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P26941

- TRPF_METTM

UniProt

P26941 - TRPF_METTM

Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tryptophan biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    BioCyciMMAR79929:GH5J-238-MONOMER.
    UniPathwayiUPA00035; UER00042.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
    Short name:
    PRAI
    Gene namesi
    Name:trpF
    Ordered Locus Names:MTBMA_c02370
    OrganismiMethanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
    Taxonomic identifieri79929 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
    ProteomesiUP000000345: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 226226N-(5'-phosphoribosyl)anthranilate isomerasePRO_0000154408Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP26941.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TrpF family.Curated

    Phylogenomic databases

    HOGENOMiHOG000161598.
    KOiK01817.
    OMAiCLDFNSG.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00135. PRAI.
    InterProiIPR013785. Aldolase_TIM.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00697. PRAI. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P26941-1 [UniParc]FASTAAdd to Basket

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    MKIKICGLTR EEDVVLADSL GADLLGFIHA RRSPRHLELG DVAELSSLIP    50
    DEKAVLVTET SETSRIMEAI DKTGIERIQL HSVSPETAGK IHESLHAEGY 100
    SLELTLAVPP LSSHICGHEF QGISGLILDS ASGGRTGGTG KIIPPSDALE 150
    LLALIRGMDP SLRVTLAGGL TLEFVRKNRE YVSKFDCLDF NSGIETGPGV 200
    KDHEMMAELM NYIEGLPTRK GAIEEI 226
    Length:226
    Mass (Da):24,383
    Last modified:August 1, 1992 - v1
    Checksum:iCDE5A34BF155E034
    GO

    Sequence cautioni

    The sequence ADL57846.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M65060 Genomic DNA. Translation: AAA73031.1.
    CP001710 Genomic DNA. Translation: ADL57846.1. Different initiation.
    RefSeqiYP_003849159.1. NC_014408.1.

    Genome annotation databases

    EnsemblBacteriaiADL57846; ADL57846; MTBMA_c02370.
    GeneIDi9703943.
    KEGGimmg:MTBMA_c02370.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M65060 Genomic DNA. Translation: AAA73031.1 .
    CP001710 Genomic DNA. Translation: ADL57846.1 . Different initiation.
    RefSeqi YP_003849159.1. NC_014408.1.

    3D structure databases

    ProteinModelPortali P26941.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADL57846 ; ADL57846 ; MTBMA_c02370 .
    GeneIDi 9703943.
    KEGGi mmg:MTBMA_c02370.

    Phylogenomic databases

    HOGENOMi HOG000161598.
    KOi K01817.
    OMAi CLDFNSG.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00042 .
    BioCyci MMAR79929:GH5J-238-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00135. PRAI.
    InterProi IPR013785. Aldolase_TIM.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00697. PRAI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Tryptophan gene cluster of Methanobacterium thermoautotrophicum Marburg: molecular cloning and nucleotide sequence of a putative trpEGCFBAD operon."
      Meile L., Stettler R., Banholzer R., Kotik M., Leisinger T.
      J. Bacteriol. 173:5017-5023(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.
    2. "Complete genome sequence of Methanothermobacter marburgensis, a methanoarchaeon model organism."
      Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H., Gottschalk G., Thauer R.K.
      J. Bacteriol. 192:5850-5851(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.

    Entry informationi

    Entry nameiTRPF_METTM
    AccessioniPrimary (citable) accession number: P26941
    Secondary accession number(s): D9PUE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3