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Protein

Interleukin-3 receptor subunit alpha

Gene

Il3ra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

In mouse, there are two classes of high-affinity IL3 receptors. One contains an IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors.

GO - Molecular functioni

  • interleukin-3 binding Source: MGI
  • interleukin-3 receptor activity Source: MGI

GO - Biological processi

  • cytokine-mediated signaling pathway Source: MGI
  • interleukin-3-mediated signaling pathway Source: MGI
  • monocyte differentiation Source: MGI
  • regulation of cell growth Source: MGI

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-114604. GPVI-mediated activation cascade.
R-MMU-392451. G beta:gamma signalling through PI3Kgamma.
R-MMU-512988. Interleukin-3, 5 and GM-CSF signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-912526. Interleukin receptor SHC signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-3 receptor subunit alpha
Short name:
IL-3 receptor subunit alpha
Short name:
IL-3R subunit alpha
Short name:
IL-3R-alpha
Short name:
IL-3RA
Alternative name(s):
Interleukin-3 receptor class II alpha chain
CD_antigen: CD123
Gene namesi
Name:Il3ra
Synonyms:Sut-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:96553. Il3ra.

Subcellular locationi

Isoform 1 :
Isoform 2 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 331ExtracellularSequence analysisAdd BLAST315
Transmembranei332 – 355HelicalSequence analysisAdd BLAST24
Topological domaini356 – 396CytoplasmicSequence analysisAdd BLAST41

GO - Cellular componenti

  • endomembrane system Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
  • plasma membrane Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001088417 – 396Interleukin-3 receptor subunit alphaAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi272N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP26952.
PaxDbiP26952.
PRIDEiP26952.

PTM databases

PhosphoSitePlusiP26952.

Expressioni

Gene expression databases

BgeeiENSMUSG00000068758.
CleanExiMM_IL3RA.
GenevisibleiP26952. MM.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.

GO - Molecular functioni

  • interleukin-3 binding Source: MGI

Protein-protein interaction databases

BioGridi200636. 3 interactors.
DIPiDIP-59621N.
STRINGi10090.ENSMUSP00000088079.

Structurei

3D structure databases

ProteinModelPortaliP26952.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi312 – 316WSXWS motif5
Motifi363 – 371Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVI5. Eukaryota.
ENOG41118NI. LUCA.
GeneTreeiENSGT00520000055993.
HOVERGENiHBG052115.
InParanoidiP26952.
KOiK04737.
OMAiPHMKDPI.
OrthoDBiEOG091G0B8U.
PhylomeDBiP26952.
TreeFamiTF331549.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003532. Short_hematopoietin_rcpt_2_CS.
IPR015321. TypeI_recpt_CBD.
PfamiView protein in Pfam
PF09240. IL6Ra-bind. 1 hit.
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiView protein in PROSITE
PS01356. HEMATOPO_REC_S_F2. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P26952-1) [UniParc]FASTAAdd to basket
Also known as: B, SP1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAANLWLILG LLASHSSDLA AVREAPPTAV TTPIQNLHID PAHYTLSWDP
60 70 80 90 100
APGADITTGA FCRKGRDIFV WADPGLARCS FQSLSLCHVT NFTVFLGKDR
110 120 130 140 150
AVAGSIQFPP DDDGDHEAAA QDLRCWVHEG QLSCQWERGP KATGDVHYRM
160 170 180 190 200
FWRDVRLGPA HNRECPHYHS LDVNTAGPAP HGGHEGCTLD LDTVLGSTPN
210 220 230 240 250
SPDLVPQVTI TVNGSGRAGP VPCMDNTVDL QRAEVLAPPT LTVECNGSEA
260 270 280 290 300
HARWVARNRF HHGLLGYTLQ VNQSSRSEPQ EYNVSIPHFW VPNAGAISFR
310 320 330 340 350
VKSRSEVYPR KLSSWSEAWG LVCPPEVMPV KTALVTSVAT VLGAGLVAAG
360 370 380 390
LLLWWRKSLL YRLCPPIPRL RLPLAGEMVV WEPALEDCEV TPVTDA
Length:396
Mass (Da):43,195
Last modified:October 1, 1993 - v1
Checksum:iF1A5BF11743AB8A3
GO
Isoform 2 (identifier: P26952-3) [UniParc]FASTAAdd to basket
Also known as: SP2

The sequence of this isoform differs from the canonical sequence as follows:
     20-112: Missing.

Show »
Length:303
Mass (Da):33,203
Checksum:i044AE7DB3E1E2587
GO
Isoform 3 (identifier: P26952-2) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     274-283: Missing.

Show »
Length:386
Mass (Da):42,017
Checksum:i9E383407D88AD774
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113D → G no nucleotide entry (PubMed:7889941).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04062320 – 112Missing in isoform 2. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_011265274 – 283Missing in isoform 3. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64534 mRNA. Translation: CAA45833.1.
FJ550346 mRNA. Translation: ACM24115.1.
CCDSiCCDS26827.1. [P26952-1]
PIRiS22909.
RefSeqiNP_032395.1. NM_008369.1. [P26952-1]
UniGeneiMm.425857.

Genome annotation databases

EnsembliENSMUST00000090591; ENSMUSP00000088079; ENSMUSG00000068758. [P26952-1]
GeneIDi16188.
KEGGimmu:16188.
UCSCiuc007sgm.1. mouse. [P26952-1]
uc011zgb.1. mouse. [P26952-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiIL3RA_MOUSE
AccessioniPrimary (citable) accession number: P26952
Secondary accession number(s): B9VI80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 7, 2017
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families