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P26955 (IL3RB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytokine receptor common subunit beta
Alternative name(s):
GM-CSF/IL-3/IL-5 receptor common beta subunit
CD_antigen=CD131
Gene names
Name:Csf2rb
Synonyms:Aic2b, Csf2rb1, Il3rb1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length896 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.

Subunit structure

Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits. Interacts with TMEM102; this interaction occurs preferentially in the absence of CSF2 By similarity. Interacts with LYN. Ref.3

Subcellular location

Membrane; Single-pass type I membrane protein.

Domain

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Post-translational modification

May be phosphorylated by LYN. Ref.3

Sequence similarities

Belongs to the type I cytokine receptor family. Type 4 subfamily.

Contains 2 fibronectin type-III domains.

Ontologies

Keywords
   Cellular componentMembrane
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncytokine receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Itgb1P090552EBI-1810026,EBI-644224

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 896874Cytokine receptor common subunit beta
PRO_0000010863

Regions

Topological domain23 – 441419Extracellular Potential
Transmembrane442 – 46322Helical; Potential
Topological domain464 – 896433Cytoplasmic Potential
Domain132 – 241110Fibronectin type-III 1
Domain343 – 44098Fibronectin type-III 2
Motif428 – 4325WSXWS motif
Motif477 – 4859Box 1 motif

Amino acid modifications

Modified residue7521Phosphoserine Ref.4
Modified residue7541Phosphoserine Ref.4
Modified residue7651Phosphotyrosine Ref.4
Glycosylation621N-linked (GlcNAc...) Potential
Glycosylation1411N-linked (GlcNAc...) Potential
Glycosylation3501N-linked (GlcNAc...) Potential
Disulfide bond39 ↔ 49 By similarity
Disulfide bond77 ↔ 99 By similarity
Disulfide bond88 ↔ 94 By similarity
Disulfide bond253 ↔ 263 By similarity
Disulfide bond292 ↔ 310 By similarity

Experimental info

Sequence conflict821E → K in AAA37204. Ref.1
Sequence conflict2131A → P in AAA37204. Ref.1
Sequence conflict2201S → Y in AAA37204. Ref.1
Sequence conflict2361V → A in AAA37204. Ref.1
Sequence conflict6341P → A in AAA37204. Ref.1
Sequence conflict6391A → V in AAA37204. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P26955 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 8E30ECB42C67F89A

FASTA89699,036
        10         20         30         40         50         60 
MDQQMALTWG LCYMALVALC WGHGVTEAEE TVPLKTLQCY NDYTNHIICS WADTEDAQGL 

        70         80         90        100        110        120 
INMTLYHQLE KKQPVSCELS EELMWSECPS SHRCVPRRCV IPYTRFSITN EDYYSFRPDS 

       130        140        150        160        170        180 
DLGIQLMVPL AQNVQPPLPK NVSISSSEDR FLLEWSVSLG DAQVSWLSSK DIEFEVAYKR 

       190        200        210        220        230        240 
LQDSWEDAYS LHTSKFQVNF EPKLFLPNSI YAARVRTRLS PGSSLSGRPS RWSPEVHWDS 

       250        260        270        280        290        300 
QPGDKAQPQN LQCFFDGIQS LHCSWEVWTQ TTGSVSFGLF YRPSPVAPEE KCSPVVKEPP 

       310        320        330        340        350        360 
GASVYTRYHC SLPVPEPSAH SQYTVSVKHL EQGKFIMSYN HIQMEPPTLN LTKNRDSYSL 

       370        380        390        400        410        420 
HWETQKMAYS FIEHTFQVQY KKKSDSWEDS KTENLDRAHS MDLSQLEPDT SYCARVRVKP 

       430        440        450        460        470        480 
ISNYDGIWSK WSEEYTWKTD WVMPTLWIVL ILVFLILTLL LILRFGCVSV YRTYRKWKEK 

       490        500        510        520        530        540 
IPNPSKSLLF QDGGKGLWPP GSMAAFATKN PALQGPQSRL LAEQQGESYA HLEDNNVSPL 

       550        560        570        580        590        600 
TIEDPNIIRV PPSGPDTTPA ASSESTEQLP NVQVEGPTPN RPRKQLPSFD FNGPYLGPPQ 

       610        620        630        640        650        660 
SHSLPDLPDQ LGSPQVGGSL KPALPGSLEY MCLPPGGQAQ LVPLSQVMGQ GQAMDVQCGS 

       670        680        690        700        710        720 
SLETSGSPSV EPKENPPVEL SMEEQEARDN PVTLPISSGG PEGSMMASDY VTPGDPVLTL 

       730        740        750        760        770        780 
PTGPLSTSLG PSLGLPSAQS PSLCLKLPRV PSGSPALGPP GFEDYVELPP SVSQAAKSPP 

       790        800        810        820        830        840 
GHPAPPVASS PTVIPGEPRE EVGPASPHPE GLLVLQQVGD YCFLPGLGPG SLSPHSKPPS 

       850        860        870        880        890 
PSLCSETEDL VQDLSVKKFP YQPMPQAPAI QFFKSLKHQD YLSLPPWDNS QSGKVC

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of a gene encoding an interleukin 3 receptor-like protein: identification of another member of the cytokine receptor gene family."
Gorman D.M., Itoh N., Kitamura T., Schreurs J., Yonehara S., Yahara I., Arai K., Miyajima A.
Proc. Natl. Acad. Sci. U.S.A. 87:5459-5463(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone marrow.
[3]"Association of Lyn tyrosine kinase to the GM-CSF and IL-3 receptor common betac subunit and role of Src tyrosine kinases in DNA synthesis and anti-apoptosis."
Dahl M.E., Arai K.I., Watanabe S.
Genes Cells 5:143-153(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION, INTERACTION WITH LYN.
[4]"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-752; SER-754 AND TYR-765, MASS SPECTROMETRY.
Tissue: Mast cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M34397 mRNA. Translation: AAA37204.1.
AK152608 mRNA. Translation: BAE31354.1.
IPIIPI00117845.
PIRA35782.
RefSeqNP_031806.3. NM_007780.4.
UniGeneMm.235324.

3D structure databases

ProteinModelPortalP26955.
SMRP26955. Positions 29-440.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-46527N.
IntActP26955. 2 interactions.

PTM databases

PhosphoSiteP26955.

Proteomic databases

PaxDbP26955.
PRIDEP26955.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000096355; ENSMUSP00000094082; ENSMUSG00000071713.
GeneID12983.
KEGGmmu:12983.
UCSCuc007woz.2. mouse.

Organism-specific databases

CTD1439.
MGIMGI:1339759. Csf2rb.

Phylogenomic databases

eggNOGNOG39324.
GeneTreeENSGT00510000048963.
HOGENOMHOG000113049.
HOVERGENHBG052113.
InParanoidQ3U7L5.
KOK04738.
OMACRWADTQ.
OrthoDBEOG40CHH2.

Gene expression databases

ArrayExpressP26955.
BgeeP26955.
GenevestigatorP26955.
GermOnlineENSMUSG00000071713. Mus musculus.

Family and domain databases

Gene3D2.60.40.10. 4 hits.
InterProIPR003961. Fibronectin_type3.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
IPR011365. IL3_rcpt_beta.
IPR015321. IL6_recept-bd.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view]
PfamPF09240. IL6Ra-bind. 1 hit.
PF09294. Interfer-bind. 1 hit.
[Graphical view]
PIRSFPIRSF001956. IL3R_beta_c. 1 hit.
SMARTSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMSSF49265. FN_III-like. 4 hits.
PROSITEPS50853. FN3. False negative.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio282764.
SOURCESearch...

Entry information

Entry nameIL3RB_MOUSE
AccessionPrimary (citable) accession number: P26955
Secondary accession number(s): Q3U7L5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 27, 2011
Last modified: May 29, 2013
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents