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Protein

Interleukin-3 receptor subunit alpha

Gene

IL3RA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is a receptor for interleukin-3.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:G66-30688-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-512988. Interleukin-3, 5 and GM-CSF signaling.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-912526. Interleukin receptor SHC signaling.
SignaLinkiP26951.
SIGNORiP26951.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-3 receptor subunit alpha
Short name:
IL-3 receptor subunit alpha
Short name:
IL-3R subunit alpha
Short name:
IL-3R-alpha
Short name:
IL-3RA
Alternative name(s):
CD_antigen: CD123
Gene namesi
Name:IL3RA
Synonyms:IL3R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:6012. IL3RA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 305ExtracellularSequence analysisAdd BLAST287
Transmembranei306 – 325HelicalSequence analysisAdd BLAST20
Topological domaini326 – 378CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3563.
OpenTargetsiENSG00000185291.
PharmGKBiPA29831.

Chemistry databases

DrugBankiDB00020. Sargramostim.

Polymorphism and mutation databases

BioMutaiIL3RA.
DMDMi417184.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001088319 – 378Interleukin-3 receptor subunit alphaAdd BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...)Sequence analysis1
Glycosylationi64N-linked (GlcNAc...)Sequence analysis1
Glycosylationi80N-linked (GlcNAc...)Sequence analysis1
Glycosylationi109N-linked (GlcNAc...)Sequence analysis1
Glycosylationi212N-linked (GlcNAc...)Sequence analysis1
Glycosylationi218N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP26951.
PeptideAtlasiP26951.
PRIDEiP26951.

PTM databases

iPTMnetiP26951.
PhosphoSitePlusiP26951.

Expressioni

Gene expression databases

BgeeiENSG00000185291.
CleanExiHS_IL3RA.
ExpressionAtlasiP26951. baseline and differential.
GenevisibleiP26951. HS.

Organism-specific databases

HPAiCAB018374.
HPA003539.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.

Protein-protein interaction databases

BioGridi109778. 11 interactors.
DIPiDIP-3293N.
IntActiP26951. 12 interactors.
MINTiMINT-7241956.
STRINGi9606.ENSP00000327890.

Structurei

Secondary structure

1378
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 33Combined sources8
Turni34 – 37Combined sources4
Beta strandi38 – 45Combined sources8
Beta strandi50 – 54Combined sources5
Turni55 – 57Combined sources3
Beta strandi58 – 61Combined sources4
Turni64 – 66Combined sources3
Beta strandi67 – 69Combined sources3
Beta strandi75 – 77Combined sources3
Beta strandi79 – 85Combined sources7
Turni86 – 89Combined sources4
Beta strandi90 – 97Combined sources8
Beta strandi106 – 115Combined sources10
Turni116 – 118Combined sources3
Beta strandi119 – 126Combined sources8
Beta strandi135 – 142Combined sources8
Turni143 – 145Combined sources3
Beta strandi147 – 150Combined sources4
Beta strandi153 – 156Combined sources4
Beta strandi162 – 168Combined sources7
Helixi170 – 173Combined sources4
Turni174 – 176Combined sources3
Beta strandi178 – 187Combined sources10
Beta strandi189 – 191Combined sources3
Beta strandi196 – 201Combined sources6
Helixi202 – 205Combined sources4
Beta strandi212 – 214Combined sources3
Beta strandi223 – 227Combined sources5
Beta strandi236 – 242Combined sources7
Beta strandi250 – 256Combined sources7
Beta strandi258 – 261Combined sources4
Beta strandi270 – 276Combined sources7
Turni277 – 279Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JZJX-ray2.80C/D20-307[»]
ProteinModelPortaliP26951.
SMRiP26951.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi282 – 286WSXWS motif5
Motifi334 – 342Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVI5. Eukaryota.
ENOG41118NI. LUCA.
GeneTreeiENSGT00520000055993.
HOGENOMiHOG000004539.
HOVERGENiHBG107484.
InParanoidiP26951.
KOiK04737.
OMAiPHMKDPI.
OrthoDBiEOG091G0B8U.
PhylomeDBiP26951.
TreeFamiTF331549.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003532. Short_hematopoietin_rcpt_2_CS.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P26951-1) [UniParc]FASTAAdd to basket
Also known as: SP1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLLWLTLLL IALPCLLQTK EDPNPPITNL RMKAKAQQLT WDLNRNVTDI
60 70 80 90 100
ECVKDADYSM PAVNNSYCQF GAISLCEVTN YTVRVANPPF STWILFPENS
110 120 130 140 150
GKPWAGAENL TCWIHDVDFL SCSWAVGPGA PADVQYDLYL NVANRRQQYE
160 170 180 190 200
CLHYKTDAQG TRIGCRFDDI SRLSSGSQSS HILVRGRSAA FGIPCTDKFV
210 220 230 240 250
VFSQIEILTP PNMTAKCNKT HSFMHWKMRS HFNRKFRYEL QIQKRMQPVI
260 270 280 290 300
TEQVRDRTSF QLLNPGTYTV QIRARERVYE FLSAWSTPQR FECDQEEGAN
310 320 330 340 350
TRAWRTSLLI ALGTLLALVC VFVICRRYLV MQRLFPRIPH MKDPIGDSFQ
360 370
NDKLVVWEAG KAGLEECLVT EVQVVQKT
Length:378
Mass (Da):43,330
Last modified:October 1, 1993 - v1
Checksum:i716CE1803F2E5FC0
GO
Isoform 2 (identifier: P26951-2) [UniParc]FASTAAdd to basket
Also known as: SP2

The sequence of this isoform differs from the canonical sequence as follows:
     22-100: DPNPPITNLR...STWILFPENS → G

Show »
Length:300
Mass (Da):34,466
Checksum:iD90ED8C49F3BD8CC
GO

Sequence cautioni

The sequence BAA08393 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02111312A → T.2 PublicationsCorresponds to variant rs6647004dbSNPEnsembl.1
Natural variantiVAR_02111477E → G.1 PublicationCorresponds to variant rs17886756dbSNPEnsembl.1
Natural variantiVAR_021115123S → T.1 PublicationCorresponds to variant rs17883572dbSNPEnsembl.1
Natural variantiVAR_021116323V → L.1 PublicationCorresponds to variant rs17883366dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04062222 – 100DPNPP…FPENS → G in isoform 2. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74782 mRNA. Translation: AAA59148.1.
D49410 Genomic DNA. Translation: BAA08393.1. Sequence problems.
FJ550347 mRNA. Translation: ACM24116.1.
AK290568 mRNA. Translation: BAF83257.1.
AY789109 Genomic DNA. Translation: AAV40832.1.
BX296563, AL683870, BX119906 Genomic DNA. Translation: CAI39694.1.
BX296563, BX119906 Genomic DNA. Translation: CAI39695.1.
BX901885 Genomic DNA. No translation available.
BC035407 mRNA. Translation: AAH35407.1.
CCDSiCCDS14113.1. [P26951-1]
CCDS59158.1. [P26951-2]
PIRiA40266.
RefSeqiNP_001254642.1. NM_001267713.1. [P26951-2]
NP_002174.1. NM_002183.3. [P26951-1]
XP_005274488.1. XM_005274431.4. [P26951-1]
XP_005274837.1. XM_005274780.4. [P26951-1]
UniGeneiHs.632790.

Genome annotation databases

EnsembliENST00000331035; ENSP00000327890; ENSG00000185291. [P26951-1]
ENST00000381469; ENSP00000370878; ENSG00000185291. [P26951-2]
GeneIDi3563.
KEGGihsa:3563.
UCSCiuc004cps.4. human. [P26951-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74782 mRNA. Translation: AAA59148.1.
D49410 Genomic DNA. Translation: BAA08393.1. Sequence problems.
FJ550347 mRNA. Translation: ACM24116.1.
AK290568 mRNA. Translation: BAF83257.1.
AY789109 Genomic DNA. Translation: AAV40832.1.
BX296563, AL683870, BX119906 Genomic DNA. Translation: CAI39694.1.
BX296563, BX119906 Genomic DNA. Translation: CAI39695.1.
BX901885 Genomic DNA. No translation available.
BC035407 mRNA. Translation: AAH35407.1.
CCDSiCCDS14113.1. [P26951-1]
CCDS59158.1. [P26951-2]
PIRiA40266.
RefSeqiNP_001254642.1. NM_001267713.1. [P26951-2]
NP_002174.1. NM_002183.3. [P26951-1]
XP_005274488.1. XM_005274431.4. [P26951-1]
XP_005274837.1. XM_005274780.4. [P26951-1]
UniGeneiHs.632790.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JZJX-ray2.80C/D20-307[»]
ProteinModelPortaliP26951.
SMRiP26951.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109778. 11 interactors.
DIPiDIP-3293N.
IntActiP26951. 12 interactors.
MINTiMINT-7241956.
STRINGi9606.ENSP00000327890.

Chemistry databases

DrugBankiDB00020. Sargramostim.

PTM databases

iPTMnetiP26951.
PhosphoSitePlusiP26951.

Polymorphism and mutation databases

BioMutaiIL3RA.
DMDMi417184.

Proteomic databases

PaxDbiP26951.
PeptideAtlasiP26951.
PRIDEiP26951.

Protocols and materials databases

DNASUi3563.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331035; ENSP00000327890; ENSG00000185291. [P26951-1]
ENST00000381469; ENSP00000370878; ENSG00000185291. [P26951-2]
GeneIDi3563.
KEGGihsa:3563.
UCSCiuc004cps.4. human. [P26951-1]

Organism-specific databases

CTDi3563.
DisGeNETi3563.
GeneCardsiIL3RA.
HGNCiHGNC:6012. IL3RA.
HPAiCAB018374.
HPA003539.
MIMi308385. gene.
430000. gene.
neXtProtiNX_P26951.
OpenTargetsiENSG00000185291.
PharmGKBiPA29831.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVI5. Eukaryota.
ENOG41118NI. LUCA.
GeneTreeiENSGT00520000055993.
HOGENOMiHOG000004539.
HOVERGENiHBG107484.
InParanoidiP26951.
KOiK04737.
OMAiPHMKDPI.
OrthoDBiEOG091G0B8U.
PhylomeDBiP26951.
TreeFamiTF331549.

Enzyme and pathway databases

BioCyciZFISH:G66-30688-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-512988. Interleukin-3, 5 and GM-CSF signaling.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-912526. Interleukin receptor SHC signaling.
SignaLinkiP26951.
SIGNORiP26951.

Miscellaneous databases

GeneWikiiIL3RA.
GenomeRNAii3563.
PROiP26951.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185291.
CleanExiHS_IL3RA.
ExpressionAtlasiP26951. baseline and differential.
GenevisibleiP26951. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003532. Short_hematopoietin_rcpt_2_CS.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL3RA_HUMAN
AccessioniPrimary (citable) accession number: P26951
Secondary accession number(s): A8K3F3
, B9VI81, Q5HYQ7, Q5HYQ8, Q9UEH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 2, 2016
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.