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Protein

Interleukin-3 receptor subunit alpha

Gene

IL3RA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a receptor for interleukin-3.

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-114604 GPVI-mediated activation cascade
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-912526 Interleukin receptor SHC signaling
SignaLinkiP26951
SIGNORiP26951

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-3 receptor subunit alpha
Short name:
IL-3 receptor subunit alpha
Short name:
IL-3R subunit alpha
Short name:
IL-3R-alpha
Short name:
IL-3RA
Alternative name(s):
CD_antigen: CD123
Gene namesi
Name:IL3RA
Synonyms:IL3R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000185291.11
HGNCiHGNC:6012 IL3RA
MIMi308385 gene
430000 gene
neXtProtiNX_P26951

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 305ExtracellularSequence analysisAdd BLAST287
Transmembranei306 – 325HelicalSequence analysisAdd BLAST20
Topological domaini326 – 378CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3563
OpenTargetsiENSG00000185291
PharmGKBiPA29831

Chemistry databases

DrugBankiDB00020 Sargramostim

Polymorphism and mutation databases

BioMutaiIL3RA
DMDMi417184

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001088319 – 378Interleukin-3 receptor subunit alphaAdd BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi218N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP26951
PeptideAtlasiP26951
PRIDEiP26951

PTM databases

iPTMnetiP26951
PhosphoSitePlusiP26951

Expressioni

Gene expression databases

BgeeiENSG00000185291
CleanExiHS_IL3RA
ExpressionAtlasiP26951 baseline and differential
GenevisibleiP26951 HS

Organism-specific databases

HPAiCAB018374
HPA003539

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109778, 11 interactors
DIPiDIP-3293N
IntActiP26951, 12 interactors
STRINGi9606.ENSP00000327890

Structurei

Secondary structure

1378
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 33Combined sources3
Turni34 – 37Combined sources4
Beta strandi38 – 40Combined sources3
Beta strandi52 – 54Combined sources3
Turni55 – 57Combined sources3
Beta strandi58 – 60Combined sources3
Turni64 – 66Combined sources3
Beta strandi67 – 69Combined sources3
Beta strandi75 – 77Combined sources3
Beta strandi79 – 83Combined sources5
Turni86 – 89Combined sources4
Beta strandi92 – 97Combined sources6
Beta strandi108 – 115Combined sources8
Turni116 – 118Combined sources3
Beta strandi119 – 125Combined sources7
Beta strandi135 – 142Combined sources8
Beta strandi148 – 150Combined sources3
Beta strandi153 – 156Combined sources4
Beta strandi162 – 168Combined sources7
Helixi170 – 174Combined sources5
Beta strandi179 – 187Combined sources9
Beta strandi189 – 191Combined sources3
Beta strandi196 – 201Combined sources6
Helixi202 – 204Combined sources3
Beta strandi212 – 216Combined sources5
Beta strandi219 – 227Combined sources9
Beta strandi236 – 243Combined sources8
Beta strandi250 – 256Combined sources7
Beta strandi258 – 264Combined sources7
Beta strandi266 – 276Combined sources11
Turni277 – 279Combined sources3
Beta strandi289 – 292Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JZJX-ray2.80C/D20-307[»]
5UV8X-ray2.70A/G20-307[»]
5UWCX-ray2.40G20-307[»]
ProteinModelPortaliP26951
SMRiP26951
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi282 – 286WSXWS motif5
Motifi334 – 342Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVI5 Eukaryota
ENOG41118NI LUCA
GeneTreeiENSGT00520000055993
HOGENOMiHOG000004539
HOVERGENiHBG107484
InParanoidiP26951
KOiK04737
OMAiPHMKDPI
OrthoDBiEOG091G0B8U
PhylomeDBiP26951
TreeFamiTF331549

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR003532 Short_hematopoietin_rcpt_2_CS
IPR015321 TypeI_recpt_CBD
PfamiView protein in Pfam
PF09240 IL6Ra-bind, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS01356 HEMATOPO_REC_S_F2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P26951-1) [UniParc]FASTAAdd to basket
Also known as: SP1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLLWLTLLL IALPCLLQTK EDPNPPITNL RMKAKAQQLT WDLNRNVTDI
60 70 80 90 100
ECVKDADYSM PAVNNSYCQF GAISLCEVTN YTVRVANPPF STWILFPENS
110 120 130 140 150
GKPWAGAENL TCWIHDVDFL SCSWAVGPGA PADVQYDLYL NVANRRQQYE
160 170 180 190 200
CLHYKTDAQG TRIGCRFDDI SRLSSGSQSS HILVRGRSAA FGIPCTDKFV
210 220 230 240 250
VFSQIEILTP PNMTAKCNKT HSFMHWKMRS HFNRKFRYEL QIQKRMQPVI
260 270 280 290 300
TEQVRDRTSF QLLNPGTYTV QIRARERVYE FLSAWSTPQR FECDQEEGAN
310 320 330 340 350
TRAWRTSLLI ALGTLLALVC VFVICRRYLV MQRLFPRIPH MKDPIGDSFQ
360 370
NDKLVVWEAG KAGLEECLVT EVQVVQKT
Length:378
Mass (Da):43,330
Last modified:October 1, 1993 - v1
Checksum:i716CE1803F2E5FC0
GO
Isoform 2 (identifier: P26951-2) [UniParc]FASTAAdd to basket
Also known as: SP2

The sequence of this isoform differs from the canonical sequence as follows:
     22-100: DPNPPITNLR...STWILFPENS → G

Show »
Length:300
Mass (Da):34,466
Checksum:iD90ED8C49F3BD8CC
GO

Sequence cautioni

The sequence BAA08393 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02111312A → T2 PublicationsCorresponds to variant dbSNP:rs6647004Ensembl.1
Natural variantiVAR_02111477E → G1 PublicationCorresponds to variant dbSNP:rs17886756Ensembl.1
Natural variantiVAR_021115123S → T1 PublicationCorresponds to variant dbSNP:rs17883572Ensembl.1
Natural variantiVAR_021116323V → L1 PublicationCorresponds to variant dbSNP:rs17883366Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04062222 – 100DPNPP…FPENS → G in isoform 2. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74782 mRNA Translation: AAA59148.1
D49410 Genomic DNA Translation: BAA08393.1 Sequence problems.
FJ550347 mRNA Translation: ACM24116.1
AK290568 mRNA Translation: BAF83257.1
AY789109 Genomic DNA Translation: AAV40832.1
BX296563, AL683870, BX119906 Genomic DNA Translation: CAI39694.1
BX296563, BX119906 Genomic DNA Translation: CAI39695.1
BX901885 Genomic DNA No translation available.
BC035407 mRNA Translation: AAH35407.1
CCDSiCCDS14113.1 [P26951-1]
CCDS59158.1 [P26951-2]
PIRiA40266
RefSeqiNP_001254642.1, NM_001267713.1 [P26951-2]
NP_002174.1, NM_002183.3 [P26951-1]
XP_005274488.1, XM_005274431.4 [P26951-1]
XP_005274837.1, XM_005274780.4 [P26951-1]
UniGeneiHs.632790

Genome annotation databases

EnsembliENST00000331035; ENSP00000327890; ENSG00000185291 [P26951-1]
ENST00000381469; ENSP00000370878; ENSG00000185291 [P26951-2]
GeneIDi3563
KEGGihsa:3563
UCSCiuc004cps.4 human [P26951-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIL3RA_HUMAN
AccessioniPrimary (citable) accession number: P26951
Secondary accession number(s): A8K3F3
, B9VI81, Q5HYQ7, Q5HYQ8, Q9UEH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: April 25, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health