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Protein

Cytokine receptor common subunit beta

Gene

Csf2rb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.

GO - Molecular functioni

GO - Biological processi

  • cytokine-mediated signaling pathway Source: MGI
  • regulation of cell growth Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-114604. GPVI-mediated activation cascade.
R-MMU-392451. G beta:gamma signalling through PI3Kgamma.
R-MMU-512988. Interleukin-3, 5 and GM-CSF signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-5683826. Surfactant metabolism.
R-MMU-912526. Interleukin receptor SHC signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokine receptor common subunit beta
Alternative name(s):
GM-CSF/IL-3/IL-5 receptor common beta subunit
CD_antigen: CD131
Gene namesi
Name:Csf2rb
Synonyms:Aic2b, Csf2rb1, Il3rb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1339759. Csf2rb.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 441ExtracellularSequence analysisAdd BLAST419
Transmembranei442 – 463HelicalSequence analysisAdd BLAST22
Topological domaini464 – 896CytoplasmicSequence analysisAdd BLAST433

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001086323 – 896Cytokine receptor common subunit betaAdd BLAST874

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 49By similarity
Glycosylationi62N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi77 ↔ 99By similarity
Disulfide bondi88 ↔ 94By similarity
Glycosylationi141N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi253 ↔ 263By similarity
Disulfide bondi292 ↔ 310By similarity
Glycosylationi350N-linked (GlcNAc...)Sequence analysis1
Modified residuei752PhosphoserineCombined sources1
Modified residuei754PhosphoserineCombined sources1
Modified residuei765PhosphotyrosineCombined sources1

Post-translational modificationi

May be phosphorylated by LYN.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP26955.
PRIDEiP26955.

PTM databases

iPTMnetiP26955.
PhosphoSitePlusiP26955.

Expressioni

Gene expression databases

BgeeiENSMUSG00000071713.
GenevisibleiP26955. MM.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits. Interacts with TMEM102; this interaction occurs preferentially in the absence of CSF2 (By similarity). Interacts with LYN.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Itgb1P090552EBI-1810026,EBI-644224

Protein-protein interaction databases

BioGridi198932. 2 interactors.
DIPiDIP-46527N.
IntActiP26955. 2 interactors.
STRINGi10090.ENSMUSP00000094082.

Structurei

3D structure databases

ProteinModelPortaliP26955.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini136 – 243Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST108
Domaini343 – 439Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi428 – 432WSXWS motif5
Motifi477 – 485Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGEX. Eukaryota.
ENOG4112BQP. LUCA.
GeneTreeiENSGT00510000048963.
HOGENOMiHOG000113049.
HOVERGENiHBG052113.
InParanoidiP26955.
KOiK04738.
OMAiCELSAGM.
OrthoDBiEOG091G05K0.
TreeFamiTF337996.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
IPR011365. IL3_rcpt_beta.
IPR015373. Interferon/interleukin_rcp_dom.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
PF09294. Interfer-bind. 1 hit.
[Graphical view]
PIRSFiPIRSF001956. IL3R_beta_c. 1 hit.
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26955-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQQMALTWG LCYMALVALC WGHGVTEAEE TVPLKTLQCY NDYTNHIICS
60 70 80 90 100
WADTEDAQGL INMTLYHQLE KKQPVSCELS EELMWSECPS SHRCVPRRCV
110 120 130 140 150
IPYTRFSITN EDYYSFRPDS DLGIQLMVPL AQNVQPPLPK NVSISSSEDR
160 170 180 190 200
FLLEWSVSLG DAQVSWLSSK DIEFEVAYKR LQDSWEDAYS LHTSKFQVNF
210 220 230 240 250
EPKLFLPNSI YAARVRTRLS PGSSLSGRPS RWSPEVHWDS QPGDKAQPQN
260 270 280 290 300
LQCFFDGIQS LHCSWEVWTQ TTGSVSFGLF YRPSPVAPEE KCSPVVKEPP
310 320 330 340 350
GASVYTRYHC SLPVPEPSAH SQYTVSVKHL EQGKFIMSYN HIQMEPPTLN
360 370 380 390 400
LTKNRDSYSL HWETQKMAYS FIEHTFQVQY KKKSDSWEDS KTENLDRAHS
410 420 430 440 450
MDLSQLEPDT SYCARVRVKP ISNYDGIWSK WSEEYTWKTD WVMPTLWIVL
460 470 480 490 500
ILVFLILTLL LILRFGCVSV YRTYRKWKEK IPNPSKSLLF QDGGKGLWPP
510 520 530 540 550
GSMAAFATKN PALQGPQSRL LAEQQGESYA HLEDNNVSPL TIEDPNIIRV
560 570 580 590 600
PPSGPDTTPA ASSESTEQLP NVQVEGPTPN RPRKQLPSFD FNGPYLGPPQ
610 620 630 640 650
SHSLPDLPDQ LGSPQVGGSL KPALPGSLEY MCLPPGGQAQ LVPLSQVMGQ
660 670 680 690 700
GQAMDVQCGS SLETSGSPSV EPKENPPVEL SMEEQEARDN PVTLPISSGG
710 720 730 740 750
PEGSMMASDY VTPGDPVLTL PTGPLSTSLG PSLGLPSAQS PSLCLKLPRV
760 770 780 790 800
PSGSPALGPP GFEDYVELPP SVSQAAKSPP GHPAPPVASS PTVIPGEPRE
810 820 830 840 850
EVGPASPHPE GLLVLQQVGD YCFLPGLGPG SLSPHSKPPS PSLCSETEDL
860 870 880 890
VQDLSVKKFP YQPMPQAPAI QFFKSLKHQD YLSLPPWDNS QSGKVC
Length:896
Mass (Da):99,036
Last modified:July 27, 2011 - v2
Checksum:i8E30ECB42C67F89A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82E → K in AAA37204 (PubMed:1695379).Curated1
Sequence conflicti213A → P in AAA37204 (PubMed:1695379).Curated1
Sequence conflicti220S → Y in AAA37204 (PubMed:1695379).Curated1
Sequence conflicti236V → A in AAA37204 (PubMed:1695379).Curated1
Sequence conflicti634P → A in AAA37204 (PubMed:1695379).Curated1
Sequence conflicti639A → V in AAA37204 (PubMed:1695379).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34397 mRNA. Translation: AAA37204.1.
AK152608 mRNA. Translation: BAE31354.1.
CCDSiCCDS27612.1.
PIRiA35782.
RefSeqiNP_031806.3. NM_007780.4.
XP_006520450.1. XM_006520387.3.
UniGeneiMm.235324.

Genome annotation databases

EnsembliENSMUST00000096355; ENSMUSP00000094082; ENSMUSG00000071713.
GeneIDi12983.
KEGGimmu:12983.
UCSCiuc007woz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34397 mRNA. Translation: AAA37204.1.
AK152608 mRNA. Translation: BAE31354.1.
CCDSiCCDS27612.1.
PIRiA35782.
RefSeqiNP_031806.3. NM_007780.4.
XP_006520450.1. XM_006520387.3.
UniGeneiMm.235324.

3D structure databases

ProteinModelPortaliP26955.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198932. 2 interactors.
DIPiDIP-46527N.
IntActiP26955. 2 interactors.
STRINGi10090.ENSMUSP00000094082.

PTM databases

iPTMnetiP26955.
PhosphoSitePlusiP26955.

Proteomic databases

PaxDbiP26955.
PRIDEiP26955.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096355; ENSMUSP00000094082; ENSMUSG00000071713.
GeneIDi12983.
KEGGimmu:12983.
UCSCiuc007woz.2. mouse.

Organism-specific databases

CTDi1439.
MGIiMGI:1339759. Csf2rb.

Phylogenomic databases

eggNOGiENOG410IGEX. Eukaryota.
ENOG4112BQP. LUCA.
GeneTreeiENSGT00510000048963.
HOGENOMiHOG000113049.
HOVERGENiHBG052113.
InParanoidiP26955.
KOiK04738.
OMAiCELSAGM.
OrthoDBiEOG091G05K0.
TreeFamiTF337996.

Enzyme and pathway databases

ReactomeiR-MMU-114604. GPVI-mediated activation cascade.
R-MMU-392451. G beta:gamma signalling through PI3Kgamma.
R-MMU-512988. Interleukin-3, 5 and GM-CSF signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-5683826. Surfactant metabolism.
R-MMU-912526. Interleukin receptor SHC signaling.

Miscellaneous databases

PROiP26955.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071713.
GenevisibleiP26955. MM.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
IPR011365. IL3_rcpt_beta.
IPR015373. Interferon/interleukin_rcp_dom.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
PF09294. Interfer-bind. 1 hit.
[Graphical view]
PIRSFiPIRSF001956. IL3R_beta_c. 1 hit.
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL3RB_MOUSE
AccessioniPrimary (citable) accession number: P26955
Secondary accession number(s): Q3U7L5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.