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P26927

- HGFL_HUMAN

UniProt

P26927 - HGFL_HUMAN

Protein

Hepatocyte growth factor-like protein

Gene

MST1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 151 (01 Oct 2014)
      Sequence version 2 (15 May 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Serine protease homolog

    Enzyme and pathway databases

    SignaLinkiP26927.

    Protein family/group databases

    MEROPSiS01.975.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hepatocyte growth factor-like protein
    Alternative name(s):
    Macrophage stimulatory protein
    Macrophage-stimulating protein
    Short name:
    MSP
    Cleaved into the following 2 chains:
    Gene namesi
    Name:MST1
    Synonyms:D3F15S2, DNF15S2, HGFL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:7380. MST1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    MST1 variant Cys-686 may be associated with inflammatory bowel disease (IBD), a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is unsure whether Cys-689 itself or a variation in linkage disequilibrium with Cys-689 is responsible for the association with IBD.2 Publications

    Organism-specific databases

    Orphaneti171. Primary sclerosing cholangitis.
    PharmGKBiPA31185.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 711693Hepatocyte growth factor-like proteinPRO_0000028085Add
    BLAST
    Chaini19 – 483465Hepatocyte growth factor-like protein alpha chainCuratedPRO_0000028086Add
    BLAST
    Chaini484 – 711228Hepatocyte growth factor-like protein beta chainCuratedPRO_0000028087Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi56 ↔ 78By similarity
    Disulfide bondi60 ↔ 66By similarity
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi110 ↔ 186By similarity
    Disulfide bondi131 ↔ 169By similarity
    Disulfide bondi157 ↔ 181By similarity
    Disulfide bondi191 ↔ 268By similarity
    Disulfide bondi194 ↔ 324By similarity
    Disulfide bondi212 ↔ 251By similarity
    Disulfide bondi240 ↔ 263By similarity
    Disulfide bondi283 ↔ 361By similarity
    Glycosylationi296 – 2961N-linked (GlcNAc...)1 Publication
    Disulfide bondi304 ↔ 343By similarity
    Disulfide bondi332 ↔ 355By similarity
    Disulfide bondi370 ↔ 448By similarity
    Disulfide bondi391 ↔ 431By similarity
    Disulfide bondi419 ↔ 443By similarity
    Disulfide bondi468 ↔ 588Interchain (between alpha and beta chains)
    Disulfide bondi507 ↔ 523By similarity
    Disulfide bondi602 ↔ 667By similarity
    Glycosylationi615 – 6151N-linked (GlcNAc...)1 Publication
    Disulfide bondi632 ↔ 646By similarity
    Disulfide bondi657 ↔ 685By similarity

    Post-translational modificationi

    Cleaved after Arg-483, probably by HPN/Hepsin, to yield the active form consisting of two disulfide-linked chains.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP26927.
    PaxDbiP26927.
    PRIDEiP26927.

    PTM databases

    PhosphoSiteiP26927.

    Miscellaneous databases

    PMAP-CutDBP26927.

    Expressioni

    Gene expression databases

    BgeeiP26927.
    CleanExiHS_MST1.
    GenevestigatoriP26927.

    Organism-specific databases

    HPAiHPA024036.

    Interactioni

    Subunit structurei

    Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts (via beta chain) with MST1R (via SEMA domain).3 Publications

    Protein-protein interaction databases

    BioGridi110591. 4 interactions.
    DIPiDIP-6028N.
    IntActiP26927. 3 interactions.
    MINTiMINT-4787531.
    STRINGi9606.ENSP00000308226.

    Structurei

    Secondary structure

    1
    711
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi495 – 4995
    Beta strandi505 – 5139
    Beta strandi516 – 5205
    Helixi521 – 5233
    Beta strandi535 – 5395
    Beta strandi541 – 5444
    Beta strandi553 – 56210
    Beta strandi569 – 5768
    Beta strandi581 – 5844
    Beta strandi601 – 6088
    Beta strandi620 – 6278
    Helixi629 – 6357
    Turni636 – 6383
    Beta strandi644 – 6474
    Beta strandi664 – 6696
    Beta strandi672 – 6798
    Beta strandi683 – 6864
    Beta strandi692 – 6965
    Helixi697 – 6993
    Helixi701 – 7077

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2ASUX-ray1.85A465-483[»]
    B484-711[»]
    ProteinModelPortaliP26927.
    SMRiP26927. Positions 22-709.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP26927.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 10585PANPROSITE-ProRule annotationAdd
    BLAST
    Domaini110 – 18677Kringle 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini191 – 26878Kringle 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini283 – 36179Kringle 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini370 – 44879Kringle 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini484 – 709226Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Plasminogen subfamily.PROSITE-ProRule annotation
    Contains 4 kringle domains.PROSITE-ProRule annotation
    Contains 1 PAN domain.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Kringle, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000112892.
    HOVERGENiHBG004381.
    InParanoidiP26927.
    PhylomeDBiP26927.

    Family and domain databases

    Gene3Di2.40.20.10. 4 hits.
    InterProiIPR024174. HGF_MST1.
    IPR000001. Kringle.
    IPR013806. Kringle-like.
    IPR018056. Kringle_CS.
    IPR003014. PAN-1_domain.
    IPR003609. Pan_app.
    IPR001254. Peptidase_S1.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00051. Kringle. 4 hits.
    PF00024. PAN_1. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001152. HGF_MST1. 1 hit.
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00130. KR. 4 hits.
    SM00473. PAN_AP. 1 hit.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    SSF57440. SSF57440. 4 hits.
    PROSITEiPS00021. KRINGLE_1. 4 hits.
    PS50070. KRINGLE_2. 4 hits.
    PS50948. PAN. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P26927-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGWLPLLLLL TQCLGVPGQR SPLNDFQVLR GTELQHLLHA VVPGPWQEDV    50
    ADAEECAGRC GPLMDCRAFH YNVSSHGCQL LPWTQHSPHT RLRRSGRCDL 100
    FQKKDYVRTC IMNNGVGYRG TMATTVGGLP CQAWSHKFPN DHKYTPTLRN 150
    GLEENFCRNP DGDPGGPWCY TTDPAVRFQS CGIKSCREAA CVWCNGEEYR 200
    GAVDRTESGR ECQRWDLQHP HQHPFEPGKF LDQGLDDNYC RNPDGSERPW 250
    CYTTDPQIER EFCDLPRCGS EAQPRQEATT VSCFRGKGEG YRGTANTTTA 300
    GVPCQRWDAQ IPHQHRFTPE KYACKDLREN FCRNPDGSEA PWCFTLRPGM 350
    RAAFCYQIRR CTDDVRPQDC YHGAGEQYRG TVSKTRKGVQ CQRWSAETPH 400
    KPQFTFTSEP HAQLEENFCR NPDGDSHGPW CYTMDPRTPF DYCALRRCAD 450
    DQPPSILDPP DQVQFEKCGK RVDRLDQRRS KLRVVGGHPG NSPWTVSLRN 500
    RQGQHFCGGS LVKEQWILTA RQCFSSCHMP LTGYEVWLGT LFQNPQHGEP 550
    SLQRVPVAKM VCGPSGSQLV LLKLERSVTL NQRVALICLP PEWYVVPPGT 600
    KCEIAGWGET KGTGNDTVLN VALLNVISNQ ECNIKHRGRV RESEMCTEGL 650
    LAPVGACEGD YGGPLACFTH NCWVLEGIII PNRVCARSRW PAVFTRVSVF 700
    VDWIHKVMRL G 711
    Length:711
    Mass (Da):80,320
    Last modified:May 15, 2007 - v2
    Checksum:i2E4B3C7D4AA9B566
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti292 – 2921R → G AA sequence (PubMed:1827141)Curated
    Sequence conflicti304 – 3041C → E AA sequence (PubMed:1827141)Curated
    Sequence conflicti306 – 3061R → E AA sequence (PubMed:1827141)Curated
    Sequence conflicti550 – 5501Missing AA sequence (PubMed:1827141)Curated
    Sequence conflicti593 – 5931W → E AA sequence (PubMed:1827141)Curated
    Sequence conflicti623 – 6231L → F in AAA59872. (PubMed:8393443)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti13 – 131C → Y.1 Publication
    VAR_006631
    Natural varianti212 – 2121C → F.
    VAR_006632
    Natural varianti551 – 5511S → G.
    Corresponds to variant rs6791037 [ dbSNP | Ensembl ].
    VAR_059787
    Natural varianti676 – 6761E → K.
    Corresponds to variant rs7798 [ dbSNP | Ensembl ].
    VAR_014569
    Natural varianti689 – 6891R → C Common polymorphism; may be associated with inflammatory bowel disease; results in reduced binding affinity to MST1R. 2 Publications
    Corresponds to variant rs3197999 [ dbSNP | Ensembl ].
    VAR_070224

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M74178 mRNA. Translation: AAA50165.1.
    U37055 Genomic DNA. Translation: AAC50471.1.
    L11924 mRNA. Translation: AAA59872.1.
    AC099668 Genomic DNA. No translation available.
    BC048330 mRNA. Translation: AAH48330.1.
    PIRiA40331. A47136.
    RefSeqiNP_066278.3. NM_020998.3.
    UniGeneiHs.349110.
    Hs.512587.

    Genome annotation databases

    EnsembliENST00000383728; ENSP00000373234; ENSG00000173531.
    GeneIDi4485.
    KEGGihsa:4485.

    Polymorphism databases

    DMDMi147744563.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M74178 mRNA. Translation: AAA50165.1 .
    U37055 Genomic DNA. Translation: AAC50471.1 .
    L11924 mRNA. Translation: AAA59872.1 .
    AC099668 Genomic DNA. No translation available.
    BC048330 mRNA. Translation: AAH48330.1 .
    PIRi A40331. A47136.
    RefSeqi NP_066278.3. NM_020998.3.
    UniGenei Hs.349110.
    Hs.512587.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2ASU X-ray 1.85 A 465-483 [» ]
    B 484-711 [» ]
    ProteinModelPortali P26927.
    SMRi P26927. Positions 22-709.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110591. 4 interactions.
    DIPi DIP-6028N.
    IntActi P26927. 3 interactions.
    MINTi MINT-4787531.
    STRINGi 9606.ENSP00000308226.

    Chemistry

    ChEMBLi CHEMBL6042.

    Protein family/group databases

    MEROPSi S01.975.

    PTM databases

    PhosphoSitei P26927.

    Polymorphism databases

    DMDMi 147744563.

    Proteomic databases

    MaxQBi P26927.
    PaxDbi P26927.
    PRIDEi P26927.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000383728 ; ENSP00000373234 ; ENSG00000173531 .
    GeneIDi 4485.
    KEGGi hsa:4485.

    Organism-specific databases

    CTDi 4485.
    GeneCardsi GC03M049696.
    H-InvDB HIX0024339.
    HGNCi HGNC:7380. MST1.
    HPAi HPA024036.
    MIMi 142408. gene.
    neXtProti NX_P26927.
    Orphaneti 171. Primary sclerosing cholangitis.
    PharmGKBi PA31185.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000112892.
    HOVERGENi HBG004381.
    InParanoidi P26927.
    PhylomeDBi P26927.

    Enzyme and pathway databases

    SignaLinki P26927.

    Miscellaneous databases

    EvolutionaryTracei P26927.
    GeneWikii MST1.
    GenomeRNAii 4485.
    NextBioi 17351.
    PMAP-CutDB P26927.
    PROi P26927.
    SOURCEi Search...

    Gene expression databases

    Bgeei P26927.
    CleanExi HS_MST1.
    Genevestigatori P26927.

    Family and domain databases

    Gene3Di 2.40.20.10. 4 hits.
    InterProi IPR024174. HGF_MST1.
    IPR000001. Kringle.
    IPR013806. Kringle-like.
    IPR018056. Kringle_CS.
    IPR003014. PAN-1_domain.
    IPR003609. Pan_app.
    IPR001254. Peptidase_S1.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00051. Kringle. 4 hits.
    PF00024. PAN_1. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001152. HGF_MST1. 1 hit.
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00130. KR. 4 hits.
    SM00473. PAN_AP. 1 hit.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    SSF57440. SSF57440. 4 hits.
    PROSITEi PS00021. KRINGLE_1. 4 hits.
    PS50070. KRINGLE_2. 4 hits.
    PS50948. PAN. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor."
      Han S., Stuart L.A., Friezner Degen S.J.
      Biochemistry 30:9768-9780(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT TYR-13.
      Tissue: Liver.
    2. "Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3."
      Yoshimura T., Yuhki N., Wang M.H., Skeel A., Leonard E.J.
      J. Biol. Chem. 268:15461-15468(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    3. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity."
      Skeel A., Yoshimura T., Showalter S.D., Tanaka S., Appella E., Leonard E.J.
      J. Exp. Med. 173:1227-1234(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 230-247; 288-310; 326-341; 484-501; 530-552; 574-596 AND 602-611, SUBUNIT.
      Tissue: Plasma.
    6. "Macrophage stimulating protein (MSP) binds to its receptor via the MSP beta chain."
      Wang M.H., Julian F.M., Breathnach R., Godowski P.J., Takehara T., Yoshikawa W., Hagiya M., Leonard E.J.
      J. Biol. Chem. 272:16999-17004(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MST1R.
    7. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-296.
      Tissue: Plasma.
    8. Cited for: POSSIBLE INVOLVEMENT IN INFLAMMATORY BOWEL DISEASE, VARIANT CYS-689.
    9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-615.
      Tissue: Liver.
    10. "Genome-wide association identifies multiple ulcerative colitis susceptibility loci."
      McGovern D.P., Gardet A., Torkvist L., Goyette P., Essers J., Taylor K.D., Neale B.M., Ong R.T., Lagace C., Li C., Green T., Stevens C.R., Beauchamp C., Fleshner P.R., Carlson M., D'Amato M., Halfvarson J., Hibberd M.L.
      , Lordal M., Padyukov L., Andriulli A., Colombo E., Latiano A., Palmieri O., Bernard E.J., Deslandres C., Hommes D.W., de Jong D.J., Stokkers P.C., Weersma R.K., Sharma Y., Silverberg M.S., Cho J.H., Wu J., Roeder K., Brant S.R., Schumm L.P., Duerr R.H., Dubinsky M.C., Glazer N.L., Haritunians T., Ippoliti A., Melmed G.Y., Siscovick D.S., Vasiliauskas E.A., Targan S.R., Annese V., Wijmenga C., Pettersson S., Rotter J.I., Xavier R.J., Daly M.J., Rioux J.D., Seielstad M.
      Nat. Genet. 42:332-337(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE INVOLVEMENT IN INFLAMMATORY BOWEL DISEASE, VARIANT CYS-689.
    11. Cited for: PROTEOLYTIC CLEAVAGE.
    12. "Protein characterization of a candidate mechanism SNP for Crohn's disease: the macrophage stimulating protein R689C substitution."
      Gorlatova N., Chao K., Pal L.R., Araj R.H., Galkin A., Turko I., Moult J., Herzberg O.
      PLoS ONE 6:E27269-E27269(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MST1R, CHARACTERIZATION OF VARIANT CYS-689.
    13. "Crystal structure of the beta-chain of human hepatocyte growth factor-like/macrophage stimulating protein."
      Carafoli F., Chirgadze D.Y., Blundell T.L., Gherardi E.
      FEBS J. 272:5799-5807(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 465-711, INTERCHAIN DISULFIDE BOND.

    Entry informationi

    Entry nameiHGFL_HUMAN
    AccessioniPrimary (citable) accession number: P26927
    Secondary accession number(s): A6NLA3
    , A8MSX3, Q13350, Q14870, Q6GTN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 151 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Although related to peptidase S1 family, the active site residues characteristic of serine proteases appear to be absent from this protein, which may therefore lack protease activity.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Peptidase families
      Classification of peptidase families and list of entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3