Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

F1 capsule-anchoring protein

Gene

caf1A

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

A probable role in capsular biogenesis. It is likely that the caf1A molecule binds F1 antigen subunits during the extracellular secretion process.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi1.B.11.3.8. the outer membrane fimbrial usher porin (fup) family.

Names & Taxonomyi

Protein namesi
Recommended name:
F1 capsule-anchoring protein
Gene namesi
Name:caf1A
Ordered Locus Names:YPMT1.83, Y1099, YP_pMT083
Encoded oniPlasmid pMT1 (pMT-1)4 Publications
Plasmid pFra1 Publication
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Plasmid pMT1 (pMT-1)
  • UP000001019 Componenti: Plasmid pMT1
  • UP000002490 Componenti: Plasmid pMT-1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000930026 – 833F1 capsule-anchoring proteinAdd BLAST808

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi807 ↔ 829Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP26949.

Interactioni

Protein-protein interaction databases

DIPiDIP-59979N.
STRINGi187410.Y1099.

Structurei

Secondary structure

1833
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi42 – 45Combined sources4
Beta strandi52 – 60Combined sources9
Beta strandi63 – 77Combined sources15
Beta strandi80 – 85Combined sources6
Helixi89 – 94Combined sources6
Helixi99 – 101Combined sources3
Helixi103 – 105Combined sources3
Beta strandi111 – 113Combined sources3
Helixi116 – 118Combined sources3
Beta strandi119 – 121Combined sources3
Beta strandi123 – 127Combined sources5
Turni128 – 131Combined sources4
Beta strandi132 – 136Combined sources5
Helixi139 – 141Combined sources3
Beta strandi147 – 150Combined sources4
Beta strandi261 – 263Combined sources3
Beta strandi266 – 286Combined sources21
Beta strandi288 – 294Combined sources7
Beta strandi296 – 301Combined sources6
Beta strandi311 – 318Combined sources8
Beta strandi324 – 331Combined sources8
Beta strandi746 – 754Combined sources9
Beta strandi765 – 768Combined sources4
Beta strandi782 – 789Combined sources8
Beta strandi791 – 799Combined sources9
Beta strandi805 – 812Combined sources8
Beta strandi823 – 831Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XETX-ray1.60A/B745-833[»]
3FCGX-ray2.85A/B253-341[»]
4B0EX-ray2.00A/B/C/D23-158[»]
4B0MX-ray1.80A23-158[»]
ProteinModelPortaliP26949.
SMRiP26949.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26949.

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial export usher family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4108D1K. Bacteria.
COG3188. LUCA.
HOGENOMiHOG000261382.
KOiK07347.
OMAiCELELMV.

Family and domain databases

InterProiIPR000015. Fimb_usher.
IPR018030. Fimbrial_membr_usher_CS.
IPR025949. PapC-like_C.
IPR025885. PapC_N.
[Graphical view]
PANTHERiPTHR30451. PTHR30451. 1 hit.
PfamiPF13953. PapC_C. 1 hit.
PF13954. PapC_N. 1 hit.
PF00577. Usher. 1 hit.
[Graphical view]
PROSITEiPS01151. FIMBRIAL_USHER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26949-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYSKLFLCA GLTLATLPCW GRAYTFDSTM LDTNSGESID VSLFNQGLQL
60 70 80 90 100
PGNYFVNVFV NGRKVDSGNI DFRLEKHNGK ELLWPCLSSL QLTKYGIDID
110 120 130 140 150
KYPDLIKSGT EQCVDLLAIP HSDVQFYFNQ QKLSLIVPPQ ALLPRFDGIM
160 170 180 190 200
PMQLWDDGIP ALFMNYNTNM QTRKFREGGK SLDSYYAQLQ PGLNIGAWRF
210 220 230 240 250
RSSTSWWKQQ GWQRSYIYAE RGLNTIKSRL TLGETYSDSS IFDSIPIKGI
260 270 280 290 300
KIASDESMVP YYQWNFAPVV RGIARTQARV EVLRDGYTVS NELVPSGPFE
310 320 330 340 350
LANLPLGGGS GELKVIIHES DGTKQVFTVP YDTPAVALRK GYFEYSMMGG
360 370 380 390 400
EYRPANDLTQ TSYVGALGMK YGLPRNLTLY GGLQGSQNYH AAALGIGAML
410 420 430 440 450
GDFGAISTDV TQADSQKNKQ KKESGQRWRV RYNKYLQSGT SLNIASEEYA
460 470 480 490 500
TEGFNKLADT LNTYCKPNTR NDCRFDYAKP KNKVQFNLSQ SIPGSGTLNF
510 520 530 540 550
SGYRKNYWRD SRSTTSFSVG YNHFFRNGMS LTLNLSKTQN INKYGEKTSE
560 570 580 590 600
LLSNIWLSFP LSRWLGNNSI NSNYQMTSDS HGNTTHEVGV YGEAFDRQLY
610 620 630 640 650
WDVRERFNEK GRKYTSNALN LNYRGTYGEI SGNYSYDQTQ SQLGIGVNGN
660 670 680 690 700
MVITQYGITA GQKTGDTIAL VQAPDISGAS VGYWPGMKTD FRGYTNYGYL
710 720 730 740 750
TPYRENKVEI NPVTLPNDAE ITNNIVSVIP TKGAVVLAKF NARIGGRLFL
760 770 780 790 800
HLKRSDNKPV PFGSIVTIEG QSSSSGIVGD NSGVYLTGLP KKSKILVKWG
810 820 830
RDKNQSCSSN VVLPEKTDIS GAYRLSTTCI LNN
Length:833
Mass (Da):93,003
Last modified:November 16, 2001 - v2
Checksum:i48F409F4E28F37BE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti366 – 367AL → VF in CAA43968 (PubMed:1551441).Curated2
Sequence conflicti377L → F in CAA43968 (PubMed:1551441).Curated1
Sequence conflicti392A → E in CAA43968 (PubMed:1551441).Curated1
Sequence conflicti706N → Y in CAA43968 (PubMed:1551441).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61996 Genomic DNA. Translation: CAA43968.1.
AF074611 Genomic DNA. Translation: AAC82757.1.
AF053947 Genomic DNA. Translation: AAC13219.1.
AL117211 Genomic DNA. Translation: CAB55265.1.
AE017045 Genomic DNA. Translation: AAS58715.1.
PIRiS20387.
T14703.
RefSeqiNP_395429.1. NC_003134.1.
NP_857693.1. NC_004835.1.
WP_002211763.1. NZ_LQBA01000048.1.
YP_093953.1. NC_006323.1.

Genome annotation databases

EnsemblBacteriaiAAC82757; AAC82757; AAC82757.
AAS58715; AAS58715; YP_pMT083.
GeneIDi1149093.
1172838.
3077339.
KEGGiype:YPMT1.83.
ypk:caf1A.pl.
ypm:YP_pMT083.
PATRICi18627918. VBIYerPes99487_4843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61996 Genomic DNA. Translation: CAA43968.1.
AF074611 Genomic DNA. Translation: AAC82757.1.
AF053947 Genomic DNA. Translation: AAC13219.1.
AL117211 Genomic DNA. Translation: CAB55265.1.
AE017045 Genomic DNA. Translation: AAS58715.1.
PIRiS20387.
T14703.
RefSeqiNP_395429.1. NC_003134.1.
NP_857693.1. NC_004835.1.
WP_002211763.1. NZ_LQBA01000048.1.
YP_093953.1. NC_006323.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XETX-ray1.60A/B745-833[»]
3FCGX-ray2.85A/B253-341[»]
4B0EX-ray2.00A/B/C/D23-158[»]
4B0MX-ray1.80A23-158[»]
ProteinModelPortaliP26949.
SMRiP26949.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59979N.
STRINGi187410.Y1099.

Protein family/group databases

TCDBi1.B.11.3.8. the outer membrane fimbrial usher porin (fup) family.

Proteomic databases

PRIDEiP26949.

Protocols and materials databases

DNASUi1149243.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC82757; AAC82757; AAC82757.
AAS58715; AAS58715; YP_pMT083.
GeneIDi1149093.
1172838.
3077339.
KEGGiype:YPMT1.83.
ypk:caf1A.pl.
ypm:YP_pMT083.
PATRICi18627918. VBIYerPes99487_4843.

Phylogenomic databases

eggNOGiENOG4108D1K. Bacteria.
COG3188. LUCA.
HOGENOMiHOG000261382.
KOiK07347.
OMAiCELELMV.

Miscellaneous databases

EvolutionaryTraceiP26949.

Family and domain databases

InterProiIPR000015. Fimb_usher.
IPR018030. Fimbrial_membr_usher_CS.
IPR025949. PapC-like_C.
IPR025885. PapC_N.
[Graphical view]
PANTHERiPTHR30451. PTHR30451. 1 hit.
PfamiPF13953. PapC_C. 1 hit.
PF13954. PapC_N. 1 hit.
PF00577. Usher. 1 hit.
[Graphical view]
PROSITEiPS01151. FIMBRIAL_USHER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAF1A_YERPE
AccessioniPrimary (citable) accession number: P26949
Secondary accession number(s): O68773
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: November 16, 2001
Last modified: November 30, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.