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P26969

- GCSP_PEA

UniProt

P26969 - GCSP_PEA

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Protein

Glycine dehydrogenase (decarboxylating), mitochondrial

Gene
GDCSP, GDCP
Organism
Pisum sativum (Garden pea)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating), mitochondrial (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:GDCSP
Synonyms:GDCP
OrganismiPisum sativum (Garden pea)
Taxonomic identifieri3888 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeFabeaePisum

Subcellular locationi

GO - Cellular componenti

  1. glycine cleavage complex Source: UniProtKB
  2. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 8686Mitochondrion1 PublicationAdd
BLAST
Chaini87 – 1057971Glycine dehydrogenase (decarboxylating), mitochondrialUniRule annotationPRO_0000010749Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei792 – 7921N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiP26969.
ProMEXiP26969.

Expressioni

Tissue specificityi

Highly expressed in leaves. Detected in roots and embryos.1 Publication

Inductioni

Induced more than 4-fold after exposure to light for 6 hours.1 Publication

Interactioni

Subunit structurei

Homodimer. The glycine cleavage system is composed of four proteins: P, T, L and H.

Protein-protein interaction databases

IntActiP26969. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP26969.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26969-1 [UniParc]FASTAAdd to Basket

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MERARRLANR ATLKRLLSEA KQNRKTESTS TTTTTPLPFS LSGSSSRYVS     50
SVSNSILRGR GSKPDNNVSR RVGGFLGVGY PSQSRSISVE ALKPSDTFPR 100
RHNSATPDEQ TKMAESVGFD TLDSLVDATV PKSIRLKEMK FNKFDGGLTE 150
GQMIEHMKDL ASKNKVFKSF IGMGYYNTHV PPVILRNIME NPAWYTQYTP 200
YQAEISQGRL ESLLNFQTMI TDLTGLPMSN ASLLDEGTAA AEAMSMCNNI 250
QKGKKKTFII ASNCHPQTID ICQTRADGFE LKVVVKDLKD IDYKSGDVCG 300
VLVQYPGTEG EVLDYGEFIK KAHANEVKVV MASDLLALTV LKPPGEFGAD 350
IVVGSAQRFG VPMGYGGPHA AFLATSQEYK RMMPGRIIGV SVDSSGKQAL 400
RMAMQTREQH IRRDKATSNI CTAQALLANM AAMYAVYHGP EGLKAIAQRV 450
HGLAGVFALG LKKLGLEVQD LGFFDTVKVK TSNAKAIADA AIKSEINLRV 500
VDGNTITAAF DETTTLEDVD KLFKVFAGGK PVSFTAASLA PEFQNAIPSG 550
LVRESPYLTH PIFNTYQTEH ELLRYIHRLQ SKDLSLCHSM IPLGSCTMKL 600
NATTEMMPVT WPSFTDLHPF APTEQAQGYQ EMFNNLGDLL CTITGFDSFS 650
LQPNAGAAGE YAGLMVIRAY HLSRGDHHRN VCIIPASAHG TNPASAAMVG 700
MKIVTIGTDA KGNINIEELK KAAEKHKDNL SAFMVTYPST HGVYEEGIDD 750
ICKIIHDNGG QVYMDGANMN AQVGLTSPGW IGADVCHLNL HKTFCIPHGG 800
GGPGMGPIGV KKHLAPFLPS HPVVPTGGIP APENPQPLGS ISAAPWGSAL 850
ILPISYTYIA MMGSQGLTDA SKIAILNANY MAKRLESYYP VLFRGVNGTV 900
AHEFIIDLRG FKNTAGIEPE DVAKRLMDYG FHGPTMSWPV AGTLMIEPTE 950
SESKAELDRF CDALISIRKE IAEVEKGNAD VHNNVLKGAP HPPSLLMADA 1000
WTKPYSREYA AFPAAWLRGA KFWPTTGRVD NVYGDRNLVC TLLPASQAVE 1050
EQAAATA 1057
Length:1,057
Mass (Da):114,686
Last modified:August 1, 1992 - v1
Checksum:i2F2EA58E9A2AC447
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti906 – 9061I → Y in CAA38252. 1 Publication
Sequence conflicti919 – 9191P → A in CAA38252. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59773 mRNA. Translation: CAA42443.1.
X54377 mRNA. Translation: CAA38252.1.
PIRiA42109.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59773 mRNA. Translation: CAA42443.1 .
X54377 mRNA. Translation: CAA38252.1 .
PIRi A42109.

3D structure databases

ProteinModelPortali P26969.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P26969. 1 interaction.

Proteomic databases

PRIDEi P26969.
ProMEXi P26969.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of the P subunit of glycine decarboxylase from pea (Pisum sativum)."
    Turner S.R., Irland R., Rawsthorne S.
    J. Biol. Chem. 267:5355-5360(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 87-94, TISSUE SPECIFICITY, INDUCTION.
    Strain: cv. Birte.
    Tissue: Leaf.
  2. Shah K.S., Kim Y., Oliver D.J.
    Submitted (AUG-1990) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 905-1057.
    Strain: cv. Alaska.

Entry informationi

Entry nameiGCSP_PEA
AccessioniPrimary (citable) accession number: P26969
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: February 19, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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