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Protein

F1 capsule-anchoring protein

Gene

caf1A

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

A probable role in capsular biogenesis. It is likely that the caf1A molecule binds F1 antigen subunits during the extracellular secretion process.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYPES214092:GKDD-4193-MONOMER.

Protein family/group databases

TCDBi1.B.11.3.8. the outer membrane fimbrial usher porin (fup) family.

Names & Taxonomyi

Protein namesi
Recommended name:
F1 capsule-anchoring protein
Gene namesi
Name:caf1A
Ordered Locus Names:YPMT1.83, Y1099, YP_pMT083
Encoded oniPlasmid pMT1 (pMT-1)4 Publications
Plasmid pFra1 Publication
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Plasmid pMT1 (pMT-1)
  • UP000001019 Componenti: Plasmid pMT1
  • UP000002490 Componenti: Plasmid pMT-1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 833808F1 capsule-anchoring proteinPRO_0000009300Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi807 ↔ 829Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP26949.

Interactioni

Protein-protein interaction databases

DIPiDIP-59979N.
STRINGi187410.Y1099.

Structurei

Secondary structure

1
833
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi42 – 454Combined sources
Beta strandi52 – 609Combined sources
Beta strandi63 – 7715Combined sources
Beta strandi80 – 856Combined sources
Helixi89 – 946Combined sources
Helixi99 – 1013Combined sources
Helixi103 – 1053Combined sources
Beta strandi111 – 1133Combined sources
Helixi116 – 1183Combined sources
Beta strandi119 – 1213Combined sources
Beta strandi123 – 1275Combined sources
Turni128 – 1314Combined sources
Beta strandi132 – 1365Combined sources
Helixi139 – 1413Combined sources
Beta strandi147 – 1504Combined sources
Beta strandi261 – 2633Combined sources
Beta strandi266 – 28621Combined sources
Beta strandi288 – 2947Combined sources
Beta strandi296 – 3016Combined sources
Beta strandi311 – 3188Combined sources
Beta strandi324 – 3318Combined sources
Beta strandi746 – 7549Combined sources
Beta strandi765 – 7684Combined sources
Beta strandi782 – 7898Combined sources
Beta strandi791 – 7999Combined sources
Beta strandi805 – 8128Combined sources
Beta strandi823 – 8319Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XETX-ray1.60A/B745-833[»]
3FCGX-ray2.85A/B253-341[»]
4B0EX-ray2.00A/B/C/D23-158[»]
4B0MX-ray1.80A23-158[»]
ProteinModelPortaliP26949.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26949.

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial export usher family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4108D1K. Bacteria.
COG3188. LUCA.
HOGENOMiHOG000261382.
KOiK07347.
OMAiCELELMV.
OrthoDBiEOG6GJBP9.

Family and domain databases

InterProiIPR000015. Fimb_usher.
IPR018030. Fimbrial_membr_usher_CS.
IPR025949. PapC-like_C.
IPR025885. PapC_N.
[Graphical view]
PANTHERiPTHR30451. PTHR30451. 1 hit.
PfamiPF13953. PapC_C. 1 hit.
PF13954. PapC_N. 1 hit.
PF00577. Usher. 1 hit.
[Graphical view]
PROSITEiPS01151. FIMBRIAL_USHER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26949-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYSKLFLCA GLTLATLPCW GRAYTFDSTM LDTNSGESID VSLFNQGLQL
60 70 80 90 100
PGNYFVNVFV NGRKVDSGNI DFRLEKHNGK ELLWPCLSSL QLTKYGIDID
110 120 130 140 150
KYPDLIKSGT EQCVDLLAIP HSDVQFYFNQ QKLSLIVPPQ ALLPRFDGIM
160 170 180 190 200
PMQLWDDGIP ALFMNYNTNM QTRKFREGGK SLDSYYAQLQ PGLNIGAWRF
210 220 230 240 250
RSSTSWWKQQ GWQRSYIYAE RGLNTIKSRL TLGETYSDSS IFDSIPIKGI
260 270 280 290 300
KIASDESMVP YYQWNFAPVV RGIARTQARV EVLRDGYTVS NELVPSGPFE
310 320 330 340 350
LANLPLGGGS GELKVIIHES DGTKQVFTVP YDTPAVALRK GYFEYSMMGG
360 370 380 390 400
EYRPANDLTQ TSYVGALGMK YGLPRNLTLY GGLQGSQNYH AAALGIGAML
410 420 430 440 450
GDFGAISTDV TQADSQKNKQ KKESGQRWRV RYNKYLQSGT SLNIASEEYA
460 470 480 490 500
TEGFNKLADT LNTYCKPNTR NDCRFDYAKP KNKVQFNLSQ SIPGSGTLNF
510 520 530 540 550
SGYRKNYWRD SRSTTSFSVG YNHFFRNGMS LTLNLSKTQN INKYGEKTSE
560 570 580 590 600
LLSNIWLSFP LSRWLGNNSI NSNYQMTSDS HGNTTHEVGV YGEAFDRQLY
610 620 630 640 650
WDVRERFNEK GRKYTSNALN LNYRGTYGEI SGNYSYDQTQ SQLGIGVNGN
660 670 680 690 700
MVITQYGITA GQKTGDTIAL VQAPDISGAS VGYWPGMKTD FRGYTNYGYL
710 720 730 740 750
TPYRENKVEI NPVTLPNDAE ITNNIVSVIP TKGAVVLAKF NARIGGRLFL
760 770 780 790 800
HLKRSDNKPV PFGSIVTIEG QSSSSGIVGD NSGVYLTGLP KKSKILVKWG
810 820 830
RDKNQSCSSN VVLPEKTDIS GAYRLSTTCI LNN
Length:833
Mass (Da):93,003
Last modified:November 16, 2001 - v2
Checksum:i48F409F4E28F37BE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti366 – 3672AL → VF in CAA43968 (PubMed:1551441).Curated
Sequence conflicti377 – 3771L → F in CAA43968 (PubMed:1551441).Curated
Sequence conflicti392 – 3921A → E in CAA43968 (PubMed:1551441).Curated
Sequence conflicti706 – 7061N → Y in CAA43968 (PubMed:1551441).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61996 Genomic DNA. Translation: CAA43968.1.
AF074611 Genomic DNA. Translation: AAC82757.1.
AF053947 Genomic DNA. Translation: AAC13219.1.
AL117211 Genomic DNA. Translation: CAB55265.1.
AE017045 Genomic DNA. Translation: AAS58715.1.
PIRiS20387.
T14703.
RefSeqiNP_395429.1. NC_003134.1.
NP_857693.1. NC_004835.1.
WP_002211763.1. NZ_LQAY01000045.1.
YP_093953.1. NC_006323.1.

Genome annotation databases

EnsemblBacteriaiAAC82757; AAC82757; AAC82757.
AAS58715; AAS58715; YP_pMT083.
GeneIDi1149093.
3077339.
KEGGipg:1149093.
pg:3077339.
ype:YPMT1.83.
ypk:caf1A.pl.
ypm:YP_pMT083.
PATRICi18627918. VBIYerPes99487_4843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61996 Genomic DNA. Translation: CAA43968.1.
AF074611 Genomic DNA. Translation: AAC82757.1.
AF053947 Genomic DNA. Translation: AAC13219.1.
AL117211 Genomic DNA. Translation: CAB55265.1.
AE017045 Genomic DNA. Translation: AAS58715.1.
PIRiS20387.
T14703.
RefSeqiNP_395429.1. NC_003134.1.
NP_857693.1. NC_004835.1.
WP_002211763.1. NZ_LQAY01000045.1.
YP_093953.1. NC_006323.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XETX-ray1.60A/B745-833[»]
3FCGX-ray2.85A/B253-341[»]
4B0EX-ray2.00A/B/C/D23-158[»]
4B0MX-ray1.80A23-158[»]
ProteinModelPortaliP26949.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59979N.
STRINGi187410.Y1099.

Protein family/group databases

TCDBi1.B.11.3.8. the outer membrane fimbrial usher porin (fup) family.

Proteomic databases

PRIDEiP26949.

Protocols and materials databases

DNASUi1149243.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC82757; AAC82757; AAC82757.
AAS58715; AAS58715; YP_pMT083.
GeneIDi1149093.
3077339.
KEGGipg:1149093.
pg:3077339.
ype:YPMT1.83.
ypk:caf1A.pl.
ypm:YP_pMT083.
PATRICi18627918. VBIYerPes99487_4843.

Phylogenomic databases

eggNOGiENOG4108D1K. Bacteria.
COG3188. LUCA.
HOGENOMiHOG000261382.
KOiK07347.
OMAiCELELMV.
OrthoDBiEOG6GJBP9.

Enzyme and pathway databases

BioCyciYPES214092:GKDD-4193-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP26949.

Family and domain databases

InterProiIPR000015. Fimb_usher.
IPR018030. Fimbrial_membr_usher_CS.
IPR025949. PapC-like_C.
IPR025885. PapC_N.
[Graphical view]
PANTHERiPTHR30451. PTHR30451. 1 hit.
PfamiPF13953. PapC_C. 1 hit.
PF13954. PapC_N. 1 hit.
PF00577. Usher. 1 hit.
[Graphical view]
PROSITEiPS01151. FIMBRIAL_USHER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new gene of the f1 operon of Y. pestis involved in the capsule biogenesis."
    Karlyshev A.V., Galyov E.E., Smirnov O.Y., Guzayev A.P., Abramov V.M., Zav'yalov V.P.
    FEBS Lett. 297:77-80(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Plasmid: pFra
  2. "Structural organization of virulence-associated plasmids of Yersinia pestis."
    Hu P., Elliott J., McCready P., Skowronski E., Garnes J., Kobayashi A., Brubaker R.R., Garcia E.
    J. Bacteriol. 180:5192-5202(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: KIM5 / Biovar Mediaevalis.
    Plasmid: pMT1 (pMT-1)
  3. "Complete DNA sequence and detailed analysis of the Yersinia pestis KIM5 plasmid encoding murine toxin and capsular antigen."
    Lindler L.E., Plano G.V., Burland V., Mayhew G.F., Blattner F.R.
    Infect. Immun. 66:5731-5742(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
    Plasmid: pMT1 (pMT-1)
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
    Plasmid: pMT1 (pMT-1)
  5. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.
    Plasmid: pMT1 (pMT-1)

Entry informationi

Entry nameiCAF1A_YERPE
AccessioniPrimary (citable) accession number: P26949
Secondary accession number(s): O68773
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: November 16, 2001
Last modified: July 6, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.