA YGTLLALVLS EARPERAQEL 190 200 210 220 230 240 ARRGWEFGQS RVICGAHWQS DVDAGRYVGA VEFARLQTIP AFQKSLAKVR EELNDKNNLL 250 SKEDHPKLNY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Horizontal transfer of a phosphatase gene as evidence for mosaic structure of the Salmonella genome." Groisman E.A., Saier M.H. Jr., Ochman H. EMBO J. 11:1309-1316(1992) [PubMed: 1339343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023.
[2]	"Molecular analysis of the Salmonella typhimurium phoN gene, which encodes nonspecific acid phosphatase." Kasahara M., Nakata A., Shinagawa H. J. Bacteriol. 173:6760-6765(1991) [PubMed: 1938882] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LT2.
[3]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X63599 Genomic DNA. Translation: CAA45144.1. X59036 Genomic DNA. Translation: CAA41760.1. Frameshift. AE008902 Genomic DNA. Translation: AAL23143.1.
PIR	A41330. S20958.
RefSeq	NP_463184.1.
3D structure databases
HSSP	HSSP built from PDB template 1IW8 based on UniProtKB Q9S1A6.
SMR	P26976. Positions 23-241.
ModBase	Search...
Genome annotation databases
GeneID	1255845.
GenomeReviews	Gene locus STM4319 in contig AE006468_GR.
KEGG	stm:STM4319.
NMPDR	fig|99287.1.peg.4157.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P26976.
OMA	P26976. SPRWKQA.
Enzyme and pathway databases
BioCyc	STYP99287:STM4319-MON.
BRENDA	3.1.3.2. 2.
Family and domain databases
InterPro	IPR011158. Acid_Pase_ClassA. IPR001011. Acid_Pase_classA_bac. IPR018296. Acid_Pase_classA_bac_CS. IPR016118. P_Acid_Pase/Cl_peroxidase_N. IPR000326. P_Acid_Pase_2/haloperoxidase. [Graphical view]
Gene3D	G3DSA:1.20.144.10. P_Acid_Pase/Cl_peroxidase_N. 1 hit.
Pfam	PF01569. PAP2. 1 hit. [Graphical view]
PIRSF	PIRSF000897. Acid_Ptase_ClsA. 1 hit.
PRINTS	PR00483. BACPHPHTASE.
ProDom	PD009838. Bac_AcPataseA. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00014. acidPPc. 1 hit. [Graphical view]
PROSITE	PS01157. ACID_PHOSPH_CL_A. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PHON_SALTY

Accession

Primary (citable) accession number: P26976

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	June 16, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)