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Protein

Hepatocyte growth factor-like protein

Gene

Mst1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

The active site residues characteristic of serine proteases appear to be absent from this protein, which may therefore lack catalytic activity.Curated

GO - Molecular functioni

GO - Biological processi

  • cellular response to hypoxia Source: Ensembl
  • embryo implantation Source: MGI
  • flagellated sperm motility Source: Ensembl
  • mammary duct terminal end bud growth Source: MGI
  • mammary gland development Source: MGI
  • negative regulation of epithelial cell apoptotic process Source: MGI
  • negative regulation of gluconeogenesis Source: UniProtKB
  • positive regulation of gene expression Source: MGI
  • positive regulation of mammary gland epithelial cell proliferation Source: MGI
  • regulation of cAMP-dependent protein kinase activity Source: UniProtKB
  • regulation of JAK-STAT cascade Source: MGI
  • regulation of macrophage chemotaxis Source: MGI
  • spermatogenesis Source: Ensembl

Keywordsi

Molecular functionSerine protease homolog

Protein family/group databases

MEROPSiS01.975

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte growth factor-like protein
Alternative name(s):
Macrophage stimulatory protein
Short name:
MSP
Cleaved into the following 2 chains:
Gene namesi
Name:Mst1
Synonyms:Hgfl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:96080 Mst1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000002808819 – 716Hepatocyte growth factor-like proteinAdd BLAST698
ChainiPRO_000002808919 – 488Hepatocyte growth factor-like protein alpha chainBy similarityAdd BLAST470
ChainiPRO_0000028090489 – 716Hepatocyte growth factor-like protein beta chainBy similarityAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 78By similarity
Disulfide bondi60 ↔ 66By similarity
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi110 ↔ 186By similarity
Disulfide bondi131 ↔ 169By similarity
Disulfide bondi157 ↔ 181By similarity
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi191 ↔ 268By similarity
Disulfide bondi194 ↔ 333Sequence analysis
Disulfide bondi212 ↔ 251By similarity
Disulfide bondi240 ↔ 263By similarity
Disulfide bondi292 ↔ 370By similarity
Glycosylationi305N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi313 ↔ 352By similarity
Disulfide bondi341 ↔ 364By similarity
Disulfide bondi379 ↔ 457By similarity
Disulfide bondi400 ↔ 440By similarity
Disulfide bondi428 ↔ 452By similarity
Disulfide bondi477 ↔ 593Interchain (between alpha and beta chains)PROSITE-ProRule annotation
Disulfide bondi512 ↔ 528By similarity
Disulfide bondi607 ↔ 672By similarity
Glycosylationi620N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi637 ↔ 651By similarity
Disulfide bondi662 ↔ 690By similarity

Post-translational modificationi

Cleaved after Arg-488, probably by HPN/Hepsin, to yield the active form consisting of two disulfide-linked chains.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP26928
PaxDbiP26928
PeptideAtlasiP26928
PRIDEiP26928
TopDownProteomicsiP26928

PTM databases

iPTMnetiP26928
PhosphoSitePlusiP26928

Expressioni

Tissue specificityi

Liver. Lower levels in lung, placenta and adrenal.

Developmental stagei

Is expressed at low levels during gestation. Just before birth the level increases dramatically and remains stable afterwards.

Gene expression databases

BgeeiENSMUSG00000032591
ExpressionAtlasiP26928 baseline and differential
GenevisibleiP26928 MM

Interactioni

Subunit structurei

Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts (via beta chain) with MST1R (via SEMA domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-60723N
IntActiP26928, 2 interactors
STRINGi10090.ENSMUSP00000035211

Structurei

3D structure databases

ProteinModelPortaliP26928
SMRiP26928
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 105PANPROSITE-ProRule annotationAdd BLAST87
Domaini110 – 186Kringle 1PROSITE-ProRule annotationAdd BLAST77
Domaini191 – 268Kringle 2PROSITE-ProRule annotationAdd BLAST78
Domaini292 – 370Kringle 3PROSITE-ProRule annotationAdd BLAST79
Domaini379 – 457Kringle 4PROSITE-ProRule annotationAdd BLAST79
Domaini489 – 714Peptidase S1PROSITE-ProRule annotationAdd BLAST226

Sequence similaritiesi

Belongs to the peptidase S1 family. Plasminogen subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Kringle, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IDXR Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119133
HOGENOMiHOG000112892
HOVERGENiHBG004381
InParanoidiP26928
OMAiDCRAFHY
OrthoDBiEOG091G0AH5
TreeFamiTF329901

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
Gene3Di2.40.20.10, 4 hits
InterProiView protein in InterPro
IPR024174 HGF-like
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR003609 Pan_app
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
PfamiView protein in Pfam
PF00051 Kringle, 4 hits
PF00024 PAN_1, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF001152 HGF_MST1, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00130 KR, 4 hits
SM00473 PAN_AP, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF57440 SSF57440, 4 hits
PROSITEiView protein in PROSITE
PS00021 KRINGLE_1, 4 hits
PS50070 KRINGLE_2, 4 hits
PS50948 PAN, 1 hit
PS50240 TRYPSIN_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26928-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWLPLLLLL VQCSRALGQR SPLNDFQLFR GTELRNLLHT AVPGPWQEDV
60 70 80 90 100
ADAEECARRC GPLLDCRAFH YNMSSHGCQL LPWTQHSLHT QLYHSSLCHL
110 120 130 140 150
FQKKDYVRTC IMDNGVSYRG TVARTAGGLP CQAWSRRFPN DHKYTPTPKN
160 170 180 190 200
GLEENFCRNP DGDPRGPWCY TTNRSVRFQS CGIKTCREAV CVLCNGEDYR
210 220 230 240 250
GEVDVTESGR ECQRWDLQHP HSHPFQPEKF LDKDLKDNYC RNPDGSERPW
260 270 280 290 300
CYTTDPNVER EFCDLPSCGP NLPPTVKGSK SQRRNKGKAL NCFRGKGEDY
310 320 330 340 350
RGTTNTTSAG VPCQRWDAQS PHQHRFVPEK YACKDLRENF CRNPDGSEAP
360 370 380 390 400
WCFTSRPGLR MAFCHQIPRC TEELVPEGCY HGSGEQYRGS VSKTRKGVQC
410 420 430 440 450
QHWSSETPHK PQFTPTSAPQ AGLEANFCRN PDGDSHGPWC YTLDPDILFD
460 470 480 490 500
YCALQRCDDD QPPSILDPPD QVVFEKCGKR VDKSNKLRVV GGHPGNSPWT
510 520 530 540 550
VSLRNRQGQH FCGGSLVKEQ WVLTARQCIW SCHEPLTGYE VWLGTINQNP
560 570 580 590 600
QPGEANLQRV PVAKAVCGPA GSQLVLLKLE RPVILNHHVA LICLPPEQYV
610 620 630 640 650
VPPGTKCEIA GWGESIGTSN NTVLHVASMN VISNQECNTK YRGHIQESEI
660 670 680 690 700
CTQGLVVPVG ACEGDYGGPL ACYTHDCWVL QGLIIPNRVC ARPRWPAIFT
710
RVSVFVDWIN KVMQLE
Length:716
Mass (Da):80,619
Last modified:July 27, 2011 - v2
Checksum:i15303C4E6105B46D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19Q → P in AAA50167 (PubMed:1832957).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74180 Genomic DNA Translation: AAA50166.1
M74181 mRNA Translation: AAA50167.1
AK040934 mRNA Translation: BAC30752.1
AK144824 mRNA Translation: BAE26084.1
CH466560 Genomic DNA Translation: EDL21265.1
BC051393 mRNA Translation: AAH51393.1
CCDSiCCDS40766.1
PIRiA40332
RefSeqiNP_032269.3, NM_008243.3
UniGeneiMm.8369

Genome annotation databases

EnsembliENSMUST00000035211; ENSMUSP00000035211; ENSMUSG00000032591
GeneIDi15235
KEGGimmu:15235
UCSCiuc009ror.2 mouse

Similar proteinsi

Entry informationi

Entry nameiHGFL_MOUSE
AccessioniPrimary (citable) accession number: P26928
Secondary accession number(s): Q6GTL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health