P26951 (IL3RA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-3 receptor subunit alpha
Short name=IL-3 receptor subunit alpha
Short name=IL-3R subunit alpha
Short name=IL-3R-alpha
Short name=IL-3RA

Alternative name(s):
CD_antigen=CD123

Gene names

Name:	IL3RA
Synonyms:	IL3R

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This is a receptor for interleukin-3.
Subunit structure	Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.
Subcellular location	Membrane; Single-pass type I membrane protein.
Domain	The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation.
Miscellaneous	The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
Sequence similarities	Belongs to the type I cytokine receptor family. Type 5 subfamily.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular function	interleukin-3 receptor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P26951-1)

Also known as: SP1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P26951-2)

Also known as: SP2;

The sequence of this isoform differs from the canonical sequence as follows:
     22-100: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 378	360	Interleukin-3 receptor subunit alpha		PRO_0000010883
Regions
	Topological domain	19 – 305	287	Extracellular Potential
	Transmembrane	306 – 325	20	Helical; Potential
	Topological domain	326 – 378	53	Cytoplasmic Potential
	Motif	282 – 286	5	WSXWS motif
	Motif	334 – 342	9	Box 1 motif
Amino acid modifications
	Glycosylation	46	1	N-linked (GlcNAc...) Potential
	Glycosylation	64	1	N-linked (GlcNAc...) Potential
	Glycosylation	80	1	N-linked (GlcNAc...) Potential
	Glycosylation	109	1	N-linked (GlcNAc...) Potential
	Glycosylation	212	1	N-linked (GlcNAc...) Potential
	Glycosylation	218	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	22 – 100	79	Missing in isoform 2.		VSP_040622
	Natural variant	12	1	A → T. Ref.4 Ref.5 Corresponds to variant rs6647004 [ dbSNP | Ensembl ].		VAR_021113
	Natural variant	77	1	E → G. Ref.4 Corresponds to variant rs17886756 [ dbSNP | Ensembl ].		VAR_021114
	Natural variant	123	1	S → T. Ref.4 Corresponds to variant rs17883572 [ dbSNP | Ensembl ].		VAR_021115
	Natural variant	323	1	V → L. Ref.4 Corresponds to variant rs17883366 [ dbSNP | Ensembl ].		VAR_021116

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (SP1) [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 716CE1803F2E5FC0	FASTA	378	43,330
	10 20 30 40 50 60 MVLLWLTLLL IALPCLLQTK EDPNPPITNL RMKAKAQQLT WDLNRNVTDI ECVKDADYSM 70 80 90 100 110 120 PAVNNSYCQF GAISLCEVTN YTVRVANPPF STWILFPENS GKPWAGAENL TCWIHDVDFL 130 140 150 160 170 180 SCSWAVGPGA PADVQYDLYL NVANRRQQYE CLHYKTDAQG TRIGCRFDDI SRLSSGSQSS 190 200 210 220 230 240 HILVRGRSAA FGIPCTDKFV VFSQIEILTP PNMTAKCNKT HSFMHWKMRS HFNRKFRYEL 250 260 270 280 290 300 QIQKRMQPVI TEQVRDRTSF QLLNPGTYTV QIRARERVYE FLSAWSTPQR FECDQEEGAN 310 320 330 340 350 360 TRAWRTSLLI ALGTLLALVC VFVICRRYLV MQRLFPRIPH MKDPIGDSFQ NDKLVVWEAG 370 KAGLEECLVT EVQVVQKT
	Isoform 2 (SP2) [UniParc]. Checksum: C67EC773A3F427D7	FASTA	299	34,409
	10 20 30 40 50 60 MVLLWLTLLL IALPCLLQTK EGKPWAGAEN LTCWIHDVDF LSCSWAVGPG APADVQYDLY 70 80 90 100 110 120 LNVANRRQQY ECLHYKTDAQ GTRIGCRFDD ISRLSSGSQS SHILVRGRSA AFGIPCTDKF 130 140 150 160 170 180 VVFSQIEILT PPNMTAKCNK THSFMHWKMR SHFNRKFRYE LQIQKRMQPV ITEQVRDRTS 190 200 210 220 230 240 FQLLNPGTYT VQIRARERVY EFLSAWSTPQ RFECDQEEGA NTRAWRTSLL IALGTLLALV 250 260 270 280 290 CVFVICRRYL VMQRLFPRIP HMKDPIGDSF QNDKLVVWEA GKAGLEECLV TEVQVVQKT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors." Kitamura T., Sato N., Arai K., Miyajima A. Cell 66:1165-1174(1991) [PubMed: 1833064] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"A new isoform of IL-3 receptor alpha with novel differentiation activity and high affinity binding mode." Chen J., Olsen J., Ford S., Mirza S., Walker A., Murphy J.M., Young I.G. J. Biol. Chem. 284:5763-5773(2009) [PubMed: 19109256] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung.
[4]	SeattleSNPs variation discovery resource Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-12; GLY-77; THR-123 AND LEU-323.
[5]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-12.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

SeattleSNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	M74782 mRNA. Translation: AAA59148.1. FJ550347 mRNA. Translation: ACM24116.1. AK290568 mRNA. Translation: BAF83257.1. AY789109 Genomic DNA. Translation: AAV40832.1. BX296563, AL683870, BX119906 Genomic DNA. Translation: CAI39694.1. BX901885 Genomic DNA. No translation available. BC035407 mRNA. Translation: AAH35407.1.
IPI	IPI00003058. IPI00553194.
PIR	A40266.
RefSeq	NP_002174.1. NM_002183.2.
UniGene	Hs.632790.
3D structure databases
ProteinModelPortal	P26951.
SMR	P26951. Positions 106-295.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3293N.
IntAct	P26951. 12 interactions.
MINT	MINT-7241956.
STRING	P26951.
Polymorphism databases
DMDM	417184.
Proteomic databases
PRIDE	P26951.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000331035; ENSP00000327890; ENSG00000185291.
GeneID	3563.
KEGG	hsa:3563.
UCSC	uc004cps.1. human.
Organism-specific databases
CTD	3563.
GeneCards	GC0XP001415.
HGNC	HGNC:6012. IL3RA.
HPA	CAB018374. HPA003539.
MIM	308385. gene. 430000. gene.
neXtProt	NX_P26951.
PharmGKB	PA29831.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG15614.
HOVERGEN	HBG107484.
InParanoid	P26951.
OMA	PRIPHMK.
OrthoDB	EOG46Q6T8.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	P26951.
Bgee	P26951.
CleanEx	HS_IL3RA.
Genevestigator	P26951.
GermOnline	ENSG00000185291. Homo sapiens.
Family and domain databases
InterPro	IPR003961. Fibronectin_type3. IPR013783. Ig-like_fold. IPR015321. IL6_recept-bd. IPR003532. Short_hematopoietin_rcpt_2_CS. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 2 hits.
KO	K04737.
Pfam	PF09240. IL6Ra-bind. 1 hit. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 2 hits.
PROSITE	PS01356. HEMATOPO_REC_S_F2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00020. Sargramostim.
NextBio	13916.
SOURCE	Search...

Entry information

Entry name

IL3RA_HUMAN

Accession

Primary (citable) accession number: P26951
Secondary accession number(s): A8K3F3, B9VI81, Q5HYQ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	December 14, 2011
This is version 110 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.