Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Urease subunit alpha

Gene

ureC

Organism
Lactobacillus fermentum
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Cofactori

Ni cationUniRule annotationNote: Binds 2 nickel ions per subunit.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit beta (ureB), Urease subunit gamma (ureA), Urease subunit gamma (ureA), Urease subunit beta (ureB)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi139 – 1391Nickel 1; via tele nitrogenUniRule annotation
Metal bindingi141 – 1411Nickel 1; via tele nitrogenUniRule annotation
Metal bindingi222 – 2221Nickel 1; via carbamate groupUniRule annotation
Metal bindingi222 – 2221Nickel 2; via carbamate groupUniRule annotation
Binding sitei224 – 2241SubstrateUniRule annotation
Metal bindingi251 – 2511Nickel 2; via pros nitrogenUniRule annotation
Metal bindingi277 – 2771Nickel 2; via tele nitrogenUniRule annotation
Active sitei325 – 3251Proton donorUniRule annotation
Metal bindingi365 – 3651Nickel 1UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Nickel

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.

Protein family/group databases

MEROPSiM38.982.

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit alphaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit alphaUniRule annotation
Gene namesi
Name:ureCUniRule annotation
OrganismiLactobacillus fermentum
Taxonomic identifieri1613 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573Urease subunit alphaPRO_0000067544Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei222 – 2221N6-carboxylysineUniRule annotation

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two nickel ions.UniRule annotation

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP26929.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini134 – 573440UreaseUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the urease family.UniRule annotation
Contains 1 urease domain.UniRule annotation

Family and domain databases

CDDicd00375. Urease_alpha. 1 hit.
Gene3Di2.30.40.10. 2 hits.
HAMAPiMF_01953. Urease_alpha. 1 hit.
InterProiIPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
IPR011612. Urease_alpha_N_dom.
IPR017950. Urease_AS.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
IPR029754. Urease_Ni-bd.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
[Graphical view]
PRINTSiPR01752. UREASE.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 2 hits.
TIGRFAMsiTIGR01792. urease_alph. 1 hit.
PROSITEiPS01120. UREASE_1. 1 hit.
PS00145. UREASE_2. 1 hit.
PS51368. UREASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26929-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFDMDHEQF ASFYGPTTGD SVRLGDTDLF AKIEKDLTVH GQESLFGGGK
60 70 80 90 100
VLRDGMGVSA TETRAENPMV ADLIISDAII IDWTGIYKAD IGIRDGKILA
110 120 130 140 150
IGKGGNPDVM DNVDFIVGAS TEAISGEGMI VTAGGIDLHV HYITPSIAQA
160 170 180 190 200
ALDNGITTLF GGGTGPANGT RSATCNPGAW YTHRMLQAVD NAPINYGLMA
210 220 230 240 250
KGSGSRPELI GEQIEAGCAA IKTHEDWGAT AAGIENSIAA ANKYDVQYAV
260 270 280 290 300
HTDSLNEGGF VENTINAFNG NTVHTFHTEG AGGGHAPDIM VVAGQDNVLP
310 320 330 340 350
SSTTPTNPYC KNTLDELFYM TMVCHNLNPK IPDDVAFAES RIRKQTEAAE
360 370 380 390 400
DVLQDMGALS MMTSDAQAMG RVGEVAMRCW QLASKMKKVR GPLDGDSKYD
410 420 430 440 450
DNNRIKRYVA KYTINPAICN GISDYVGSIE VGKYADLNIW DPKYFGTKPD
460 470 480 490 500
MVIKNGMITY GIAGDPSSSL PTPEPVLERF LYGAEGRAVN HTCVTYVSQY
510 520 530 540 550
AYDHGIKEQL GLNKTILPVH NTRSLTKANM KLNNYTPKTI EIDPQTYDVK
560 570
IDGKLITCDA APTLPLTQRY YLY
Length:573
Mass (Da):61,806
Last modified:August 1, 1992 - v1
Checksum:i2D2619781C39E54B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10605 Genomic DNA. Translation: BAA01460.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10605 Genomic DNA. Translation: BAA01460.1.

3D structure databases

ProteinModelPortaliP26929.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM38.982.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.

Family and domain databases

CDDicd00375. Urease_alpha. 1 hit.
Gene3Di2.30.40.10. 2 hits.
HAMAPiMF_01953. Urease_alpha. 1 hit.
InterProiIPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
IPR011612. Urease_alpha_N_dom.
IPR017950. Urease_AS.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
IPR029754. Urease_Ni-bd.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
[Graphical view]
PRINTSiPR01752. UREASE.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 2 hits.
TIGRFAMsiTIGR01792. urease_alph. 1 hit.
PROSITEiPS01120. UREASE_1. 1 hit.
PS00145. UREASE_2. 1 hit.
PS51368. UREASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiURE1_LACFE
AccessioniPrimary (citable) accession number: P26929
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.