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P26969

- GCSP_PEA

UniProt

P26969 - GCSP_PEA

Protein

Glycine dehydrogenase (decarboxylating), mitochondrial

Gene

GDCSP

Organism
Pisum sativum (Garden pea)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.

    Cofactori

    Pyridoxal phosphate.

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating), mitochondrial (EC:1.4.4.2)
    Alternative name(s):
    Glycine cleavage system P protein
    Glycine decarboxylase
    Glycine dehydrogenase (aminomethyl-transferring)
    Gene namesi
    Name:GDCSP
    Synonyms:GDCP
    OrganismiPisum sativum (Garden pea)
    Taxonomic identifieri3888 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeFabeaePisum

    Subcellular locationi

    GO - Cellular componenti

    1. glycine cleavage complex Source: UniProtKB
    2. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 8686Mitochondrion1 PublicationAdd
    BLAST
    Chaini87 – 1057971Glycine dehydrogenase (decarboxylating), mitochondrialPRO_0000010749Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei792 – 7921N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PRIDEiP26969.
    ProMEXiP26969.

    Expressioni

    Tissue specificityi

    Highly expressed in leaves. Detected in roots and embryos.1 Publication

    Inductioni

    Induced more than 4-fold after exposure to light for 6 hours.1 Publication

    Interactioni

    Subunit structurei

    Homodimer. The glycine cleavage system is composed of four proteins: P, T, L and H.

    Protein-protein interaction databases

    IntActiP26969. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP26969.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.Curated

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P26969-1 [UniParc]FASTAAdd to Basket

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    MERARRLANR ATLKRLLSEA KQNRKTESTS TTTTTPLPFS LSGSSSRYVS     50
    SVSNSILRGR GSKPDNNVSR RVGGFLGVGY PSQSRSISVE ALKPSDTFPR 100
    RHNSATPDEQ TKMAESVGFD TLDSLVDATV PKSIRLKEMK FNKFDGGLTE 150
    GQMIEHMKDL ASKNKVFKSF IGMGYYNTHV PPVILRNIME NPAWYTQYTP 200
    YQAEISQGRL ESLLNFQTMI TDLTGLPMSN ASLLDEGTAA AEAMSMCNNI 250
    QKGKKKTFII ASNCHPQTID ICQTRADGFE LKVVVKDLKD IDYKSGDVCG 300
    VLVQYPGTEG EVLDYGEFIK KAHANEVKVV MASDLLALTV LKPPGEFGAD 350
    IVVGSAQRFG VPMGYGGPHA AFLATSQEYK RMMPGRIIGV SVDSSGKQAL 400
    RMAMQTREQH IRRDKATSNI CTAQALLANM AAMYAVYHGP EGLKAIAQRV 450
    HGLAGVFALG LKKLGLEVQD LGFFDTVKVK TSNAKAIADA AIKSEINLRV 500
    VDGNTITAAF DETTTLEDVD KLFKVFAGGK PVSFTAASLA PEFQNAIPSG 550
    LVRESPYLTH PIFNTYQTEH ELLRYIHRLQ SKDLSLCHSM IPLGSCTMKL 600
    NATTEMMPVT WPSFTDLHPF APTEQAQGYQ EMFNNLGDLL CTITGFDSFS 650
    LQPNAGAAGE YAGLMVIRAY HLSRGDHHRN VCIIPASAHG TNPASAAMVG 700
    MKIVTIGTDA KGNINIEELK KAAEKHKDNL SAFMVTYPST HGVYEEGIDD 750
    ICKIIHDNGG QVYMDGANMN AQVGLTSPGW IGADVCHLNL HKTFCIPHGG 800
    GGPGMGPIGV KKHLAPFLPS HPVVPTGGIP APENPQPLGS ISAAPWGSAL 850
    ILPISYTYIA MMGSQGLTDA SKIAILNANY MAKRLESYYP VLFRGVNGTV 900
    AHEFIIDLRG FKNTAGIEPE DVAKRLMDYG FHGPTMSWPV AGTLMIEPTE 950
    SESKAELDRF CDALISIRKE IAEVEKGNAD VHNNVLKGAP HPPSLLMADA 1000
    WTKPYSREYA AFPAAWLRGA KFWPTTGRVD NVYGDRNLVC TLLPASQAVE 1050
    EQAAATA 1057
    Length:1,057
    Mass (Da):114,686
    Last modified:August 1, 1992 - v1
    Checksum:i2F2EA58E9A2AC447
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti906 – 9061I → Y in CAA38252. 1 PublicationCurated
    Sequence conflicti919 – 9191P → A in CAA38252. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59773 mRNA. Translation: CAA42443.1.
    X54377 mRNA. Translation: CAA38252.1.
    PIRiA42109.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59773 mRNA. Translation: CAA42443.1 .
    X54377 mRNA. Translation: CAA38252.1 .
    PIRi A42109.

    3D structure databases

    ProteinModelPortali P26969.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P26969. 1 interaction.

    Proteomic databases

    PRIDEi P26969.
    ProMEXi P26969.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the P subunit of glycine decarboxylase from pea (Pisum sativum)."
      Turner S.R., Irland R., Rawsthorne S.
      J. Biol. Chem. 267:5355-5360(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 87-94, TISSUE SPECIFICITY, INDUCTION.
      Strain: cv. Birte.
      Tissue: Leaf.
    2. Shah K.S., Kim Y., Oliver D.J.
      Submitted (AUG-1990) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 905-1057.
      Strain: cv. Alaska.

    Entry informationi

    Entry nameiGCSP_PEA
    AccessioniPrimary (citable) accession number: P26969
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3