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Protein

Hepatocyte growth factor-like protein

Gene

Mst1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • embryo implantation Source: MGI
  • mammary duct terminal end bud growth Source: MGI
  • mammary gland development Source: MGI
  • negative regulation of epithelial cell apoptotic process Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of mammary gland epithelial cell proliferation Source: MGI
  • regulation of JAK-STAT cascade Source: MGI
  • regulation of macrophage chemotaxis Source: MGI
  • spermatogenesis Source: Ensembl
  • sperm motility Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Serine protease homolog

Protein family/group databases

MEROPSiS01.975.

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte growth factor-like protein
Alternative name(s):
Macrophage stimulatory protein
Short name:
MSP
Cleaved into the following 2 chains:
Gene namesi
Name:Mst1
Synonyms:Hgfl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:96080. Mst1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • vacuole Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 716698Hepatocyte growth factor-like proteinPRO_0000028088Add
BLAST
Chaini19 – 488470Hepatocyte growth factor-like protein alpha chainBy similarityPRO_0000028089Add
BLAST
Chaini489 – 716228Hepatocyte growth factor-like protein beta chainBy similarityPRO_0000028090Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 78By similarity
Disulfide bondi60 ↔ 66By similarity
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence analysis
Disulfide bondi110 ↔ 186By similarity
Disulfide bondi131 ↔ 169By similarity
Disulfide bondi157 ↔ 181By similarity
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence analysis
Disulfide bondi191 ↔ 268By similarity
Disulfide bondi194 ↔ 333Sequence analysis
Disulfide bondi212 ↔ 251By similarity
Disulfide bondi240 ↔ 263By similarity
Disulfide bondi292 ↔ 370By similarity
Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence analysis
Disulfide bondi313 ↔ 352By similarity
Disulfide bondi341 ↔ 364By similarity
Disulfide bondi379 ↔ 457By similarity
Disulfide bondi400 ↔ 440By similarity
Disulfide bondi428 ↔ 452By similarity
Disulfide bondi477 ↔ 593Interchain (between alpha and beta chains)PROSITE-ProRule annotation
Disulfide bondi512 ↔ 528By similarity
Disulfide bondi607 ↔ 672By similarity
Glycosylationi620 – 6201N-linked (GlcNAc...)Sequence analysis
Disulfide bondi637 ↔ 651By similarity
Disulfide bondi662 ↔ 690By similarity

Post-translational modificationi

Cleaved after Arg-488, probably by HPN/Hepsin, to yield the active form consisting of two disulfide-linked chains.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP26928.
PRIDEiP26928.
TopDownProteomicsiP26928.

PTM databases

iPTMnetiP26928.
PhosphoSiteiP26928.

Expressioni

Tissue specificityi

Liver. Lower levels in lung, placenta and adrenal.

Developmental stagei

Is expressed at low levels during gestation. Just before birth the level increases dramatically and remains stable afterwards.

Gene expression databases

BgeeiP26928.
ExpressionAtlasiP26928. baseline and differential.
GenevisibleiP26928. MM.

Interactioni

Subunit structurei

Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts (via beta chain) with MST1R (via SEMA domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-60723N.
STRINGi10090.ENSMUSP00000035211.

Structurei

3D structure databases

ProteinModelPortaliP26928.
SMRiP26928. Positions 22-714.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 10587PANPROSITE-ProRule annotationAdd
BLAST
Domaini110 – 18677Kringle 1PROSITE-ProRule annotationAdd
BLAST
Domaini191 – 26878Kringle 2PROSITE-ProRule annotationAdd
BLAST
Domaini292 – 37079Kringle 3PROSITE-ProRule annotationAdd
BLAST
Domaini379 – 45779Kringle 4PROSITE-ProRule annotationAdd
BLAST
Domaini489 – 714226Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Plasminogen subfamily.PROSITE-ProRule annotation
Contains 4 kringle domains.PROSITE-ProRule annotation
Contains 1 PAN domain.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Kringle, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IDXR. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119133.
HOGENOMiHOG000112892.
HOVERGENiHBG004381.
InParanoidiP26928.
OMAiDCRAFHY.
OrthoDBiEOG75B84T.
TreeFamiTF329901.

Family and domain databases

InterProiIPR024174. HGF-like.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR003609. Pan_app.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
[Graphical view]
PfamiPF00051. Kringle. 4 hits.
PF00024. PAN_1. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001152. HGF_MST1. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00130. KR. 4 hits.
SM00473. PAN_AP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 4 hits.
PROSITEiPS00021. KRINGLE_1. 4 hits.
PS50070. KRINGLE_2. 4 hits.
PS50948. PAN. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26928-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWLPLLLLL VQCSRALGQR SPLNDFQLFR GTELRNLLHT AVPGPWQEDV
60 70 80 90 100
ADAEECARRC GPLLDCRAFH YNMSSHGCQL LPWTQHSLHT QLYHSSLCHL
110 120 130 140 150
FQKKDYVRTC IMDNGVSYRG TVARTAGGLP CQAWSRRFPN DHKYTPTPKN
160 170 180 190 200
GLEENFCRNP DGDPRGPWCY TTNRSVRFQS CGIKTCREAV CVLCNGEDYR
210 220 230 240 250
GEVDVTESGR ECQRWDLQHP HSHPFQPEKF LDKDLKDNYC RNPDGSERPW
260 270 280 290 300
CYTTDPNVER EFCDLPSCGP NLPPTVKGSK SQRRNKGKAL NCFRGKGEDY
310 320 330 340 350
RGTTNTTSAG VPCQRWDAQS PHQHRFVPEK YACKDLRENF CRNPDGSEAP
360 370 380 390 400
WCFTSRPGLR MAFCHQIPRC TEELVPEGCY HGSGEQYRGS VSKTRKGVQC
410 420 430 440 450
QHWSSETPHK PQFTPTSAPQ AGLEANFCRN PDGDSHGPWC YTLDPDILFD
460 470 480 490 500
YCALQRCDDD QPPSILDPPD QVVFEKCGKR VDKSNKLRVV GGHPGNSPWT
510 520 530 540 550
VSLRNRQGQH FCGGSLVKEQ WVLTARQCIW SCHEPLTGYE VWLGTINQNP
560 570 580 590 600
QPGEANLQRV PVAKAVCGPA GSQLVLLKLE RPVILNHHVA LICLPPEQYV
610 620 630 640 650
VPPGTKCEIA GWGESIGTSN NTVLHVASMN VISNQECNTK YRGHIQESEI
660 670 680 690 700
CTQGLVVPVG ACEGDYGGPL ACYTHDCWVL QGLIIPNRVC ARPRWPAIFT
710
RVSVFVDWIN KVMQLE
Length:716
Mass (Da):80,619
Last modified:July 27, 2011 - v2
Checksum:i15303C4E6105B46D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191Q → P in AAA50167 (PubMed:1832957).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74180 Genomic DNA. Translation: AAA50166.1.
M74181 mRNA. Translation: AAA50167.1.
AK040934 mRNA. Translation: BAC30752.1.
AK144824 mRNA. Translation: BAE26084.1.
CH466560 Genomic DNA. Translation: EDL21265.1.
BC051393 mRNA. Translation: AAH51393.1.
CCDSiCCDS40766.1.
PIRiA40332.
RefSeqiNP_032269.3. NM_008243.3.
UniGeneiMm.8369.

Genome annotation databases

EnsembliENSMUST00000035211; ENSMUSP00000035211; ENSMUSG00000032591.
GeneIDi15235.
KEGGimmu:15235.
UCSCiuc009ror.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74180 Genomic DNA. Translation: AAA50166.1.
M74181 mRNA. Translation: AAA50167.1.
AK040934 mRNA. Translation: BAC30752.1.
AK144824 mRNA. Translation: BAE26084.1.
CH466560 Genomic DNA. Translation: EDL21265.1.
BC051393 mRNA. Translation: AAH51393.1.
CCDSiCCDS40766.1.
PIRiA40332.
RefSeqiNP_032269.3. NM_008243.3.
UniGeneiMm.8369.

3D structure databases

ProteinModelPortaliP26928.
SMRiP26928. Positions 22-714.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60723N.
STRINGi10090.ENSMUSP00000035211.

Protein family/group databases

MEROPSiS01.975.

PTM databases

iPTMnetiP26928.
PhosphoSiteiP26928.

Proteomic databases

PaxDbiP26928.
PRIDEiP26928.
TopDownProteomicsiP26928.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035211; ENSMUSP00000035211; ENSMUSG00000032591.
GeneIDi15235.
KEGGimmu:15235.
UCSCiuc009ror.2. mouse.

Organism-specific databases

CTDi4485.
MGIiMGI:96080. Mst1.

Phylogenomic databases

eggNOGiENOG410IDXR. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119133.
HOGENOMiHOG000112892.
HOVERGENiHBG004381.
InParanoidiP26928.
OMAiDCRAFHY.
OrthoDBiEOG75B84T.
TreeFamiTF329901.

Miscellaneous databases

NextBioi287835.
PROiP26928.
SOURCEiSearch...

Gene expression databases

BgeeiP26928.
ExpressionAtlasiP26928. baseline and differential.
GenevisibleiP26928. MM.

Family and domain databases

InterProiIPR024174. HGF-like.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR003609. Pan_app.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
[Graphical view]
PfamiPF00051. Kringle. 4 hits.
PF00024. PAN_1. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001152. HGF_MST1. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00130. KR. 4 hits.
SM00473. PAN_AP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 4 hits.
PROSITEiPS00021. KRINGLE_1. 4 hits.
PS50070. KRINGLE_2. 4 hits.
PS50948. PAN. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development."
    Friezner Degen S.J., Stuart L.A., Han S., Jamison C.S.
    Biochemistry 30:9781-9791(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: BALB/cJ.
    Tissue: Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Aorta and Lung.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiHGFL_MOUSE
AccessioniPrimary (citable) accession number: P26928
Secondary accession number(s): Q6GTL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

The active site residues characteristic of serine proteases appear to be absent from this protein, which may therefore lack catalytic activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.