P26941 (TRPF_METTM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase
Short name=PRAI
EC=5.3.1.24

Gene names

Name:	trpF
Ordered Locus Names:	MTBMA_c02370

Organism

Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum) [Complete proteome] [HAMAP]

Taxonomic identifier

79929 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter › Methanothermobacter marburgensis

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate. HAMAP-Rule MF_00135
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5. HAMAP-Rule MF_00135
Sequence similarities	Belongs to the TrpF family.
Sequence caution	The sequence ADL57846.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	phosphoribosylanthranilate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 226	226	N-(5'-phosphoribosyl)anthranilate isomerase HAMAP-Rule MF_00135		PRO_0000154408

Sequences

	Sequence		Length	Mass (Da)
	P26941 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: CDE5A34BF155E034	FASTA	226	24,383
	10 20 30 40 50 60 MKIKICGLTR EEDVVLADSL GADLLGFIHA RRSPRHLELG DVAELSSLIP DEKAVLVTET 70 80 90 100 110 120 SETSRIMEAI DKTGIERIQL HSVSPETAGK IHESLHAEGY SLELTLAVPP LSSHICGHEF 130 140 150 160 170 180 QGISGLILDS ASGGRTGGTG KIIPPSDALE LLALIRGMDP SLRVTLAGGL TLEFVRKNRE 190 200 210 220 YVSKFDCLDF NSGIETGPGV KDHEMMAELM NYIEGLPTRK GAIEEI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Tryptophan gene cluster of Methanobacterium thermoautotrophicum Marburg: molecular cloning and nucleotide sequence of a putative trpEGCFBAD operon." Meile L., Stettler R., Banholzer R., Kotik M., Leisinger T. J. Bacteriol. 173:5017-5023(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.
[2]	"Complete genome sequence of Methanothermobacter marburgensis, a methanoarchaeon model organism." Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H., Gottschalk G., Thauer R.K. J. Bacteriol. 192:5850-5851(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M65060 Genomic DNA. Translation: AAA73031.1. CP001710 Genomic DNA. Translation: ADL57846.1. Different initiation.
RefSeq	YP_003849159.1. NC_014408.1.
3D structure databases
ProteinModelPortal	P26941.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADL57846; ADL57846; MTBMA_c02370.
GeneID	9703943.
KEGG	mmg:MTBMA_c02370.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000161598.
KO	K01817.
OMA	CLDFNSG.
Enzyme and pathway databases
BioCyc	MMAR79929:GH5J-242-MONOMER.
UniPathway	UPA00035; UER00042.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_00135. PRAI.
InterPro	IPR013785. Aldolase_TIM. IPR001240. PRAI. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Pfam	PF00697. PRAI. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPF_METTM

Accession

Primary (citable) accession number: P26941
Secondary accession number(s): D9PUE8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program