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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

Pathwayi

GO - Molecular functioni

  1. phosphoribosylanthranilate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciMMAR79929:GH5J-238-MONOMER.
UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpF
Ordered Locus Names:MTBMA_c02370
OrganismiMethanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri79929 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000000345: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226N-(5'-phosphoribosyl)anthranilate isomerasePRO_0000154408Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP26941.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.Curated

Phylogenomic databases

HOGENOMiHOG000161598.
KOiK01817.
OMAiCLDFNSG.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

P26941-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIKICGLTR EEDVVLADSL GADLLGFIHA RRSPRHLELG DVAELSSLIP
60 70 80 90 100
DEKAVLVTET SETSRIMEAI DKTGIERIQL HSVSPETAGK IHESLHAEGY
110 120 130 140 150
SLELTLAVPP LSSHICGHEF QGISGLILDS ASGGRTGGTG KIIPPSDALE
160 170 180 190 200
LLALIRGMDP SLRVTLAGGL TLEFVRKNRE YVSKFDCLDF NSGIETGPGV
210 220
KDHEMMAELM NYIEGLPTRK GAIEEI
Length:226
Mass (Da):24,383
Last modified:August 1, 1992 - v1
Checksum:iCDE5A34BF155E034
GO

Sequence cautioni

The sequence ADL57846.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65060 Genomic DNA. Translation: AAA73031.1.
CP001710 Genomic DNA. Translation: ADL57846.1. Different initiation.
RefSeqiYP_003849159.1. NC_014408.1.

Genome annotation databases

EnsemblBacteriaiADL57846; ADL57846; MTBMA_c02370.
GeneIDi9703943.
KEGGimmg:MTBMA_c02370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65060 Genomic DNA. Translation: AAA73031.1.
CP001710 Genomic DNA. Translation: ADL57846.1. Different initiation.
RefSeqiYP_003849159.1. NC_014408.1.

3D structure databases

ProteinModelPortaliP26941.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADL57846; ADL57846; MTBMA_c02370.
GeneIDi9703943.
KEGGimmg:MTBMA_c02370.

Phylogenomic databases

HOGENOMiHOG000161598.
KOiK01817.
OMAiCLDFNSG.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.
BioCyciMMAR79929:GH5J-238-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Tryptophan gene cluster of Methanobacterium thermoautotrophicum Marburg: molecular cloning and nucleotide sequence of a putative trpEGCFBAD operon."
    Meile L., Stettler R., Banholzer R., Kotik M., Leisinger T.
    J. Bacteriol. 173:5017-5023(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.
  2. "Complete genome sequence of Methanothermobacter marburgensis, a methanoarchaeon model organism."
    Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H., Gottschalk G., Thauer R.K.
    J. Bacteriol. 192:5850-5851(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.

Entry informationi

Entry nameiTRPF_METTM
AccessioniPrimary (citable) accession number: P26941
Secondary accession number(s): D9PUE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: February 4, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.