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Protein

Interleukin-3 receptor subunit alpha

Gene

Il3ra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

In mouse, there are two classes of high-affinity IL3 receptors. One contains an IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors.

GO - Molecular functioni

  • interleukin-3 binding Source: MGI
  • interleukin-3 receptor activity Source: MGI

GO - Biological processi

  • cytokine-mediated signaling pathway Source: MGI
  • interleukin-3-mediated signaling pathway Source: MGI
  • monocyte differentiation Source: MGI
  • regulation of cell growth Source: MGI

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-392451 G beta:gamma signalling through PI3Kgamma
R-MMU-512988 Interleukin-3, 5 and GM-CSF signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-912526 Interleukin receptor SHC signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-3 receptor subunit alpha
Short name:
IL-3 receptor subunit alpha
Short name:
IL-3R subunit alpha
Short name:
IL-3R-alpha
Short name:
IL-3RA
Alternative name(s):
Interleukin-3 receptor class II alpha chain
CD_antigen: CD123
Gene namesi
Name:Il3ra
Synonyms:Sut-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:96553 Il3ra

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 331ExtracellularSequence analysisAdd BLAST315
Transmembranei332 – 355HelicalSequence analysisAdd BLAST24
Topological domaini356 – 396CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001088417 – 396Interleukin-3 receptor subunit alphaAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi272N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP26952
PaxDbiP26952
PRIDEiP26952

PTM databases

PhosphoSitePlusiP26952

Expressioni

Gene expression databases

BgeeiENSMUSG00000068758
CleanExiMM_IL3RA
GenevisibleiP26952 MM

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.

GO - Molecular functioni

  • interleukin-3 binding Source: MGI

Protein-protein interaction databases

BioGridi200636, 3 interactors
DIPiDIP-59621N
IntActiP26952, 1 interactor
STRINGi10090.ENSMUSP00000088079

Structurei

3D structure databases

ProteinModelPortaliP26952
SMRiP26952
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi312 – 316WSXWS motif5
Motifi363 – 371Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVI5 Eukaryota
ENOG41118NI LUCA
GeneTreeiENSGT00520000055993
HOVERGENiHBG052115
InParanoidiP26952
KOiK04737
OMAiPHMKDPI
OrthoDBiEOG091G0B8U
PhylomeDBiP26952
TreeFamiTF331549

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR003532 Short_hematopoietin_rcpt_2_CS
IPR015321 TypeI_recpt_CBD
PfamiView protein in Pfam
PF09240 IL6Ra-bind, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS01356 HEMATOPO_REC_S_F2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P26952-1) [UniParc]FASTAAdd to basket
Also known as: B, SP1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAANLWLILG LLASHSSDLA AVREAPPTAV TTPIQNLHID PAHYTLSWDP
60 70 80 90 100
APGADITTGA FCRKGRDIFV WADPGLARCS FQSLSLCHVT NFTVFLGKDR
110 120 130 140 150
AVAGSIQFPP DDDGDHEAAA QDLRCWVHEG QLSCQWERGP KATGDVHYRM
160 170 180 190 200
FWRDVRLGPA HNRECPHYHS LDVNTAGPAP HGGHEGCTLD LDTVLGSTPN
210 220 230 240 250
SPDLVPQVTI TVNGSGRAGP VPCMDNTVDL QRAEVLAPPT LTVECNGSEA
260 270 280 290 300
HARWVARNRF HHGLLGYTLQ VNQSSRSEPQ EYNVSIPHFW VPNAGAISFR
310 320 330 340 350
VKSRSEVYPR KLSSWSEAWG LVCPPEVMPV KTALVTSVAT VLGAGLVAAG
360 370 380 390
LLLWWRKSLL YRLCPPIPRL RLPLAGEMVV WEPALEDCEV TPVTDA
Length:396
Mass (Da):43,195
Last modified:October 1, 1993 - v1
Checksum:iF1A5BF11743AB8A3
GO
Isoform 2 (identifier: P26952-3) [UniParc]FASTAAdd to basket
Also known as: SP2

The sequence of this isoform differs from the canonical sequence as follows:
     20-112: Missing.

Show »
Length:303
Mass (Da):33,203
Checksum:i044AE7DB3E1E2587
GO
Isoform 3 (identifier: P26952-2) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     274-283: Missing.

Show »
Length:386
Mass (Da):42,017
Checksum:i9E383407D88AD774
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113D → G no nucleotide entry (PubMed:7889941).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04062320 – 112Missing in isoform 2. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_011265274 – 283Missing in isoform 3. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64534 mRNA Translation: CAA45833.1
FJ550346 mRNA Translation: ACM24115.1
CCDSiCCDS26827.1 [P26952-1]
PIRiS22909
RefSeqiNP_032395.1, NM_008369.1 [P26952-1]
UniGeneiMm.425857

Genome annotation databases

EnsembliENSMUST00000090591; ENSMUSP00000088079; ENSMUSG00000068758 [P26952-1]
ENSMUST00000224163; ENSMUSP00000153358; ENSMUSG00000068758 [P26952-1]
ENSMUST00000224877; ENSMUSP00000153086; ENSMUSG00000068758 [P26952-3]
GeneIDi16188
KEGGimmu:16188
UCSCiuc007sgm.1 mouse [P26952-1]
uc011zgb.1 mouse [P26952-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiIL3RA_MOUSE
AccessioniPrimary (citable) accession number: P26952
Secondary accession number(s): B9VI80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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