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Protein

Urease subunit alpha

Gene

ureC

Organism
Lactobacillus fermentum
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Cofactori

Ni cationUniRule annotationNote: Binds 2 nickel ions per subunit.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit beta (ureB), Urease subunit gamma (ureA), Urease subunit gamma (ureA), Urease subunit beta (ureB)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi139Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi141Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi222Nickel 1; via carbamate groupUniRule annotation1
Metal bindingi222Nickel 2; via carbamate groupUniRule annotation1
Binding sitei224SubstrateUniRule annotation1
Metal bindingi251Nickel 2; via pros nitrogenUniRule annotation1
Metal bindingi277Nickel 2; via tele nitrogenUniRule annotation1
Active sitei325Proton donorUniRule annotation1
Metal bindingi365Nickel 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Nickel

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370

Protein family/group databases

MEROPSiM38.982

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit alphaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit alphaUniRule annotation
Gene namesi
Name:ureCUniRule annotation
OrganismiLactobacillus fermentum
Taxonomic identifieri1613 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000675441 – 573Urease subunit alphaAdd BLAST573

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei222N6-carboxylysineUniRule annotation1

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two nickel ions.UniRule annotation

Proteomic databases

PRIDEiP26929

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP26929
SMRiP26929
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 573UreaseUniRule annotationAdd BLAST440

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.UniRule annotation

Family and domain databases

CDDicd00375 Urease_alpha, 1 hit
Gene3Di2.30.40.10, 2 hits
HAMAPiMF_01953 Urease_alpha, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
IPR011612 Urease_alpha_N_dom
IPR017950 Urease_AS
IPR005848 Urease_asu
IPR017951 Urease_asu_c
IPR029754 Urease_Ni-bd
PANTHERiPTHR43440 PTHR43440, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
PF00449 Urease_alpha, 1 hit
PRINTSiPR01752 UREASE
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 2 hits
TIGRFAMsiTIGR01792 urease_alph, 1 hit
PROSITEiView protein in PROSITE
PS01120 UREASE_1, 1 hit
PS00145 UREASE_2, 1 hit
PS51368 UREASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

P26929-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFDMDHEQF ASFYGPTTGD SVRLGDTDLF AKIEKDLTVH GQESLFGGGK
60 70 80 90 100
VLRDGMGVSA TETRAENPMV ADLIISDAII IDWTGIYKAD IGIRDGKILA
110 120 130 140 150
IGKGGNPDVM DNVDFIVGAS TEAISGEGMI VTAGGIDLHV HYITPSIAQA
160 170 180 190 200
ALDNGITTLF GGGTGPANGT RSATCNPGAW YTHRMLQAVD NAPINYGLMA
210 220 230 240 250
KGSGSRPELI GEQIEAGCAA IKTHEDWGAT AAGIENSIAA ANKYDVQYAV
260 270 280 290 300
HTDSLNEGGF VENTINAFNG NTVHTFHTEG AGGGHAPDIM VVAGQDNVLP
310 320 330 340 350
SSTTPTNPYC KNTLDELFYM TMVCHNLNPK IPDDVAFAES RIRKQTEAAE
360 370 380 390 400
DVLQDMGALS MMTSDAQAMG RVGEVAMRCW QLASKMKKVR GPLDGDSKYD
410 420 430 440 450
DNNRIKRYVA KYTINPAICN GISDYVGSIE VGKYADLNIW DPKYFGTKPD
460 470 480 490 500
MVIKNGMITY GIAGDPSSSL PTPEPVLERF LYGAEGRAVN HTCVTYVSQY
510 520 530 540 550
AYDHGIKEQL GLNKTILPVH NTRSLTKANM KLNNYTPKTI EIDPQTYDVK
560 570
IDGKLITCDA APTLPLTQRY YLY
Length:573
Mass (Da):61,806
Last modified:August 1, 1992 - v1
Checksum:i2D2619781C39E54B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10605 Genomic DNA Translation: BAA01460.1

Similar proteinsi

Entry informationi

Entry nameiURE1_LACFE
AccessioniPrimary (citable) accession number: P26929
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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